Pharmaceutical compositions

ABSTRACT

Compositions, methods, etc. for addressing the first-pass effect.

BACKGROUND OF THE INVENTION

[0001] 1. Field of the Invention

[0002] The present invention relates to anti-first-pass effectcompounds, compositions, and methods for their use, preparation,synthesis, and formulation. Preferably, the invention compounds andcompositions are provided as a dietary supplement or as a medical foodor as some other type of food product, or as a drug, pharmaceutical ordrug preparation, or in some other physical form. In addition to anyother function they have, the invention compounds and compositionsfunction as inhibitors of the first-pass effect of orally-administereddrugs. Beneficiaries of this invention are animals, preferably mammals,particularly, humans, who require drugs, etc. subject to the first-passeffect.

[0003] 2. Discussion of the Background

[0004] The “first-pass effect” of drugs given orally refers to theprocess of drug degradation during a drug's transition from initialingestion to circulation in the blood stream. Often discussed in termsof “bioavailability”, it is not uncommon for a drug that is administeredto a patient orally to be given in a 5-fold or greater amount thanultimately necessary due to the degradation that occurs in the patient'sbody after intake. For example, the impact of the first-pass effect canbe demonstrated with the case of the antihistamine terfenadine, wherein99.5% of a tablet given by mouth is quickly changed to metabolites;hence, the bioavailability of terfenadine is approximately 0.5% (D.Garteiz et al., Arzneim.-Forsch., 1982; 32:1185-1190). As a furtherexample, cyclosporin A, administered to organ transplant patients, has amedian oral bioavailability of approximately 30% and a bioavailabilityrange of approximately 8-92% among patients. Because of this largeinterindividual variation in cyclosporin bioavailability, frequentmonitoring of blood concentrations during therapy initiation isnecessary.

[0005] The inhibition of a particular xenobiotic metabolism as amechanism of action generally, as well as the inhibition of thefirst-pass effect with chemical agents specifically, is well known inthe art and has been for some time. Examples include the treatment ofmethanol (wood alcohol) poisoning with ethanol and the inhibition of thefirst-pass effect of cyclosporin with ketoconazole. See, for example,First, R. M. et al., The Lancet, 1198, Nov. 18, 1989, incorporatedherein by reference.

[0006] Although the agent(s), enzyme type(s), biological processes, etc.responsible for the first-pass effect have not been fully identified,research has focused on agents capable of inhibiting the cytochrome P450system. Inhibition of the P450 system is a model for in vitrodetermination of in vivo bioavailability enhancement. See, e.g., U.S.Pat. Nos. 5,478,723 and 5,567,592, both incorporated herein byreference, for a more full description of the P450 system. As reportedby A. Keogh et al. (N. Eng. J. Med., Vol. 333, No. 10, p. 628, 1995) andS. Butman et al. (J. Heart Lung Transpl., Vol. 10, No. 3, p. 351, 1991),the dose of cyclosporin required by heart transplant patients could bereduced by approximately 85% when cyclosporin was co-administered withketoconazole. In economic terms, both references estimated the costsavings to be equal to approximately $5,000 per year per patient. Otherdrugs which are subject to the first-pass effect and whosebioavailability is increased by inhibitors commonly given to humansinclude midazolam (K. Olkkola et al., Clin. Pharmacol. Ther., 1993,53:298-305), terfenadine (Seldane®) (P. Honig et al., JAMA, Vol. 269,No. 12, 1513, 1993) and triazolam (Varhe, A. et al, Clin. Pharmocol.Ther., 1994, 56:601-7).

[0007] In addition to ketoconazole, the drugs fluconazole, ritonavir,itraconazole, micronazole, erythromycin and troleandomycin have beenidentified as inhibitors of the first-pass effect, in addition to anypharmacological effect they possess. These compounds, however, areantiviral, antimicrobial, or antifungal agents. Because of theheightened current awareness of the fact that overuse of such agents canresult in resistant microbial strains, because some of the mosteffective inhibitors are antimicrobials, and because transplant andHIV-infected patients have compromised immune systems, the use of theseinhibitors of the first-pass effect has significant drawbacks and, forexample, in the case of ketoconazole, the purposeful co-administrationof this inhibitor with drugs susceptible to the first-pass effect hasnot become widespread. In fact, the emergence of antifungal drugresistance in immunocompromised patients is already known (T. J. Walsh:“Emergence of Antifungal Drug Resistance in Immunocompromised Patients”Seminar, National Institutes of Health, Feb. 7, 1996; Georgopapadakou,N. H. et al, Antimicrobial Agents and Chemotherapy, February 1996, p.279-291).

[0008] Dietary supplements, medicines, compounds, extracts, etc. thatare based on materials isolated from nature are increasingly beingstudied and made available to consumers. This trend is largely due tothe fact that obtaining patent protection for these materials has becomeroutine (see, for example, U.S. Pat. Nos. 4,708,948, 5,409,938,5,314,899, 5,591,770 and 5,654,432, all incorporated herein byreference). Not surprisingly, this trend is now spreading to first-passeffective agents.

[0009] In 1991, Bailey et al. reported (Bailey, D. G., et al, TheLancet, Vol. 337, Feb. 2, 1991, p. 268, incorporated herein byreference) that grapefruit juice increased the bioavailability offelodipine, and indicated that the inhibition of cytochrome P450 enzymesby bioflavonoids could explain their findings. This identification ofbioflavonoids as the active ingredient in grapefruit juice wasimmediately challenged by R. Chayen et al. (The Lancet, Vol. 337, Apr.6, 1991, p. 854) who suggested that sesquiterpenoid compounds ratherthan flavonoids were the active ingredients in grapefruit juiceresponsible for inhibition of the first-pass effect. Although Bailey andEdgar were granted a patent (U.S. Pat. No. 5,229,116, incorporatedherein by reference) directed to a method of increasing thebioavailability of a pharmaceutical agent by co-administration of aflavonoid such as naringin, their own recent work has openly broughtinto question the accuracy of their initial identification of flavonoidsas active ingredient. See, for example, Bailey et al., Clin.Pharmacokinet. 26 (2): 91-98, 1994, particularly pages 95 and 96thereof. See also Edwards, D. J. et al, Life Sciences, Vol. 59, No. 13,pp. 1025-1030, 1996.

[0010] The reported effects of grapefruit juice as an effectiveinhibitor of the first-pass effect has lead to numerous researcharticles regarding the inhibition of the first-pass effect by grapefruitjuice on. e.g., nifedipine, nitrendipine, nisoldipine, cyclosporin A,midazolam, triazolam, coumarin, and caffeine. As these results havebecome better known, the so-called “grapefruit juice effect” has becomethe subject of newspaper articles, newsletters and medical textsintended for the general public. See, for example, “The Medical Letter”,Vol. 37 (issue 955) Aug. 18, 1995. The Peoples Pharmacy, Chapter 4 (St.Martin's Press) 1996, p. 41, the Feb. 19, 1991 newspaper articleregarding felodopine and grapefruit juice in the New York Times (sectionC, page 3, column 1) and a recent article in the Washington Post(Section A, p. 11, Aug. 30, 1996).

[0011] A review of the published studies that demonstrate the grapefruitjuice effect also shows that the magnitude of the effect varies widely,and it is the present inventors' suspicion that this variation istraceable to the source of the juice. In fact, the production ofcommercial citrus juice involves a complicated series of factors thatincrease the variability of the final product's composition. Thesefactors include the squeezing technique, the concentration technique,the origin of the fruit, the ripeness of the fruit at harvest, theadmixture of fruits differing in origin and ripeness, the admixture ofjuice and fruit tailings, etc. Because the active agents in thegrapefruit juice that inhibit the first-pass effect were unknown ormisidentified, scientists and consumers could not choose a grapefruitjuice preparation and rely upon its utility to inhibit the first-passeffect.

[0012] Moreover, grapefruit juice in particular and citrus products ingeneral are known to contain phototoxic furocoumarin derivativesincluding psoralen, xanthotoxin and bergapten. While these compounds areuseful for the controlled, clinical treatment of selected dermatologicaldiseases including vitiligo, psoriasis and mycosis fungoides, they arealso known to be toxic, in particular, phototoxic. Thestructure-activity relationship for the pbototoxicity of furocoumarinshas been clearly delineated from human studies (for example, L. Musajoet al, Herba Hungarica, 1971, Tom. 10, No. 2-3, pp. 79-94), and thesestudies show that photosensitizing activity is removed by ringhydroxylation or by lengthening the alkyl-chain length of ethersubstituents.

[0013] Careful evaluation of the literature shows that psoralen andcertain low carbon number ether-substituted furocoumarins that are givento humans in large doses do inhibit cytochrome P450. See, for example,D. Bickers et al., J. Investigative Dermatology, 79:201-205, 1982, M.Tinel et al., Biochemical Pharmacology, Vol. 36, No. 6, 951-955, 1987,H. Fouin-Fortunet et al., J. Pharm. Experimental Therapeutics, Vol. 236,No. 1,237-247, 1986, and D. Mays et al, Clin. Pharmacol. Ther.,42:621-626, 1987. Thus, and because the known successful inhibitors ofthe first-pass effect generally inhibit cytochrome P450, a temptingconclusion, particularly in view of the recent disclaimers by Bailey,are others, is that these low molecular weight furocoumarins present incitrus are the active first-pass inhibitors in grapefruit juice. Infact, and as will be described more fully below with regard to thepresent invention, the present inventor has found that this is not thecase. Because the present inventor has discovered specific compoundsthat inhibit the first-pass effect it is now possible to produce areliable, safe composition that both inhibits the first-pass effect and,if desired, that is citrus-based or of citrus origin and which containsno or reduced amounts of low molecular weight phototoxic furocoumarins.

BRIEF DESCRIPTION OF THE DRAWINGS

[0014]FIG. 1 shows inhibitor results for various inhibitors.

[0015]FIG. 2 shows inhibitor results for various inhibitors.

OBJECTS OF THE PRESENT INVENTION

[0016] It is one object of this invention to provide chemical compoundsand compositions that inhibit the first-pass effect and which are in aform, concentration, purity, etc. other than that which is naturally orcommercially occurring.

[0017] Another object of the present invention is to provide a reliable,safe citrus-based or citrus-origin product that comprises one or moreinvention compounds in non-naturally and non-commercially occurringamounts and inhibits the first-pass effect and which, optionally, isfree of or contains a reduced amount (as compared to a naturally orcommercially occurring amount) of phototoxic and, optionally,non-first-pass inhibiting low molecular weight furocoumarins, which isuseful as a food or dietary supplement, a pharmaceutical, a drug, etc.

[0018] Another object of the present invention is to provide acomposition comprising one or more invention compounds that is effectiveagainst the first-pass effect.

[0019] Another object of the present invention is to provide acomposition that contains one or more of the invention compounds and noor reduced amounts as compared to naturally or commercially occurringamounts of phototoxic low molecular weight furocoumarins.

[0020] Another object of the present invention is to provide acomposition comprising at least one invention compound and providingconsistent and reliable first-pass inhibiting activity.

[0021] Another object of the present invention is to provide theabove-described compounds and compositions as a component of productsand mixtures that provide active ingredients, therapeutic agents, drugs,etc. or other substances that are subject to the first-pass effect inhumans.

[0022] Another object of the present invention is to provide first-passeffect inhibiting compounds, also called bioenhancers and inhibitorsherein, in non-natural and non-commercially occurring forms.

[0023] Another object of the present invention is to provide mixtures ofone or more invention firs-pass effect inhibiting compounds with varioustherapeutic agents, active agents, drugs or other substances(hereinafter referred to as “drugs”) that are subject to the first-passeffect.

[0024] Another object of the present invention is a method forinhibiting the first-pass effect in human patients, animals, etc. takingdrugs having a first-pass effect.

[0025] Another object of the present invention is a method for preparingthe above-described compositions, compounds, mixtures. etc.

[0026] Another object of the present invention is a method for preparinga citrus-based or citrus-origin composition containing no or reducedamounts as compared to naturally and commercially occurring amounts ofphototoxic and non-first-pass inhibiting furocoumarins preferably usingreagents that the U.S. Food and Drug Administration regards may be usedfor food or drug manufacturing, including GRAS materials (in thisapplication, “non-first-pass inhibiting” includes first-pass activityprovided by 2000 nM bergamottin or imperatorin according to Protocol Cor C′ herein).

[0027] Another object of the present invention is to provide and usefirst-pass effective compounds and compositions containing a first passeffective amount (in aggregate or individually) of at least oneinvention compound in isolated form and/or pyrogen-free form and/orsterile form and/or substantially pure form and/or pharmaceutical formand/or chemically pure form and/or in a form comprising a higherconcentration or purity of invention compounds than found both in natureand commercially. As used herein “commercially” means products producedand sold locally, nationally and internationally, especially by thecitrus-processing industry. These forms, as their names specify, aredifferent from the invention compounds, as they naturally occur in, forexample, commercial citrus and in citrus products such as juice, coldpressed oils, juice concentrates, oils, etc.

[0028] Another object of the invention is to provide a method ofinhibiting the first-pass effect by administration of at least oneinvention compound, composition etc. to humans.

[0029] These and other objects will become apparent to those of ordinaryskill in this art upon a full appreciation of the invention as describedbelow with regard to preferred embodiments.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

[0030] The present inventor has discovered chemical compounds whichinhibit the first-pass effect of orally administered drugs in humans.The present inventor has also discovered that phototoxic low molecularweight furocoumarins and certain ether-substituted furocoumarins thatare naturally present in citrus extracts, juices, byproducts, etc. maybe removed therefrom or reduced in concentration without destroying thefirst-pass effect inhibiting compounds therein. The present inventor hasalso discovered a method for preparing citrus-based compositions usingonly FDA or USP acceptable reagents. The present invention has beencompleted on the basis of these findings and will be described in moredetail below.

[0031] The invention chemical compounds which inhibit the first-passeffect in animals, including humans, are, in one preferred embodiment,compounds according to the following Formulae I-IV:

[0032] In each of the above structures, R is, independently, H or anoptionally substituted C₁-C₁₅ alkyl group,

[0033] L is an optionally substituted C₁-C₁₅ linear or branched,saturated, monounsaturated or polyunsaturated alkyl group optionallyinterrupted by one or plural nonadjacent sulfur or oxygen atoms andoptionally terminated at one or both ends by oxygen,

[0034] HAr is an optionally substituted C₆-C₂₄ aromatic group orheteroaromatic group optionally containing one or plural ring atomsselected from the group consisting of N, O, S, and P,

[0035] and E is —OH, —COOH, —COOR (where R is defined above) or anoptionally substituted C₁-C₈ linear or branched, saturated,monounsaturated or polyunsaturated alkyl group optionally interrupted byone or plural nonadjacent oxygen or sulfur atoms, or E is a C₃-C₈optionally substituted cyclic saturated, monounsaturated orpolyunsaturated alkyl group optionally interrupted by one or pluralnonadjacent oxygen or sulfur atoms, or E is optionally substituted HAr.Preferably, the compounds of Formulae I-IV as well as those describedbelow do not contain a peroxide (0-0) group. Disulfide groups (S—S) arenot preferred, but may be present. Preferably E is an epoxide ordihydroxy radical such as —CH(OH)₂. E may also be an acid-opened epoxidegroup.

[0036] The compounds of the invention as described above are unlimitedwith regard to stereochemistry, E-Z isomerism and all possibilities areincluded. Racemic mixtures are included as are each and every enantiomerand diasteriomer. Preferred stereochemistry is shown later.

[0037] The groups R, L, HAr, and E may optionally be substituted with aC₁-C₆ linear, branched or cyclic alkyl group, —OH, a halogen atom, aC₁-C₅ alkoxy group, a C₁-C₅ alkyl carbonyloxy group, a C₁-C₅alkoxycarbonyl group, etc. Such substituents also may be optionallysubstituted directly on the ring structures of Formulae I-IV regardlessof whether such substituents appear on R, L, HAr or E.

[0038] A second preferred embodiment of the present invention chemicalcompounds which inhibit the first-pass effect are depicted by FormulaeV-X:

[0039] As noted above for Formulae I-IV, Formulae V-X are unlimited withregard to stereochemistry, E-Z isomerism, etc.

[0040] The most preferred compounds according to the present invention,which inhibit the first-pass effect, are those according to the secondembodiment above and having the following stereochemistry (formulaeXI-XVI):

[0041] The compositions of the present invention contain at least oneinvention first-pass effective chemical compound preferably in afirst-pass effective amount. Citrus-based compositions of the inventionfurther contain a citrus-derived extract, concentrate, peel, juice, oil,by-product, etc., (hereinafter referred to as the citrus-derivedsubstance) and may be provided by any combination of these forms and maybe derived from more than one citrus fruit. Useful citrus fruits hereininclude grapefruit, lemon, lime and, preferably, any citrus fruitnaturally containing an invention first-pass effect inhibiting compoundor mixture of such compounds. Prior work in the field indicates that acommon type of orange (Citrus sinensis) does not inhibit the first-passeffect. Citrus fruits that contain one or more substances that inhibitthe first-pass effect are included in the invention, including all crossbreeds, etc. and are referred to herein as “first-pass citrus”. Apreferred citrus fruit useful in the present invention is grapefruit.

[0042] First-pass effective compounds, substances and compositionsdescribed herein are materials that prevent or retard the degradation oforally administered drugs in the body. Preferably, the first-passeffective materials of the invention, including substances,compositions, mixtures, invention compounds, etc. increase drugbioavailability by at least 1%, preferably by more than 5% and mostpreferably by more than 15% including 20, 25, 30, 35, 40, 45, 50, 55,60, 65, 70, 75, 80, 85, 90, 100, 150, 200, 250, 300, etc. percent asmeasured by the Area Under the Curve (AUC) method. See U.S. Pat. No.5,567,592 incorporated herein by reference. A several-fold, including 5,10, 15, 20-fold, etc. increase in bioavailability (i.e., severalhundreds or thousands of percent AUC increase) is not unusual with thepresent invention. The first-pass effectiveness of invention compounds,composition, mixtures, materials, etc. may also be measured by, andpreferably meet the criteria of, the methods and characterizationsdescribed in WO 97/15269, U.S. Pat. No. 5,665,386 and PCT/US96/09607,all incorporated herein by reference.

[0043] Preferred citrus-derived substances of the invention includecold-pressed citrus oil, particularly cold-pressed grapefruit, lime,lemon, etc., oil, and citrus by-products including tailings from citruspacking/juice plants. Cold-pressed citrus oils, including cold-pressedorange (except Citrus sinensis), grapefruit lime and lemon oil, arecommodities and are described, for example, in the Food Chemicals Codex,Fourth Edition, National Academy Press, Washington, D.C. 1996,incorporated herein by reference. Other citrus-derived substances usefulherein include the various other citrus oils (distilled, essential,desert type, etc.), bitter cold-pressed oils, etc. Geographical originof the invention citrus providing the citrus-derived substance isunimportant herein. Citrus juices or peel (rind) may also be used, aswell as any first-pass effective solid, semi-solid or liquid portion ofa first-pass citrus. Mixtures may be used.

[0044] The citrus-derived substance present in invention compositionsmay make up the entire citrus-based composition or may be only a partthereof. Thus, if the citrus-based substance is prepared such that itcontains one or more compounds according to Formulae I-XVI in afirst-pass effective amount no further compound need be added. Foodgrade or pharmaceutically acceptable diluents, excipients, carriers,etc., may be added, if desired.

[0045] The citrus-derived substance of the present invention compositionis preferably treated so as to reduce the amount of phototoxic and,optionally, non-first-pass effective, furocoumarins naturally presenttherein. Preferably, these furocoumarins are completely removed, meaningthat they are removed to an extent such that their presence isundetectable by liquid and, preferably, gas chromatography.

[0046] The invention method for removing phototoxic low molecular weightfurocoumarins from invention citrus-derived components preferablycomprises optional removal of volatile components (components removedafter 12-48 h at a pressure of 10⁻²-10⁻³ Torr) and extraction withmixtures of at least one C₁-C₁₀ alcohol (preferably ethanol) and water,optionally in the presence of base. In certain situations it ispreferable not to remove volatile components such as naturally-occurringterpenes but rather to use these volatiles essentially as solvent infurther processing. The extraction mixture of alcohol and water may bediscarded and what is left is useful herein. C₂-C₅ alcohols are alsopreferred as are C₂ and C₃ and C₄ alcohols. The alcohol (ethanol) mayeither be 100% alcohol or may be conveniently supplied and used incommonly available alcohol-water dilutions (e.g., 95% ethanol/5% water,etc.). In all cases the alcohol (ethanol) reagent is preferably U.S.P.grade or better. The water used herein for extracting the inventioncitrus-derived substance (component) is preferably distilled water, andis also preferably U.S.P. grade or better. Any combination of solventsor single solvent may be used herein for extraction. The solvent(s) arepreferably FDA acceptable for food and drug manufacturing.

[0047] The present invention method for removing phototoxic lowmolecular weight furocoumarins may include successive extractions withalcohol (ethanol)/water mixtures, and the successive alcohol(ethanol)/water mixtures used may either be of the same volume ratio ordifferent volume ratios. Preferred alcohol (ethanol):water volume ratiosrange from 1:10-10:1, are more preferably 1:1 (±3%, 5%, 8% or 10%) andmay be 20-80 or 45-60% alcohol (ethanol) on a volume/volume basis, andinclude 2:1, 3:1, 1:2, 1:3, etc. as well as 55/45, 60/40, 65/35, 70/30,10/90, 15/85, 20/80, 25/75, 30/70, 35/65, 40/60, 45/55, 40/60, 35/65,30/70, etc. alcohol/water. The extractions may be accomplished by anymethod known in the art including liquid-liquid extraction, liquid-solidextraction, continuous extraction etc. When the raw material used toprepare the invention citrus-derived extract is, for example, an oil,the alcohol (ethanol)/water mixture used for extraction can be simplyadded thereto, shaken therewith, and separated naturally or with thehelp of a centrifuge. Repeated extraction is helpful, as are continuousextraction methods such as countercurrent extraction, etc.

[0048] As noted above, base is preferably used in removing phototoxicfurocoumarins and may be added to the water or alcohol or both.Preferred bases are the alkali and alkaline earth hydroxides and oxides,most preferably sodium hydroxide and potassium hydroxide. The base isgenerally present in amounts from 0.01-80 grams per liter ofalcohol/water mixture.

[0049] Preferably, the invention method for removing phototoxic lowmolecular weight furocoumarins significantly diminishes, and preferablycompletely removes beyond the detection limits of liquid and,preferably, gas chromatography, methoxy-substituted linear and angularfurocoumarins including xanthotoxin (8-methoxypsoralen), bergapten(5-methoxypsoralen), isobergapten, isopimpinellin, etc., andunsubstituted linear and angular furocoumarins (psoralen, angelicin,etc.). Furocoumarins that have been determined herein to be ineffectivefirst-pass effect furocoumarins may also be removed, if desired. Thesecompounds include bergamottin, psoralen, angelicin, isopimpinellin,marmin, 6′,7′-dihydroxybergamottin, and imperatorin.

[0050] The invention citrus-derived substance, invention compositions,invention mixtures, invention pharmaceutical compositions, etc.preferably contain a first-pass effective amount of at least onefirst-pass effective compound of Formulae I-XVI above. In thealterative, several compounds of Formulae I-XVI may be present, each innon-first-pass effective amounts where the sum of the concentrations ofsaid compounds provides first-pass effectiveness.

[0051] In addition to the description above, one or more of the hydrogenatoms depicted in these formulae (i.e., Formulae I-XVI) may be replacedby one or any combination of two or more of hydroxy, halogen, linear orbranched C₁-C₄₀ hydrocarbon, C₁-C₄₀ linear or branched ether (—OR whereR is linear or branched hydrocarbon), C₁-C₄₀ alkylhydroxy (—ROH where Ris linear or branched hydrocarbon and OH is bonded to a primary,secondary or tertiary carbon), etc. As used herein “hydrocarbon” meansbranched and linear alkyl and branched and linear alkenyl. Alkenyl isany hydrocarbon with at least one double bond but including multipleconjugated and nonconjugated double bonds. All salts, particularlypharmaceutically acceptable salts, and stereoisomers, physical forms,etc. are also included. The compounds described in formulae I-XVI may besynthesized by any general technique known in the art, and theirsynthesis is within the skill of the ordinary artisan in this field. Nowthat they have been identified they can also be isolated from acitrus-derived substance as shown herein.

[0052] Preferred methods for making the invention compounds of FormulaeI-XVI include the following schemes:

[0053] Such reactions are within the skill of the ordinary artisan. See,for example, Chemistry Letters, 2019-2022, 1990, Can. J. Chem.,63:2673-2678, 1985, Australian journal of Chemistry, 42:1235-1248, 1989,East German patent DD 275687 and Soviet Union patent SU 1397449, allincorporated herein by reference. Although each of the reaction schemashown above yield either Formulae I+II or Formulae III+IV, each methodcan give Formulae I-IV if the appropriate reactants are used. Thepresent invention compounds, citrus-derived substance, mixtures,pharmaceutical compositions, etc. preferably contain at least onecompound according to Formulae I-XVI above. Mixtures may be used.

[0054] The use of present invention citrus-derived substance,compositions, mixtures, inhibitors, compounds, etc. are not limited andmay preferably be administered in amounts of 2 nanograms-2 g and moreper patient per day to increase the bioavailability of drugs takenorally by a patient. Compositions of the invention may contain,preferably, more of the invention compounds than naturally present incitrus products. Dosages are determinable by those of ordinary skill inthe art and depend upon the extent to which a e.g., active agent (drug)is subject to the first-pass effect, etc. Dosage forms include oraladministration forms, topical administration forms, injection forms. Theinvention compounds, citrus-derived substance, compositions, mixtures,etc. may optionally be part of or added to a citrus-based composition orother edible material which is preferably a taste-masking flavor, juice,etc.

[0055] The citrus-derived substance, mixtures, compositions andcompounds of the invention inhibit the first-pass effect of drugs takenorally by humans and other animals. A “first-pass effective amount” ofan invention material is any amount that increases the oralbioavailability of any substance by any amount (e.g., 1%, 5%, 10%, etc.;see above where the AUC method is described, including all values andranges between these values) as compared to the case where no inventionmaterial is administered in such a situation. A “first-pass effective”invention citrus-derived substance, mixture, composition or compound isa material that inhibits the observed first-pass effect of at least onedrug in an animal, preferably a human, preferably the first-pass effectcaused by the cytochrome P450 system. This is also referred to herein asanti-first-pass activity. Administration is preferablyco-administration, meaning just before, just after, or with drug, activeagent, therapeutic agent, medical food, etc. subject to the first-passeffect. “Just before” and “just after” include all times where theinvention material provides a benefit by inhibiting the first-passeffect. Preferred forms of the invention comprise the inventioncompounds, citrus-derived substance, mixture, composition, etc. insideof, e.g., a gel capsule, or co-formulated with food-grade orpharmaceutically-acceptable binders, diluents, etc. Dosage forms (saltor base, tablet or gum, etc.) as well as binders, salt forms,excipients, etc. which are useful are found in, e.g., U.S. Pat. Nos.5,576,448, 5,576,446, 5,576,437, 5,576,439, 5,576,438, 5,576,337,5,576,339 and 5,576,336, all incorporated herein by reference. Theinvention citrus-derived substance, mixtures, compositions and compoundsare preferably provided in an amount that provides consistent, reliablepotency from batch to batch regardless of the form in which it isprovided.

[0056] The word “drug” as used herein is defined as a chemical capableof administration to an organism which modifies or alters the organism'sphysiology. More preferably the word “drug” as used herein is defined asany substance intended for use in the treatment or prevention ofdisease, particularly for humans. Drug includes synthetic and naturallyoccurring toxins and bioaffecting substances as well as recognizedpharmaceuticals, such as those listed in Merck Index, Twelfth Ed., MerckResearch Laboratories, Whitehouse Station, N.J., 1996, “The PhysiciansDesk Reference,” 47th edition, 1993, pages 101-321; “Goodman andGilman's The Pharmacological Basis of Therapeutics” 8th Edition (1990),pages 84-1614 and 1655-1715; and “The United States Pharmacopeia, TheNational Formulary”, USP XXII NF XVII (1990), the compounds of thesereferences being herein incorporated by reference. The term drug alsoincludes compounds that have the indicated properties that are not yetdiscovered or available in the U.S. The term drug includes pro-active,activated and metabolized forms of drugs. The present invention can beused with drugs consisting of charged, uncharged, hydrophilic,zwitter-ionic, or hydrophobic species, as well as any combination ofthese physical characteristics. A hydrophobic drug is defined as a drugwhich in its non-ionized form is more soluble in lipid or fat than inwater. Preferably, a hydrophobic drug is defined as a drug more solublein octanol than in water. See U.S. Pat. No. 5,567,592, incorporatedherein by reference. The invention can be used with humans and animalssuch as mammals.

[0057] The present invention compounds and citrus-derived substances maybe co-formulated with drugs, preferably drugs that are subject to thefirst-pass effect. Preferably the drug has an oral-bioavailability of92% or less, more preferably 50% or less. Examples include, in additionto those incorporated by reference above, saquinavir, indinavir,L-deprenyl, tacrolimus, cyclosporin A (Sandimmune®), cyclosporin A(Neoral®), nelfinavir, VX-478/141W94, felodipine, nifedipine andsumatriptan. Such co-formulations include the invention citrus-derivedsubstance and/or one or more compounds in amounts mentioned above with,typically, lesser amounts than currently necessary of drug activeingredients that are subject to the first-pass effect. Binders,diluents, etc. acceptable for pharmaceutical use can also be added. Oneof ordinary skill in the art is capable of determining the dosage of theinvention compounds based on simple testing procedures well known in theart and including pharmacological expcriments which determine the amountof drug in the blood stream over a given time period afteradministration.

[0058] Other products useful for co-formulation herein are any and alldrug, medical food, or other products that are subject to the first-passeffect. Examples of drugs are listed in the Merck Index, Twelfth Ed.,Merck Research Laboratories, Whitehouse Station, N.J., 1996,incorporated herein by reference. Determining whether a substance issubject to the first-pass effect is within the skill of the averageartisan in this field.

[0059] It is preferred that invention materials be protected fromstomach acid by, e.g., a coating. Such coatings are well known in theart, and include enteric coatings, etc. See the Kirk-Othmer Encyclopediaof Chemical Technology, 3rd Ed. Vol. 17, p. 281 ff, incorporated hereinby reference. Other useful pharmaceutical forms may also be used, suchas time-release forms (coatings), hard-and soft-shell gelatin capsules,etc.

EXAMPLES

[0060] Synthesis of a Spiro Ortho Ester (Formula XVII):

[0061] Benzyl 6,7epoxygeranyl ether was placed in an evacuated chamber(0.1 torr) overnight in order to remove extraneous water from thesample; 190 mg (730 μmol) was weighed. Three equivalents of7-methoxycoumarin (0.386 g) was dissolved in 3 mL CH₂Cl₂, and thisliquid was transferred to a closed glass container. Helium was used topurge the system during the reaction period, the container wasmaintained at 5-6° C., and the reaction solution was magneticallystirred. Forty-three μL of a 1M solution of SnCl₄ in CH₂Cl₂ and 16 μmolof BF₃.Et₂O were added; 5 minutes passed, then the epoxide, dissolved in4 mL CH₂Cl₂, was added in 4 equal portions; each portion was followed by4 μmol BF₃.Et₂O. The reaction was held at 5-6° C. and stirred for 3.5hours, and the reaction apparatus was then disassembled. The reactionmixture was treated immediately as follows: the mixture contains a totalof 75 μmol of BF₃ and SnCl₄, so 3 equivalents of pyridine (225 μmol)were added (reaction mixture held at 5-6° C., with stirring) to destroythe Lewis acid catalysts. After 30 minutes of stirring, the solvent wasremoved, and the residue was dissolved in 3.16 mL of 95% ethanol; 0.6 mLof 50% KOH in water (w/v) was added, and the solution was mixedvigorously. Water (2.24 mL) was added, and this solution was then placedin a Speed Vac apparatus overnight to remove the ethanol. Approximately50% of the original volume remained. The aqueous solution was extractedtwice with 3 mL CH₂Cl₂, and the pooled CH₂Cl₂ was extracted twice with10 mL 5% KOH in water (w/v) and twice with 10 rmL 5% NaCl in water(w/v). The CH₂Cl₂ was removed, and the residue was dissolved inacetonitrile.

[0062] This acetonitrile solution may be used directly for HPLCpurification of the spiro ortho ester product via the preferredconditions that follow. Linear gradients were used for elution and wereformed by mixing mobile phase A composed of water with mobile phase Bcomposed of acetonitrile (instrument: Hewlett Packard). The elutiontime, in minutes, as well as the percentage of acetonitrile present inthe mixed mobile phase were as follows: 0, 55; 5, 55; 10, 90; 11, 98;17, 98; 18, 55; 22, 55. The chromatographic column had dimensions of 250mm length×4.6 mm internal diameter, was packed with C18 bonded to 4micron silica particles (9% carbon load; YMC, Inc.), was protected witha 23 mm length×4 mm internal diameter column containing the samematerial and with a 0.5 micron filter, and was maintained at 40±0.2° C.The flow rate was maintained at 1.0 mL/min during the 22 min run cycle.The column eluate from each 10 μL injection was monitored at 259±2 andwas fractionated using a robotic collector (Gilson). The retention timeof Formula XVII in this system was 13.4 minutes. ¹H N.M.R. δ (400 MHZ,CD₃OD) 1.15, s and 1.26, s and 1.39, s, 4′-Me (diasteriomers); 1.64, s,8′-Me; 1.6-1.9, m, H6′, 6′; 2.0-2.3, m, H7′; 3.70, s, 7-OMe; 3.83, m and4.20, t, H5′ (diasteriomers); 4.01, d, H10′; 4.45, s, H12′; 5.39, t,H9′; 5.45, d, H3; 6.40, s, H8; 6.49, d, H6; 6.71, d, H4; 7.06, d, H5;7.20-7.35, m, phenyl. Mass spectrum m/z (electrospray): MS, 437 (MH⁺);MS/MS, 261, 177, 153 (fragments of MH⁺).

[0063] Bulk Pretreatment of Cold-Pressed Grapefruit Oil for SubsequentFractionation by Reversed-Phase HPLC

[0064] 1. Prepare 1:1 ethanol:water (v/v) containing 12.5 g KOH/L usingdenatured reagent alcohol.

[0065] 2. Mix 1.0 L of cold-pressed grapefruit oil and 330 mL of thebasic ethanolic solution in a 2 L separatory funnel for 2.0 min.

[0066] 3. Wait 5.0 min, then remove the bottom ethanolic phase from thefunnel.

[0067] 4. Repeat steps 2 & 3 four times using fresh 330-mL portions ofthe basic ethanolic solution.

[0068] 5. Repeat steps 2 & 3 once using a 330-mL portion of: 1:1ethanol:water that is prepared without KOH. When KOH is absent, aseveral-hours wait is required (preferably overnight) in order for thephases to clearly separate. Assessment of the bottom ethanolic phasewith pH paper should show that the solution pH is near neutral (=6, inmost cases).

[0069] 6. Place the oil phase (yield should be greater than 0.9 L) in avacuum chamber and place the system under vacuum (0.5 torr or better)for 3-4 days. The process is complete when swirling the viscous liquidwhile under vacuum no longer initiates boiling.

[0070] 7. Wash the nonvolatile material with portions of acetonitrile,to a total of 200 mL, and separate the acetonitrile-soluble and-insoluble materials by centrifugation (5 min at speed 50, IEC modelK2).

[0071] 8. Remove the acetonitrile from the acetonitrile-soluble phase(step 7) using a Speed Vac apparatus, and weigh the residue (22-25 gwould be expected).

[0072] 9. Add acetonitrile to the residue such that each 5-mL portioncontains 1.5 grams of residue, and divide the solution into 5-mLportions.

[0073] 10. Add 15-mL of iso-octane to each 5-mL portion, cap, vortexmix, and centrifuge the mixture (2 min at speed 35). Discard the topiso-octane phase.

[0074] 11. Repeat step 10 nine times; acetonitrile should be addedoccasionally to insure that the bottom phase volume approximates 5 mL.

[0075] 12. Remove the acetonitrile from the bottom phase (step 11) usinga Speed Vac apparat and weigh the residue (approximately 20% of theoriginal weight {step 8} would be expected).

[0076] 13. Dissolve the residue (step 12) in acetonitrile such that a0.25-0.30 g/mL solution is established, filter the solution through a0.2 μm Teflon cartridge, and store the solution at −20° C.

[0077] Bulk Pretreatment of Cold-Pressed Grapefruit Oil for Further Useas Dietary Food Supplement, Drug, ConFormulation Ingredient, etc.

[0078] 1. Prepare a 70:30 water:ethanol solution (v/v) that contains 5%potassium hydroxide (w/v) using USP-grade ethanol, NF/FCC-grade KOH, andpurified water.

[0079] 2. Mix the ethanolic solution prepared in step 1 with anequivalent volume (or slight excess) of whole, untreated cold-pressedgrapefruit oil (Food Chemicals Codex grade), and transfer the mixture toa heat-and pressure-resistant food-grade container.

[0080] 3. The sealed container is maintained at 95-100° C. for 1 hour.The container is cooled, the ethanolic phase (lower phase of two-phasesystem) is removed, and a fresh portion of ethanolic solution(equivalent to the volume used in step 2) is added.

[0081] 4. Repeat the boiling cycle (step 3) until the desired degree ofsample purity is achieved. Ten cycles will remove >99% of polarcoumarins and furocoumarins, will remove >90% of prominent nonpolarcoumarins and furocoumarins (i.e., epoxyaurapten, epoxybergamottin), andwill not appreciably decrease the content of the inhibitory spiro orthoesters.

[0082] 5. Wash the oil with purified water until the discarded washwater pH becomes neutral.

[0083] 6. Place the oil phase under vacuum (0.1-0.3 torr) until volatilematerials are no longer removed from the sample (as assessed by, forexample, inspection of an empty in-line trap maintained at −60 to −90°C.). In general, approximately 95% of the volume of the sample will beremoved in this step.

[0084] 7. Mix the product of step 6 with an equivalent volume of USPethanol, and centrifuge the mixture. Repeat until the bottom phase issubstantially free of spiro ortho ester inhibitors. This method removesethanol-insoluble materials from the oil novolatile preparation.

[0085] 8. Optionally, but preferably, place the pooled ethanol extractsfrom step 7 under vacuum until the ethanol has been substantiallyremoved (e.g., 99%) or reduced (e.g. 10%).

[0086] Because adulteration of raw materials is known in the food,flavor, and fiance industries, citrus-derived components of theinvention including cold-pressed citrus oils should preferably beassessed before they are used further in the production of, e.g.,compositions of dietary supplements containing a first-pass effectiveamount of one or a mixture of compounds of Formulae I-XVI. One strategyconsists of sample preparation (Protocol A; Protocol A′), followed bychromatography (Protocol B; Protocol B′; Protocol B″), and ending withcomparisons to historical standards. Such assessment can provideconsistent batches.

[0087] The following protocols are useful in preparing variousembodiments of the invention.

[0088] Protocol A: Preparation of Citrus Oils for FurtherChromatographic Processing or for Administration to Humans by Removal ofToxic, Low Molecular Weight Furocoumarins.

[0089] A volume of cold-pressed citrus oil (Food Chemicals Codex grade)was transferred to a container, and all volatile materials were removed.Although several methods exist for removing volatiles (e.g.,distillation, distillation under reduced pressures evaporation underambient conditions), the preferred method uses Speed Vac concentrators(Savant Instruments; process requires 12-24 h and pressures of 10⁻²-10⁻³torr, and the system is run without added heat) because this method isgentle and expedient. The nonvolatile product yield is generally 0.04 to0.1 times the initial volume and is a viscous liquid.

[0090] Low molecular weight, phototoxic furocoumarins were removed fromthe nonvolatile preparation by liquid-liquid extraction: 16 times thevolume of viscous liquid of 1:1 ethanol:water (v/v; each U.S.P. grade)were added to the nonvolatile preparation, the container capped, thesolution mixed vigorously, the container centrifuged (InternationalEquipment Company, Model K-2, 5 min at setting 35), and the topethanolic phase discarded. The extraction was repeated twice. Extraneouswater and ethanol may be removed from the preparation if desired by use,e.g., of a Speed Vac apparatus. The product of this process may be usedfor human administration in, e.g., filled capsules.

[0091] Protocol A′: Pretreatment of Citrus Oils Prior to Chromatography.

[0092] Most citrus oils are not directly suitable for long-termpreparative high pressure liquid chromatography because of thesubstantial presence of materials that show poor solubility in thepreferred mobile phase systems. Hence the sample preparation protocolthat follows is used prior to chromatography.

[0093] Cold-pressed citrus oil (Food Chemicals Codex grade) istransferred to a suitable container, and all volatile materials areremoved under reduced pressure (10⁻²-10⁻³ torr, 3-4 days). Thenonvolatile product yield is generally only 5-10% of the originalvolume. The citrus nonvolatiles are mixed with acetonitrile in a ratioof 2:1 (w/w), the mixture is centrifuged (International EquipmentCompany, Model K-2, 5 min at setting 35), and the upperacetonitrile-containing phase is removed. The extraction withacetonitrile is repeated once, the lower phase is discarded, the firstand second acetonitrile phases are pooled, and acetonitrile is removedusing Speed Vac concentrators (Savant Instruments; 12 h at 10⁻²-10⁻³torr, without added heat). The nonvolatile material is mixed withethanolic base (1:1 ethanol:water {v/v; each U.S.P. grade} containing12.5 g potassium hydroxide/L) in a ratio of 1:4 (w/v), the mixture iscentrifuged for 5 min at setting 35, and the upper ethanolic phase isremoved and discarded. The nonvolatile material is washed an additionalnine times with ethanolic base and, then, once with 1:1 ethanol:water(v/v). The residue that remains is extracted twice with sufficientvolumes of acetonitrile such that all colored material is removed. Theacetonitrile solution is washed six times with two volumes of hexane oriso-octane, with each hexane extract (upper layer) being removed anddiscarded, and the resulting acetonitrile solution is filtered through a0.2 micron Teflon® membrane and evaporated to dryness using a Speed Vacconcentrator.

[0094] The final product of the above process should appear as aviscous, deep red oil, but seasonal variations in the starting material(citrus oils) apparently can change the quality and appearance of theproduct of the above process. Hence, if a copious orange crystallinematerial contaminates the deep red oil, then the number of additionalwashes with ethanolic base should be increased from nine to nineteen.

[0095] Protocol B: Chromatography Methods for Processed Citrus Oils

[0096] The product of the above Protocol A is not suitable for any highpressure liquid chromatography because of the substantial presence ofmaterials that are not soluble in the preferred mobile phase systems.Hence the sample preparation protocol that follows is used prior tochromatography. One volume of the product of Protocol A is mixed withfour volumes of acetonitrile, the container is capped, the solution ismixed vigorously, the container is centrifuged (5 min at setting 35),and the top acetonitrile layer is filtered through a 0.22 micron Teflon®membrane. The filtered solution is stored in a closed container at −20°C. for 2 days or more and then is passed through filter paper while coldto remove a copious precipitate. The precipitation and filtration stepis repeated once. The volume of the acetonitrile solution is noted, andthe acetonitrile is removed using a Speed Vac apparatus. The residue isdissolved in half the original volume of acetonitrile, taking care notto disturb any crystalline precipitate, and the solution may now be usedfor HPLC assessment.

[0097] If preparative fractionation of the washed nonvolatile portion ofcitrus oil is desired, then the HPLC conditions given below arepreferred. Linear gradients are used for elution and are formed bymixing mobile phase A composed of water with mobile phase B composed ofacetonitrile (instrument: Hewlett Packard). The elution time, inminutes, as well as the percentage of acetonitrile present in the mixedmobile phase are as follows: 0, 75; 5, 75; 10, 90; 11, 98; 17, 98; 18,75; 22, 75. The chromatographic column has dimensions of 250 mmlength×4.6 mm internal diameter, is packed with C18 bonded to 4 micronsilica particles (9% carbon load; ODS-L80, YMC, Inc.), is protected witha 23 mm length×4 mm internal diameter column containing the samematerial and with a 0.5 micron filter, and is maintained at 40±0.2° C.The flow rate is maintained at 1.0 mL/min during the 22 min run cycle.The column eluate from each 25 uL injection is monitored at 400±200 nmand at 310±2 nm and is fractionated using a robotic collector (Gilson).

[0098] If qualitative or quantitative assessments of citrus oils,fractions thereof, or reference standards are desired, then the HPLCconditions given below are preferred. Linear gradients are used forelution and are formed by mixing mobile phase A composed of water withmobile phase B composed of acetonitrile (instrument: Hewlett Packard).The elution time, in minutes, as well as the percentage of acetonitrilepresent in the mixed mobile phase are as follows: 0, 10; 5, 10; 30, 80;40, 80; 41, 95; 50, 95; 53, 10; 60, 10. The chromatographic column hasdimensions of 150 mm length×2.0 mm internal diameter, is packed with C18bonded to 4 micron silica particles (14% carbon load; ODS-M80, YMC,Inc.), is protected with a 2 mm internal diameter column packed with aproprietary material (Prism, Keystone Scientific, Inc.) and with a PTFEfilter, and is maintained at 35±0.2° C. The flow rate is maintained at0.20 mL/min during the 60 min run cycle. The column eluate from each 10uL injection is monitored for absorbance at 400±200 nm and at 310±2 nmand for fluorescence with excitation at 229 mm, emission at 450 nm, andbandpass filtration at 370 nm.

[0099] Protocol B′: Chromatography Methods for Processed Citrus Oils

[0100] If preparative fractionation of the washed nonvolatile portion ofcitrus oil (product of Protocol A′) is desired, then the HPLC conditionsgiven below are preferred. Linear gradients arc used for elution and areformed by mixing mobile phase A composed of water with mobile phase Bcomposed of acetonitrile (instrument: Hewlett Packard). The elutiontime, in minutes, as well as the percentage of acetonitrile present inthe mixed mobile phase are as follows: 0, 75; 5, 75; 10, 90; 11, 98; 17,98; 18, 75; 22, 75. The chromatographic column has dimensions of 250 mmlength×4.6 mm internal diameter, is packed with C18 bonded to 4 micronsilica particles (9% carbon load; ODS-L80 YMC, Inc.), is protected witha 23 mm length×4 mm internal diameter column containing the samematerial and with a 0.5 micron filter, and is maintained at 40±0.2° C.The flow rate is maintained at 1.0 mL/min during the 22 min run cycle.The column eluate from each 25 uL injection of acetonitrile solutionobtained by Protocol A′ is monitored at 400±200 nm and at 310±2 nm andis fractionated using a robotic collector (Gilson).

[0101] If qualitative or quantitative assessments of citrus oils,fractions thereof, or reference standards are desired, then the HPLCconditions given below are preferred. Linear gradients are used forelution and are formed by mixing mobile phase A composed of water withmobile phase B composed of acetonitrile (instrument: Hewlett Packard).The elution time, in minutes, as well as the percentage of acetonitrilepresent in the mixed mobile phase are as follows: 0, 10; 5, 10; 30, 80;40, 80; 41, 95; 50, 95; 53, 10; 60, 10. The chromatographic column hasdimensions of 150 mm length×2.0 mm internal diameter, is packed with C18bonded to 4 micron silica particles (14% carbon load; ODS-M80, YMC,Inc.), is protected with a 2 mm internal diameter guard column packedwith a proprietary material (Prism, Keystone Scientific, Inc.) and witha PTFE filter, and is maintained at 35±0.2 C. The flow rate ismaintained at 0.20 mL/min during the 60 min run cycle. The column eluatefrom each 10 uL injection is monitored for absorbance at 400±200 nm andat 310±2 nm and for fluorescence with excitation at 229 nm, emission at450 nm, and bandpass filtration at 370 nm.

[0102] Protocol B″: Purification of Invention Compounds Using a ChiralHPLC Column

[0103] Pooled residues that result from fractionation of the 11-12.5 minregion (Protocol B or B′ and solvent removal (Speed Vac, no heat added)are subjected to chiral liquid chromatography. Isocratic elution isemployed (mobile phase consists of 3.4 L iso-octane, 0.6 L 95% ethanol{remainder is water} and 0.2 L isopropanol) to elute Inhibitors XI-XVIfrom the column (250×4.6 mm, Keystone Scientific, Inc., Chiral from each25 uL injection (residue is dissolved in mobile phase) is monitored at400±200 nm and at 310±2 nm and is fractionated using a robotic collector(Gilson).

[0104] Protocol C: Assessment of Human Cytochrome P450-MediatedBiotransformation

[0105] The process of preparing incubation mixtures begins by mixing 10uL of ethanol or an ethanolic solution containing an inhibitor with 100uL of 100 mg/mL bovine serum albumin (Sigma) dissolved in reactionbuffer at room temperature. Reaction buffer is composed of 0.10 M sodiumphosphate, 1.0 mM ethylenediaminetetraacetic acid, and 5.0 mM magnesiumchloride, pH 7.4 (all reagents: Fisher Scientific). Inhibitory chemicalsused were ketoconazole (Research Diagnostics, Inc.), miconazole,bergapten, xanthotoxin (previous three from Sigma), bergamotin,imperatorin, isopimpinellin, psoralen, angelicin (previous five fromIndofine Chemical Company, Inc.), and fractions or precipitatesresulting from Protocols A, A′, B, B′, or B″ above. When possible, finalinhibitor concentrations were expressed in molarity by calculation fromthe weighed material or by interpolation from HPLC calibration curvesprepared with reference materials; otherwise, concentrations areexpressed as weight per volume. Reaction tubes are placed on ice inpreparation for the manipulations that follow. Sufficient reactionbuffer is added so that the final volume of each tube will be 500 uL, 5uL of a 100-fold concentrate for generating reduced nicotinamide adeninedinucleotide phosphate is added (such that completed reaction mixturecontains 1.0 mM nicotinamide adenine dinucleotide phosphate, 1 U/mLglucose-6-phosphate dehydrogenase, and 10 mM glucose-6-phosphate; allfrom Sigma), and then human hepatic S9 (Anatomic Gift Foundation) isthawed and added in sufficient amounts to cause readily detectableamounts of metabolites to be formed in control reactions (amountnecessary varies among individuals, but 10 uL is typical). Reactions arepre-incubated for 3 min at 37° C. in a Dubnoff-type water bath, thereaction mixture is completed by the addition of 10 uL of 100 uMterfenadine (Sigma) dissolved in 1:1 acetonitrile:water and by gentlemixing, the samples are incubated for 15 min at 37° C., and the reactionis stopped by placing the tube on ice and adding 2.5 mL of 300 nMterfenadine-related compound A (internal standard; U.S. Pharmacopeia)dissolved in acetonitrile.

[0106] The samples prepared above are readied for HPLC assessment usingthe protocol that follows. Each tube is vortex mixed and centrifuged for10 min at setting 35, the resulting supernatant is transferred to aclean tube, and the liquid is evaporated using a Speed Vac apparatus.The residue in each tube is first dissolved in 40 uL 1:1acetonitrile:water, 2.5 mL of acetonitrile is added, and thecentrifuge-transfer-evaporate step just described is repeated.

[0107] The dry residue resulting from the above-described experimentsand sample preparation protocol may be analyzed for terfenadinemetabolites using the HPLC method described below and may also be usedto quantitate the inhibitory chemicals that were added to the reaction(see Protocols B and B′). Linear gradients are used for elution and areformed by mixing mobile phase A composed of water with mobile phase Bcomposed of 0.025% (v/v) formic acid in acetonitrile (instrument:Hewlett Packard). The elution time, in minutes, the percentage of mobilephase B present in the mixed mobile phase, and the flow rate (mL/min)are as follows: 0, 10, 0.10; 2, 10, 0.10; 3.5, 10, 0.20; 4, 10, 0.25; 5,10, 0.25; 30, 55, 0.25; 32, 98, 0.25; 33, 98, 0.40; 39.8, 98, 0.40; 40,98, 0.25; 45, 10, 0.25; 45.25, 10, 0.20; 50, 10, 0.20; 50.25, 10, 0.10.The chromatographic column has dimensions of 150 mm length×2.1 mminternal diameter, is packed with a proprietary material (Prism,Keystone Scientific, Inc.), is protected with a 2 mm internal diametercolumn containing the same material and with a PTFE filter, and ismaintained at 35±0.20° C. The dry sample residue is mixed with 60 uL of1:1 acetonitrile:water followed by 40 uL water just prior to each 50.25min run cycle. The column eluate from each 10 uL injection is monitoredfor fluorescence with excitation at 228 nm, emission at 291 nm, andbandpass filtration at 280 nm. Under these conditions, the retentiontimes of terfenadine alcohol metabolite, terfenadine carboxylic acidmetabolite, and the internal standard are 16.2 min, 17.4 min, and 22.2min, respectively.

[0108] Protocol C′: Assessment of Human Cytochrome P450-MediatedBiotransformation

[0109] The process of preparing incubation mixtures begins by mixing 10uL of ethanol (control reactions) or an ethanolic solution containing aninhibitor with 100 uL of 100 mg/mL bovine serum albumin (Sigma)dissolved in reaction buffer at room temperature. Reaction buffer iscomposed of 0.10 M sodium phosphate, 1.0 mM ethylenediaminetetraaceticacid, and 5.0 mM magnesium chloride, pH 7.4 (all reagents: FisherScientific). Inhibitory chemicals used are ketoconazole (ResearchDiagnostics, Inc.), ritonavir (Norvir™, Abbott Laboratories), inhibitorychemicals described in Protocol C, and fractions resulting from ProtocolB″ above. Final inhibitor concentrations were expressed in molarity bycalculation from the weighed material or by use of Beer's law. Reactiontubes are placed on ice in preparation for the manipulations thatfollow. Sufficient reaction buffer is added so that the final volume ofeach tube will be 500 uL, 5 uL of a 100-fold concentrate for generatingreduced nicotinamide adenine dinucleotide phosphate is added (such thatcompleted reaction mixture contains 1.0 mM nicotinamide adeninedinucleotide phosphate, 1 U/mL glucose-6-phosphate dehydrogenase, and 10mM glucose-6-phosphate; all from Sigma), and then human hepatic S9(Anatomic Gift Foundation) is thawed and added in sufficient amounts tocause readily detectable amounts of metabolites to be formed in controlreactions (amount necessary varies among individuals, but 10 uL istypical). Reactions are pre-incubated for 3 min at 37° C. in aDubnoff-type water bath the reaction mixture is completed by theaddition of 10 uL of 500 uM saquinavir (Invirase™, Roche Laboratories)dissolved in 1:1 ethanol:water and by gentle mixing, the samples areincubated for 15 min at 37° C., and the reaction is stopped by placingthe tube on ice and adding 2.5 mL of acetonitrile.

[0110] The samples prepared above are readied for HPLC assessment usingthe protocol that follows. Each tube is vortex mixed and centrifuged for10 min at setting 35, the resulting supernatant is transferred to aclean tube, and the liquid is evaporated using a Speed Vac apparatus.The residue in each tube is first dissolved in 40 uL 1:1acetonitrile:water, 2.5 mL of acetonitrile is added, and thecentrifuge-transfer-evaporate step just described is repeated.

[0111] The dry residue resulting from the above-described experimentsand sample preparation protocol may be analyzed for saquinavir andsaquinavir metabolites using the HPLC method described below and mayalso be used to quantitate the inhibitory chemicals that were added tothe reaction (see Protocols B and B″). Linear gradients are used forelution and are formed by mixing mobile phase A composed of water withmobile phase B composed of acetonitrile (instrument: Hewlett Packard).The elution time, in minutes, and the percentage of mobile phase Bpresent in the mixed mobile phase are as follows: 0, 10; 5, 10; 30, 80;31, 95; 40, 95; 43, 10; 48, 10. The flow rate is 0.2 mL/min throughoutthe run. The chromatographic column has dimensions of 150 mm length×2.1mm internal diameter, is packed with a proprietary material (Prism,Keystone Scientific, Inc.), is protected with a 2 mm internal diametercolumn containing the same material and with a PTFE filter, and ismaintained at 35±0.2° C. In order to minimize the degradation ofanalytes, the dry sample residue is mixed with 50 uL of 1:1acetonitrile:water just prior to each 48 min run cycle. The columneluate from each 10 uL injection is monitored for absorbance at 239±2nm. Under these conditions, the retention times of saquinavir principalmetabolite A, saquinavir principal metabolite B, and saquinavir are 24.2min, 26.0 min, and 30.0 min, respectively.

[0112] Demonstration of Effectiveness

[0113] In order to demonstrate the first-pass effectiveness of thepresent invention, experiments with invention compounds and inventioncitrus-derived substances were conducted according to Protocol C′ abovewhere generation of saquinavir metabolites were measured in the presenceof various concentrations of inhibitor. Citrus-derived substancesaccording to the present invention were prepared according to ProtocolsA′, B′, and B″ above and were compared to known inhibitor Ketoconazole.FIG. 1 shows results for invention compounds of Formulae XI and XIII andalso shows that bergamottin and imperatorin are essentially ineffectivefirst-pass inhibitors. FIG. 2 shows how invention compounds compare toknown inhibitors Ritonavir and Ketoconazole.

[0114] In the invention compounds it is preferred that the furan ringposition of the furocoumarin rings be completely free of substitution.

[0115] With regard to purification and processing methods, the followingembodiments are preferred:

[0116] A. A method for processing citrus and selectively removingphototoxic furocoumarins from a first-pass effective citrus-derivedsubstance, comprising the step of extracting said citrus-derivedsubstance with a mixture of at least one C₂-C₄ alcohol, water, andoptionally base, said first-pass effective citrus-derived substancemaintaining anti-first-pass activity after said extraction.

[0117] B. The method of embodiment A, wherein said citrus-derivedsubstance is a cold pressed citrus oil.

[0118] C. The method of embodiment A, wherein said mixture of ethanoland water is a 30/70 volume/volume mixture of ethanol and wateroptionally containing 1-10% potassium hydroxide (W/V).

[0119] Other preferred embodiments include:

[0120] D. A first-pass effective citrus-derived substance which has beenextracted with a mixture of at least one C₂-C₄ alcohol and water so asto reduce the amount of phototoxic furocoumarins therein.

[0121] E. The citrus-derived substance of embodiment D, wherein saidsubstance is a cold-pressed citrus oil.

[0122] F. The citrus-derived substance of embodiment D, which has beenextracted with a 30/70 volume/volume mixture of ethanol and wateroptionally containing 1-10% potassium hydroxide (W/V).

[0123] G. A method for inhibiting the first-pass-effect of a materialtaken orally by a patient which is subject to the first-pass effect,comprising the step of co-administering to said patient the first-passeffective citrus-derived substance of embodiments A and D.

[0124] Invention compositions preferably comprise invention inhibitormaterial (compound, etc.) (e.g., alone, mixed with drug(s), and/ordiluent(s) and/or carrier(s) etc.) such that they inhibit saquinavirbiotransformation according to Protocol C′ above better than pureketoconazole on an equal molar (preferred) or weight concentrationbasis. Alternatively, invention compounds, compositions, mixtures,formulations, etc. (materials) preferably provide a Y-axis value inProtocol C′ (see FIG. 1) of less than 0.5, preferably 0.45, 0.4, 0.35,0.3, 0.25, 0.22, 0.2, 0.18, 0.15, 0.12, 0.1, 0.08, 0.05 or 0.03 or lesswhen 0.01-0.25 mg, including 0.02, 0.04, 0.06, 0.08, 0.1, 0.12, 0.14,0.16, 0.18, 0.2, 0.22 and 0.24, and all ranges between all values, ofinvention material is diluted or dissolved to one liter.

[0125] A commercial form of citrus containing the invention compounds iscold-pressed grapefruit oil, which has a total concentration ofcompounds of Formulae XI-XVI in the range of perhaps up to 0.15-0.25mg/ml. The six compounds are distributed as: XI+XII+XIII+XIV equalsapproximately 50%, with XV and XVI the remainder. For XI-XIV thedistribution is about 3:2:2:1, respectively and about 2:1 for XV:XVI.Compositions according to the invention in one embodiment thuspreferably contain higher concentrations of invention compounds (i.e.,total concentration of all invention compounds therein) than those whichoccur in nature and commercial forms of citrus. These concentrations arereferred to as “concentrated amounts”. Examples of preferredconcentrations include greater than 0.25 mg/ml, 0.3, 0.8, 1, 2, 5, 8,32, 128, 200 mg/ml, etc. With regard to invention compounds, thecompounds in one embodiment of the invention are in a form distinct fromthat found in nature or commercially due to purity. The term“substantially pure” and “substantially pure form” refers to a puritygreater than that found commercially and in nature for the inventioncompounds. These concentrations and forms are easily derminable by thoseof ordinary skill now that the present inventor has identified theactive compounds responsible for the “grapefruit effect”. Otherlanguage, phrases, etc. useful to describe the embodiments of thepresent invention and distinguish them patentably and otherwise fromnaturally or commercially occurring forms are found in the followingpatents assigned to the U.S. government and to others, all incorporatedherein by reference: U.S. Pat. Nos. 4,708,948, 5,409,938, 5,455,251,4,977,244, 5,462,956, 5,314,899, 5,104,977, 5,484,889, 5,591,770,5,599,839, 5,672,607, 5,674,900, 5,648,354, 5,691,386, 5,681,829 and5,654,432. Another description of how the present invention may be used,in what amounts, and how administered appears in U.S. Pat. No.5,665,386, WO 97/15269 and WO 96/40192, all incorporated herein byreference.

[0126] The following patent applications, provisional or otherwise, areincorporated herein by reference: 60/056,382, 60/048,183, 60/043,878,Ser. Nos. 08/764,081 and 08/673,800 (Attorney Docket Numbers7552-001-99, 7552-004-99, 7552-005-99, 7552-006-99 and 7552-007-99) andAttorney Docket Number 7552-008-99, application Ser. No. 08/997,259,filed Dec. 23, 1997.

[0127] Other compounds useful herein are described by the followingFormulae where R, L, E and HAr are as described above. As with the abovecompounds, these compounds include all stereoisomers, E-Z isomers, etc.Where naturally or commercially occurring, these compounds arepreferably in the forms described above regarding purity, concentration,etc. These compounds may be optionally substituted as compounds ofFormulae I-XVI are.

[0128] In the invention compounds a preferred group of sustituents,optional and otherwise, comprise the following: hydrogen, C₁-C₄ alkyl,—S(C₁-C₄ alkyl), —O(C₁-C₄ alkyl), —NH₂, —NH(C₁-C₄ alkyl) —N(C₁-C₂ alkyl)(C₁-C₄ alkyl), hydroxy, —O(C₁-C₂ alkyl), fluoro, C₁-C₆ alkyl, chloro,bromo, iodo, C₁-C₄ alkoxy, —CF₃, —C(═O)O—(C₁-C₄) alkyl, —OC(═O)(C₁-C₄alkyl), —OC(═O)N (C₁-C₄ alkyl)(C₁-C₂ alkyl), —NHCO(C₁-C₄ alkyl), —COOH,—COO(C₁-C₄ alkyl), —CONH(C₁-C₄ alkyl), —CON(C₁-C₄ alkyl) (C₁-C₂ alkyl),—S(C₁-C₄ alkyl), —CN, —NO₂, —SO(C₁-C₄ alkyl), —SO₂(C₁-C₄ alkyl),—SO₂NH(C₁-C₄ alkyl) and —SO₂N(C₁-C₄ alkyl)(C₁-C₂ alkyl).

[0129] Another group of preferred substituents, optional and otherwise,comprise: C₁-C₁₂ alkyl, aryl, (C₁-C₄ alkylene) aryl, phenyl, naphthyl,thienyl, benzothienyl, pyridyl, quinolyl, pyrazinyl, pyrimidinyl,imidazolyl, furanyl, benzofuranyl, benzothiazolyl, isothiazolyl,pyrazolyl, pyrrolyl, indolyl, pyrrolopyridyl, oxazolyl and benzoxazolyl,C₃-C₈ cycloalkyl or (C₁-C₆ alkylene)(C₃-C₈ cycloalkyl), C₁-C₄ alkyl,benzyl, C₁-C₄ alkanoyl, C₁-C₆ alkoxy, —OC(═O)(C₁-C₆ alkyl),—OC(═O)N(C₁-C₄ alkyl)(C₁-C₂ alkyl), —S(C₁-C₆ alkyl), amino, —NH(C₁-C₂alkyl), —N(C₁-C₂ alkyl)(C₁-C₄ alkyl), —N(C₁-C₄ alkyl)-CO—(C₁-C₄ alkyl),—NHCO(C₁-C₄ alkyl), —COOH, —COO(C₁-C₄ alkyl), —CONH(C₁-C₄ alkyl),—CON(C₁-C₄ alkyl)(C₁-C₂ alkyl), —SH, —SO(C₁-C₄ alkyl) —SO₂(C₁-C₄ alkyl),—SO₂NH(C₁-C₄ alkyl) and —SO₂N(C₁-C₄ alkyl)(C₁-C₂ alkyl).

[0130] A third group of preferred substituents, optional and otherwise,comprise: —S(C₁-C₄ alkyl) or —SO₂(C₁-C₄ alkyl)(C₁-C₆ alkyl), —N(C₁-C₄alkyl)(C₁-C₂ alkyl), —S(C₁-C₄ alkyl), —SO(C₁-C₄ alkyl), —CO(C₁-C₄alkyl), —CO(═O)H, —C(═O)O(C₁-C₄ alkyl), C₁-C₃ alkoxy, dimethylamino,methylamino, ethylamino, —NHC(═O)CH₃, C₁-C₃ thioalkyl, —COOH,—C(═O)O(C₁-C₄ alkyl), —C(═O)O(C₁-C₄ alkyl), —NO₂ phenyl, naphthyl,thienyl, benzothienyl, pyridyl, quinolyl, pyrazinyl, furanyl,benzofuranyl, benzothiazolyl, benzisothiazolyl, benzisoxazolyl,benzimidazolyl, indolyl, benzoxazolyl or C₃-C₈ cycloalkyl, chloro, C₁-C₆alkyl, —O(C₁-C₆ alkyl) bromo, iodo, formyl, —CN, —CF₃, —NO₂, —NH₂,—NH(C₁-C₄ alkyl), —N(C₁-C₂ alkyl)(C₁-C₆ alkyl), —C(═O)O(C₁-C₄ alkyl),—C(═O)(C₁-C₄ alkyl), —COOH, —SO₂NH(C₁-C₄ alkyl), —SO₂N(C₁-C₂alkyl)(C₁-C₄ alkyl), —SO₂NH₂, —NHSO₂(C₁-C₄ alkyl), —S(C₁-C₆ alkyl) and—SO₂(C₁-C₆ alkyl), fluoro, hydroxy, amino, methylamino, dimethylamino,acetyl, hydrogen, C₁-C₄ alkyl, halo (e.g., chloro, fluoro, iodo orbromo), hydroxy, —O(C₁-C₄ alkyl), —C(═O)(C₁-C₄ alkyl), —C(═O)O(C₁-C₄alkyl), —OCF₃, —CF₃, —CH₂OH or —CH₂O(C₁-C₂ alkyl) hydroxy, methoxy andfluoro.

[0131] Within these three groups of preferred substituents are alsospecific examples of HAr (i.e., C₆-C₂₄ aromatic groups or heteroaromaticgroups).

[0132] In the present invention prodrugs and active metabolites of theinvention compounds, compositions, etc. are included. Such prodrugs arecompounds which give rise to an invention compound upon administrationto a mammal such as a human. Active metabolites are compounds formedupon administration of an invention compound, composition, etc. to amammal, preferably a human, which are first-pass effective. Someexamples of invention prodrugs and metabolites include:

[0133] Invention compounds, metabolites, prodrugs, etc. may preferablybe substituted with deuterium and/or fluorine to increase residence timein the patient/animal/etc.

[0134] Pharmaceutical carriers, diluents, excipients, etc. are known tothose of skill in this art. Examples are provided in several above-notedpatents and publications.

[0135] A preferred method of extraction is exemplified in the Examplessection above where the bulk pretreatment of cold-pressed grapefruit oilfor further use as a dietary food supplement, drug, etc. is described.In such situations it is preferred that polar coumarins andfurocoumarins (see supra) be removed with both heat and base, althoughboth are optional. It is also preferred to use more water than C₂-C₄alcohol, with 70:30 (V/V) water:ethanol highly preferred. In addition,it is preferred not to remove volatiles present in the first-passeffective citrus-derived substance (a citrus-derived substancecontaining at least one invention compound, metabolite, prodrug, etc.)during initial extraction. A preferred citrus-derived substance iscold-pressed grapefruit oil.

[0136] If heating is used 40-120° C. is preferred, 60-110° C. morepreferred, 80-105° C. most preferred including 80, 85, 90, 95, 100 and105° C. In the extraction the alcohol/water mixture contacts thefirst-pass effective citrus derived substance once or more than once inany manner known in the art, optionally with heating (i.e., elevatedtemperature). Base such as NaOH, KOH, or any other base which willdissolve in alcohol/water mixtures can be used in amounts of 1-15%,preferably 3-10%, more preferably 4, 5, 6, 7, 8 or 9% (W/V) based ontotal volume of water and alcohol.

[0137] One manner of determining if the extracted product is ready foruse is to monitor the pH of a wash, preferably using water alone. Nearneutral values (6-7.5) are preferred. pH adjustors such aspharmaceutically—and food grade acceptable—acids may be used. The extentof removal of furocoumarins, coumarins, etc., can be monitored as abovewith HPLC, GC, etc.

[0138] One manner of ensuring that alcohol-insoluble materials are notpresent in the purified extract according to the invention is to mix theextract with alcohol followed by centrifuging to remove insolublematerials.

[0139] As noted above, the compositions according to the inventionpreferably contain higher concentrations of invention compounds (i.e.,total concentration of all invention compounds therein) than those whichoccur in nature and in commercial forms of citrus. Examples of suchconcentrations are given previously, and further include the followingconcentrations on a weight/weight basis: greater than 0.029%, 0.03%,0.05%, 0.1%, 0.3%, 0.5%, 1%, etc.

[0140] The co-administration of commercial grapefruit oil, especially“folded oils” (e.g., oil with 5-fold, 10-fold, 20-fold, etc.concentration) in the invention methods of inhibiting the first-passeffect is included herein. Oils and folded oils having reducedphototoxic chemical content are preferred. See above.

[0141] Of course, and as noted above, the present invention alsocontemplates the invention compounds in compositions which are notnatural, such as mixtures with pharmaceutically-acceptable diluents(including solids, liquids, etc), mixtures with liquids such as water,ethanol, etc. The amount of invention compounds present in thesenon-naturally occurring compositions can be lower than theconcentrations described above. One of ordinary skill in this art iscapable of determining the appropriate amount to be given based upon thepurpose of administration.

[0142] The present invention includes co-administration of inventioncompounds with drugs preferably having bioavailability problems, meaninglow or poor bioavailability. Such drugs are described in Fecik, et al,Med. Res. Rev. 18: 149-185, 1998, incorporated herein by reference.While the invention compounds may be co-administered with any knowndrug, they may preferably be coadministered with one or more of thefollowing drugs: ABT-378, acebutolol, acyclovir, aldesleukin,alfentanil, alteplace, amikacin, amphotericin B, amprenavir,anistreplase, atacurium, auranofin, azithromycin, azthreonam,benazepril, bisulfan, bleomycin, bretylium, bromocriptine, budesonide,buspirone, capreomycin, carbenicillin, carboplatin, carmustine,carvedilol, cefaclor, cefonicid, cefoperazone, ceforanide, cefotaxime,cefotetan, ceftazidime, ceftizoxime, ceftriaxone, cephalothin,cephapirin, chlorpromazine, cisplatin, clemastine, cyclosporin,cytarabine, desipramine, didanosine, dobutamine, doxepin, doxorubicin,edrophonium, erythromycin, esmolol, ethosuximide, felodipine, fentanyl,flumazenil, fluorouracil, foscarnet, fosinopril, ganciclovir,gentamicin, heparin hydralazine, imipramine, indinavir, isradipine,kanamycin, ketamine, labetalol, L-deprenyl, lidocaine, lincomycin,lisinopril, lovastatin, neifinavir, mercaptopurine, methicillin,methohexital, metocurine, metoprolol, mezlocillin, morphine, moxalactam,nabumetone, nadolol, nafcillin, nalbuphine, naloxone, naltrexone,netilmicin, nicardipine, nicotine, nimodipine, nitredipine,nitroglycerin, norfloxacin, octreotide, oxacillin, paclitaxel,pancuronium, pentamidine, pentoxifylline, pipecuronium, piperacillin,pravastatin, propranolol, pyridostigmine, rifabutin, rimantadine,saquinavir, scopolamine, selegiline, sertialine, simvastatin,spironolactone, streptokinase, streptomycin, sufentanil, sumatriptan,tacrine, tacrolimus, tamoxifen, teniposide, terbutaline, terfenadine,thiopental, ticarcillin, tipranavir, tobramycin, triamcionoloneacetonide, tubocurarine, vancomycin, vecuronium, venlafaxine, verapamil.

[0143] Drugs, active agents, etc. useful in the coadministrationmethodology of the invention include the following: Analgesics,antibiotics, antirheumatics, antiasthmatic agents, muscle relaxants,narcotic antagonists, NSAIDs, anesthetics, antiinflammatory bioactiveagents, neuromuscular blockers, sedatives, antimicrobials, antiarthriticbioactive agents, anticancer agents, aminoglycosides, antifungals,antimalarials, antiparasitics, antituberculars, antiarrhythmic agents,antivirals, carbapenems, cephalosporins, fluoroquinolones, macrolides,penicillins, sulfonamides, tetracyclines, cardiovascular agents,colinergic agonists, angiotensin II inhibitors, ACE inhibitors, proteaseinhibitors, renin inhibitors, antiadrenergic agents, antidysrythmics,antihyperlipidemic agents, antihypotensives, antihypertensives,antiplatelet agents, beta blockers, calcium channel blockers, diuretics,nitrates, pressors, steroids, thrombolytics, contrast media, dermatologyagents, antibacterials, endocrine and metabolic agents,androgens/anabolic steroids, biphosphonates, corticosteroids,chemotherapeutic bioactive agents, diabetes-related agents, gout-relatedagents, minerals, nutritionals, thyroid agents, vitamins,antihistamines, antitussives, decongestants, gastroenterology agents,antidiarrheals, antiemetics, antiulcer agents, hematology agents,anticoagulants, immunosuppressive agents, neurology agents,anticonvulsants, antimigraine agents, parkinsonian agents, obstetricsand gynecology agents, estrogens, GnRH agonists, appetite suppressants,hormone replacement combinations, labor induction agents, hormonalagents, progestins, tocolytics, oncology agents, ophthalmology agents,corticosteroids, glaucoma agents, psychiatry agents, alzheimer's diseaseagents, antidepressants, tranquilizers, antispasmodics, contraceptives,antimaniacs, antipsychotics, anxiolytics/hypnotics, drug dependencetherapy agents, sympathomimetics, stimulants, anorexiants, receptoragonists, recepotor antagonists, pulmonary agents, urology agents,bladder spasm agents, erectile dysfunction agents, opioids,nephrolithiasis agents, prostate cancer agents, vasoconstrictors.

[0144] Other drugs useful in the coadministration schemes describedherein are described in the paragraph bridging pages 13 and 14 of WO95/20980, incorporated herein by reference, including those drugsdescribed in The Physicians Desk Reference, Goodman and Gilman's ThePharmacological Basis of Therapeutics, and The United StatesPharmacopeia, The National Formulary, referred to in this passage. Otheruseful drugs appear in Table I at page 18 of WO 95/20980, incorporatedherein by reference, and those described at page 19, lines 10-18 of WO95/20980, incorporated herein by reference. Also included are drugs fromclasses described at the following passages of WO 95/20980, allincorporated herein by reference: page 24, lines 12-21, Table 2 at page26, claims 12 and 13 at page 44, claim 27 at page 46 and claim 28 atpage 47. Similarly, drugs useful herein include those described in WO96/40192 at the following passages, all incorporated herein byreference: from page 16, line 15 to page 17, line 9, claim 5 at pages41-42 and claim 13 at page 44.

[0145] In the present invention methods, no theory of operation isincluded or implied. Inhibition of the first-pass effect is includedwherever and however it occurs in mammals and humans, for example in theliver, bowel, a combination of the two, etc.

[0146] In addition to the methodology for preparing invention compoundsand obtaining invention compounds as described above, two furthermethods are available, as follows:

[0147] Juice Derived Solids:

[0148] A. Pour a 2.0-L portion of freshly-squeezed grapefruit juicethrough either a 500 μm or a 212 μm stainless steel testing sieve (VWRScientific; A.S.T.M.E-11 Specification; 8-inch diameter) (≧200 μm ispreferred) to produce an initial filtrate. Gentle rocking of the sievecan increase the flow rate through the apparatus. The initial filtrateis then passed through either a 75 μm or 25 μm stainless steel testingsieve to give a second filtrate. Gentle rocking of the sieve canincrease the flow rate through the apparatus. The solid material thatwas trapped by the 500 μm or the 212 μm sieve is washed with three 2.0-Lportions of cold, warm, or hot water, and this wash water is then usedto wash the solids that were trapped by the 75 μm or 25 μm stainlesssteel testing sieve. A washed grapefruit juice-derived solidspreparation, enriched in invention spiro ortho esters (specifically, thesolids preparation that was trapped by the 75 μm or 25 μm stainlesssteel testing sieve), is produced with this method.

[0149] B. Centrifuge a 2.0-L portion of freshly-squeezed grapefruitjuice at 1000 ×G (±20%) for 10 (±50%) minutes. The supernatant isremoved via aspiration and discarded, taking care not to disturb thepellet. The pellet is resuspended in 1.5-2.0 L of room-temperaturewater, the centrifugation is repeated, and the supernatant is removedand discarded. The pellet is resuspended again in 1.5-2.0 L of water,the centrifugation is repeated, and the supernatant is removed anddiscarded. A washed grapefruit juice-derived solids preparation,enriched in invention spiro ortho esters, is produced with this method.

[0150] Drying the Juice-Derived Solids (Optional): The washed, enrichedsolids prepared above may be transferred to appropriate containers usingminimal volumes of water to assure a quantitative transfer, then frozenand lyophilized to dryness directly. Alternatively, they may betransferred, frozen, and then allowed to thaw; in this way, much of thewater may be separated from the solids, with minimal loss of theinvention spiro ortho esters, by pouring off, filtering away, etc. thewater. The solids are then frozen and lyophilized to dryness.

[0151] Extraction of the Dry, Washed Solids (Optional): The lyophilizedmaterial is transferred to bottles, and the bottles are considered fullwhen no further material can be forced into the bottles by handcompression. Each bottle is then filled completely with USP-gradeethanol (either 190 or 200 proof). Each bottle is capped, shaken ormixed for two days, and the alcohol is drained from the bottle. Themethod is repeated until the solids have been extracted with alcoholfour times. The alcohol is removed via a vacuum concentrator to give anextract.

[0152] Purification of the Extract (Optional): The extract is weighed,and 3-5 mL of USP-grade ethanol is added for every gram of extractpresent. The liquid is mixed until the extract is fully dissolved.Sufficient water is added to give a 75:25 ethanol:water (v/v) mixture.The solution is allowed to stand for 5-10 minutes while a precipitantforms, and then the solution is centrifuged at 3200×G for 15 minutes.All solvents are removed from the supernatant using a vacuumconcentrator to give a dietary supplement.

[0153] A further embodiment of the present invention relates to theinvention compounds described herein and the use of the chemical andstructural information of these compounds in molecular modeling softwaresystems to provide a method in the design of anti-first-pass effectcompounds. Such computer-assisted modeling and inhibitor design mayutilize information such as chemical conformational analysis,electrostatic potential of the compound molecules, etc to ultimatelygive superior inhibitors of the first-pass effect including, forexample, transition-state analogs, mechanism-based inactivators, etc. ofenzymes such as cytochrome P450 enzymes. Such molecular modelingaccording to the invention can include comparison of the inventioncompounds with proposed modified compounds in the areas of overallstructure, size, volume, electron density, polarity, etc.Structure-activity diagrams also are included in the development of newcompounds using, for example, the assays described herein. The inventionmethod may include synthesizing a new molecule designed according tothis methodology and assaying the new molecule as herein. Thisembodiment further includes the use of the invention compounds describedherein including their structure, etc. in a traditional rationalinhibitor design protocol, as is well known to those of ordinary skillin this art. See, for example, U.S. Pat. No. 5,830,742, incorporatedherein by reference.

[0154] Examples of such computer-assisted modeling and inhibitor design,including rational inhibitor design, are provided in the chapterentitled “Enzyme Inhibitors” in Volume 9 of the Encyclopedia of ChemicalTechnology (Kirk-Othmer), Fourth edition, page 646-671, 1994,incorporated herein by reference. Enzymes and polypeptides useful insuch invention methods using the invention compounds (and modifiedinvention compounds arrived at through the above computer-assistedmodeling, inhibitor design and rational inhibitor design protocols,etc.), include P450 enzymes, preferably mammalian P450 enzymes, and mostpreferably the P450 101, P450 102, P450 108, P450_(nor), and P450_(ery)Fenzymes. However, the present invention modeling and designmethodologies are not limited to these enzymes and may use any enzyme orpolypeptide whose chemical structure, 3-D structure, and/or X-raystructure is known. Modeling using the present invention compounds inthe pursuit of transition-state analogs is included, as is the optionaleventual synthesis and testing of the resultant rationally-designed orcomputer-assisted model compounds. In the invention methods related tocomputer-aided inhibitor design, the invention compounds describedherein can act as what is known in the art as a “lead compound”. Theinvention lead compounds can then be optimized using a three-dimensionalstructure of the target enzyme or of a model constructed from relatedenzymes, or the biological activities and structures of structurallyrelated inhibitors of the particular enzyme, including other inventioncompounds described herein, and/or the pharmacophore for a particularenzyme, or a combination of the above. See, for example, N. C. Cohen etal. J. Med. Chem. 33, 883-894, (1990), incorporated herein by reference.Utilization of the computer program DOCK is contemplated herein,including variations of this computer program. Also included herein isthe use of the invention compounds in quantitative structure-activityrelationship (QSAR) methods, comparative molecular field analysismethods, pharmacophore-based design algorithms, and perturbationfree-energy calculations.

[0155] In addition to those compounds described above, the compoundslisted in the following Table are also included within the invention, ascompounds and for use in all purposes, compositions and methodsdescribed above. These compounds are presented in tabular form wheresubstituents are identified as R or L-E. R and L-E are described above.It should be noted that E may be optionally substituted HAr. Inaddition, in the compounds listed in the following Table the definitionof R is expanded to include, independently, hydrogen and all thosegroups identified above as optional substituents (e.g., C₁-C₆ linear,branched or cyclic ally group, —OH, a halogen atom, etc., hydrogen,C₁-C₄ alkyl, —S(C₁-C₄ alkyl), etc., C₁-C₁₂ alkyl, aryl, (C₁-C₄ alkylene)aryl, etc., —S(C₁-C₄ alkyl) or —SO(C₁-C₄ alkyl) (C₁-C₆ alkyl), etc.). Asis clear from the several compounds described herein, the invention inits broadest sense relates to compositions containing, and methods ofinhibiting the first-pass effect using, compounds having the basiccentral core of the compound of Formula I above and/or Formula III abovewhere such “cores” are depicted by removing the R, L-HAr and L-E groupsfrom these formulae. Also included herein are compounds and compositionscontaining, and methods of inhibiting the first-pass effect using,compounds having the basic central cores shown by the 14 chemicalstructures below that precede the Table below. Further included hereinare the methods for inhibiting the first-pass effect as described abovebut comprising co-administering a drug and an anti-first-pass amount ofa compound from the Family Rutaceae and/or Family Umbelliferae, or thecompounds described in Phytochem, 17: 845-864, 1978, incorporated hereinby reference, including to a human. As noted above, the compoundsdescribed herein are not limited with regard to stereochemistry, E-Zisomerism, etc. Ser. No. 09/001,218 is incorporated herein by reference.

Z₁ Z₂ Z₃ Z₄ Z₅ Z₆ Z₇ Z₈ Z₉ Z₁₀ R R R R R R R R R R R R R R L-E R R R R RR R R R R L-E R R R R R R R R R R L-E R R R R R R R R R R L-E R R R R RR R R R R L-E R R R R R R R R R R L-E R R R R L-E L-E R R R R R R R RL-E R L-E R R R R R R R L-E R R L-E R R R R R R L-E R R R L-E R R R R RL-E R R R R L-E R R R R R L-E L-E R R R R R R R R L-E R L-E R R R R R RR L-E R R L-E R R R R R R L-E R R R L-E R R R R R R L-E L-E R R R R R RR R L-E R L-E R R R R R R R L-E R R L-E R R R R R R R L-E L-E R R R R RR R R L-E R L-E R R R R R R R R L-E L-E L-E R R R R R R R R R L-E R R RL-E R R R R R L-E R R R R L-E R R R R L-E R R R R R L-E R R R L-E R R RR R R L-E R R L-E R R R R R R R L-E R L-E R R R R R R R R L-E L-E R R RL-E L-E R R R R L-E R R R L-E R L-E R R R L-E R R R L-E R R L-E R R L-ER R R L-E R R R L-E R L-E R R R L-E R R R R L-E L-E R R R R L-E L-E R RR L-E R R R R L-E R L-E R R L-E R R R R L-E R R L-E R L-E R R R R L-E RR R L-E L-E R R R R R L-E L-E R R L-E R R R R R L-E R L-E R L-E R R R RR L-E R R L-E L-E R R R R R R L-E L-E R L-E R R R R R R L-E R L-E L-E RR R R R R R L-E L-E L-E L-E R R R R R R R R L-E L-E R R L-E R R R R RL-E L-E R R R L-E R R R R L-E L-E R R R R L-E R R R L-E L-E R R R R RL-E R R L-E L-E R R R R R R L-E R L-E L-E R R R R R R R L-E L-E L-E R RL-E L-E R R R R L-E L-E R R L-E R L-E R R R L-E L-E R R L-E R R L-E R RL-E L-E R R L-E R R R L-E R L-E L-E R R L-E R R R R L-E L-E L-E R R RL-E L-E R R R L-E L-E R R R L-E R L-E R R L-E L-E R R R L-E R R L-E RL-E L-E R R R L-E R R R L-E L-E L-E R R R R L-E L-E R R L-E L-E R R R RL-E R L-E R L-E L-E R R R R L-E R R L-E L-E L-E R R R R R L-E L-E R L-EL-E R R R R R L-E R L-E L-E L-E R R R R R R L-E L-E L-E R L-E R R R R RR R L-E R L-E R L-E R R R R R L-E R L-E R R L-E R R R R L-E R L-E R R RL-E R R R L-E R L-E R R R R L-E R R L-E R L-E R R R R R L-E R L-E R L-ER R R R R R L-E L-E R L-E R L-E L-E R R R R L-E R L-E R L-E R L-E R R RL-E R L-E R L-E R R L-E R R L-E R L-E R L-E R R R L-E R L-E R L-E R L-ER R R R L-E L-E R L-E R R L-E L-E R R R L-E R L-E R R L-E R L-E R R L-ER L-E R R L-E R R L-E R L-E R L-E R R L-E R R R L-E L-E R L-E R R R L-EL-E R R L-E R L-E R R R L-E R L-E R L-E R L-E R R R L-E R R L-E L-E RL-E R R R R L-E L-E R L-E R L-E R R R R L-E R L-E L-E R L-E R R R R RL-E L-E L-E L-E L-E R R R R R R R L-E L-E L-E R L-E R R R R R L-E L-EL-E R R L-E R R R R L-E L-E L-E R R R L-E R R R L-E L-E L-E R R R R L-ER R L-E L-E L-E R R R R R L-E R L-E L-E L-E R R R R R R L-E L-E L-E L-ER L-E L-E R R R R L-E L-E L-E R L-E R L-E R R R L-E L-E L-E R L-E R RL-E R R L-E L-E L-E R L-E R R R L-E R L-E L-E L-E R L-E R R R R L-E L-EL-E L-E R R L-E L-E R R R L-E L-E L-E R R L-E R L-E R R L-E L-E L-E R RL-E R R L-E R L-E L-E L-E R R L-E R R R L-E L-E L-E L-E R R R L-E L-E RR L-E L-E L-E R R R L-E R L-E R L-E L-E L-E R R R L-E R R L-E L-E L-EL-E R R R R L-E L-E R L-E L-E L-E R R R R L-E R L-E L-E L-E L-E R R R RR L-E L-E L-E L-E L-E L-E R R R R R R L-E L-E L-E L-E L-E R R R R R L-EL-E L-E L-E R L-E R R R R L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-ER R R L-E R R L-E L-E L-E L-E R R R R L-E R L-E L-E L-E L-E R R R R RL-E L-E L-E L-E L-E L-E L-E R R R R L-E L-E L-E L-E L-E R L-E R R R L-EL-E L-E L-E L-E R R L-E R R L-E L-E L-E L-E L-E R R R L-E R L-E L-E L-EL-E L-E R R R R L-E L-E L-E L-E L-E R L-E L-E R R R L-E L-E L-E L-E RL-E R L-E R R L-E L-E L-E L-E R L-E R R L-E R L-E L-E L-E L-E R L-E R RR L-E L-E L-E L-E L-E R R L-E L-E R R L-E L-E L-E L-E R R L-E R L-E RL-E L-E L-E L-E R R L-E R R L-E L-E L-E L-E L-E R R R L-E L-E R L-E L-EL-E L-E R R R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E

Z₁ Z₂ Z₃ Z₄ Z₅ Z₆ Z₇ Z₈ Z₉ Z₁₀ R R R R R R R R R R R R R R L-E R R R R RR R R R R L-E R R R R R R R R R R L-E R R R R R R R R R R L-E R R R R RR R R R R L-E R R R R R R R R R R L-E R R R R L-E L-E R R R R R R R RL-E R L-E R R R R R R R L-E R R L-E R R R R R R L-E R R R L-E R R R R RL-E R R R R L-E R R R R R L-E L-E R R R R R R R R L-E R L-E R R R R R RR L-E R R L-E R R R R R R L-E R R R L-E R R R R R R L-E L-E R R R R R RR R L-E R L-E R R R R R R R L-E R R L-E R R R R R R R L-E L-E R R R R RR R R L-E R L-E R R R R R R R R L-E L-E L-E R R R R R R R R R L-E R R RL-E R R R R R L-E R R R R L-E R R R R L-E R R R R R L-E R R R L-E R R RR R R L-E R R L-E R R R R R R R L-E R L-E R R R R R R R R L-E L-E R R RL-E L-E R R R R L-E R R R L-E R L-E R R R L-E R R R L-E R R L-E R R L-ER R R L-E R R R L-E R L-E R R R L-E R R R R L-E L-E R R R R L-E L-E R RR L-E R R R R L-E R L-E R R L-E R R R R L-E R R L-E R L-E R R R R L-E RR R L-E L-E R R R R R L-E L-E R R L-E R R R R R L-E R L-E R L-E R R R RR L-E R R L-E L-E R R R R R R L-E L-E R L-E R R R R R R L-E R L-E L-E RR R R R R R L-E L-E L-E L-E R R R R R R R R L-E L-E R R L-E R R R R RL-E L-E R R R L-E R R R R L-E L-E R R R R L-E R R R L-E L-E R R R R RL-E R R L-E L-E R R R R R R L-E R L-E L-E R R R R R R R L-E L-E L-E R RL-E L-E R R R R L-E L-E R R L-E R L-E R R R L-E L-E R R L-E R R L-E R RL-E L-E R R L-E R R R L-E R L-E L-E R R L-E R R R R L-E L-E L-E R R RL-E L-E R R R L-E L-E R R R L-E R L-E R R L-E L-E R R R L-E R R L-E RL-E L-E R R R L-E R R R L-E L-E L-E R R R R L-E L-E R R L-E L-E R R R RL-E R L-E R L-E L-E R R R R L-E R R L-E L-E L-E R R R R R L-E L-E R L-EL-E R R R R R L-E R L-E L-E L-E R R R R R R L-E L-E L-E R L-E R R R R RR R L-E R L-E R L-E R R R R R L-E R L-E R R L-E R R R R L-E R L-E R R RL-E R R R L-E R L-E R R R R L-E R R L-E R L-E R R R R R L-E R L-E R L-ER R R R R R L-E L-E R L-E R L-E L-E R R R R L-E R L-E R L-E R L-E R R RL-E R L-E R L-E R R L-E R R L-E R L-E R L-E R R R L-E R L-E R L-E R L-ER R R R L-E L-E R L-E R R L-E L-E R R R L-E R L-E R R L-E R L-E R R L-ER L-E R R L-E R R L-E R L-E R L-E R R L-E R R R L-E L-E R L-E R R R L-EL-E R R L-E R L-E R R R L-E R L-E R L-E R L-E R R R L-E R R L-E L-E RL-E R R R R L-E L-E R L-E R L-E R R R R L-E R L-E L-E R L-E R R R R RL-E L-E L-E L-E L-E R R R R R R R L-E L-E L-E R L-E R R R R R L-E L-EL-E R R L-E R R R R L-E L-E L-E R R R L-E R R R L-E L-E L-E R R R R L-ER R L-E L-E L-E R R R R R L-E R L-E L-E L-E R R R R R R L-E L-E L-E L-ER L-E L-E R R R R L-E L-E L-E R L-E R L-E R R R L-E L-E L-E R L-E R RL-E R R L-E L-E L-E R L-E R R R L-E R L-E L-E L-E R L-E R R R R L-E L-EL-E L-E R R L-E L-E R R R L-E L-E L-E R R L-E R L-E R R L-E L-E L-E R RL-E R R L-E R L-E L-E L-E R R L-E R R R L-E L-E L-E L-E R R R L-E L-E RR L-E L-E L-E R R R L-E R L-E R L-E L-E L-E R R R L-E R R L-E L-E L-EL-E R R R R L-E L-E R L-E L-E L-E R R R R L-E R L-E L-E L-E L-E R R R RR L-E L-E L-E L-E L-E L-E R R R R R R L-E L-E L-E L-E L-E R R R R R L-EL-E L-E L-E R L-E R R R R L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-ER R R L-E R R L-E L-E L-E L-E R R R R L-E R L-E L-E L-E L-E R R R R RL-E L-E L-E L-E L-E L-E L-E R R R R L-E L-E L-E L-E L-E R L-E R R R L-EL-E L-E L-E L-E R R L-E R R L-E L-E L-E L-E L-E R R R L-E R L-E L-E L-EL-E L-E R R R R L-E L-E L-E L-E L-E R L-E L-E R R R L-E L-E L-E L-E RL-E R L-E R R L-E L-E L-E L-E R L-E R R L-E R L-E L-E L-E L-E R L-E R RR L-E L-E L-E L-E L-E R R L-E L-E R R L-E L-E L-E L-E R R L-E R L-E RL-E L-E L-E L-E R R L-E R R L-E L-E L-E L-E L-E R R R L-E L-E R L-E L-EL-E L-E R R R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E

Z₁ Z₂ Z₃ Z₄ Z₅ Z₆ Z₇ Z₈ Z₉ Z₁₀ R R R R R R R R R R R R R R L-E R R R R RR R R R R L-E R R R R R R R R R R L-E R R R R R R R R R R L-E R R R R RR R R R R L-E R R R R R R R R R R L-E R R R R L-E L-E R R R R R R R RL-E R L-E R R R R R R R L-E R R L-E R R R R R R L-E R R R L-E R R R R RL-E R R R R L-E R R R R R L-E L-E R R R R R R R R L-E R L-E R R R R R RR L-E R R L-E R R R R R R L-E R R R L-E R R R R R R L-E L-E R R R R R RR R L-E R L-E R R R R R R R L-E R R L-E R R R R R R R L-E L-E R R R R RR R R L-E R L-E R R R R R R R R L-E L-E L-E R R R R R R R R R L-E R R RL-E R R R R R L-E R R R R L-E R R R R L-E R R R R R L-E R R R L-E R R RR R R L-E R R L-E R R R R R R R L-E R L-E R R R R R R R R L-E L-E R R RL-E L-E R R R R L-E R R R L-E R L-E R R R L-E R R R L-E R R L-E R R L-ER R R L-E R R R L-E R L-E R R R L-E R R R R L-E L-E R R R R L-E L-E R RR L-E R R R R L-E R L-E R R L-E R R R R L-E R R L-E R L-E R R R R L-E RR R L-E L-E R R R R R L-E L-E R R L-E R R R R R L-E R L-E R L-E R R R RR L-E R R L-E L-E R R R R R R L-E L-E R L-E R R R R R R L-E R L-E L-E RR R R R R R L-E L-E L-E L-E R R R R R R R R L-E L-E R R L-E R R R R RL-E L-E R R R L-E R R R R L-E L-E R R R R L-E R R R L-E L-E R R R R RL-E R R L-E L-E R R R R R R L-E R L-E L-E R R R R R R R L-E L-E L-E R RL-E L-E R R R R L-E L-E R R L-E R L-E R R R L-E L-E R R L-E R R L-E R RL-E L-E R R L-E R R R L-E R L-E L-E R R L-E R R R R L-E L-E L-E R R RL-E L-E R R R L-E L-E R R R L-E R L-E R R L-E L-E R R R L-E R R L-E RL-E L-E R R R L-E R R R L-E L-E L-E R R R R L-E L-E R R L-E L-E R R R RL-E R L-E R L-E L-E R R R R L-E R R L-E L-E L-E R R R R R L-E L-E R L-EL-E R R R R R L-E R L-E L-E L-E R R R R R R L-E L-E L-E R L-E R R R R RR R L-E R L-E R L-E R R R R R L-E R L-E R R L-E R R R R L-E R L-E R R RL-E R R R L-E R L-E R R R R L-E R R L-E R L-E R R R R R L-E R L-E R L-ER R R R R R L-E L-E R L-E R L-E L-E R R R R L-E R L-E R L-E R L-E R R RL-E R L-E R L-E R R L-E R R L-E R L-E R L-E R R R L-E R L-E R L-E R L-ER R R R L-E L-E R L-E R R L-E L-E R R R L-E R L-E R R L-E R L-E R R L-ER L-E R R L-E R R L-E R L-E R L-E R R L-E R R R L-E L-E R L-E R R R L-EL-E R R L-E R L-E R R R L-E R L-E R L-E R L-E R R R L-E R R L-E L-E RL-E R R R R L-E L-E R L-E R L-E R R R R L-E R L-E L-E R L-E R R R R RL-E L-E L-E L-E L-E R R R R R R R L-E L-E L-E R L-E R R R R R L-E L-EL-E R R L-E R R R R L-E L-E L-E R R R L-E R R R L-E L-E L-E R R R R L-ER R L-E L-E L-E R R R R R L-E R L-E L-E L-E R R R R R R L-E L-E L-E L-ER L-E L-E R R R R L-E L-E L-E R L-E R L-E R R R L-E L-E L-E R L-E R RL-E R R L-E L-E L-E R L-E R R R L-E R L-E L-E L-E R L-E R R R R L-E L-EL-E L-E R R L-E L-E R R R L-E L-E L-E R R L-E R L-E R R L-E L-E L-E R RL-E R R L-E R L-E L-E L-E R R L-E R R R L-E L-E L-E L-E R R R L-E L-E RR L-E L-E L-E R R R L-E R L-E R L-E L-E L-E R R R L-E R R L-E L-E L-EL-E R R R R L-E L-E R L-E L-E L-E R R R R L-E R L-E L-E L-E L-E R R R RR L-E L-E L-E L-E L-E L-E R R R R R R L-E L-E L-E L-E L-E R R R R R L-EL-E L-E L-E R L-E R R R R L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-ER R R L-E R R L-E L-E L-E L-E R R R R L-E R L-E L-E L-E L-E R R R R RL-E L-E L-E L-E L-E L-E L-E R R R R L-E L-E L-E L-E L-E R L-E R R R L-EL-E L-E L-E L-E R R L-E R R L-E L-E L-E L-E L-E R R R L-E R L-E L-E L-EL-E L-E R R R R L-E L-E L-E L-E L-E R L-E L-E R R R L-E L-E L-E L-E RL-E R L-E R R L-E L-E L-E L-E R L-E R R L-E R L-E L-E L-E L-E R L-E R RR L-E L-E L-E L-E L-E R R L-E L-E R R L-E L-E L-E L-E R R L-E R L-E RL-E L-E L-E L-E R R L-E R R L-E L-E L-E L-E L-E R R R L-E L-E R L-E L-EL-E L-E R R R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E

Z₁ Z₂ Z₃ Z₄ Z₅ Z₆ Z₇ Z₈ Z₉ Z₁₀ R R R R R R R R R R R R R R L-E R R R R RR R R R R L-E R R R R R R R R R R L-E R R R R R R R R R R L-E R R R R RR R R R R L-E R R R R R R R R R R L-E R R R R L-E L-E R R R R R R R RL-E R L-E R R R R R R R L-E R R L-E R R R R R R L-E R R R L-E R R R R RL-E R R R R L-E R R R R R L-E L-E R R R R R R R R L-E R L-E R R R R R RR L-E R R L-E R R R R R R L-E R R R L-E R R R R R R L-E L-E R R R R R RR R L-E R L-E R R R R R R R L-E R R L-E R R R R R R R L-E L-E R R R R RR R R L-E R L-E R R R R R R R R L-E L-E L-E R R R R R R R R R L-E R R RL-E R R R R R L-E R R R R L-E R R R R L-E R R R R R L-E R R R L-E R R RR R R L-E R R L-E R R R R R R R L-E R L-E R R R R R R R R L-E L-E R R RL-E L-E R R R R L-E R R R L-E R L-E R R R L-E R R R L-E R R L-E R R L-ER R R L-E R R R L-E R L-E R R R L-E R R R R L-E L-E R R R R L-E L-E R RR L-E R R R R L-E R L-E R R L-E R R R R L-E R R L-E R L-E R R R R L-E RR R L-E L-E R R R R R L-E L-E R R L-E R R R R R L-E R L-E R L-E R R R RR L-E R R L-E L-E R R R R R R L-E L-E R L-E R R R R R R L-E R L-E L-E RR R R R R R L-E L-E L-E L-E R R R R R R R R L-E L-E R R L-E R R R R RL-E L-E R R R L-E R R R R L-E L-E R R R R L-E R R R L-E L-E R R R R RL-E R R L-E L-E R R R R R R L-E R L-E L-E R R R R R R R L-E L-E L-E R RL-E L-E R R R R L-E L-E R R L-E R L-E R R R L-E L-E R R L-E R R L-E R RL-E L-E R R L-E R R R L-E R L-E L-E R R L-E R R R R L-E L-E L-E R R RL-E L-E R R R L-E L-E R R R L-E R L-E R R L-E L-E R R R L-E R R L-E RL-E L-E R R R L-E R R R L-E L-E L-E R R R R L-E L-E R R L-E L-E R R R RL-E R L-E R L-E L-E R R R R L-E R R L-E L-E L-E R R R R R L-E L-E R L-EL-E R R R R R L-E R L-E L-E L-E R R R R R R L-E L-E L-E R L-E R R R R RR R L-E R L-E R L-E R R R R R L-E R L-E R R L-E R R R R L-E R L-E R R RL-E R R R L-E R L-E R R R R L-E R R L-E R L-E R R R R R L-E R L-E R L-ER R R R R R L-E L-E R L-E R L-E L-E R R R R L-E R L-E R L-E R L-E R R RL-E R L-E R L-E R R L-E R R L-E R L-E R L-E R R R L-E R L-E R L-E R L-ER R R R L-E L-E R L-E R R L-E L-E R R R L-E R L-E R R L-E R L-E R R L-ER L-E R R L-E R R L-E R L-E R L-E R R L-E R R R L-E L-E R L-E R R R L-EL-E R R L-E R L-E R R R L-E R L-E R L-E R L-E R R R L-E R R L-E L-E RL-E R R R R L-E L-E R L-E R L-E R R R R L-E R L-E L-E R L-E R R R R RL-E L-E L-E L-E L-E R R R R R R R L-E L-E L-E R L-E R R R R R L-E L-EL-E R R L-E R R R R L-E L-E L-E R R R L-E R R R L-E L-E L-E R R R R L-ER R L-E L-E L-E R R R R R L-E R L-E L-E L-E R R R R R R L-E L-E L-E L-ER L-E L-E R R R R L-E L-E L-E R L-E R L-E R R R L-E L-E L-E R L-E R RL-E R R L-E L-E L-E R L-E R R R L-E R L-E L-E L-E R L-E R R R R L-E L-EL-E L-E R R L-E L-E R R R L-E L-E L-E R R L-E R L-E R R L-E L-E L-E R RL-E R R L-E R L-E L-E L-E R R L-E R R R L-E L-E L-E L-E R R R L-E L-E RR L-E L-E L-E R R R L-E R L-E R L-E L-E L-E R R R L-E R R L-E L-E L-EL-E R R R R L-E L-E R L-E L-E L-E R R R R L-E R L-E L-E L-E L-E R R R RR L-E L-E L-E L-E L-E L-E R R R R R R L-E L-E L-E L-E L-E R R R R R L-EL-E L-E L-E R L-E R R R R L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-ER R R L-E R R L-E L-E L-E L-E R R R R L-E R L-E L-E L-E L-E R R R R RL-E L-E L-E L-E L-E L-E L-E R R R R L-E L-E L-E L-E L-E R L-E R R R L-EL-E L-E L-E L-E R R L-E R R L-E L-E L-E L-E L-E R R R L-E R L-E L-E L-EL-E L-E R R R R L-E L-E L-E L-E L-E R L-E L-E R R R L-E L-E L-E L-E RL-E R L-E R R L-E L-E L-E L-E R L-E R R L-E R L-E L-E L-E L-E R L-E R RR L-E L-E L-E L-E L-E R R L-E L-E R R L-E L-E L-E L-E R R L-E R L-E RL-E L-E L-E L-E R R L-E R R L-E L-E L-E L-E L-E R R R L-E L-E R L-E L-EL-E L-E R R R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E

Z₁ Z₂ Z₃ Z₄ Z₅ Z₆ Z₇ Z₈ Z₉ Z₁₀ R R R R R R R R R R R R R R L-E R R R R RR R R R R L-E R R R R R R R R R R L-E R R R R R R R R R R L-E R R R R RR R R R R L-E R R R R R R R R R R L-E R R R R L-E L-E R R R R R R R RL-E R L-E R R R R R R R L-E R R L-E R R R R R R L-E R R R L-E R R R R RL-E R R R R L-E R R R R R L-E L-E R R R R R R R R L-E R L-E R R R R R RR L-E R R L-E R R R R R R L-E R R R L-E R R R R R R L-E L-E R R R R R RR R L-E R L-E R R R R R R R L-E R R L-E R R R R R R R L-E L-E R R R R RR R R L-E R L-E R R R R R R R R L-E L-E L-E R R R R R R R R R L-E R R RL-E R R R R R L-E R R R R L-E R R R R L-E R R R R R L-E R R R L-E R R RR R R L-E R R L-E R R R R R R R L-E R L-E R R R R R R R R L-E L-E R R RL-E L-E R R R R L-E R R R L-E R L-E R R R L-E R R R L-E R R L-E R R L-ER R R L-E R R R L-E R L-E R R R L-E R R R R L-E L-E R R R R L-E L-E R RR L-E R R R R L-E R L-E R R L-E R R R R L-E R R L-E R L-E R R R R L-E RR R L-E L-E R R R R R L-E L-E R R L-E R R R R R L-E R L-E R L-E R R R RR L-E R R L-E L-E R R R R R R L-E L-E R L-E R R R R R R L-E R L-E L-E RR R R R R R L-E L-E L-E L-E R R R R R R R R L-E L-E R R L-E R R R R RL-E L-E R R R L-E R R R R L-E L-E R R R R L-E R R R L-E L-E R R R R RL-E R R L-E L-E R R R R R R L-E R L-E L-E R R R R R R R L-E L-E L-E R RL-E L-E R R R R L-E L-E R R L-E R L-E R R R L-E L-E R R L-E R R L-E R RL-E L-E R R L-E R R R L-E R L-E L-E R R L-E R R R R L-E L-E L-E R R RL-E L-E R R R L-E L-E R R R L-E R L-E R R L-E L-E R R R L-E R R L-E RL-E L-E R R R L-E R R R L-E L-E L-E R R R R L-E L-E R R L-E L-E R R R RL-E R L-E R L-E L-E R R R R L-E R R L-E L-E L-E R R R R R L-E L-E R L-EL-E R R R R R L-E R L-E L-E L-E R R R R R R L-E L-E L-E R L-E R R R R RR R L-E R L-E R L-E R R R R R L-E R L-E R R L-E R R R R L-E R L-E R R RL-E R R R L-E R L-E R R R R L-E R R L-E R L-E R R R R R L-E R L-E R L-ER R R R R R L-E L-E R L-E R L-E L-E R R R R L-E R L-E R L-E R L-E R R RL-E R L-E R L-E R R L-E R R L-E R L-E R L-E R R R L-E R L-E R L-E R L-ER R R R L-E L-E R L-E R R L-E L-E R R R L-E R L-E R R L-E R L-E R R L-ER L-E R R L-E R R L-E R L-E R L-E R R L-E R R R L-E L-E R L-E R R R L-EL-E R R L-E R L-E R R R L-E R L-E R L-E R L-E R R R L-E R R L-E L-E RL-E R R R R L-E L-E R L-E R L-E R R R R L-E R L-E L-E R L-E R R R R RL-E L-E L-E L-E L-E R R R R R R R L-E L-E L-E R L-E R R R R R L-E L-EL-E R R L-E R R R R L-E L-E L-E R R R L-E R R R L-E L-E L-E R R R R L-ER R L-E L-E L-E R R R R R L-E R L-E L-E L-E R R R R R R L-E L-E L-E L-ER L-E L-E R R R R L-E L-E L-E R L-E R L-E R R R L-E L-E L-E R L-E R RL-E R R L-E L-E L-E R L-E R R R L-E R L-E L-E L-E R L-E R R R R L-E L-EL-E L-E R R L-E L-E R R R L-E L-E L-E R R L-E R L-E R R L-E L-E L-E R RL-E R R L-E R L-E L-E L-E R R L-E R R R L-E L-E L-E L-E R R R L-E L-E RR L-E L-E L-E R R R L-E R L-E R L-E L-E L-E R R R L-E R R L-E L-E L-EL-E R R R R L-E L-E R L-E L-E L-E R R R R L-E R L-E L-E L-E L-E R R R RR L-E L-E L-E L-E L-E L-E R R R R R R L-E L-E L-E L-E L-E R R R R R L-EL-E L-E L-E R L-E R R R R L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-ER R R L-E R R L-E L-E L-E L-E R R R R L-E R L-E L-E L-E L-E R R R R RL-E L-E L-E L-E L-E L-E L-E R R R R L-E L-E L-E L-E L-E R L-E R R R L-EL-E L-E L-E L-E R R L-E R R L-E L-E L-E L-E L-E R R R L-E R L-E L-E L-EL-E L-E R R R R L-E L-E L-E L-E L-E R L-E L-E R R R L-E L-E L-E L-E RL-E R L-E R R L-E L-E L-E L-E R L-E R R L-E R L-E L-E L-E L-E R L-E R RR L-E L-E L-E L-E L-E R R L-E L-E R R L-E L-E L-E L-E R R L-E R L-E RL-E L-E L-E L-E R R L-E R R L-E L-E L-E L-E L-E R R R L-E L-E R L-E L-EL-E L-E R R R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E

Z₁ Z₂ Z₃ Z₄ Z₅ Z₆ Z₇ Z₈ Z₉ Z₁₀ R R R R R R R R R R R R R R L-E R R R R RR R R R R L-E R R R R R R R R R R L-E R R R R R R R R R R L-E R R R R RR R R R R L-E R R R R R R R R R R L-E R R R R L-E L-E R R R R R R R RL-E R L-E R R R R R R R L-E R R L-E R R R R R R L-E R R R L-E R R R R RL-E R R R R L-E R R R R R L-E L-E R R R R R R R R L-E R L-E R R R R R RR L-E R R L-E R R R R R R L-E R R R L-E R R R R R R L-E L-E R R R R R RR R L-E R L-E R R R R R R R L-E R R L-E R R R R R R R L-E L-E R R R R RR R R L-E R L-E R R R R R R R R L-E L-E L-E R R R R R R R R R L-E R R RL-E R R R R R L-E R R R R L-E R R R R L-E R R R R R L-E R R R L-E R R RR R R L-E R R L-E R R R R R R R L-E R L-E R R R R R R R R L-E L-E R R RL-E L-E R R R R L-E R R R L-E R L-E R R R L-E R R R L-E R R L-E R R L-ER R R L-E R R R L-E R L-E R R R L-E R R R R L-E L-E R R R R L-E L-E R RR L-E R R R R L-E R L-E R R L-E R R R R L-E R R L-E R L-E R R R R L-E RR R L-E L-E R R R R R L-E L-E R R L-E R R R R R L-E R L-E R L-E R R R RR L-E R R L-E L-E R R R R R R L-E L-E R L-E R R R R R R L-E R L-E L-E RR R R R R R L-E L-E L-E L-E R R R R R R R R L-E L-E R R L-E R R R R RL-E L-E R R R L-E R R R R L-E L-E R R R R L-E R R R L-E L-E R R R R RL-E R R L-E L-E R R R R R R L-E R L-E L-E R R R R R R R L-E L-E L-E R RL-E L-E R R R R L-E L-E R R L-E R L-E R R R L-E L-E R R L-E R R L-E R RL-E L-E R R L-E R R R L-E R L-E L-E R R L-E R R R R L-E L-E L-E R R RL-E L-E R R R L-E L-E R R R L-E R L-E R R L-E L-E R R R L-E R R L-E RL-E L-E R R R L-E R R R L-E L-E L-E R R R R L-E L-E R R L-E L-E R R R RL-E R L-E R L-E L-E R R R R L-E R R L-E L-E L-E R R R R R L-E L-E R L-EL-E R R R R R L-E R L-E L-E L-E R R R R R R L-E L-E L-E R L-E R R R R RR R L-E R L-E R L-E R R R R R L-E R L-E R R L-E R R R R L-E R L-E R R RL-E R R R L-E R L-E R R R R L-E R R L-E R L-E R R R R R L-E R L-E R L-ER R R R R R L-E L-E R L-E R L-E L-E R R R R L-E R L-E R L-E R L-E R R RL-E R L-E R L-E R R L-E R R L-E R L-E R L-E R R R L-E R L-E R L-E R L-ER R R R L-E L-E R L-E R R L-E L-E R R R L-E R L-E R R L-E R L-E R R L-ER L-E R R L-E R R L-E R L-E R L-E R R L-E R R R L-E L-E R L-E R R R L-EL-E R R L-E R L-E R R R L-E R L-E R L-E R L-E R R R L-E R R L-E L-E RL-E R R R R L-E L-E R L-E R L-E R R R R L-E R L-E L-E R L-E R R R R RL-E L-E L-E L-E L-E R R R R R R R L-E L-E L-E R L-E R R R R R L-E L-EL-E R R L-E R R R R L-E L-E L-E R R R L-E R R R L-E L-E L-E R R R R L-ER R L-E L-E L-E R R R R R L-E R L-E L-E L-E R R R R R R L-E L-E L-E L-ER L-E L-E R R R R L-E L-E L-E R L-E R L-E R R R L-E L-E L-E R L-E R RL-E R R L-E L-E L-E R L-E R R R L-E R L-E L-E L-E R L-E R R R R L-E L-EL-E L-E R R L-E L-E R R R L-E L-E L-E R R L-E R L-E R R L-E L-E L-E R RL-E R R L-E R L-E L-E L-E R R L-E R R R L-E L-E L-E L-E R R R L-E L-E RR L-E L-E L-E R R R L-E R L-E R L-E L-E L-E R R R L-E R R L-E L-E L-EL-E R R R R L-E L-E R L-E L-E L-E R R R R L-E R L-E L-E L-E L-E R R R RR L-E L-E L-E L-E L-E L-E R R R R R R L-E L-E L-E L-E L-E R R R R R L-EL-E L-E L-E R L-E R R R R L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-ER R R L-E R R L-E L-E L-E L-E R R R R L-E R L-E L-E L-E L-E R R R R RL-E L-E L-E L-E L-E L-E L-E R R R R L-E L-E L-E L-E L-E R L-E R R R L-EL-E L-E L-E L-E R R L-E R R L-E L-E L-E L-E L-E R R R L-E R L-E L-E L-EL-E L-E R R R R L-E L-E L-E L-E L-E R L-E L-E R R R L-E L-E L-E L-E RL-E R L-E R R L-E L-E L-E L-E R L-E R R L-E R L-E L-E L-E L-E R L-E R RR L-E L-E L-E L-E L-E R R L-E L-E R R L-E L-E L-E L-E R R L-E R L-E RL-E L-E L-E L-E R R L-E R R L-E L-E L-E L-E L-E R R R L-E L-E R L-E L-EL-E L-E R R R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E R R R R R R R RR R R R R R L-E R R R R R R R R R R L-E R R R R R R R R R R L-E R R R RR R R R R R L-E R R R R R R R R R R L-E R R R R R R R R R R L-E R R R RL-E L-E R R R R R R R R L-E R L-E R R R R R R R L-E R R L-E R R R R R RL-E R R R L-E R R R R R L-E R R R R L-E R R R R R L-E L-E R R R R R R RR L-E R L-E R R R R R R R L-E R R L-E R R R R R R L-E R R R L-E R R R RR R L-E L-E R R R R R R R R L-E R L-E R R R R R R R L-E R R L-E R R R RR R R L-E L-E R R R R R R R R L-E R L-E R R R R R R R R L-E L-E L-E R RR R R R R R R L-E R R R L-E R R R R R L-E R R R R L-E R R R R L-E R R RR R L-E R R R L-E R R R R R R L-E R R L-E R R R R R R R L-E R L-E R R RR R R R R L-E L-E R R R L-E L-E R R R R L-E R R R L-E R L-E R R R L-E RR R L-E R R L-E R R L-E R R R L-E R R R L-E R L-E R R R L-E R R R R L-EL-E R R R R L-E L-E R R R L-E R R R R L-E R L-E R R L-E R R R R L-E R RL-E R L-E R R R R L-E R R R L-E L-E R R R R R L-E L-E R R L-E R R R R RL-E R L-E R L-E R R R R R L-E R R L-E L-E R R R R R R L-E L-E R L-E R RR R R R L-E R L-E L-E R R R R R R R L-E L-E

Z₁ Z₂ Z₃ Z₄ Z₅ Z₆ Z₇ Z₈ Z₉ Z₁₀ L-E L-E R R R R R R R R L-E L-E R R L-E RR R R R L-E L-E R R R L-E R R R R L-E L-E R R R R L-E R R R L-E L-E R RR R R L-E R R L-E L-E R R R R R R L-E R L-E L-E R R R R R R R L-E L-EL-E R R L-E L-E R R R R L-E L-E R R L-E R L-E R R R L-E L-E R R L-E R RL-E R R L-E L-E R R L-E R R R L-E R L-E L-E R R L-E R R R R L-E L-E L-ER R R L-E L-E R R R L-E L-E R R R L-E R L-E R R L-E L-E R R R L-E R RL-E R L-E L-E R R R L-E R R R L-E L-E L-E R R R R L-E L-E R R L-E L-E RR R R L-E R L-E R L-E L-E R R R R L-E R R L-E L-E L-E R R R R R L-E L-ER L-E L-E R R R R R L-E R L-E L-E L-E R R R R R R L-E L-E L-E R L-E R RR R R R R L-E R L-E R L-E R R R R R L-E R L-E R R L-E R R R R L-E R L-ER R R L-E R R R L-E R L-E R R R R L-E R R L-E R L-E R R R R R L-E R L-ER L-E R R R R R R L-E L-E R L-E R L-E L-E R R R R L-E R L-E R L-E R L-ER R R L-E R L-E R L-E R R L-E R R L-E R L-E R L-E R R R L-E R L-E R L-ER L-E R R R R L-E L-E R L-E R R L-E L-E R R R L-E R L-E R R L-E R L-E RR L-E R L-E R R L-E R R L-E R L-E R L-E R R L-E R R R L-E L-E R L-E R RR L-E L-E R R L-E R L-E R R R L-E R L-E R L-E R L-E R R R L-E R R L-EL-E R L-E R R R R L-E L-E R L-E R L-E R R R R L-E R L-E L-E R L-E R R RR R L-E L-E L-E L-E L-E R R R R R R R L-E L-E L-E R L-E R R R R R L-EL-E L-E R R L-E R R R R L-E L-E L-E R R R L-E R R R L-E L-E L-E R R R RL-E R R L-E L-E L-E R R R R R L-E R L-E L-E L-E R R R R R R L-E L-E L-EL-E R L-E L-E R R R R L-E L-E L-E R L-E R L-E R R R L-E L-E L-E R L-E RR L-E R R L-E L-E L-E R L-E R R R L-E R L-E L-E L-E R L-E R R R R L-EL-E L-E L-E R R L-E L-E R R R L-E L-E L-E R R L-E R L-E R R L-E L-E L-ER R L-E R R L-E R L-E L-E L-E R R L-E R R R L-E L-E L-E L-E R R R L-EL-E R R L-E L-E L-E R R R L-E R L-E R L-E L-E L-E R R R L-E R R L-E L-EL-E L-E R R R R L-E L-E R L-E L-E L-E R R R R L-E R L-E L-E L-E L-E R RR R R L-E L-E L-E L-E L-E L-E R R R R R R L-E L-E L-E L-E L-E R R R R RL-E L-E L-E L-E R L-E R R R R L-E L-E L-E L-E R R L-E R R R L-E L-E L-EL-E R R R L-E R R L-E L-E L-E L-E R R R R L-E R L-E L-E L-E L-E R R R RR L-E L-E L-E L-E L-E L-E L-E R R R R L-E L-E L-E L-E L-E R L-E R R RL-E L-E L-E L-E L-E R R L-E R R L-E L-E L-E L-E L-E R R R L-E R L-E L-EL-E L-E L-E R R R R L-E L-E L-E L-E L-E R L-E L-E R R R L-E L-E L-E L-ER L-E R L-E R R L-E L-E L-E L-E R L-E R R L-E R L-E L-E L-E L-E R L-E RR R L-E L-E L-E L-E L-E R R L-E L-E R R L-E L-E L-E L-E R R L-E R L-E RL-E L-E L-E L-E R R L-E R R L-E L-E L-E L-E L-E R R R L-E L-E R L-E L-EL-E L-E R R R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E

Z₁ Z₂ Z₃ Z₄ Z₅ Z₆ Z₇ Z₈ Z₉ Z₁₀ Z₁₁ Z₁₂ R R R R R R R R R R R R R R R RL-E R R R R R R R R R R R R L-E R R R R R R R R R R R R L-E R R R R R RR R R R R R L-E R R R R R R R R R R R R L-E R R R R R R R R R R R R L-ER R R R R R L-E L-E R R R R R R R R R R L-E R L-E R R R R R R R R R L-ER R L-E R R R R R R R R L-E R R R L-E R R R R R R R L-E R R R R L-E R RR R R R R L-E L-E R R R R R R R R R R L-E R L-E R R R R R R R R R L-E RR L-E R R R R R R R R L-E R R R L-E R R R R R R R R L-E L-E R R R R R RR R R R L-E R L-E R R R R R R R R R L-E R R L-E R R R R R R R R R L-EL-E R R R R R R R R R R L-E R L-E R R R R R R R R R R L-E L-E R R R R RR R R R R R R L-E R R R R R L-E R R R R R L-E R R R R R R L-E R R R RL-E R R R R R R R L-E R R R L-E R R R R R R R R L-E R R L-E R R R R R RR R R L-E R L-E R R R R R R R R R R L-E L-E R R R R R L-E L-E R R R RL-E R R R R R L-E R L-E R R R L-E R R R R R L-E R R L-E R R L-E R R R RR L-E R R R L-E R L-E R R R R R L-E R R R R L-E L-E R R R R R R L-E L-ER R R L-E R R R R R R L-E R L-E R R L-E R R R R R R L-E R R L-E R L-E RR R R R R L-E R R R L-E L-E R R R R R R R L-E L-E R R L-E R R R R R R RL-E R L-E R L-E R R R R R R R L-E R R L-E L-E R R R R R R R R L-E L-E RL-E R R R R R R R R L-E R L-E L-E R R R R R R R R R L-E L-E L-E R R R RR R R R R R R R L-E R R R R L-E R R R R R R L-E R R R R R L-E R R R R RL-E R R R R R R L-E R R R R L-E R R R R R R R L-E R R R L-E R R R R R RR R L-E R R L-E R R R R R R R R R L-E R L-E R R R R L-E L-E R R R R RL-E R R R R L-E R L-E R R R R L-E R R R R L-E R R L-E R R R L-E R R R RL-E R R R L-E R R L-E R R R R L-E R R R R L-E R L-E R R R R R L-E L-E RR R R L-E R R R R R L-E R L-E R R R L-E R R R R R L-E R R L-E R R L-E RR R R R L-E R R R L-E R L-E R R R R R R L-E L-E R R R L-E R R R R R RL-E R L-E R R L-E R R R R R R L-E R R L-E R L-E R R R R R R R L-E L-E RR L-E R R R R R R R L-E R L-E R L-E R R R R R R R R L-E L-E R L-E R R RR R R R R R R L-E L-E R R R R L-E R R R R R L-E L-E R R R R R L-E R R RR L-E L-E R R R R R R L-E R R R L-E L-E R R R R R R R L-E R R L-E L-E RR R R R R R R L-E R L-E L-E R R R R R R R R R L-E L-E L-E R R R R L-EL-E R R R R L-E L-E R R R R L-E R L-E R R R L-E L-E R R R R L-E R R L-ER R L-E L-E R R R R L-E R R R L-E R L-E L-E R R R R L-E R R R R L-E L-EL-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E R L-E R R L-E L-E R RR R R L-E R R L-E R L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R RL-E L-E R R L-E L-E R R R R R R L-E R L-E R L-E L-E R R R R R R L-E R RL-E L-E L-E R R R R R R R L-E L-E R L-E L-E R R R R R R R L-E R L-E L-EL-E R R R R R R R R L-E L-E L-E L-E L-E R R R R R R R R R R R L-E R R RL-E R R R R R R R L-E R R R R L-E R R R R R R L-E R R R R R L-E R R R RR L-E R R R R R R L-E R R R R L-E R R R R R R R L-E R R R L-E R R R R RR R R L-E R R L-E R R R L-E L-E R R R R R R L-E R R R L-E R L-E R R R RR L-E R R R L-E R R L-E R R R R L-E R R R L-E R R R L-E R R R L-E R R RL-E R R R R L-E R R L-E R R R R L-E L-E R R R R R L-E R R R R L-E R L-ER R R R L-E R R R R L-E R R L-E R R R L-E R R R R L-E R R R L-E R R L-ER R R R R L-E L-E R R R R L-E R R R R R L-E R L-E R R R L-E R R R R RL-E R R L-E R R L-E R R R R R R L-E L-E R R R L-E R R R R R R L-E R L-ER R L-E R R R R R R R L-E L-E R R L-E R R R R R R R R R L-E R L-E R R RL-E R R R R R L-E R L-E R R R R L-E R R R R L-E R L-E R R R R R L-E R RR L-E R L-E R R R R R R L-E R R L-E R L-E R R R R R R R L-E R L-E R L-ER R R R R R R R L-E L-E R L-E R R R L-E L-E R R R R L-E R L-E R R R L-ER L-E R R R L-E R L-E R R R L-E R R L-E R R L-E R L-E R R R L-E R R RL-E R L-E R L-E R R R L-E R R R R L-E L-E R L-E R R R R L-E L-E R R RL-E R L-E R R R R L-E R L-E R R L-E R L-E R R R R L-E R R L-E R L-E RL-E R R R R L-E R R R L-E L-E R L-E R R R R R L-E L-E R R L-E R L-E R RR R R L-E R L-E R L-E R L-E R R R R R L-E R R L-E L-E R L-E R R R R R RL-E L-E R L-E R L-E R R R R R R L-E R L-E L-E R L-E R R R R R R R L-EL-E L-E R L-E R R R R R R R R R R L-E L-E R R R L-E R R R R R R L-E L-ER R R R L-E R R R R R L-E L-E R R R R R L-E R R R R L-E L-E R R R R R RL-E R R R L-E L-E R R R R R R R L-E R R L-E L-E R R R R R R R R L-E RL-E L-E R R R L-E L-E R R R R R L-E L-E R R R L-E R L-E R R R R L-E L-ER R R L-E R R L-E R R R L-E L-E R R R L-E R R R L-E R R L-E L-E R R RL-E R R R R L-E R L-E L-E R R R R L-E L-E R R R R L-E L-E R R R R L-E RL-E R R R L-E L-E R R R R L-E R R L-E R R L-E L-E R R R R L-E R R R L-ER L-E L-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E R L-E R R L-EL-E R R R R R L-E R R L-E R L-E L-E R R R R R R L-E L-E R R L-E L-E R RR R R R L-E R L-E R L-E L-E R R R R R R R L-E L-E R L-E L-E R R R R R RR R R L-E L-E L-E R R R L-E R R R R R L-E L-E L-E R R R R L-E R R R RL-E L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R R L-E R R L-E L-EL-E R R R R R R R L-E R L-E L-E L-E R R R R R R R R L-E L-E L-E L-E R RR L-E L-E R R R R L-E L-E L-E R R R L-E R L-E R R R L-E L-E L-E R R RL-E R R L-E R R L-E L-E L-E R R R L-E R R R L-E R L-E L-E L-E R R R L-ER R R R L-E L-E L-E L-E R R R R L-E L-E R R R L-E L-E L-E R R R R L-E RL-E R R L-E L-E L-E R R R R L-E R R L-E R L-E L-E L-E R R R R L-E R R RL-E L-E L-E L-E R R R R R L-E L-E R R L-E L-E L-E R R R R R L-E R L-E RL-E L-E L-E R R R R R L-E R R L-E L-E L-E L-E R R R R R R L-E L-E R L-EL-E L-E R R R R R R L-E R L-E L-E L-E L-E R R R R R R R L-E L-E L-E L-EL-E L-E R R R R R R R R R R L-E L-E R R L-E R R R R R R R L-E L-E R R RL-E R R R R R R L-E L-E R R R R L-E R R R R R L-E L-E R R R R R L-E R RR R L-E L-E R R R R R R L-E R R R L-E L-E R R R R R R R L-E R R L-E L-ER R L-E L-E R R R R R R L-E L-E R R L-E R L-E R R R R R L-E L-E R R L-ER R L-E R R R R L-E L-E R R L-E R R R L-E R R R L-E L-E R R L-E R R R RL-E R R L-E L-E R R R L-E L-E R R R R R L-E L-E R R R L-E R L-E R R R RL-E L-E R R R L-E R R L-E R R R L-E L-E R R R L-E R R R L-E R R L-E L-ER R R R L-E L-E R R R R L-E L-E R R R R L-E R L-E R R R L-E L-E R R R RL-E R R L-E R R L-E L-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E RL-E R R L-E L-E R R R R R R L-E L-E R R L-E L-E R R R R R R R R L-E RL-E L-E R R L-E R R R R R L-E R L-E L-E R R R L-E R R R R L-E R L-E L-ER R R R L-E R R R L-E R L-E L-E R R R R R L-E R R L-E R L-E L-E R R R RR R L-E R L-E R L-E L-E R R R R R R R L-E L-E R L-E L-E R R L-E L-E R RR R L-E R L-E L-E R R L-E R L-E R R R L-E R L-E L-E R R L-E R R L-E R RL-E R L-E L-E R R L-E R R R L-E R L-E R L-E L-E R R L-E R R R R L-E L-ER L-E L-E R R R L-E L-E R R R L-E R L-E L-E R R R L-E R L-E R R L-E RL-E L-E R R R L-E R R L-E R L-E R L-E L-E R R R L-E R R R L-E L-E R L-EL-E R R R R L-E L-E R R L-E R L-E L-E R R R R L-E R L-E R L-E R L-E L-ER R R R L-E R R L-E L-E R L-E L-E R R R R R L-E L-E R L-E R L-E L-E R RR R R L-E R L-E L-E R L-E L-E R R R R R R L-E L-E L-E R L-E L-E R R R RR R R R R L-E L-E L-E R R L-E R R R R R R L-E L-E L-E R R R L-E R R R RR L-E L-E L-E R R R R L-E R R R R L-E L-E L-E R R R R R L-E R R R L-EL-E L-E R R R R R R L-E R R L-E L-E L-E R R R R R R R L-E R L-E L-E L-ER R L-E L-E R R R R R L-E L-E L-E R R L-E R L-E R R R R L-E L-E L-E R RL-E R R L-E R R R L-E L-E L-E R R L-E R R R L-E R R L-E L-E L-E R R L-ER R R R L-E R L-E L-E L-E R R R L-E L-E R R R R L-E L-E L-E R R R L-E RL-E R R R L-E L-E L-E R R R L-E R R L-E R R L-E L-E L-E R R R L-E R R RL-E R L-E L-E L-E R R R R L-E L-E R R R L-E L-E L-E R R R R L-E R L-E RR L-E L-E L-E R R R R L-E R R L-E R L-E L-E L-E R R R R R L-E L-E R RL-E L-E L-E R R R R R L-E R L-E R L-E L-E L-E R R R R R R L-E L-E R L-EL-E L-E R R R R R R R R L-E L-E L-E L-E R R L-E R R R R R L-E L-E L-EL-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-E R R R L-E L-E L-E L-ER R R R R L-E R R L-E L-E L-E L-E R R R R R R L-E R L-E L-E L-E L-E R RR R R R R L-E L-E L-E L-E L-E R R L-E L-E R R R R L-E L-E L-E L-E R RL-E R L-E R R R L-E L-E L-E L-E R R L-E R R L-E R R L-E L-E L-E L-E R RL-E R R R L-E R L-E L-E L-E L-E R R L-E R R R R L-E L-E L-E L-E L-E R RR L-E L-E R R R L-E L-E L-E L-E R R R L-E R L-E R R L-E L-E L-E L-E R RR L-E R R L-E R L-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R RR R L-E L-E R R L-E L-E L-E L-E R R R R L-E R L-E R L-E L-E L-E L-E R RR R L-E R R L-E L-E L-E L-E L-E R R R R R L-E L-E R L-E L-E L-E L-E R RR R R L-E R L-E L-E L-E L-E L-E R R R R R R L-E L-E L-E L-E L-E R L-E RR R R R R R R R L-E R L-E R L-E R R R R R R R L-E R L-E R R L-E R R R RR R L-E R L-E R R R L-E R R R R R L-E R L-E R R R R L-E R R R R L-E RL-E R R R R R L-E R R R L-E R L-E R R R R R R L-E R R L-E R L-E R L-EL-E R R R R R R L-E R L-E R L-E R L-E R R R R R L-E R L-E R L-E R R L-ER R R R L-E R L-E R L-E R R R L-E R R R L-E R L-E R L-E R R R R L-E R RL-E R L-E R R L-E L-E R R R R R L-E R L-E R R L-E R L-E R R R R L-E RL-E R R L-E R R L-E R R R L-E R L-E R R L-E R R R L-E R R L-E R L-E R RR L-E L-E R R R R L-E R L-E R R R L-E R L-E R R R L-E R L-E R R R L-E RR L-E R R L-E R L-E R R R R L-E L-E R R R L-E R L-E R R R R L-E R L-E RR L-E R L-E R R R R R L-E L-E R R L-E R L-E R R R R R R R L-E R L-E RL-E R L-E R R R R R L-E R L-E R L-E R R L-E R R R R L-E R L-E R L-E R RR L-E R R R L-E R L-E R L-E R R R R L-E R R L-E R L-E R L-E R R R R RL-E R L-E R L-E R L-E R R R R R R L-E L-E R L-E R L-E R L-E L-E R R R RL-E R L-E R L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R R L-E R R L-ER L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R L-E R R R R L-E L-E RL-E R L-E R R L-E L-E R R R L-E R L-E R L-E R R L-E R L-E R R L-E R L-ER L-E R R L-E R R L-E R L-E R L-E R L-E R R L-E R R R L-E L-E R L-E RL-E R R R L-E L-E R R L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R L-ER R R L-E R R L-E L-E R L-E R L-E R R R R L-E L-E R L-E R L-E R L-E R RR R L-E R L-E L-E R L-E R L-E R R R R R L-E L-E L-E R L-E R L-E R R R RR R R R L-E L-E R L-E R L-E R R R R R R L-E L-E R L-E R R L-E R R R R RL-E L-E R L-E R R R L-E R R R R L-E L-E R L-E R R R R L-E R R R L-E L-ER L-E R R R R R L-E R R L-E L-E R L-E R R R R R R L-E R L-E L-E R L-E RL-E L-E R R R R R L-E L-E R L-E R L-E R L-E R R R R L-E L-E R L-E R L-ER R L-E R R R L-E L-E R L-E R L-E R R R L-E R R L-E L-E R L-E R L-E R RR R L-E R L-E L-E R L-E R R L-E L-E R R R R L-E L-E R L-E R R L-E R L-ER R R L-E L-E R L-E R R L-E R R L-E R R L-E L-E R L-E R R L-E R R R L-ER L-E L-E R L-E R R R L-E L-E R R R L-E L-E R L-E R R R L-E R L-E R RL-E L-E R L-E R R R L-E R R L-E R L-E L-E R L-E R R R R L-E L-E R R L-EL-E R L-E R R R R L-E R L-E R L-E L-E R L-E R R R R R L-E L-E R L-E L-ER L-E R R R R R R R L-E L-E L-E R L-E R L-E R R R R R L-E L-E L-E R L-ER R L-E R R R R L-E L-E L-E R L-E R R R L-E R R R L-E L-E L-E R L-E R RR R L-E R R L-E L-E L-E R L-E R R R R R L-E R L-E L-E L-E R L-E R R R RR R L-E L-E L-E L-E R L-E R L-E L-E R R R R L-E L-E L-E R L-E R L-E RL-E R R R L-E L-E L-E R L-E R L-E R R L-E R R L-E L-E L-E R L-E R L-E RR R L-E R L-E L-E L-E R L-E R L-E R R R R L-E L-E L-E L-E R L-E R R L-EL-E R R R L-E L-E L-E R L-E R R L-E R L-E R R L-E L-E L-E R L-E R R L-ER R L-E R L-E L-E L-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R RL-E L-E R R L-E L-E L-E R L-E R R R L-E R L-E R L-E L-E L-E R L-E R R RL-E R R L-E L-E L-E L-E R L-E R R R R L-E L-E R L-E L-E L-E R L-E R R RR L-E R L-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-E L-E L-E R RR R R R R R R L-E L-E L-E R L-E R R R R R R R L-E L-E L-E R R L-E R R RR R R L-E L-E L-E R R R L-E R R R R R L-E L-E L-E R R R R L-E R R R RL-E L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R R L-E R R L-E L-EL-E R L-E L-E R R R R R R L-E L-E L-E R L-E R L-E R R R R R L-E L-E L-ER L-E R R L-E R R R R L-E L-E L-E R L-E R R R L-E R R R L-E L-E L-E RL-E R R R R L-E R R L-E L-E L-E R R L-E L-E R R R R R L-E L-E L-E R RL-E R L-E R R R R L-E L-E L-E R R L-E R R L-E R R R L-E L-E L-E R R L-ER R R L-E R R L-E L-E L-E R R R L-E L-E R R R R L-E L-E L-E R R R L-E RL-E R R R L-E L-E L-E R R R L-E R R L-E R R L-E L-E L-E R R R R L-E L-ER R R L-E L-E L-E R R R R L-E R L-E R R L-E L-E L-E R R R R R L-E L-E RR L-E L-E L-E R R R R R R R L-E R L-E L-E L-E R L-E R R R R R L-E R L-EL-E L-E R R L-E R R R R L-E R L-E L-E L-E R R R L-E R R R L-E R L-E L-EL-E R R R R L-E R R L-E R L-E L-E L-E R R R R R L-E R L-E R L-E L-E L-ER R R R R R L-E L-E R L-E L-E L-E R L-E L-E R R R R L-E R L-E L-E L-E RL-E R L-E R R R L-E R L-E L-E L-E R L-E R R L-E R R L-E R L-E L-E L-E RL-E R R R L-E R L-E R L-E L-E L-E R L-E R R R R L-E L-E R L-E L-E L-E RR L-E L-E R R R L-E R L-E L-E L-E R R L-E R L-E R R L-E R L-E L-E L-E RR L-E R R L-E R L-E R L-E L-E L-E R R L-E R R R L-E L-E R L-E L-E L-E RR R L-E L-E R R L-E R L-E L-E L-E R R R L-E R L-E R L-E R L-E L-E L-E RR R L-E R R L-E L-E R L-E L-E L-E R R R R L-E L-E R L-E R L-E L-E L-E RR R R L-E R L-E L-E R L-E L-E L-E R R R R R L-E L-E L-E R L-E L-E L-E RR R R R R R R L-E L-E L-E L-E R L-E R R R R R R L-E L-E L-E L-E R R L-ER R R R R L-E L-E L-E L-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-ER R R L-E L-E L-E L-E R R R R R L-E R R L-E L-E L-E L-E R R R R R R L-ER L-E L-E L-E L-E R L-E L-E R R R R R L-E L-E L-E L-E R L-E R L-E R R RR L-E L-E L-E L-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R R L-E RR L-E L-E L-E L-E R L-E R R R R L-E R L-E L-E L-E L-E R R L-E L-E R R RR L-E L-E L-E L-E R R L-E R L-E R R R L-E L-E L-E L-E R R L-E R R L-E RR L-E L-E L-E L-E R R L-E R R R L-E R L-E L-E L-E L-E R R R L-E L-E R RR L-E L-E L-E L-E R R R L-E R L-E R R L-E L-E L-E L-E R R R L-E R R L-ER L-E L-E L-E L-E R R R R L-E L-E R R L-E L-E L-E L-E R R R R L-E R L-ER L-E L-E L-E L-E R R R R R L-E L-E R L-E L-E L-E L-E R R R R R R R L-EL-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-E R R L-E R R R R L-EL-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R R R R L-E R R L-EL-E L-E L-E L-E R R R R R L-E R L-E L-E L-E L-E L-E R R R R R R L-E L-EL-E L-E L-E L-E R L-E L-E R R R R L-E L-E L-E L-E L-E R L-E R L-E R R RL-E L-E L-E L-E L-E R L-E R R L-E R R L-E L-E L-E L-E L-E R L-E R R RL-E R L-E L-E L-E L-E L-E R L-E R R R R L-E L-E L-E L-E L-E L-E R R L-EL-E R R R L-E L-E L-E L-E L-E R R L-E R L-E R R L-E L-E L-E L-E L-E R RL-E R R L-E R L-E L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-E L-E L-ER R R L-E L-E R R L-E L-E L-E L-E L-E R R R L-E R L-E R L-E L-E L-E L-EL-E R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R L-E L-E R L-E L-E L-EL-E L-E R R R R L-E R L-E L-E L-E L-E L-E L-E R R R R R L-E L-E L-E L-EL-E L-E L-E L-E R R R R R R R R L-E L-E L-E L-E L-E R R R R R R R L-EL-E L-E L-E R L-E R R R R R R L-E L-E L-E L-E R R L-E R R R R R L-E L-EL-E L-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-E R R R L-E L-E L-EL-E R R R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R R R L-E L-E L-EL-E L-E R L-E R R R R R L-E L-E L-E L-E L-E R R L-E R R R R L-E L-E L-EL-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R R R R L-E R R L-E L-E L-EL-E R L-E L-E R R R R R L-E L-E L-E L-E R L-E R L-E R R R R L-E L-E L-EL-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R R L-E R R L-E L-E L-EL-E R R L-E L-E R R R R L-E L-E L-E L-E R R L-E R L-E R R R L-E L-E L-EL-E R R L-E R R L-E R R L-E L-E L-E L-E R R R L-E L-E R R R L-E L-E L-EL-E R R R L-E R L-E R R L-E L-E L-E L-E R R R R L-E L-E R R L-E L-E L-EL-E R R R R R R L-E R L-E L-E L-E L-E L-E R R R R R L-E R L-E L-E L-EL-E R L-E R R R R L-E R L-E L-E L-E L-E R R L-E R R R L-E R L-E L-E L-EL-E R R R L-E R R L-E R L-E L-E L-E L-E R R R R L-E R L-E R L-E L-E L-EL-E R R R R R L-E L-E R L-E L-E L-E L-E L-E L-E R R R R L-E R L-E L-EL-E L-E L-E R L-E R R R L-E R L-E L-E L-E L-E L-E R R L-E R R L-E R L-EL-E L-E L-E L-E R R R L-E R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E RL-E L-E L-E L-E R L-E L-E R R R L-E R L-E L-E L-E L-E R L-E R L-E R RL-E R L-E L-E L-E L-E R L-E R R L-E R L-E R L-E L-E L-E L-E R L-E R R RL-E L-E R L-E L-E L-E L-E R R L-E L-E R R L-E R L-E L-E L-E L-E R R L-ER L-E R L-E R L-E L-E L-E L-E R R L-E R R L-E L-E R L-E L-E L-E L-E R RR L-E L-E R L-E R L-E L-E L-E L-E R R R L-E R L-E L-E R L-E L-E L-E L-ER R R R L-E L-E L-E R L-E L-E L-E L-E R R R R R R R L-E L-E L-E L-E L-EL-E R R R R R R L-E L-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-ER R L-E R R R R L-E L-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-ER R R R L-E R R L-E L-E L-E L-E L-E R R R R R L-E R L-E L-E L-E L-E L-EL-E L-E R R R R R L-E L-E L-E L-E L-E L-E R L-E R R R R L-E L-E L-E L-EL-E L-E R R L-E R R R L-E L-E L-E L-E L-E L-E R R R L-E R R L-E L-E L-EL-E L-E L-E R R R R L-E R L-E L-E L-E L-E L-E R L-E L-E R R R R L-E L-EL-E L-E L-E R L-E R L-E R R R L-E L-E L-E L-E L-E R L-E R R L-E R R L-EL-E L-E L-E L-E R L-E R R R L-E R L-E L-E L-E L-E L-E R R L-E L-E R R RL-E L-E L-E L-E L-E R R L-E R L-E R R L-E L-E L-E L-E L-E R R L-E R RL-E R L-E L-E L-E L-E L-E R R R L-E L-E R R L-E L-E L-E L-E L-E R R RL-E R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E R L-E L-E L-E L-E L-E RR R R R R L-E L-E L-E L-E L-E L-E L-E R R R R R L-E L-E L-E L-E L-E L-ER L-E R R R R L-E L-E L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-E L-EL-E R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R L-E R L-E L-E L-E L-EL-E L-E R R R R R L-E L-E L-E L-E L-E L-E L-E L-E L-E R R R R L-E L-EL-E L-E L-E L-E L-E R L-E R R R L-E L-E L-E L-E L-E L-E L-E R R L-E R RL-E L-E L-E L-E L-E L-E L-E R R R L-E R L-E L-E L-E L-E L-E L-E L-E R RR R L-E L-E L-E L-E L-E L-E L-E R L-E L-E R R R L-E L-E L-E L-E L-E L-ER L-E R L-E R R L-E L-E L-E L-E L-E L-E R L-E R R L-E R L-E L-E L-E L-EL-E L-E R L-E R R R L-E L-E L-E L-E L-E L-E L-E R R L-E L-E R R L-E L-EL-E L-E L-E L-E R R L-E R L-E R L-E L-E L-E L-E L-E L-E R R L-E R R L-EL-E L-E L-E L-E L-E L-E R R R L-E L-E R L-E L-E L-E L-E L-E L-E R R RL-E R L-E L-E L-E L-E L-E L-E L-E R R R R L-E L-E L-E L-E

Z₁ Z₂ Z₃ Z₄ Z₅ Z₆ Z₇ Z₈ Z₉ Z₁₀ Z₁₁ Z₁₂ R R R R R R R R R R R R R R R RL-E R R R R R R R R R R R R L-E R R R R R R R R R R R R L-E R R R R R RR R R R R R L-E R R R R R R R R R R R R L-E R R R R R R R R R R R R L-ER R R R R R L-E L-E R R R R R R R R R R L-E R L-E R R R R R R R R R L-ER R L-E R R R R R R R R L-E R R R L-E R R R R R R R L-E R R R R L-E R RR R R R R L-E L-E R R R R R R R R R R L-E R L-E R R R R R R R R R L-E RR L-E R R R R R R R R L-E R R R L-E R R R R R R R R L-E L-E R R R R R RR R R R L-E R L-E R R R R R R R R R L-E R R L-E R R R R R R R R R L-EL-E R R R R R R R R R R L-E R L-E R R R R R R R R R R L-E L-E R R R R RR R R R R R R L-E R R R R R L-E R R R R R L-E R R R R R R L-E R R R RL-E R R R R R R R L-E R R R L-E R R R R R R R R L-E R R L-E R R R R R RR R R L-E R L-E R R R R R R R R R R L-E L-E R R R R R L-E L-E R R R RL-E R R R R R L-E R L-E R R R L-E R R R R R L-E R R L-E R R L-E R R R RR L-E R R R L-E R L-E R R R R R L-E R R R R L-E L-E R R R R R R L-E L-ER R R L-E R R R R R R L-E R L-E R R L-E R R R R R R L-E R R L-E R L-E RR R R R R L-E R R R L-E L-E R R R R R R R L-E L-E R R L-E R R R R R R RL-E R L-E R L-E R R R R R R R L-E R R L-E L-E R R R R R R R R L-E L-E RL-E R R R R R R R R L-E R L-E L-E R R R R R R R R R L-E L-E L-E R R R RR R R R R R R R L-E R R R R L-E R R R R R R L-E R R R R R L-E R R R R RL-E R R R R R R L-E R R R R L-E R R R R R R R L-E R R R L-E R R R R R RR R L-E R R L-E R R R R R R R R R L-E R L-E R R R R L-E L-E R R R R RL-E R R R R L-E R L-E R R R R L-E R R R R L-E R R L-E R R R L-E R R R RL-E R R R L-E R R L-E R R R R L-E R R R R L-E R L-E R R R R R L-E L-E RR R R L-E R R R R R L-E R L-E R R R L-E R R R R R L-E R R L-E R R L-E RR R R R L-E R R R L-E R L-E R R R R R R L-E L-E R R R L-E R R R R R RL-E R L-E R R L-E R R R R R R L-E R R L-E R L-E R R R R R R R L-E L-E RR L-E R R R R R R R L-E R L-E R L-E R R R R R R R R L-E L-E R L-E R R RR R R R R R R L-E L-E R R R R L-E R R R R R L-E L-E R R R R R L-E R R RR L-E L-E R R R R R R L-E R R R L-E L-E R R R R R R R L-E R R L-E L-E RR R R R R R R L-E R L-E L-E R R R R R R R R R L-E L-E L-E R R R R L-EL-E R R R R L-E L-E R R R R L-E R L-E R R R L-E L-E R R R R L-E R R L-ER R L-E L-E R R R R L-E R R R L-E R L-E L-E R R R R L-E R R R R L-E L-EL-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E R L-E R R L-E L-E R RR R R L-E R R L-E R L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R RL-E L-E R R L-E L-E R R R R R R L-E R L-E R L-E L-E R R R R R R L-E R RL-E L-E L-E R R R R R R R L-E L-E R L-E L-E R R R R R R R L-E R L-E L-EL-E R R R R R R R R L-E L-E L-E L-E L-E R R R R R R R R R R R L-E R R RL-E R R R R R R R L-E R R R R L-E R R R R R R L-E R R R R R L-E R R R RR L-E R R R R R R L-E R R R R L-E R R R R R R R L-E R R R L-E R R R R RR R R L-E R R L-E R R R L-E L-E R R R R R R L-E R R R L-E R L-E R R R RR L-E R R R L-E R R L-E R R R R L-E R R R L-E R R R L-E R R R L-E R R RL-E R R R R L-E R R L-E R R R R L-E L-E R R R R R L-E R R R R L-E R L-ER R R R L-E R R R R L-E R R L-E R R R L-E R R R R L-E R R R L-E R R L-ER R R R R L-E L-E R R R R L-E R R R R R L-E R L-E R R R L-E R R R R RL-E R R L-E R R L-E R R R R R R L-E L-E R R R L-E R R R R R R L-E R L-ER R L-E R R R R R R R L-E L-E R R L-E R R R R R R R R R L-E R L-E R R RL-E R R R R R L-E R L-E R R R R L-E R R R R L-E R L-E R R R R R L-E R RR L-E R L-E R R R R R R L-E R R L-E R L-E R R R R R R R L-E R L-E R L-ER R R R R R R R L-E L-E R L-E R R R L-E L-E R R R R L-E R L-E R R R L-ER L-E R R R L-E R L-E R R R L-E R R L-E R R L-E R L-E R R R L-E R R RL-E R L-E R L-E R R R L-E R R R R L-E L-E R L-E R R R R L-E L-E R R RL-E R L-E R R R R L-E R L-E R R L-E R L-E R R R R L-E R R L-E R L-E RL-E R R R R L-E R R R L-E L-E R L-E R R R R R L-E L-E R R L-E R L-E R RR R R L-E R L-E R L-E R L-E R R R R R L-E R R L-E L-E R L-E R R R R R RL-E L-E R L-E R L-E R R R R R R L-E R L-E L-E R L-E R R R R R R R L-EL-E L-E R L-E R R R R R R R R R R L-E L-E R R R L-E R R R R R R L-E L-ER R R R L-E R R R R R L-E L-E R R R R R L-E R R R R L-E L-E R R R R R RL-E R R R L-E L-E R R R R R R R L-E R R L-E L-E R R R R R R R R L-E RL-E L-E R R R L-E L-E R R R R R L-E L-E R R R L-E R L-E R R R R L-E L-ER R R L-E R R L-E R R R L-E L-E R R R L-E R R R L-E R R L-E L-E R R RL-E R R R R L-E R L-E L-E R R R R L-E L-E R R R R L-E L-E R R R R L-E RL-E R R R L-E L-E R R R R L-E R R L-E R R L-E L-E R R R R L-E R R R L-ER L-E L-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E R L-E R R L-EL-E R R R R R L-E R R L-E R L-E L-E R R R R R R L-E L-E R R L-E L-E R RR R R R L-E R L-E R L-E L-E R R R R R R R L-E L-E R L-E L-E R R R R R RR R R L-E L-E L-E R R R L-E R R R R R L-E L-E L-E R R R R L-E R R R RL-E L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R R L-E R R L-E L-EL-E R R R R R R R L-E R L-E L-E L-E R R R R R R R R L-E L-E L-E L-E R RR L-E L-E R R R R L-E L-E L-E R R R L-E R L-E R R R L-E L-E L-E R R RL-E R R L-E R R L-E L-E L-E R R R L-E R R R L-E R L-E L-E L-E R R R L-ER R R R L-E L-E L-E L-E R R R R L-E L-E R R R L-E L-E L-E R R R R L-E RL-E R R L-E L-E L-E R R R R L-E R R L-E R L-E L-E L-E R R R R L-E R R RL-E L-E L-E L-E R R R R R L-E L-E R R L-E L-E L-E R R R R R L-E R L-E RL-E L-E L-E R R R R R L-E R R L-E L-E L-E L-E R R R R R R L-E L-E R L-EL-E L-E R R R R R R L-E R L-E L-E L-E L-E R R R R R R R L-E L-E L-E L-EL-E L-E R R R R R R R R R R L-E L-E R R L-E R R R R R R R L-E L-E R R RL-E R R R R R R L-E L-E R R R R L-E R R R R R L-E L-E R R R R R L-E R RR R L-E L-E R R R R R R L-E R R R L-E L-E R R R R R R R L-E R R L-E L-ER R L-E L-E R R R R R R L-E L-E R R L-E R L-E R R R R R L-E L-E R R L-ER R L-E R R R R L-E L-E R R L-E R R R L-E R R R L-E L-E R R L-E R R R RL-E R R L-E L-E R R R L-E L-E R R R R R L-E L-E R R R L-E R L-E R R R RL-E L-E R R R L-E R R L-E R R R L-E L-E R R R L-E R R R L-E R R L-E L-ER R R R L-E L-E R R R R L-E L-E R R R R L-E R L-E R R R L-E L-E R R R RL-E R R L-E R R L-E L-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E RL-E R R L-E L-E R R R R R R L-E L-E R R L-E L-E R R R R R R R R L-E RL-E L-E R R L-E R R R R R L-E R L-E L-E R R R L-E R R R R L-E R L-E L-ER R R R L-E R R R L-E R L-E L-E R R R R R L-E R R L-E R L-E L-E R R R RR R L-E R L-E R L-E L-E R R R R R R R L-E L-E R L-E L-E R R L-E L-E R RR R L-E R L-E L-E R R L-E R L-E R R R L-E R L-E L-E R R L-E R R L-E R RL-E R L-E L-E R R L-E R R R L-E R L-E R L-E L-E R R L-E R R R R L-E L-ER L-E L-E R R R L-E L-E R R R L-E R L-E L-E R R R L-E R L-E R R L-E RL-E L-E R R R L-E R R L-E R L-E R L-E L-E R R R L-E R R R L-E L-E R L-EL-E R R R R L-E L-E R R L-E R L-E L-E R R R R L-E R L-E R L-E R L-E L-ER R R R L-E R R L-E L-E R L-E L-E R R R R R L-E L-E R L-E R L-E L-E R RR R R L-E R L-E L-E R L-E L-E R R R R R R L-E L-E L-E R L-E L-E R R R RR R R R R L-E L-E L-E R R L-E R R R R R R L-E L-E L-E R R R L-E R R R RR L-E L-E L-E R R R R L-E R R R R L-E L-E L-E R R R R R L-E R R R L-EL-E L-E R R R R R R L-E R R L-E L-E L-E R R R R R R R L-E R L-E L-E L-ER R L-E L-E R R R R R L-E L-E L-E R R L-E R L-E R R R R L-E L-E L-E R RL-E R R L-E R R R L-E L-E L-E R R L-E R R R L-E- R R L-E L-E L-E R R L-ER R R R L-E R L-E L-E L-E R R R L-E L-E R R R R L-E L-E L-E R R R L-E RL-E R R R L-E L-E L-E R R R L-E R R L-E R R L-E L-E L-E R R R L-E R R RL-E R L-E L-E L-E R R R R L-E L-E R R R L-E L-E L-E R R R R L-E R L-E RR L-E L-E L-E R R R R L-E R R L-E R L-E L-E L-E R R R R R L-E L-E R RL-E L-E L-E R R R R R L-E R L-E R L-E L-E L-E R R R R R R L-E L-E R L-EL-E L-E R R R R R R R R L-E L-E L-E L-E R R L-E R R R R R L-E L-E L-EL-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-E R R R L-E L-E L-E L-ER R R R R L-E R R L-E L-E L-E L-E R R R R R R L-E R L-E L-E L-E L-E R RR R R R R L-E L-E L-E L-E L-E R R L-E L-E R R R R L-E L-E L-E L-E R RL-E R L-E R R R L-E L-E L-E L-E R R L-E R R L-E R R L-E L-E L-E L-E R RL-E R R R L-E R L-E L-E L-E L-E R R L-E R R R R L-E L-E L-E L-E L-E R RR L-E L-E R R R L-E L-E L-E L-E R R R L-E R L-E R R L-E L-E L-E L-E R RR L-E R R L-E R L-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R RR R L-E L-E R R L-E L-E L-E L-E R R R R L-E R L-E R L-E L-E L-E L-E R RR R L-E R R L-E L-E L-E L-E L-E R R R R R L-E L-E R L-E L-E L-E L-E R RR R R L-E R L-E L-E L-E L-E L-E R R R R R R L-E L-E L-E L-E L-E R L-E RR R R R R R R R L-E R L-E R L-E R R R R R R R L-E R L-E R R L-E R R R RR R L-E R L-E R R R L-E R R R R R L-E R L-E R R R R L-E R R R R L-E RL-E R R R R R L-E R R R L-E R L-E R R R R R R L-E R R L-E R L-E R L-EL-E R R R R R R L-E R L-E R L-E R L-E R R R R R L-E R L-E R L-E R R L-ER R R R L-E R L-E R L-E R R R L-E R R R L-E R L-E R L-E R R R R L-E R RL-E R L-E R R L-E L-E R R R R R L-E R L-E R R L-E R L-E R R R R L-E RL-E R R L-E R R L-E R R R L-E R L-E R R L-E R R R L-E R R L-E R L-E R RR L-E L-E R R R R L-E R L-E R R R L-E R L-E R R R L-E R L-E R R R L-E RR L-E R R L-E R L-E R R R R L-E L-E R R R L-E R L-E R R R R L-E R L-E RR L-E R L-E R R R R R L-E L-E R R L-E R L-E R R R R R R R L-E R L-E RL-E R L-E R R R R R L-E R L-E R L-E R R L-E R R R R L-E R L-E R L-E R RR L-E R R R L-E R L-E R L-E R R R R L-E R R L-E R L-E R L-E R R R R RL-E R L-E R L-E R L-E R R R R R R L-E L-E R L-E R L-E R L-E L-E R R R RL-E R L-E R L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R R L-E R R L-ER L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R L-E R R R R L-E L-E RL-E R L-E R R L-E L-E R R R L-E R L-E R L-E R R L-E R L-E R R L-E R L-ER L-E R R L-E R R L-E R L-E R L-E R L-E R R L-E R R R L-E L-E R L-E RL-E R R R L-E L-E R R L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R L-ER R R L-E R R L-E L-E R L-E R L-E R R R R L-E L-E R L-E R L-E R L-E R RR R L-E R L-E L-E R L-E R L-E R R R R R L-E L-E L-E R L-E R L-E R R R RR R R R L-E L-E R L-E R L-E R R R R R R L-E L-E R L-E R R L-E R R R R RL-E L-E R L-E R R R L-E R R R R L-E L-E R L-E R R R R L-E R R R L-E L-ER L-E R R R R R L-E R R L-E L-E R L-E R R R R R R L-E R L-E L-E R L-E RL-E L-E R R R R R L-E L-E R L-E R L-E R L-E R R R R L-E L-E R L-E R L-ER R L-E R R R L-E L-E R L-E R L-E R R R L-E R R L-E L-E R L-E R L-E R RR R L-E R L-E L-E R L-E R R L-E L-E R R R R L-E L-E R L-E R R L-E R L-ER R R L-E L-E R L-E R R L-E R R L-E R R L-E L-E R L-E R R L-E R R R L-ER L-E L-E R L-E R R R L-E L-E R R R L-E L-E R L-E R R R L-E R L-E R RL-E L-E R L-E R R R L-E R R L-E R L-E L-E R L-E R R R R L-E L-E R R L-EL-E R L-E R R R R L-E R L-E R L-E L-E R L-E R R R R R L-E L-E R L-E L-ER L-E R R R R R R R L-E L-E L-E R L-E R L-E R R R R R L-E L-E L-E R L-ER R L-E R R R R L-E L-E L-E R L-E R R R L-E R R R L-E L-E L-E R L-E R RR R L-E R R L-E L-E L-E R L-E R R R R R L-E R L-E L-E L-E R L-E R R R RR R L-E L-E L-E L-E R L-E R L-E L-E R R R R L-E L-E L-E R L-E R L-E RL-E R R R L-E L-E L-E R L-E R L-E R R L-E R R L-E L-E L-E R L-E R L-E RR R L-E R L-E L-E L-E R L-E R L-E R R R R L-E L-E L-E L-E R L-E R R L-EL-E R R R L-E L-E L-E R L-E R R L-E R L-E R R L-E L-E L-E R L-E R R L-ER R L-E R L-E L-E L-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R RL-E L-E R R L-E L-E L-E R L-E R R R L-E R L-E R L-E L-E L-E R L-E R R RL-E R R L-E L-E L-E L-E R L-E R R R R L-E L-E R L-E L-E L-E R L-E R R RR L-E R L-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-E L-E L-E R RR R R R R R R L-E L-E L-E R L-E R R R R R R R L-E L-E L-E R R L-E R R RR R R L-E L-E L-E R R R L-E R R R R R L-E L-E L-E R R R R L-E R R R RL-E L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R R L-E R R L-E L-EL-E R L-E L-E R R R R R R L-E L-E L-E R L-E R L-E R R R R R L-E L-E L-ER L-E R R L-E R R R R L-E L-E L-E R L-E R R R L-E R R R L-E L-E L-E RL-E R R R R L-E R R L-E L-E L-E R R L-E L-E R R R R R L-E L-E L-E R RL-E R L-E R R R R L-E L-E L-E R R L-E R R L-E R R R L-E L-E L-E R R L-ER R R L-E R R L-E L-E L-E R R R L-E L-E R R R R L-E L-E L-E R R R L-E RL-E R R R L-E L-E L-E R R R L-E R R L-E R R L-E L-E L-E R R R R L-E L-ER R R L-E L-E L-E R R R R L-E R L-E R R L-E L-E L-E R R R R R L-E L-E RR L-E L-E L-E R R R R R R R L-E R L-E L-E L-E R L-E R R R R R L-E R L-EL-E L-E R R L-E R R R R L-E R L-E L-E L-E R R R L-E R R R L-E R L-E L-EL-E R R R R L-E R R L-E R L-E L-E L-E R R R R R L-E R L-E R L-E L-E L-ER R R R R R L-E L-E R L-E L-E L-E R L-E L-E R R R R L-E R L-E L-E L-E RL-E R L-E R R R L-E R L-E L-E L-E R L-E R R L-E R R L-E R L-E L-E L-E RL-E R R R L-E R L-E R L-E L-E L-E R L-E R R R R L-E L-E R L-E L-E L-E RR L-E L-E R R R L-E R L-E L-E L-E R R L-E R L-E R R L-E R L-E L-E L-E RR L-E R R L-E R L-E R L-E L-E L-E R R L-E R R R L-E L-E R L-E L-E L-E RR R L-E L-E R R L-E R L-E L-E L-E R R R L-E R L-E R L-E R L-E L-E L-E RR R L-E R R L-E L-E R L-E L-E L-E R R R R L-E L-E R L-E R L-E L-E L-E RR R R L-E R L-E L-E R L-E L-E L-E R R R R R L-E L-E L-E R L-E L-E L-E RR R R R R R R L-E L-E L-E L-E R L-E R R R R R R L-E L-E L-E L-E R R L-ER R R R R L-E L-E L-E L-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-ER R R L-E L-E L-E L-E R R R R R L-E R R L-E L-E L-E L-E R R R R R R L-ER L-E L-E L-E L-E R L-E L-E R R R R R L-E L-E L-E L-E R L-E R L-E R R RR L-E L-E L-E L-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R R L-E RR L-E L-E L-E L-E R L-E R R R R L-E R L-E L-E L-E L-E R R L-E L-E R R RR L-E L-E L-E L-E R R L-E R L-E R R R L-E L-E L-E L-E R R L-E R R L-E RR L-E L-E L-E L-E R R L-E R R R L-E R L-E L-E L-E L-E R R R L-E L-E R RR L-E L-E L-E L-E R R R L-E R L-E R R L-E L-E L-E L-E R R R L-E R R L-ER L-E L-E L-E L-E R R R R L-E L-E R R L-E L-E L-E L-E R R R R L-E R L-ER L-E L-E L-E L-E R R R R R L-E L-E R L-E L-E L-E L-E R R R R R R R L-EL-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-E R R L-E R R R R L-EL-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R R R R L-E R R L-EL-E L-E L-E L-E R R R R R L-E R L-E L-E L-E L-E L-E R R R R R R L-E L-EL-E L-E L-E L-E R L-E L-E R R R R L-E L-E L-E L-E L-E R L-E R L-E R R RL-E L-E L-E L-E L-E R L-E R R L-E R R L-E L-E L-E L-E L-E R L-E R R RL-E R L-E L-E L-E L-E L-E R L-E R R R R L-E L-E L-E L-E L-E L-E R R L-EL-E R R R L-E L-E L-E L-E L-E R R L-E R L-E R R L-E L-E L-E L-E L-E R RL-E R R L-E R L-E L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-E L-E L-ER R R L-E L-E R R L-E L-E L-E L-E L-E R R R L-E R L-E R L-E L-E L-E L-EL-E R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R L-E L-E R L-E L-E L-EL-E L-E R R R R L-E R L-E L-E L-E L-E L-E L-E R R R R R L-E L-E L-E L-EL-E L-E L-E L-E R R R R R R R R L-E L-E L-E L-E L-E R R R R R R R L-EL-E L-E L-E R L-E R R R R R R L-E L-E L-E L-E R R L-E R R R R R L-E L-EL-E L-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-E R R R L-E L-E L-EL-E R R R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R R R L-E L-E L-EL-E L-E R L-E R R R R R L-E L-E L-E L-E L-E R R L-E R R R R L-E L-E L-EL-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R R R R L-E R R L-E L-E L-EL-E R L-E L-E R R R R R L-E L-E L-E L-E R L-E R L-E R R R R L-E L-E L-EL-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R R L-E R R L-E L-E L-EL-E R R L-E L-E R R R R L-E L-E L-E L-E R R L-E R L-E R R R L-E L-E L-EL-E R R L-E R R L-E R R L-E L-E L-E L-E R R R L-E L-E R R R L-E L-E L-EL-E R R R L-E R L-E R R L-E L-E L-E L-E R R R R L-E L-E R R L-E L-E L-EL-E R R R R R R L-E R L-E L-E L-E L-E L-E R R R R R L-E R L-E L-E L-EL-E R L-E R R R R L-E R L-E L-E L-E L-E R R L-E R R R L-E R L-E L-E L-EL-E R R R L-E R R L-E R L-E L-E L-E L-E R R R R L-E R L-E R L-E L-E L-EL-E R R R R R L-E L-E R L-E L-E L-E L-E L-E L-E R R R R L-E R L-E L-EL-E L-E L-E R L-E R R R L-E R L-E L-E L-E L-E L-E R R L-E R R L-E R L-EL-E L-E L-E L-E R R R L-E R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E RL-E L-E L-E L-E R L-E L-E R R R L-E R L-E L-E L-E L-E R L-E R L-E R RL-E R L-E L-E L-E L-E R L-E R R L-E R L-E R L-E L-E L-E L-E R L-E R R RL-E L-E R L-E L-E L-E L-E R R L-E L-E R R L-E R L-E L-E L-E L-E R R L-ER L-E R L-E R L-E L-E L-E L-E R R L-E R R L-E L-E R L-E L-E L-E L-E R RR L-E L-E R L-E R L-E L-E L-E L-E R R R L-E R L-E L-E R L-E L-E L-E L-ER R R R L-E L-E L-E R L-E L-E L-E L-E R R R R R R R L-E L-E L-E L-E L-EL-E R R R R R R L-E L-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-ER R L-E R R R R L-E L-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-ER R R R L-E R R L-E L-E L-E L-E L-E R R R R R L-E R L-E L-E L-E L-E L-EL-E L-E R R R R R L-E L-E L-E L-E L-E L-E R L-E R R R R L-E L-E L-E L-EL-E L-E R R L-E R R R L-E L-E L-E L-E L-E L-E R R R L-E R R L-E L-E L-EL-E L-E L-E R R R R L-E R L-E L-E L-E L-E L-E R L-E L-E R R R R L-E L-EL-E L-E L-E R L-E R L-E R R R L-E L-E L-E L-E L-E R L-E R R L-E R R L-EL-E L-E L-E L-E R L-E R R R L-E R L-E L-E L-E L-E L-E R R L-E L-E R R RL-E L-E L-E L-E L-E R R L-E R L-E R R L-E L-E L-E L-E L-E R R L-E R RL-E R L-E L-E L-E L-E L-E R R R L-E L-E R R L-E L-E L-E L-E L-E R R RL-E R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E R L-E L-E L-E L-E L-E RR R R R R L-E L-E L-E L-E L-E L-E L-E R R R R R L-E L-E L-E L-E L-E L-ER L-E R R R R L-E L-E L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-E L-EL-E R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R L-E R L-E L-E L-E L-EL-E L-E R R R R R L-E L-E L-E L-E L-E L-E L-E L-E L-E R R R R L-E L-EL-E L-E L-E L-E L-E R L-E R R R L-E L-E L-E L-E L-E L-E L-E R R L-E R RL-E L-E L-E L-E L-E L-E L-E R R R L-E R L-E L-E L-E L-E L-E L-E L-E R RR R L-E L-E L-E L-E L-E L-E L-E R L-E L-E R R R L-E L-E L-E L-E L-E L-ER L-E R L-E R R L-E L-E L-E L-E L-E L-E R L-E R R L-E R L-E L-E L-E L-EL-E L-E R L-E R R R L-E L-E L-E L-E L-E L-E L-E R R L-E L-E R R L-E L-EL-E L-E L-E L-E R R L-E R L-E R L-E L-E L-E L-E L-E L-E R R L-E R R L-EL-E L-E L-E L-E L-E L-E R R R L-E L-E R L-E L-E L-E L-E L-E L-E R R RL-E R L-E L-E L-E L-E L-E L-E L-E R R R R L-E L-E L-E L-E

Z₁ Z₂ Z₃ Z₄ Z₅ Z₆ Z₇ Z₈ Z₉ Z₁₀ Z₁₁ Z₁₂ R R R R R R R R R R R R R R R RL-E R R R R R R R R R R R R L-E R R R R R R R R R R R R L-E R R R R R RR R R R R R L-E R R R R R R R R R R R R L-E R R R R R R R R R R R R L-ER R R R R R L-E L-E R R R R R R R R R R L-E R L-E R R R R R R R R R L-ER R L-E R R R R R R R R L-E R R R L-E R R R R R R R L-E R R R R L-E R RR R R R R L-E L-E R R R R R R R R R R L-E R L-E R R R R R R R R R L-E RR L-E R R R R R R R R L-E R R R L-E R R R R R R R R L-E L-E R R R R R RR R R R L-E R L-E R R R R R R R R R L-E R R L-E R R R R R R R R R L-EL-E R R R R R R R R R R L-E R L-E R R R R R R R R R R L-E L-E R R R R RR R R R R R R L-E R R R R R L-E R R R R R L-E R R R R R R L-E R R R RL-E R R R R R R R L-E R R R L-E R R R R R R R R L-E R R L-E R R R R R RR R R L-E R L-E R R R R R R R R R R L-E L-E R R R R R L-E L-E R R R RL-E R R R R R L-E R L-E R R R L-E R R R R R L-E R R L-E R R L-E R R R RR L-E R R R L-E R L-E R R R R R L-E R R R R L-E L-E R R R R R R L-E L-ER R R L-E R R R R R R L-E R L-E R R L-E R R R R R R L-E R R L-E R L-E RR R R R R L-E R R R L-E L-E R R R R R R R L-E L-E R R L-E R R R R R R RL-E R L-E R L-E R R R R R R R L-E R R L-E L-E R R R R R R R R L-E L-E RL-E R R R R R R R R L-E R L-E L-E R R R R R R R R R L-E L-E L-E R R R RR R R R R R R R L-E R R R R L-E R R R R R R L-E R R R R R L-E R R R R RL-E R R R R R R L-E R R R R L-E R R R R R R R L-E R R R L-E R R R R R RR R L-E R R L-E R R R R R R R R R L-E R L-E R R R R L-E L-E R R R R RL-E R R R R L-E R L-E R R R R L-E R R R R L-E R R L-E R R R L-E R R R RL-E R R R L-E R R L-E R R R R L-E R R R R L-E R L-E R R R R R L-E L-E RR R R L-E R R R R R L-E R L-E R R R L-E R R R R R L-E R R L-E R R L-E RR R R R L-E R R R L-E R L-E R R R R R R L-E L-E R R R L-E R R R R R RL-E R L-E R R L-E R R R R R R L-E R R L-E R L-E R R R R R R R L-E L-E RR L-E R R R R R R R L-E R L-E R L-E R R R R R R R R L-E L-E R L-E R R RR R R R R R R L-E L-E R R R R L-E R R R R R L-E L-E R R R R R L-E R R RR L-E L-E R R R R R R L-E R R R L-E L-E R R R R R R R L-E R R L-E L-E RR R R R R R R L-E R L-E L-E R R R R R R R R R L-E L-E L-E R R R R L-EL-E R R R R L-E L-E R R R R L-E R L-E R R R L-E L-E R R R R L-E R R L-ER R L-E L-E R R R R L-E R R R L-E R L-E L-E R R R R L-E R R R R L-E L-EL-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E R L-E R R L-E L-E R RR R R L-E R R L-E R L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R RL-E L-E R R L-E L-E R R R R R R L-E R L-E R L-E L-E R R R R R R L-E R RL-E L-E L-E R R R R R R R L-E L-E R L-E L-E R R R R R R R L-E R L-E L-EL-E R R R R R R R R L-E L-E L-E L-E L-E R R R R R R R R R R R L-E R R RL-E R R R R R R R L-E R R R R L-E R R R R R R L-E R R R R R L-E R R R RR L-E R R R R R R L-E R R R R L-E R R R R R R R L-E R R R L-E R R R R RR R R L-E R R L-E R R R L-E L-E R R R R R R L-E R R R L-E R L-E R R R RR L-E R R R L-E R R L-E R R R R L-E R R R L-E R R R L-E R R R L-E R R RL-E R R R R L-E R R L-E R R R R L-E L-E R R R R R L-E R R R R L-E R L-ER R R R L-E R R R R L-E R R L-E R R R L-E R R R R L-E R R R L-E R R L-ER R R R R L-E L-E R R R R L-E R R R R R L-E R L-E R R R L-E R R R R RL-E R R L-E R R L-E R R R R R R L-E L-E R R R L-E R R R R R R L-E R L-ER R L-E R R R R R R R L-E L-E R R L-E R R R R R R R R R L-E R L-E R R RL-E R R R R R L-E R L-E R R R R L-E R R R R L-E R L-E R R R R R L-E R RR L-E R L-E R R R R R R L-E R R L-E R L-E R R R R R R R L-E R L-E R L-ER R R R R R R R L-E L-E R L-E R R R L-E L-E R R R R L-E R L-E R R R L-ER L-E R R R L-E R L-E R R R L-E R R L-E R R L-E R L-E R R R L-E R R RL-E R L-E R L-E R R R L-E R R R R L-E L-E R L-E R R R R L-E L-E R R RL-E R L-E R R R R L-E R L-E R R L-E R L-E R R R R L-E R R L-E R L-E RL-E R R R R L-E R R R L-E L-E R L-E R R R R R L-E L-E R R L-E R L-E R RR R R L-E R L-E R L-E R L-E R R R R R L-E R R L-E L-E R L-E R R R R R RL-E L-E R L-E R L-E R R R R R R L-E R L-E L-E R L-E R R R R R R R L-EL-E L-E R L-E R R R R R R R R R R L-E L-E R R R L-E R R R R R R L-E L-ER R R R L-E R R R R R L-E L-E R R R R R L-E R R R R L-E L-E R R R R R RL-E R R R L-E L-E R R R R R R R L-E R R L-E L-E R R R R R R R R L-E RL-E L-E R R R L-E L-E R R R R R L-E L-E R R R L-E R L-E R R R R L-E L-ER R R L-E R R L-E R R R L-E L-E R R R L-E R R R L-E R R L-E L-E R R RL-E R R R R L-E R L-E L-E R R R R L-E L-E R R R R L-E L-E R R R R L-E RL-E R R R L-E L-E R R R R L-E R R L-E R R L-E L-E R R R R L-E R R R L-ER L-E L-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E R L-E R R L-EL-E R R R R R L-E R R L-E R L-E L-E R R R R R R L-E L-E R R L-E L-E R RR R R R L-E R L-E R L-E L-E R R R R R R R L-E L-E R L-E L-E R R R R R RR R R L-E L-E L-E R R R L-E R R R R R L-E L-E L-E R R R R L-E R R R RL-E L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R R L-E R R L-E L-EL-E R R R R R R R L-E R L-E L-E L-E R R R R R R R R L-E L-E L-E L-E R RR L-E L-E R R R R L-E L-E L-E R R R L-E R L-E R R R L-E L-E L-E R R RL-E R R L-E R R L-E L-E L-E R R R L-E R R R L-E R L-E L-E L-E R R R L-ER R R R L-E L-E L-E L-E R R R R L-E L-E R R R L-E L-E L-E R R R R L-E RL-E R R L-E L-E L-E R R R R L-E R R L-E R L-E L-E L-E R R R R L-E R R RL-E L-E L-E L-E R R R R R L-E L-E R R L-E L-E L-E R R R R R L-E R L-E RL-E L-E L-E R R R R R L-E R R L-E L-E L-E L-E R R R R R R L-E L-E R L-EL-E L-E R R R R R R L-E R L-E L-E L-E L-E R R R R R R R L-E L-E L-E L-EL-E L-E R R R R R R R R R R L-E L-E R R L-E R R R R R R R L-E L-E R R RL-E R R R R R R L-E L-E R R R R L-E R R R R R L-E L-E R R R R R L-E R RR R L-E L-E R R R R R R L-E R R R L-E L-E R R R R R R R L-E R R L-E L-ER R L-E L-E R R R R R R L-E L-E R R L-E R L-E R R R R R L-E L-E R R L-ER R L-E R R R R L-E L-E R R L-E R R R L-E R R R L-E L-E R R L-E R R R RL-E R R L-E L-E R R R L-E L-E R R R R R L-E L-E R R R L-E R L-E R R R RL-E L-E R R R L-E R R L-E R R R L-E L-E R R R L-E R R R L-E R R L-E L-ER R R R L-E L-E R R R R L-E L-E R R R R L-E R L-E R R R L-E L-E R R R RL-E R R L-E R R L-E L-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E RL-E R R L-E L-E R R R R R R L-E L-E R R L-E L-E R R R R R R R R L-E RL-E L-E R R L-E R R R R R L-E R L-E L-E R R R L-E R R R R L-E R L-E L-ER R R R L-E R R R L-E R L-E L-E R R R R R L-E R R L-E R L-E L-E R R R RR R L-E R L-E R L-E L-E R R R R R R R L-E L-E R L-E L-E R R L-E L-E R RR R L-E R L-E L-E R R L-E R L-E R R R L-E R L-E L-E R R L-E R R L-E R RL-E R L-E L-E R R L-E R R R L-E R L-E R L-E L-E R R L-E R R R R L-E L-ER L-E L-E R R R L-E L-E R R R L-E R L-E L-E R R R L-E R L-E R R L-E RL-E L-E R R R L-E R R L-E R L-E R L-E L-E R R R L-E R R R L-E L-E R L-EL-E R R R R L-E L-E R R L-E R L-E L-E R R R R L-E R L-E R L-E R L-E L-ER R R R L-E R R L-E L-E R L-E L-E R R R R R L-E L-E R L-E R L-E L-E R RR R R L-E R L-E L-E R L-E L-E R R R R R R L-E L-E L-E R L-E L-E R R R RR R R R R L-E L-E L-E R R L-E R R R R R R L-E L-E L-E R R R L-E R R R RR L-E L-E L-E R R R R L-E R R R R L-E L-E L-E R R R R R L-E R R R L-EL-E L-E R R R R R R L-E R R L-E L-E L-E R R R R R R R L-E R L-E L-E L-ER R L-E L-E R R R R R L-E L-E L-E R R L-E R L-E R R R R L-E L-E L-E R RL-E R R L-E R R R L-E L-E L-E R R L-E R R R L-E R R L-E L-E L-E R R L-ER R R R L-E R L-E L-E L-E R R R L-E L-E R R R R L-E L-E L-E R R R L-E RL-E R R R L-E L-E L-E R R R L-E R R L-E R R L-E L-E L-E R R R L-E R R RL-E R L-E L-E L-E R R R R L-E L-E R R R L-E L-E L-E R R R R L-E R L-E RR L-E L-E L-E R R R R L-E R R L-E R L-E L-E L-E R R R R R L-E L-E R RL-E L-E L-E R R R R R L-E R L-E R L-E L-E L-E R R R R R R L-E L-E R L-EL-E L-E R R R R R R R R L-E L-E L-E L-E R R L-E R R R R R L-E L-E L-EL-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-E R R R L-E L-E L-E L-ER R R R R L-E R R L-E L-E L-E L-E R R R R R R L-E R L-E L-E L-E L-E R RR R R R R L-E L-E L-E L-E L-E R R L-E L-E R R R R L-E L-E L-E L-E R RL-E R L-E R R R L-E L-E L-E L-E R R L-E R R L-E R R L-E L-E L-E L-E R RL-E R R R L-E R L-E L-E L-E L-E R R L-E R R R R L-E L-E L-E L-E L-E R RR L-E L-E R R R L-E L-E L-E L-E R R R L-E R L-E R R L-E L-E L-E L-E R RR L-E R R L-E R L-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R RR R L-E L-E R R L-E L-E L-E L-E R R R R L-E R L-E R L-E L-E L-E L-E R RR R L-E R R L-E L-E L-E L-E L-E R R R R R L-E L-E R L-E L-E L-E L-E R RR R R L-E R L-E L-E L-E L-E L-E R R R R R R L-E L-E L-E L-E L-E R L-E RR R R R R R R R L-E R L-E R L-E R R R R R R R L-E R L-E R R L-E R R R RR R L-E R L-E R R R L-E R R R R R L-E R L-E R R R R L-E R R R R L-E RL-E R R R R R L-E R R R L-E R L-E R R R R R R L-E R R L-E R L-E R L-EL-E R R R R R R L-E R L-E R L-E R L-E R R R R R L-E R L-E R L-E R R L-ER R R R L-E R L-E R L-E R R R L-E R R R L-E R L-E R L-E R R R R L-E R RL-E R L-E R R L-E L-E R R R R R L-E R L-E R R L-E R L-E R R R R L-E RL-E R R L-E R R L-E R R R L-E R L-E R R L-E R R R L-E R R L-E R L-E R RR L-E L-E R R R R L-E R L-E R R R L-E R L-E R R R L-E R L-E R R R L-E RR L-E R R L-E R L-E R R R R L-E L-E R R R L-E R L-E R R R R L-E R L-E RR L-E R L-E R R R R R L-E L-E R R L-E R L-E R R R R R R R L-E R L-E RL-E R L-E R R R R R L-E R L-E R L-E R R L-E R R R R L-E R L-E R L-E R RR L-E R R R L-E R L-E R L-E R R R R L-E R R L-E R L-E R L-E R R R R RL-E R L-E R L-E R L-E R R R R R R L-E L-E R L-E R L-E R L-E L-E R R R RL-E R L-E R L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R R L-E R R L-ER L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R L-E R R R R L-E L-E RL-E R L-E R R L-E L-E R R R L-E R L-E R L-E R R L-E R L-E R R L-E R L-ER L-E R R L-E R R L-E R L-E R L-E R L-E R R L-E R R R L-E L-E R L-E RL-E R R R L-E L-E R R L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R L-ER R R L-E R R L-E L-E R L-E R L-E R R R R L-E L-E R L-E R L-E R L-E R RR R L-E R L-E L-E R L-E R L-E R R R R R L-E L-E L-E R L-E R L-E R R R RR R R R L-E L-E R L-E R L-E R R R R R R L-E L-E R L-E R R L-E R R R R RL-E L-E R L-E R R R L-E R R R R L-E L-E R L-E R R R R L-E R R R L-E L-ER L-E R R R R R L-E R R L-E L-E R L-E R R R R R R L-E R L-E L-E R L-E RL-E L-E R R R R R L-E L-E R L-E R L-E R L-E R R R R L-E L-E R L-E R L-ER R L-E R R R L-E L-E R L-E R L-E R R R L-E R R L-E L-E R L-E R L-E R RR R L-E R L-E L-E R L-E R R L-E L-E R R R R L-E L-E R L-E R R L-E R L-ER R R L-E L-E R L-E R R L-E R R L-E R R L-E L-E R L-E R R L-E R R R L-ER L-E L-E R L-E R R R L-E L-E R R R L-E L-E R L-E R R R L-E R L-E R RL-E L-E R L-E R R R L-E R R L-E R L-E L-E R L-E R R R R L-E L-E R R L-EL-E R L-E R R R R L-E R L-E R L-E L-E R L-E R R R R R L-E L-E R L-E L-ER L-E R R R R R R R L-E L-E L-E R L-E R L-E R R R R R L-E L-E L-E R L-ER R L-E R R R R L-E L-E L-E R L-E R R R L-E R R R L-E L-E L-E R L-E R RR R L-E R R L-E L-E L-E R L-E R R R R R L-E R L-E L-E L-E R L-E R R R RR R L-E L-E L-E L-E R L-E R L-E L-E R R R R L-E L-E L-E R L-E R L-E RL-E R R R L-E L-E L-E R L-E R L-E R R L-E R R L-E L-E L-E R L-E R L-E RR R L-E R L-E L-E L-E R L-E R L-E R R R R L-E L-E L-E L-E R L-E R R L-EL-E R R R L-E L-E L-E R L-E R R L-E R L-E R R L-E L-E L-E R L-E R R L-ER R L-E R L-E L-E L-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R RL-E L-E R R L-E L-E L-E R L-E R R R L-E R L-E R L-E L-E L-E R L-E R R RL-E R R L-E L-E L-E L-E R L-E R R R R L-E L-E R L-E L-E L-E R L-E R R RR L-E R L-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-E L-E L-E R RR R R R R R R L-E L-E L-E R L-E R R R R R R R L-E L-E L-E R R L-E R R RR R R L-E L-E L-E R R R L-E R R R R R L-E L-E L-E R R R R L-E R R R RL-E L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R R L-E R R L-E L-EL-E R L-E L-E R R R R R R L-E L-E L-E R L-E R L-E R R R R R L-E L-E L-ER L-E R R L-E R R R R L-E L-E L-E R L-E R R R L-E R R R L-E L-E L-E RL-E R R R R L-E R R L-E L-E L-E R R L-E L-E R R R R R L-E L-E L-E R RL-E R L-E R R R R L-E L-E L-E R R L-E R R L-E R R R L-E L-E L-E R R L-ER R R L-E R R L-E L-E L-E R R R L-E L-E R R R R L-E L-E L-E R R R L-E RL-E R R R L-E L-E L-E R R R L-E R R L-E R R L-E L-E L-E R R R R L-E L-ER R R L-E L-E L-E R R R R L-E R L-E R R L-E L-E L-E R R R R R L-E L-E RR L-E L-E L-E R R R R R R R L-E R L-E L-E L-E R L-E R R R R R L-E R L-EL-E L-E R R L-E R R R R L-E R L-E L-E L-E R R R L-E R R R L-E R L-E L-EL-E R R R R L-E R R L-E R L-E L-E L-E R R R R R L-E R L-E R L-E L-E L-ER R R R R R L-E L-E R L-E L-E L-E R L-E L-E R R R R L-E R L-E L-E L-E RL-E R L-E R R R L-E R L-E L-E L-E R L-E R R L-E R R L-E R L-E L-E L-E RL-E R R R L-E R L-E R L-E L-E L-E R L-E R R R R L-E L-E R L-E L-E L-E RR L-E L-E R R R L-E R L-E L-E L-E R R L-E R L-E R R L-E R L-E L-E L-E RR L-E R R L-E R L-E R L-E L-E L-E R R L-E R R R L-E L-E R L-E L-E L-E RR R L-E L-E R R L-E R L-E L-E L-E R R R L-E R L-E R L-E R L-E L-E L-E RR R L-E R R L-E L-E R L-E L-E L-E R R R R L-E L-E R L-E R L-E L-E L-E RR R R L-E R L-E L-E R L-E L-E L-E R R R R R L-E L-E L-E R L-E L-E L-E RR R R R R R R L-E L-E L-E L-E R L-E R R R R R R L-E L-E L-E L-E R R L-ER R R R R L-E L-E L-E L-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-ER R R L-E L-E L-E L-E R R R R R L-E R R L-E L-E L-E L-E R R R R R R L-ER L-E L-E L-E L-E R L-E L-E R R R R R L-E L-E L-E L-E R L-E R L-E R R RR L-E L-E L-E L-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R R L-E RR L-E L-E L-E L-E R L-E R R R R L-E R L-E L-E L-E L-E R R L-E L-E R R RR L-E L-E L-E L-E R R L-E R L-E R R R L-E L-E L-E L-E R R L-E R R L-E RR L-E L-E L-E L-E R R L-E R R R L-E R L-E L-E L-E L-E R R R L-E L-E R RR L-E L-E L-E L-E R R R L-E R L-E R R L-E L-E L-E L-E R R R L-E R R L-ER L-E L-E L-E L-E R R R R L-E L-E R R L-E L-E L-E L-E R R R R L-E R L-ER L-E L-E L-E L-E R R R R R L-E L-E R L-E L-E L-E L-E R R R R R R R L-EL-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-E R R L-E R R R R L-EL-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R R R R L-E R R L-EL-E L-E L-E L-E R R R R R L-E R L-E L-E L-E L-E L-E R R R R R R L-E L-EL-E L-E L-E L-E R L-E L-E R R R R L-E L-E L-E L-E L-E R L-E R L-E R R RL-E L-E L-E L-E L-E R L-E R R L-E R R L-E L-E L-E L-E L-E R L-E R R RL-E R L-E L-E L-E L-E L-E R L-E R R R R L-E L-E L-E L-E L-E L-E R R L-EL-E R R R L-E L-E L-E L-E L-E R R L-E R L-E R R L-E L-E L-E L-E L-E R RL-E R R L-E R L-E L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-E L-E L-ER R R L-E L-E R R L-E L-E L-E L-E L-E R R R L-E R L-E R L-E L-E L-E L-EL-E R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R L-E L-E R L-E L-E L-EL-E L-E R R R R L-E R L-E L-E L-E L-E L-E L-E R R R R R L-E L-E L-E L-EL-E L-E L-E L-E R R R R R R R R L-E L-E L-E L-E L-E R R R R R R R L-EL-E L-E L-E R L-E R R R R R R L-E L-E L-E L-E R R L-E R R R R R L-E L-EL-E L-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-E R R R L-E L-E L-EL-E R R R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R R R L-E L-E L-EL-E L-E R L-E R R R R R L-E L-E L-E L-E L-E R R L-E R R R R L-E L-E L-EL-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R R R R L-E R R L-E L-E L-EL-E R L-E L-E R R R R R L-E L-E L-E L-E R L-E R L-E R R R R L-E L-E L-EL-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R R L-E R R L-E L-E L-EL-E R R L-E L-E R R R R L-E L-E L-E L-E R R L-E R L-E R R R L-E L-E L-EL-E R R L-E R R L-E R R L-E L-E L-E L-E R R R L-E L-E R R R L-E L-E L-EL-E R R R L-E R L-E R R L-E L-E L-E L-E R R R R L-E L-E R R L-E L-E L-EL-E R R R R R R L-E R L-E L-E L-E L-E L-E R R R R R L-E R L-E L-E L-EL-E R L-E R R R R L-E R L-E L-E L-E L-E R R L-E R R R L-E R L-E L-E L-EL-E R R R L-E R R L-E R L-E L-E L-E L-E R R R R L-E R L-E R L-E L-E L-EL-E R R R R R L-E L-E R L-E L-E L-E L-E L-E L-E R R R R L-E R L-E L-EL-E L-E L-E R L-E R R R L-E R L-E L-E L-E L-E L-E R R L-E R R L-E R L-EL-E L-E L-E L-E R R R L-E R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E RL-E L-E L-E L-E R L-E L-E R R R L-E R L-E L-E L-E L-E R L-E R L-E R RL-E R L-E L-E L-E L-E R L-E R R L-E R L-E R L-E L-E L-E L-E R L-E R R RL-E L-E R L-E L-E L-E L-E R R L-E L-E R R L-E R L-E L-E L-E L-E R R L-ER L-E R L-E R L-E L-E L-E L-E R R L-E R R L-E L-E R L-E L-E L-E L-E R RR L-E L-E R L-E R L-E L-E L-E L-E R R R L-E R L-E L-E R L-E L-E L-E L-ER R R R L-E L-E L-E R L-E L-E L-E L-E R R R R R R R L-E L-E L-E L-E L-EL-E R R R R R R L-E L-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-ER R L-E R R R R L-E L-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-ER R R R L-E R R L-E L-E L-E L-E L-E R R R R R L-E R L-E L-E L-E L-E L-EL-E L-E R R R R R L-E L-E L-E L-E L-E L-E R L-E R R R R L-E L-E L-E L-EL-E L-E R R L-E R R R L-E L-E L-E L-E L-E L-E R R R L-E R R L-E L-E L-EL-E L-E L-E R R R R L-E R L-E L-E L-E L-E L-E R L-E L-E R R R R L-E L-EL-E L-E L-E R L-E R L-E R R R L-E L-E L-E L-E L-E R L-E R R L-E R R L-EL-E L-E L-E L-E R L-E R R R L-E R L-E L-E L-E L-E L-E R R L-E L-E R R RL-E L-E L-E L-E L-E R R L-E R L-E R R L-E L-E L-E L-E L-E R R L-E R RL-E R L-E L-E L-E L-E L-E R R R L-E L-E R R L-E L-E L-E L-E L-E R R RL-E R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E R L-E L-E L-E L-E L-E RR R R R R L-E L-E L-E L-E L-E L-E L-E R R R R R L-E L-E L-E L-E L-E L-ER L-E R R R R L-E L-E L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-E L-EL-E R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R L-E R L-E L-E L-E L-EL-E L-E R R R R R L-E L-E L-E L-E L-E L-E L-E L-E L-E R R R R L-E L-EL-E L-E L-E L-E L-E R L-E R R R L-E L-E L-E L-E L-E L-E L-E R R L-E R RL-E L-E L-E L-E L-E L-E L-E R R R L-E R L-E L-E L-E L-E L-E L-E L-E R RR R L-E L-E L-E L-E L-E L-E L-E R L-E L-E R R R L-E L-E L-E L-E L-E L-ER L-E R L-E R R L-E L-E L-E L-E L-E L-E R L-E R R L-E R L-E L-E L-E L-EL-E L-E R L-E R R R L-E L-E L-E L-E L-E L-E L-E R R L-E L-E R R L-E L-EL-E L-E L-E L-E R R L-E R L-E R L-E L-E L-E L-E L-E L-E R R L-E R R L-EL-E L-E L-E L-E L-E L-E R R R L-E L-E R L-E L-E L-E L-E L-E L-E R R RL-E R L-E L-E L-E L-E L-E L-E L-E R R R R L-E L-E L-E L-E

Z₁ Z₂ Z₃ Z₄ Z₅ Z₆ Z₇ Z₈ Z₉ Z₁₀ Z₁₁ Z₁₂ R R R R R R R R R R R R R R R RL-E R R R R R R R R R R R R L-E R R R R R R R R R R R R L-E R R R R R RR R R R R R L-E R R R R R R R R R R R R L-E R R R R R R R R R R R R L-ER R R R R R L-E L-E R R R R R R R R R R L-E R L-E R R R R R R R R R L-ER R L-E R R R R R R R R L-E R R R L-E R R R R R R R L-E R R R R L-E R RR R R R R L-E L-E R R R R R R R R R R L-E R L-E R R R R R R R R R L-E RR L-E R R R R R R R R L-E R R R L-E R R R R R R R R L-E L-E R R R R R RR R R R L-E R L-E R R R R R R R R R L-E R R L-E R R R R R R R R R L-EL-E R R R R R R R R R R L-E R L-E R R R R R R R R R R L-E L-E R R R R RR R R R R R R L-E R R R R R L-E R R R R R L-E R R R R R R L-E R R R RL-E R R R R R R R L-E R R R L-E R R R R R R R R L-E R R L-E R R R R R RR R R L-E R L-E R R R R R R R R R R L-E L-E R R R R R L-E L-E R R R RL-E R R R R R L-E R L-E R R R L-E R R R R R L-E R R L-E R R L-E R R R RR L-E R R R L-E R L-E R R R R R L-E R R R R L-E L-E R R R R R R L-E L-ER R R L-E R R R R R R L-E R L-E R R L-E R R R R R R L-E R R L-E R L-E RR R R R R L-E R R R L-E L-E R R R R R R R L-E L-E R R L-E R R R R R R RL-E R L-E R L-E R R R R R R R L-E R R L-E L-E R R R R R R R R L-E L-E RL-E R R R R R R R R L-E R L-E L-E R R R R R R R R R L-E L-E L-E R R R RR R R R R R R R L-E R R R R L-E R R R R R R L-E R R R R R L-E R R R R RL-E R R R R R R L-E R R R R L-E R R R R R R R L-E R R R L-E R R R R R RR R L-E R R L-E R R R R R R R R R L-E R L-E R R R R L-E L-E R R R R RL-E R R R R L-E R L-E R R R R L-E R R R R L-E R R L-E R R R L-E R R R RL-E R R R L-E R R L-E R R R R L-E R R R R L-E R L-E R R R R R L-E L-E RR R R L-E R R R R R L-E R L-E R R R L-E R R R R R L-E R R L-E R R L-E RR R R R L-E R R R L-E R L-E R R R R R R L-E L-E R R R L-E R R R R R RL-E R L-E R R L-E R R R R R R L-E R R L-E R L-E R R R R R R R L-E L-E RR L-E R R R R R R R L-E R L-E R L-E R R R R R R R R L-E L-E R L-E R R RR R R R R R R L-E L-E R R R R L-E R R R R R L-E L-E R R R R R L-E R R RR L-E L-E R R R R R R L-E R R R L-E L-E R R R R R R R L-E R R L-E L-E RR R R R R R R L-E R L-E L-E R R R R R R R R R L-E L-E L-E R R R R L-EL-E R R R R L-E L-E R R R R L-E R L-E R R R L-E L-E R R R R L-E R R L-ER R L-E L-E R R R R L-E R R R L-E R L-E L-E R R R R L-E R R R R L-E L-EL-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E R L-E R R L-E L-E R RR R R L-E R R L-E R L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R RL-E L-E R R L-E L-E R R R R R R L-E R L-E R L-E L-E R R R R R R L-E R RL-E L-E L-E R R R R R R R L-E L-E R L-E L-E R R R R R R R L-E R L-E L-EL-E R R R R R R R R L-E L-E L-E L-E L-E R R R R R R R R R R R L-E R R RL-E R R R R R R R L-E R R R R L-E R R R R R R L-E R R R R R L-E R R R RR L-E R R R R R R L-E R R R R L-E R R R R R R R L-E R R R L-E R R R R RR R R L-E R R L-E R R R L-E L-E R R R R R R L-E R R R L-E R L-E R R R RR L-E R R R L-E R R L-E R R R R L-E R R R L-E R R R L-E R R R L-E R R RL-E R R R R L-E R R L-E R R R R L-E L-E R R R R R L-E R R R R L-E R L-ER R R R L-E R R R R L-E R R L-E R R R L-E R R R R L-E R R R L-E R R L-ER R R R R L-E L-E R R R R L-E R R R R R L-E R L-E R R R L-E R R R R RL-E R R L-E R R L-E R R R R R R L-E L-E R R R L-E R R R R R R L-E R L-ER R L-E R R R R R R R L-E L-E R R L-E R R R R R R R R R L-E R L-E R R RL-E R R R R R L-E R L-E R R R R L-E R R R R L-E R L-E R R R R R L-E R RR L-E R L-E R R R R R R L-E R R L-E R L-E R R R R R R R L-E R L-E R L-ER R R R R R R R L-E L-E R L-E R R R L-E L-E R R R R L-E R L-E R R R L-ER L-E R R R L-E R L-E R R R L-E R R L-E R R L-E R L-E R R R L-E R R RL-E R L-E R L-E R R R L-E R R R R L-E L-E R L-E R R R R L-E L-E R R RL-E R L-E R R R R L-E R L-E R R L-E R L-E R R R R L-E R R L-E R L-E RL-E R R R R L-E R R R L-E L-E R L-E R R R R R L-E L-E R R L-E R L-E R RR R R L-E R L-E R L-E R L-E R R R R R L-E R R L-E L-E R L-E R R R R R RL-E L-E R L-E R L-E R R R R R R L-E R L-E L-E R L-E R R R R R R R L-EL-E L-E R L-E R R R R R R R R R R L-E L-E R R R L-E R R R R R R L-E L-ER R R R L-E R R R R R L-E L-E R R R R R L-E R R R R L-E L-E R R R R R RL-E R R R L-E L-E R R R R R R R L-E R R L-E L-E R R R R R R R R L-E RL-E L-E R R R L-E L-E R R R R R L-E L-E R R R L-E R L-E R R R R L-E L-ER R R L-E R R L-E R R R L-E L-E R R R L-E R R R L-E R R L-E L-E R R RL-E R R R R L-E R L-E L-E R R R R L-E L-E R R R R L-E L-E R R R R L-E RL-E R R R L-E L-E R R R R L-E R R L-E R R L-E L-E R R R R L-E R R R L-ER L-E L-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E R L-E R R L-EL-E R R R R R L-E R R L-E R L-E L-E R R R R R R L-E L-E R R L-E L-E R RR R R R L-E R L-E R L-E L-E R R R R R R R L-E L-E R L-E L-E R R R R R RR R R L-E L-E L-E R R R L-E R R R R R L-E L-E L-E R R R R L-E R R R RL-E L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R R L-E R R L-E L-EL-E R R R R R R R L-E R L-E L-E L-E R R R R R R R R L-E L-E L-E L-E R RR L-E L-E R R R R L-E L-E L-E R R R L-E R L-E R R R L-E L-E L-E R R RL-E R R L-E R R L-E L-E L-E R R R L-E R R R L-E R L-E L-E L-E R R R L-ER R R R L-E L-E L-E L-E R R R R L-E L-E R R R L-E L-E L-E R R R R L-E RL-E R R L-E L-E L-E R R R R L-E R R L-E R L-E L-E L-E R R R R L-E R R RL-E L-E L-E L-E R R R R R L-E L-E R R L-E L-E L-E R R R R R L-E R L-E RL-E L-E L-E R R R R R L-E R R L-E L-E L-E L-E R R R R R R L-E L-E R L-EL-E L-E R R R R R R L-E R L-E L-E L-E L-E R R R R R R R L-E L-E L-E L-EL-E L-E R R R R R R R R R R L-E L-E R R L-E R R R R R R R L-E L-E R R RL-E R R R R R R L-E L-E R R R R L-E R R R R R L-E L-E R R R R R L-E R RR R L-E L-E R R R R R R L-E R R R L-E L-E R R R R R R R L-E R R L-E L-ER R L-E L-E R R R R R R L-E L-E R R L-E R L-E R R R R R L-E L-E R R L-ER R L-E R R R R L-E L-E R R L-E R R R L-E R R R L-E L-E R R L-E R R R RL-E R R L-E L-E R R R L-E L-E R R R R R L-E L-E R R R L-E R L-E R R R RL-E L-E R R R L-E R R L-E R R R L-E L-E R R R L-E R R R L-E R R L-E L-ER R R R L-E L-E R R R R L-E L-E R R R R L-E R L-E R R R L-E L-E R R R RL-E R R L-E R R L-E L-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E RL-E R R L-E L-E R R R R R R L-E L-E R R L-E L-E R R R R R R R R L-E RL-E L-E R R L-E R R R R R L-E R L-E L-E R R R L-E R R R R L-E R L-E L-ER R R R L-E R R R L-E R L-E L-E R R R R R L-E R R L-E R L-E L-E R R R RR R L-E R L-E R L-E L-E R R R R R R R L-E L-E R L-E L-E R R L-E L-E R RR R L-E R L-E L-E R R L-E R L-E R R R L-E R L-E L-E R R L-E R R L-E R RL-E R L-E L-E R R L-E R R R L-E R L-E R L-E L-E R R L-E R R R R L-E L-ER L-E L-E R R R L-E L-E R R R L-E R L-E L-E R R R L-E R L-E R R L-E RL-E L-E R R R L-E R R L-E R L-E R L-E L-E R R R L-E R R R L-E L-E R L-EL-E R R R R L-E L-E R R L-E R L-E L-E R R R R L-E R L-E R L-E R L-E L-ER R R R L-E R R L-E L-E R L-E L-E R R R R R L-E L-E R L-E R L-E L-E R RR R R L-E R L-E L-E R L-E L-E R R R R R R L-E L-E L-E R L-E L-E R R R RR R R R R L-E L-E L-E R R L-E R R R R R R L-E L-E L-E R R R L-E R R R RR L-E L-E L-E R R R R L-E R R R R L-E L-E L-E R R R R R L-E R R R L-EL-E L-E R R R R R R L-E R R L-E L-E L-E R R R R R R R L-E R L-E L-E L-ER R L-E L-E R R R R R L-E L-E L-E R R L-E R L-E R R R R L-E L-E L-E R RL-E R R L-E R R R L-E L-E L-E R R L-E R R R L-E- R R L-E L-E L-E R R L-ER R R R L-E R L-E L-E L-E R R R L-E L-E R R R R L-E L-E L-E R R R L-E RL-E R R R L-E L-E L-E R R R L-E R R L-E R R L-E L-E L-E R R R L-E R R RL-E R L-E L-E L-E R R R R L-E L-E R R R L-E L-E L-E R R R R L-E R L-E RR L-E L-E L-E R R R R L-E R R L-E R L-E L-E L-E R R R R R L-E L-E R RL-E L-E L-E R R R R R L-E R L-E R L-E L-E L-E R R R R R R L-E L-E R L-EL-E L-E R R R R R R R R L-E L-E L-E L-E R R L-E R R R R R L-E L-E L-EL-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-E R R R L-E L-E L-E L-ER R R R R L-E R R L-E L-E L-E L-E R R R R R R L-E R L-E L-E L-E L-E R RR R R R R L-E L-E L-E L-E L-E R R L-E L-E R R R R L-E L-E L-E L-E R RL-E R L-E R R R L-E L-E L-E L-E R R L-E R R L-E R R L-E L-E L-E L-E R RL-E R R R L-E R L-E L-E L-E L-E R R L-E R R R R L-E L-E L-E L-E L-E R RR L-E L-E R R R L-E L-E L-E L-E R R R L-E R L-E R R L-E L-E L-E L-E R RR L-E R R L-E R L-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R RR R L-E L-E R R L-E L-E L-E L-E R R R R L-E R L-E R L-E L-E L-E L-E R RR R L-E R R L-E L-E L-E L-E L-E R R R R R L-E L-E R L-E L-E L-E L-E R RR R R L-E R L-E L-E L-E L-E L-E R R R R R R L-E L-E L-E L-E L-E R L-E RR R R R R R R R L-E R L-E R L-E R R R R R R R L-E R L-E R R L-E R R R RR R L-E R L-E R R R L-E R R R R R L-E R L-E R R R R L-E R R R R L-E RL-E R R R R R L-E R R R L-E R L-E R R R R R R L-E R R L-E R L-E R L-EL-E R R R R R R L-E R L-E R L-E R L-E R R R R R L-E R L-E R L-E R R L-ER R R R L-E R L-E R L-E R R R L-E R R R L-E R L-E R L-E R R R R L-E R RL-E R L-E R R L-E L-E R R R R R L-E R L-E R R L-E R L-E R R R R L-E RL-E R R L-E R R L-E R R R L-E R L-E R R L-E R R R L-E R R L-E R L-E R RR L-E L-E R R R R L-E R L-E R R R L-E R L-E R R R L-E R L-E R R R L-E RR L-E R R L-E R L-E R R R R L-E L-E R R R L-E R L-E R R R R L-E R L-E RR L-E R L-E R R R R R L-E L-E R R L-E R L-E R R R R R R R L-E R L-E RL-E R L-E R R R R R L-E R L-E R L-E R R L-E R R R R L-E R L-E R L-E R RR L-E R R R L-E R L-E R L-E R R R R L-E R R L-E R L-E R L-E R R R R RL-E R L-E R L-E R L-E R R R R R R L-E L-E R L-E R L-E R L-E L-E R R R RL-E R L-E R L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R R L-E R R L-ER L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R L-E R R R R L-E L-E RL-E R L-E R R L-E L-E R R R L-E R L-E R L-E R R L-E R L-E R R L-E R L-ER L-E R R L-E R R L-E R L-E R L-E R L-E R R L-E R R R L-E L-E R L-E RL-E R R R L-E L-E R R L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R L-ER R R L-E R R L-E L-E R L-E R L-E R R R R L-E L-E R L-E R L-E R L-E R RR R L-E R L-E L-E R L-E R L-E R R R R R L-E L-E L-E R L-E R L-E R R R RR R R R L-E L-E R L-E R L-E R R R R R R L-E L-E R L-E R R L-E R R R R RL-E L-E R L-E R R R L-E R R R R L-E L-E R L-E R R R R L-E R R R L-E L-ER L-E R R R R R L-E R R L-E L-E R L-E R R R R R R L-E R L-E L-E R L-E RL-E L-E R R R R R L-E L-E R L-E R L-E R L-E R R R R L-E L-E R L-E R L-ER R L-E R R R L-E L-E R L-E R L-E R R R L-E R R L-E L-E R L-E R L-E R RR R L-E R L-E L-E R L-E R R L-E L-E R R R R L-E L-E R L-E R R L-E R L-ER R R L-E L-E R L-E R R L-E R R L-E R R L-E L-E R L-E R R L-E R R R L-ER L-E L-E R L-E R R R L-E L-E R R R L-E L-E R L-E R R R L-E R L-E R RL-E L-E R L-E R R R L-E R R L-E R L-E L-E R L-E R R R R L-E L-E R R L-EL-E R L-E R R R R L-E R L-E R L-E L-E R L-E R R R R R L-E L-E R L-E L-ER L-E R R R R R R R L-E L-E L-E R L-E R L-E R R R R R L-E L-E L-E R L-ER R L-E R R R R L-E L-E L-E R L-E R R R L-E R R R L-E L-E L-E R L-E R RR R L-E R R L-E L-E L-E R L-E R R R R R L-E R L-E L-E L-E R L-E R R R RR R L-E L-E L-E L-E R L-E R L-E L-E R R R R L-E L-E L-E R L-E R L-E RL-E R R R L-E L-E L-E R L-E R L-E R R L-E R R L-E L-E L-E R L-E R L-E RR R L-E R L-E L-E L-E R L-E R L-E R R R R L-E L-E L-E L-E R L-E R R L-EL-E R R R L-E L-E L-E R L-E R R L-E R L-E R R L-E L-E L-E R L-E R R L-ER R L-E R L-E L-E L-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R RL-E L-E R R L-E L-E L-E R L-E R R R L-E R L-E R L-E L-E L-E R L-E R R RL-E R R L-E L-E L-E L-E R L-E R R R R L-E L-E R L-E L-E L-E R L-E R R RR L-E R L-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-E L-E L-E R RR R R R R R R L-E L-E L-E R L-E R R R R R R R L-E L-E L-E R R L-E R R RR R R L-E L-E L-E R R R L-E R R R R R L-E L-E L-E R R R R L-E R R R RL-E L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R R L-E R R L-E L-EL-E R L-E L-E R R R R R R L-E L-E L-E R L-E R L-E R R R R R L-E L-E L-ER L-E R R L-E R R R R L-E L-E L-E R L-E R R R L-E R R R L-E L-E L-E RL-E R R R R L-E R R L-E L-E L-E R R L-E L-E R R R R R L-E L-E L-E R RL-E R L-E R R R R L-E L-E L-E R R L-E R R L-E R R R L-E L-E L-E R R L-ER R R L-E R R L-E L-E L-E R R R L-E L-E R R R R L-E L-E L-E R R R L-E RL-E R R R L-E L-E L-E R R R L-E R R L-E R R L-E L-E L-E R R R R L-E L-ER R R L-E L-E L-E R R R R L-E R L-E R R L-E L-E L-E R R R R R L-E L-E RR L-E L-E L-E R R R R R R R L-E R L-E L-E L-E R L-E R R R R R L-E R L-EL-E L-E R R L-E R R R R L-E R L-E L-E L-E R R R L-E R R R L-E R L-E L-EL-E R R R R L-E R R L-E R L-E L-E L-E R R R R R L-E R L-E R L-E L-E L-ER R R R R R L-E L-E R L-E L-E L-E R L-E L-E R R R R L-E R L-E L-E L-E RL-E R L-E R R R L-E R L-E L-E L-E R L-E R R L-E R R L-E R L-E L-E L-E RL-E R R R L-E R L-E R L-E L-E L-E R L-E R R R R L-E L-E R L-E L-E L-E RR L-E L-E R R R L-E R L-E L-E L-E R R L-E R L-E R R L-E R L-E L-E L-E RR L-E R R L-E R L-E R L-E L-E L-E R R L-E R R R L-E L-E R L-E L-E L-E RR R L-E L-E R R L-E R L-E L-E L-E R R R L-E R L-E R L-E R L-E L-E L-E RR R L-E R R L-E L-E R L-E L-E L-E R R R R L-E L-E R L-E R L-E L-E L-E RR R R L-E R L-E L-E R L-E L-E L-E R R R R R L-E L-E L-E R L-E L-E L-E RR R R R R R R L-E L-E L-E L-E R L-E R R R R R R L-E L-E L-E L-E R R L-ER R R R R L-E L-E L-E L-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-ER R R L-E L-E L-E L-E R R R R R L-E R R L-E L-E L-E L-E R R R R R R L-ER L-E L-E L-E L-E R L-E L-E R R R R R L-E L-E L-E L-E R L-E R L-E R R RR L-E L-E L-E L-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R R L-E RR L-E L-E L-E L-E R L-E R R R R L-E R L-E L-E L-E L-E R R L-E L-E R R RR L-E L-E L-E L-E R R L-E R L-E R R R L-E L-E L-E L-E R R L-E R R L-E RR L-E L-E L-E L-E R R L-E R R R L-E R L-E L-E L-E L-E R R R L-E L-E R RR L-E L-E L-E L-E R R R L-E R L-E R R L-E L-E L-E L-E R R R L-E R R L-ER L-E L-E L-E L-E R R R R L-E L-E R R L-E L-E L-E L-E R R R R L-E R L-ER L-E L-E L-E L-E R R R R R L-E L-E R L-E L-E L-E L-E R R R R R R R L-EL-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-E R R L-E R R R R L-EL-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R R R R L-E R R L-EL-E L-E L-E L-E R R R R R L-E R L-E L-E L-E L-E L-E R R R R R R L-E L-EL-E L-E L-E L-E R L-E L-E R R R R L-E L-E L-E L-E L-E R L-E R L-E R R RL-E L-E L-E L-E L-E R L-E R R L-E R R L-E L-E L-E L-E L-E R L-E R R RL-E R L-E L-E L-E L-E L-E R L-E R R R R L-E L-E L-E L-E L-E L-E R R L-EL-E R R R L-E L-E L-E L-E L-E R R L-E R L-E R R L-E L-E L-E L-E L-E R RL-E R R L-E R L-E L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-E L-E L-ER R R L-E L-E R R L-E L-E L-E L-E L-E R R R L-E R L-E R L-E L-E L-E L-EL-E R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R L-E L-E R L-E L-E L-EL-E L-E R R R R L-E R L-E L-E L-E L-E L-E L-E R R R R R L-E L-E L-E L-EL-E L-E L-E L-E R R R R R R R R L-E L-E L-E L-E L-E R R R R R R R L-EL-E L-E L-E R L-E R R R R R R L-E L-E L-E L-E R R L-E R R R R R L-E L-EL-E L-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-E R R R L-E L-E L-EL-E R R R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R R R L-E L-E L-EL-E L-E R L-E R R R R R L-E L-E L-E L-E L-E R R L-E R R R R L-E L-E L-EL-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R R R R L-E R R L-E L-E L-EL-E R L-E L-E R R R R R L-E L-E L-E L-E R L-E R L-E R R R R L-E L-E L-EL-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R R L-E R R L-E L-E L-EL-E R R L-E L-E R R R R L-E L-E L-E L-E R R L-E R L-E R R R L-E L-E L-EL-E R R L-E R R L-E R R L-E L-E L-E L-E R R R L-E L-E R R R L-E L-E L-EL-E R R R L-E R L-E R R L-E L-E L-E L-E R R R R L-E L-E R R L-E L-E L-EL-E R R R R R R L-E R L-E L-E L-E L-E L-E R R R R R L-E R L-E L-E L-EL-E R L-E R R R R L-E R L-E L-E L-E L-E R R L-E R R R L-E R L-E L-E L-EL-E R R R L-E R R L-E R L-E L-E L-E L-E R R R R L-E R L-E R L-E L-E L-EL-E R R R R R L-E L-E R L-E L-E L-E L-E L-E L-E R R R R L-E R L-E L-EL-E L-E L-E R L-E R R R L-E R L-E L-E L-E L-E L-E R R L-E R R L-E R L-EL-E L-E L-E L-E R R R L-E R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E RL-E L-E L-E L-E R L-E L-E R R R L-E R L-E L-E L-E L-E R L-E R L-E R RL-E R L-E L-E L-E L-E R L-E R R L-E R L-E R L-E L-E L-E L-E R L-E R R RL-E L-E R L-E L-E L-E L-E R R L-E L-E R R L-E R L-E L-E L-E L-E R R L-ER L-E R L-E R L-E L-E L-E L-E R R L-E R R L-E L-E R L-E L-E L-E L-E R RR L-E L-E R L-E R L-E L-E L-E L-E R R R L-E R L-E L-E R L-E L-E L-E L-ER R R R L-E L-E L-E R L-E L-E L-E L-E R R R R R R R L-E L-E L-E L-E L-EL-E R R R R R R L-E L-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-ER R L-E R R R R L-E L-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-ER R R R L-E R R L-E L-E L-E L-E L-E R R R R R L-E R L-E L-E L-E L-E L-EL-E L-E R R R R R L-E L-E L-E L-E L-E L-E R L-E R R R R L-E L-E L-E L-EL-E L-E R R L-E R R R L-E L-E L-E L-E L-E L-E R R R L-E R R L-E L-E L-EL-E L-E L-E R R R R L-E R L-E L-E L-E L-E L-E R L-E L-E R R R R L-E L-EL-E L-E L-E R L-E R L-E R R R L-E L-E L-E L-E L-E R L-E R R L-E R R L-EL-E L-E L-E L-E R L-E R R R L-E R L-E L-E L-E L-E L-E R R L-E L-E R R RL-E L-E L-E L-E L-E R R L-E R L-E R R L-E L-E L-E L-E L-E R R L-E R RL-E R L-E L-E L-E L-E L-E R R R L-E L-E R R L-E L-E L-E L-E L-E R R RL-E R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E R L-E L-E L-E L-E L-E RR R R R R L-E L-E L-E L-E L-E L-E L-E R R R R R L-E L-E L-E L-E L-E L-ER L-E R R R R L-E L-E L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-E L-EL-E R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R L-E R L-E L-E L-E L-EL-E L-E R R R R R L-E L-E L-E L-E L-E L-E L-E L-E L-E R R R R L-E L-EL-E L-E L-E L-E L-E R L-E R R R L-E L-E L-E L-E L-E L-E L-E R R L-E R RL-E L-E L-E L-E L-E L-E L-E R R R L-E R L-E L-E L-E L-E L-E L-E L-E R RR R L-E L-E L-E L-E L-E L-E L-E R L-E L-E R R R L-E L-E L-E L-E L-E L-ER L-E R L-E R R L-E L-E L-E L-E L-E L-E R L-E R R L-E R L-E L-E L-E L-EL-E L-E R L-E R R R L-E L-E L-E L-E L-E L-E L-E R R L-E L-E R R L-E L-EL-E L-E L-E L-E R R L-E R L-E R L-E L-E L-E L-E L-E L-E R R L-E R R L-EL-E L-E L-E L-E L-E L-E R R R L-E L-E R L-E L-E L-E L-E L-E L-E R R RL-E R L-E L-E L-E L-E L-E L-E L-E R R R R L-E L-E L-E L-E

Z₁ Z₂ Z₃ Z₄ Z₅ Z₆ Z₇ Z₈ Z₉ Z₁₀ Z₁₁ Z₁₂ R R R R R R R R R R R R R R R RL-E R R R R R R R R R R R R L-E R R R R R R R R R R R R L-E R R R R R RR R R R R R L-E R R R R R R R R R R R R L-E R R R R R R R R R R R R L-ER R R R R R L-E L-E R R R R R R R R R R L-E R L-E R R R R R R R R R L-ER R L-E R R R R R R R R L-E R R R L-E R R R R R R R L-E R R R R L-E R RR R R R R L-E L-E R R R R R R R R R R L-E R L-E R R R R R R R R R L-E RR L-E R R R R R R R R L-E R R R L-E R R R R R R R R L-E L-E R R R R R RR R R R L-E R L-E R R R R R R R R R L-E R R L-E R R R R R R R R R L-EL-E R R R R R R R R R R L-E R L-E R R R R R R R R R R L-E L-E R R R R RR R R R R R R L-E R R R R R L-E R R R R R L-E R R R R R R L-E R R R RL-E R R R R R R R L-E R R R L-E R R R R R R R R L-E R R L-E R R R R R RR R R L-E R L-E R R R R R R R R R R L-E L-E R R R R R L-E L-E R R R RL-E R R R R R L-E R L-E R R R L-E R R R R R L-E R R L-E R R L-E R R R RR L-E R R R L-E R L-E R R R R R L-E R R R R L-E L-E R R R R R R L-E L-ER R R L-E R R R R R R L-E R L-E R R L-E R R R R R R L-E R R L-E R L-E RR R R R R L-E R R R L-E L-E R R R R R R R L-E L-E R R L-E R R R R R R RL-E R L-E R L-E R R R R R R R L-E R R L-E L-E R R R R R R R R L-E L-E RL-E R R R R R R R R L-E R L-E L-E R R R R R R R R R L-E L-E L-E R R R RR R R R R R R R L-E R R R R L-E R R R R R R L-E R R R R R L-E R R R R RL-E R R R R R R L-E R R R R L-E R R R R R R R L-E R R R L-E R R R R R RR R L-E R R L-E R R R R R R R R R L-E R L-E R R R R L-E L-E R R R R RL-E R R R R L-E R L-E R R R R L-E R R R R L-E R R L-E R R R L-E R R R RL-E R R R L-E R R L-E R R R R L-E R R R R L-E R L-E R R R R R L-E L-E RR R R L-E R R R R R L-E R L-E R R R L-E R R R R R L-E R R L-E R R L-E RR R R R L-E R R R L-E R L-E R R R R R R L-E L-E R R R L-E R R R R R RL-E R L-E R R L-E R R R R R R L-E R R L-E R L-E R R R R R R R L-E L-E RR L-E R R R R R R R L-E R L-E R L-E R R R R R R R R L-E L-E R L-E R R RR R R R R R R L-E L-E R R R R L-E R R R R R L-E L-E R R R R R L-E R R RR L-E L-E R R R R R R L-E R R R L-E L-E R R R R R R R L-E R R L-E L-E RR R R R R R R L-E R L-E L-E R R R R R R R R R L-E L-E L-E R R R R L-EL-E R R R R L-E L-E R R R R L-E R L-E R R R L-E L-E R R R R L-E R R L-ER R L-E L-E R R R R L-E R R R L-E R L-E L-E R R R R L-E R R R R L-E L-EL-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E R L-E R R L-E L-E R RR R R L-E R R L-E R L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R RL-E L-E R R L-E L-E R R R R R R L-E R L-E R L-E L-E R R R R R R L-E R RL-E L-E L-E R R R R R R R L-E L-E R L-E L-E R R R R R R R L-E R L-E L-EL-E R R R R R R R R L-E L-E L-E L-E L-E R R R R R R R R R R R L-E R R RL-E R R R R R R R L-E R R R R L-E R R R R R R L-E R R R R R L-E R R R RR L-E R R R R R R L-E R R R R L-E R R R R R R R L-E R R R L-E R R R R RR R R L-E R R L-E R R R L-E L-E R R R R R R L-E R R R L-E R L-E R R R RR L-E R R R L-E R R L-E R R R R L-E R R R L-E R R R L-E R R R L-E R R RL-E R R R R L-E R R L-E R R R R L-E L-E R R R R R L-E R R R R L-E R L-ER R R R L-E R R R R L-E R R L-E R R R L-E R R R R L-E R R R L-E R R L-ER R R R R L-E L-E R R R R L-E R R R R R L-E R L-E R R R L-E R R R R RL-E R R L-E R R L-E R R R R R R L-E L-E R R R L-E R R R R R R L-E R L-ER R L-E R R R R R R R L-E L-E R R L-E R R R R R R R R R L-E R L-E R R RL-E R R R R R L-E R L-E R R R R L-E R R R R L-E R L-E R R R R R L-E R RR L-E R L-E R R R R R R L-E R R L-E R L-E R R R R R R R L-E R L-E R L-ER R R R R R R R L-E L-E R L-E R R R L-E L-E R R R R L-E R L-E R R R L-ER L-E R R R L-E R L-E R R R L-E R R L-E R R L-E R L-E R R R L-E R R RL-E R L-E R L-E R R R L-E R R R R L-E L-E R L-E R R R R L-E L-E R R RL-E R L-E R R R R L-E R L-E R R L-E R L-E R R R R L-E R R L-E R L-E RL-E R R R R L-E R R R L-E L-E R L-E R R R R R L-E L-E R R L-E R L-E R RR R R L-E R L-E R L-E R L-E R R R R R L-E R R L-E L-E R L-E R R R R R RL-E L-E R L-E R L-E R R R R R R L-E R L-E L-E R L-E R R R R R R R L-EL-E L-E R L-E R R R R R R R R R R L-E L-E R R R L-E R R R R R R L-E L-ER R R R L-E R R R R R L-E L-E R R R R R L-E R R R R L-E L-E R R R R R RL-E R R R L-E L-E R R R R R R R L-E R R L-E L-E R R R R R R R R L-E RL-E L-E R R R L-E L-E R R R R R L-E L-E R R R L-E R L-E R R R R L-E L-ER R R L-E R R L-E R R R L-E L-E R R R L-E R R R L-E R R L-E L-E R R RL-E R R R R L-E R L-E L-E R R R R L-E L-E R R R R L-E L-E R R R R L-E RL-E R R R L-E L-E R R R R L-E R R L-E R R L-E L-E R R R R L-E R R R L-ER L-E L-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E R L-E R R L-EL-E R R R R R L-E R R L-E R L-E L-E R R R R R R L-E L-E R R L-E L-E R RR R R R L-E R L-E R L-E L-E R R R R R R R L-E L-E R L-E L-E R R R R R RR R R L-E L-E L-E R R R L-E R R R R R L-E L-E L-E R R R R L-E R R R RL-E L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R R L-E R R L-E L-EL-E R R R R R R R L-E R L-E L-E L-E R R R R R R R R L-E L-E L-E L-E R RR L-E L-E R R R R L-E L-E L-E R R R L-E R L-E R R R L-E L-E L-E R R RL-E R R L-E R R L-E L-E L-E R R R L-E R R R L-E R L-E L-E L-E R R R L-ER R R R L-E L-E L-E L-E R R R R L-E L-E R R R L-E L-E L-E R R R R L-E RL-E R R L-E L-E L-E R R R R L-E R R L-E R L-E L-E L-E R R R R L-E R R RL-E L-E L-E L-E R R R R R L-E L-E R R L-E L-E L-E R R R R R L-E R L-E RL-E L-E L-E R R R R R L-E R R L-E L-E L-E L-E R R R R R R L-E L-E R L-EL-E L-E R R R R R R L-E R L-E L-E L-E L-E R R R R R R R L-E L-E L-E L-EL-E L-E R R R R R R R R R R L-E L-E R R L-E R R R R R R R L-E L-E R R RL-E R R R R R R L-E L-E R R R R L-E R R R R R L-E L-E R R R R R L-E R RR R L-E L-E R R R R R R L-E R R R L-E L-E R R R R R R R L-E R R L-E L-ER R L-E L-E R R R R R R L-E L-E R R L-E R L-E R R R R R L-E L-E R R L-ER R L-E R R R R L-E L-E R R L-E R R R L-E R R R L-E L-E R R L-E R R R RL-E R R L-E L-E R R R L-E L-E R R R R R L-E L-E R R R L-E R L-E R R R RL-E L-E R R R L-E R R L-E R R R L-E L-E R R R L-E R R R L-E R R L-E L-ER R R R L-E L-E R R R R L-E L-E R R R R L-E R L-E R R R L-E L-E R R R RL-E R R L-E R R L-E L-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E RL-E R R L-E L-E R R R R R R L-E L-E R R L-E L-E R R R R R R R R L-E RL-E L-E R R L-E R R R R R L-E R L-E L-E R R R L-E R R R R L-E R L-E L-ER R R R L-E R R R L-E R L-E L-E R R R R R L-E R R L-E R L-E L-E R R R RR R L-E R L-E R L-E L-E R R R R R R R L-E L-E R L-E L-E R R L-E L-E R RR R L-E R L-E L-E R R L-E R L-E R R R L-E R L-E L-E R R L-E R R L-E R RL-E R L-E L-E R R L-E R R R L-E R L-E R L-E L-E R R L-E R R R R L-E L-ER L-E L-E R R R L-E L-E R R R L-E R L-E L-E R R R L-E R L-E R R L-E RL-E L-E R R R L-E R R L-E R L-E R L-E L-E R R R L-E R R R L-E L-E R L-EL-E R R R R L-E L-E R R L-E R L-E L-E R R R R L-E R L-E R L-E R L-E L-ER R R R L-E R R L-E L-E R L-E L-E R R R R R L-E L-E R L-E R L-E L-E R RR R R L-E R L-E L-E R L-E L-E R R R R R R L-E L-E L-E R L-E L-E R R R RR R R R R L-E L-E L-E R R L-E R R R R R R L-E L-E L-E R R R L-E R R R RR L-E L-E L-E R R R R L-E R R R R L-E L-E L-E R R R R R L-E R R R L-EL-E L-E R R R R R R L-E R R L-E L-E L-E R R R R R R R L-E R L-E L-E L-ER R L-E L-E R R R R R L-E L-E L-E R R L-E R L-E R R R R L-E L-E L-E R RL-E R R L-E R R R L-E L-E L-E R R L-E R R R L-E- R R L-E L-E L-E R R L-ER R R R L-E R L-E L-E L-E R R R L-E L-E R R R R L-E L-E L-E R R R L-E RL-E R R R L-E L-E L-E R R R L-E R R L-E R R L-E L-E L-E R R R L-E R R RL-E R L-E L-E L-E R R R R L-E L-E R R R L-E L-E L-E R R R R L-E R L-E RR L-E L-E L-E R R R R L-E R R L-E R L-E L-E L-E R R R R R L-E L-E R RL-E L-E L-E R R R R R L-E R L-E R L-E L-E L-E R R R R R R L-E L-E R L-EL-E L-E R R R R R R R R L-E L-E L-E L-E R R L-E R R R R R L-E L-E L-EL-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-E R R R L-E L-E L-E L-ER R R R R L-E R R L-E L-E L-E L-E R R R R R R L-E R L-E L-E L-E L-E R RR R R R R L-E L-E L-E L-E L-E R R L-E L-E R R R R L-E L-E L-E L-E R RL-E R L-E R R R L-E L-E L-E L-E R R L-E R R L-E R R L-E L-E L-E L-E R RL-E R R R L-E R L-E L-E L-E L-E R R L-E R R R R L-E L-E L-E L-E L-E R RR L-E L-E R R R L-E L-E L-E L-E R R R L-E R L-E R R L-E L-E L-E L-E R RR L-E R R L-E R L-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R RR R L-E L-E R R L-E L-E L-E L-E R R R R L-E R L-E R L-E L-E L-E L-E R RR R L-E R R L-E L-E L-E L-E L-E R R R R R L-E L-E R L-E L-E L-E L-E R RR R R L-E R L-E L-E L-E L-E L-E R R R R R R L-E L-E L-E L-E L-E R L-E RR R R R R R R R L-E R L-E R L-E R R R R R R R L-E R L-E R R L-E R R R RR R L-E R L-E R R R L-E R R R R R L-E R L-E R R R R L-E R R R R L-E RL-E R R R R R L-E R R R L-E R L-E R R R R R R L-E R R L-E R L-E R L-EL-E R R R R R R L-E R L-E R L-E R L-E R R R R R L-E R L-E R L-E R R L-ER R R R L-E R L-E R L-E R R R L-E R R R L-E R L-E R L-E R R R R L-E R RL-E R L-E R R L-E L-E R R R R R L-E R L-E R R L-E R L-E R R R R L-E RL-E R R L-E R R L-E R R R L-E R L-E R R L-E R R R L-E R R L-E R L-E R RR L-E L-E R R R R L-E R L-E R R R L-E R L-E R R R L-E R L-E R R R L-E RR L-E R R L-E R L-E R R R R L-E L-E R R R L-E R L-E R R R R L-E R L-E RR L-E R L-E R R R R R L-E L-E R R L-E R L-E R R R R R R R L-E R L-E RL-E R L-E R R R R R L-E R L-E R L-E R R L-E R R R R L-E R L-E R L-E R RR L-E R R R L-E R L-E R L-E R R R R L-E R R L-E R L-E R L-E R R R R RL-E R L-E R L-E R L-E R R R R R R L-E L-E R L-E R L-E R L-E L-E R R R RL-E R L-E R L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R R L-E R R L-ER L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R L-E R R R R L-E L-E RL-E R L-E R R L-E L-E R R R L-E R L-E R L-E R R L-E R L-E R R L-E R L-ER L-E R R L-E R R L-E R L-E R L-E R L-E R R L-E R R R L-E L-E R L-E RL-E R R R L-E L-E R R L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R L-ER R R L-E R R L-E L-E R L-E R L-E R R R R L-E L-E R L-E R L-E R L-E R RR R L-E R L-E L-E R L-E R L-E R R R R R L-E L-E L-E R L-E R L-E R R R RR R R R L-E L-E R L-E R L-E R R R R R R L-E L-E R L-E R R L-E R R R R RL-E L-E R L-E R R R L-E R R R R L-E L-E R L-E R R R R L-E R R R L-E L-ER L-E R R R R R L-E R R L-E L-E R L-E R R R R R R L-E R L-E L-E R L-E RL-E L-E R R R R R L-E L-E R L-E R L-E R L-E R R R R L-E L-E R L-E R L-ER R L-E R R R L-E L-E R L-E R L-E R R R L-E R R L-E L-E R L-E R L-E R RR R L-E R L-E L-E R L-E R R L-E L-E R R R R L-E L-E R L-E R R L-E R L-ER R R L-E L-E R L-E R R L-E R R L-E R R L-E L-E R L-E R R L-E R R R L-ER L-E L-E R L-E R R R L-E L-E R R R L-E L-E R L-E R R R L-E R L-E R RL-E L-E R L-E R R R L-E R R L-E R L-E L-E R L-E R R R R L-E L-E R R L-EL-E R L-E R R R R L-E R L-E R L-E L-E R L-E R R R R R L-E L-E R L-E L-ER L-E R R R R R R R L-E L-E L-E R L-E R L-E R R R R R L-E L-E L-E R L-ER R L-E R R R R L-E L-E L-E R L-E R R R L-E R R R L-E L-E L-E R L-E R RR R L-E R R L-E L-E L-E R L-E R R R R R L-E R L-E L-E L-E R L-E R R R RR R L-E L-E L-E L-E R L-E R L-E L-E R R R R L-E L-E L-E R L-E R L-E RL-E R R R L-E L-E L-E R L-E R L-E R R L-E R R L-E L-E L-E R L-E R L-E RR R L-E R L-E L-E L-E R L-E R L-E R R R R L-E L-E L-E L-E R L-E R R L-EL-E R R R L-E L-E L-E R L-E R R L-E R L-E R R L-E L-E L-E R L-E R R L-ER R L-E R L-E L-E L-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R RL-E L-E R R L-E L-E L-E R L-E R R R L-E R L-E R L-E L-E L-E R L-E R R RL-E R R L-E L-E L-E L-E R L-E R R R R L-E L-E R L-E L-E L-E R L-E R R RR L-E R L-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-E L-E L-E R RR R R R R R R L-E L-E L-E R L-E R R R R R R R L-E L-E L-E R R L-E R R RR R R L-E L-E L-E R R R L-E R R R R R L-E L-E L-E R R R R L-E R R R RL-E L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R R L-E R R L-E L-EL-E R L-E L-E R R R R R R L-E L-E L-E R L-E R L-E R R R R R L-E L-E L-ER L-E R R L-E R R R R L-E L-E L-E R L-E R R R L-E R R R L-E L-E L-E RL-E R R R R L-E R R L-E L-E L-E R R L-E L-E R R R R R L-E L-E L-E R RL-E R L-E R R R R L-E L-E L-E R R L-E R R L-E R R R L-E L-E L-E R R L-ER R R L-E R R L-E L-E L-E R R R L-E L-E R R R R L-E L-E L-E R R R L-E RL-E R R R L-E L-E L-E R R R L-E R R L-E R R L-E L-E L-E R R R R L-E L-ER R R L-E L-E L-E R R R R L-E R L-E R R L-E L-E L-E R R R R R L-E L-E RR L-E L-E L-E R R R R R R R L-E R L-E L-E L-E R L-E R R R R R L-E R L-EL-E L-E R R L-E R R R R L-E R L-E L-E L-E R R R L-E R R R L-E R L-E L-EL-E R R R R L-E R R L-E R L-E L-E L-E R R R R R L-E R L-E R L-E L-E L-ER R R R R R L-E L-E R L-E L-E L-E R L-E L-E R R R R L-E R L-E L-E L-E RL-E R L-E R R R L-E R L-E L-E L-E R L-E R R L-E R R L-E R L-E L-E L-E RL-E R R R L-E R L-E R L-E L-E L-E R L-E R R R R L-E L-E R L-E L-E L-E RR L-E L-E R R R L-E R L-E L-E L-E R R L-E R L-E R R L-E R L-E L-E L-E RR L-E R R L-E R L-E R L-E L-E L-E R R L-E R R R L-E L-E R L-E L-E L-E RR R L-E L-E R R L-E R L-E L-E L-E R R R L-E R L-E R L-E R L-E L-E L-E RR R L-E R R L-E L-E R L-E L-E L-E R R R R L-E L-E R L-E R L-E L-E L-E RR R R L-E R L-E L-E R L-E L-E L-E R R R R R L-E L-E L-E R L-E L-E L-E RR R R R R R R L-E L-E L-E L-E R L-E R R R R R R L-E L-E L-E L-E R R L-ER R R R R L-E L-E L-E L-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-ER R R L-E L-E L-E L-E R R R R R L-E R R L-E L-E L-E L-E R R R R R R L-ER L-E L-E L-E L-E R L-E L-E R R R R R L-E L-E L-E L-E R L-E R L-E R R RR L-E L-E L-E L-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R R L-E RR L-E L-E L-E L-E R L-E R R R R L-E R L-E L-E L-E L-E R R L-E L-E R R RR L-E L-E L-E L-E R R L-E R L-E R R R L-E L-E L-E L-E R R L-E R R L-E RR L-E L-E L-E L-E R R L-E R R R L-E R L-E L-E L-E L-E R R R L-E L-E R RR L-E L-E L-E L-E R R R L-E R L-E R R L-E L-E L-E L-E R R R L-E R R L-ER L-E L-E L-E L-E R R R R L-E L-E R R L-E L-E L-E L-E R R R R L-E R L-ER L-E L-E L-E L-E R R R R R L-E L-E R L-E L-E L-E L-E R R R R R R R L-EL-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-E R R L-E R R R R L-EL-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R R R R L-E R R L-EL-E L-E L-E L-E R R R R R L-E R L-E L-E L-E L-E L-E R R R R R R L-E L-EL-E L-E L-E L-E R L-E L-E R R R R L-E L-E L-E L-E L-E R L-E R L-E R R RL-E L-E L-E L-E L-E R L-E R R L-E R R L-E L-E L-E L-E L-E R L-E R R RL-E R L-E L-E L-E L-E L-E R L-E R R R R L-E L-E L-E L-E L-E L-E R R L-EL-E R R R L-E L-E L-E L-E L-E R R L-E R L-E R R L-E L-E L-E L-E L-E R RL-E R R L-E R L-E L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-E L-E L-ER R R L-E L-E R R L-E L-E L-E L-E L-E R R R L-E R L-E R L-E L-E L-E L-EL-E R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R L-E L-E R L-E L-E L-EL-E L-E R R R R L-E R L-E L-E L-E L-E L-E L-E R R R R R L-E L-E L-E L-EL-E L-E L-E L-E R R R R R R R R L-E L-E L-E L-E L-E R R R R R R R L-EL-E L-E L-E R L-E R R R R R R L-E L-E L-E L-E R R L-E R R R R R L-E L-EL-E L-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-E R R R L-E L-E L-EL-E R R R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R R R L-E L-E L-EL-E L-E R L-E R R R R R L-E L-E L-E L-E L-E R R L-E R R R R L-E L-E L-EL-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R R R R L-E R R L-E L-E L-EL-E R L-E L-E R R R R R L-E L-E L-E L-E R L-E R L-E R R R R L-E L-E L-EL-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R R L-E R R L-E L-E L-EL-E R R L-E L-E R R R R L-E L-E L-E L-E R R L-E R L-E R R R L-E L-E L-EL-E R R L-E R R L-E R R L-E L-E L-E L-E R R R L-E L-E R R R L-E L-E L-EL-E R R R L-E R L-E R R L-E L-E L-E L-E R R R R L-E L-E R R L-E L-E L-EL-E R R R R R R L-E R L-E L-E L-E L-E L-E R R R R R L-E R L-E L-E L-EL-E R L-E R R R R L-E R L-E L-E L-E L-E R R L-E R R R L-E R L-E L-E L-EL-E R R R L-E R R L-E R L-E L-E L-E L-E R R R R L-E R L-E R L-E L-E L-EL-E R R R R R L-E L-E R L-E L-E L-E L-E L-E L-E R R R R L-E R L-E L-EL-E L-E L-E R L-E R R R L-E R L-E L-E L-E L-E L-E R R L-E R R L-E R L-EL-E L-E L-E L-E R R R L-E R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E RL-E L-E L-E L-E R L-E L-E R R R L-E R L-E L-E L-E L-E R L-E R L-E R RL-E R L-E L-E L-E L-E R L-E R R L-E R L-E R L-E L-E L-E L-E R L-E R R RL-E L-E R L-E L-E L-E L-E R R L-E L-E R R L-E R L-E L-E L-E L-E R R L-ER L-E R L-E R L-E L-E L-E L-E R R L-E R R L-E L-E R L-E L-E L-E L-E R RR L-E L-E R L-E R L-E L-E L-E L-E R R R L-E R L-E L-E R L-E L-E L-E L-ER R R R L-E L-E L-E R L-E L-E L-E L-E R R R R R R R L-E L-E L-E L-E L-EL-E R R R R R R L-E L-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-ER R L-E R R R R L-E L-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-ER R R R L-E R R L-E L-E L-E L-E L-E R R R R R L-E R L-E L-E L-E L-E L-EL-E L-E R R R R R L-E L-E L-E L-E L-E L-E R L-E R R R R L-E L-E L-E L-EL-E L-E R R L-E R R R L-E L-E L-E L-E L-E L-E R R R L-E R R L-E L-E L-EL-E L-E L-E R R R R L-E R L-E L-E L-E L-E L-E R L-E L-E R R R R L-E L-EL-E L-E L-E R L-E R L-E R R R L-E L-E L-E L-E L-E R L-E R R L-E R R L-EL-E L-E L-E L-E R L-E R R R L-E R L-E L-E L-E L-E L-E R R L-E L-E R R RL-E L-E L-E L-E L-E R R L-E R L-E R R L-E L-E L-E L-E L-E R R L-E R RL-E R L-E L-E L-E L-E L-E R R R L-E L-E R R L-E L-E L-E L-E L-E R R RL-E R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E R L-E L-E L-E L-E L-E RR R R R R L-E L-E L-E L-E L-E L-E L-E R R R R R L-E L-E L-E L-E L-E L-ER L-E R R R R L-E L-E L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-E L-EL-E R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R L-E R L-E L-E L-E L-EL-E L-E R R R R R L-E L-E L-E L-E L-E L-E L-E L-E L-E R R R R L-E L-EL-E L-E L-E L-E L-E R L-E R R R L-E L-E L-E L-E L-E L-E L-E R R L-E R RL-E L-E L-E L-E L-E L-E L-E R R R L-E R L-E L-E L-E L-E L-E L-E L-E R RR R L-E L-E L-E L-E L-E L-E L-E R L-E L-E R R R L-E L-E L-E L-E L-E L-ER L-E R L-E R R L-E L-E L-E L-E L-E L-E R L-E R R L-E R L-E L-E L-E L-EL-E L-E R L-E R R R L-E L-E L-E L-E L-E L-E L-E R R L-E L-E R R L-E L-EL-E L-E L-E L-E R R L-E R L-E R L-E L-E L-E L-E L-E L-E R R L-E R R L-EL-E L-E L-E L-E L-E L-E R R R L-E L-E R L-E L-E L-E L-E L-E L-E R R RL-E R L-E L-E L-E L-E L-E L-E L-E R R R R L-E L-E L-E L-E

Z₁ Z₂ Z₃ Z₄ Z₅ Z₆ Z₇ Z₈ Z₉ Z₁₀ Z₁₁ Z₁₂ R R R R R R R R R R R R R R R RL-E R R R R R R R R R R R R L-E R R R R R R R R R R R R L-E R R R R R RR R R R R R L-E R R R R R R R R R R R R L-E R R R R R R R R R R R R L-ER R R R R R L-E L-E R R R R R R R R R R L-E R L-E R R R R R R R R R L-ER R L-E R R R R R R R R L-E R R R L-E R R R R R R R L-E R R R R L-E R RR R R R R L-E L-E R R R R R R R R R R L-E R L-E R R R R R R R R R L-E RR L-E R R R R R R R R L-E R R R L-E R R R R R R R R L-E L-E R R R R R RR R R R L-E R L-E R R R R R R R R R L-E R R L-E R R R R R R R R R L-EL-E R R R R R R R R R R L-E R L-E R R R R R R R R R R L-E L-E R R R R RR R R R R R R L-E R R R R R L-E R R R R R L-E R R R R R R L-E R R R RL-E R R R R R R R L-E R R R L-E R R R R R R R R L-E R R L-E R R R R R RR R R L-E R L-E R R R R R R R R R R L-E L-E R R R R R L-E L-E R R R RL-E R R R R R L-E R L-E R R R L-E R R R R R L-E R R L-E R R L-E R R R RR L-E R R R L-E R L-E R R R R R L-E R R R R L-E L-E R R R R R R L-E L-ER R R L-E R R R R R R L-E R L-E R R L-E R R R R R R L-E R R L-E R L-E RR R R R R L-E R R R L-E L-E R R R R R R R L-E L-E R R L-E R R R R R R RL-E R L-E R L-E R R R R R R R L-E R R L-E L-E R R R R R R R R L-E L-E RL-E R R R R R R R R L-E R L-E L-E R R R R R R R R R L-E L-E L-E R R R RR R R R R R R R L-E R R R R L-E R R R R R R L-E R R R R R L-E R R R R RL-E R R R R R R L-E R R R R L-E R R R R R R R L-E R R R L-E R R R R R RR R L-E R R L-E R R R R R R R R R L-E R L-E R R R R L-E L-E R R R R RL-E R R R R L-E R L-E R R R R L-E R R R R L-E R R L-E R R R L-E R R R RL-E R R R L-E R R L-E R R R R L-E R R R R L-E R L-E R R R R R L-E L-E RR R R L-E R R R R R L-E R L-E R R R L-E R R R R R L-E R R L-E R R L-E RR R R R L-E R R R L-E R L-E R R R R R R L-E L-E R R R L-E R R R R R RL-E R L-E R R L-E R R R R R R L-E R R L-E R L-E R R R R R R R L-E L-E RR L-E R R R R R R R L-E R L-E R L-E R R R R R R R R L-E L-E R L-E R R RR R R R R R R L-E L-E R R R R L-E R R R R R L-E L-E R R R R R L-E R R RR L-E L-E R R R R R R L-E R R R L-E L-E R R R R R R R L-E R R L-E L-E RR R R R R R R L-E R L-E L-E R R R R R R R R R L-E L-E L-E R R R R L-EL-E R R R R L-E L-E R R R R L-E R L-E R R R L-E L-E R R R R L-E R R L-ER R L-E L-E R R R R L-E R R R L-E R L-E L-E R R R R L-E R R R R L-E L-EL-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E R L-E R R L-E L-E R RR R R L-E R R L-E R L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R RL-E L-E R R L-E L-E R R R R R R L-E R L-E R L-E L-E R R R R R R L-E R RL-E L-E L-E R R R R R R R L-E L-E R L-E L-E R R R R R R R L-E R L-E L-EL-E R R R R R R R R L-E L-E L-E L-E L-E R R R R R R R R R R R L-E R R RL-E R R R R R R R L-E R R R R L-E R R R R R R L-E R R R R R L-E R R R RR L-E R R R R R R L-E R R R R L-E R R R R R R R L-E R R R L-E R R R R RR R R L-E R R L-E R R R L-E L-E R R R R R R L-E R R R L-E R L-E R R R RR L-E R R R L-E R R L-E R R R R L-E R R R L-E R R R L-E R R R L-E R R RL-E R R R R L-E R R L-E R R R R L-E L-E R R R R R L-E R R R R L-E R L-ER R R R L-E R R R R L-E R R L-E R R R L-E R R R R L-E R R R L-E R R L-ER R R R R L-E L-E R R R R L-E R R R R R L-E R L-E R R R L-E R R R R RL-E R R L-E R R L-E R R R R R R L-E L-E R R R L-E R R R R R R L-E R L-ER R L-E R R R R R R R L-E L-E R R L-E R R R R R R R R R L-E R L-E R R RL-E R R R R R L-E R L-E R R R R L-E R R R R L-E R L-E R R R R R L-E R RR L-E R L-E R R R R R R L-E R R L-E R L-E R R R R R R R L-E R L-E R L-ER R R R R R R R L-E L-E R L-E R R R L-E L-E R R R R L-E R L-E R R R L-ER L-E R R R L-E R L-E R R R L-E R R L-E R R L-E R L-E R R R L-E R R RL-E R L-E R L-E R R R L-E R R R R L-E L-E R L-E R R R R L-E L-E R R RL-E R L-E R R R R L-E R L-E R R L-E R L-E R R R R L-E R R L-E R L-E RL-E R R R R L-E R R R L-E L-E R L-E R R R R R L-E L-E R R L-E R L-E R RR R R L-E R L-E R L-E R L-E R R R R R L-E R R L-E L-E R L-E R R R R R RL-E L-E R L-E R L-E R R R R R R L-E R L-E L-E R L-E R R R R R R R L-EL-E L-E R L-E R R R R R R R R R R L-E L-E R R R L-E R R R R R R L-E L-ER R R R L-E R R R R R L-E L-E R R R R R L-E R R R R L-E L-E R R R R R RL-E R R R L-E L-E R R R R R R R L-E R R L-E L-E R R R R R R R R L-E RL-E L-E R R R L-E L-E R R R R R L-E L-E R R R L-E R L-E R R R R L-E L-ER R R L-E R R L-E R R R L-E L-E R R R L-E R R R L-E R R L-E L-E R R RL-E R R R R L-E R L-E L-E R R R R L-E L-E R R R R L-E L-E R R R R L-E RL-E R R R L-E L-E R R R R L-E R R L-E R R L-E L-E R R R R L-E R R R L-ER L-E L-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E R L-E R R L-EL-E R R R R R L-E R R L-E R L-E L-E R R R R R R L-E L-E R R L-E L-E R RR R R R L-E R L-E R L-E L-E R R R R R R R L-E L-E R L-E L-E R R R R R RR R R L-E L-E L-E R R R L-E R R R R R L-E L-E L-E R R R R L-E R R R RL-E L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R R L-E R R L-E L-EL-E R R R R R R R L-E R L-E L-E L-E R R R R R R R R L-E L-E L-E L-E R RR L-E L-E R R R R L-E L-E L-E R R R L-E R L-E R R R L-E L-E L-E R R RL-E R R L-E R R L-E L-E L-E R R R L-E R R R L-E R L-E L-E L-E R R R L-ER R R R L-E L-E L-E L-E R R R R L-E L-E R R R L-E L-E L-E R R R R L-E RL-E R R L-E L-E L-E R R R R L-E R R L-E R L-E L-E L-E R R R R L-E R R RL-E L-E L-E L-E R R R R R L-E L-E R R L-E L-E L-E R R R R R L-E R L-E RL-E L-E L-E R R R R R L-E R R L-E L-E L-E L-E R R R R R R L-E L-E R L-EL-E L-E R R R R R R L-E R L-E L-E L-E L-E R R R R R R R L-E L-E L-E L-EL-E L-E R R R R R R R R R R L-E L-E R R L-E R R R R R R R L-E L-E R R RL-E R R R R R R L-E L-E R R R R L-E R R R R R L-E L-E R R R R R L-E R RR R L-E L-E R R R R R R L-E R R R L-E L-E R R R R R R R L-E R R L-E L-ER R L-E L-E R R R R R R L-E L-E R R L-E R L-E R R R R R L-E L-E R R L-ER R L-E R R R R L-E L-E R R L-E R R R L-E R R R L-E L-E R R L-E R R R RL-E R R L-E L-E R R R L-E L-E R R R R R L-E L-E R R R L-E R L-E R R R RL-E L-E R R R L-E R R L-E R R R L-E L-E R R R L-E R R R L-E R R L-E L-ER R R R L-E L-E R R R R L-E L-E R R R R L-E R L-E R R R L-E L-E R R R RL-E R R L-E R R L-E L-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E RL-E R R L-E L-E R R R R R R L-E L-E R R L-E L-E R R R R R R R R L-E RL-E L-E R R L-E R R R R R L-E R L-E L-E R R R L-E R R R R L-E R L-E L-ER R R R L-E R R R L-E R L-E L-E R R R R R L-E R R L-E R L-E L-E R R R RR R L-E R L-E R L-E L-E R R R R R R R L-E L-E R L-E L-E R R L-E L-E R RR R L-E R L-E L-E R R L-E R L-E R R R L-E R L-E L-E R R L-E R R L-E R RL-E R L-E L-E R R L-E R R R L-E R L-E R L-E L-E R R L-E R R R R L-E L-ER L-E L-E R R R L-E L-E R R R L-E R L-E L-E R R R L-E R L-E R R L-E RL-E L-E R R R L-E R R L-E R L-E R L-E L-E R R R L-E R R R L-E L-E R L-EL-E R R R R L-E L-E R R L-E R L-E L-E R R R R L-E R L-E R L-E R L-E L-ER R R R L-E R R L-E L-E R L-E L-E R R R R R L-E L-E R L-E R L-E L-E R RR R R L-E R L-E L-E R L-E L-E R R R R R R L-E L-E L-E R L-E L-E R R R RR R R R R L-E L-E L-E R R L-E R R R R R R L-E L-E L-E R R R L-E R R R RR L-E L-E L-E R R R R L-E R R R R L-E L-E L-E R R R R R L-E R R R L-EL-E L-E R R R R R R L-E R R L-E L-E L-E R R R R R R R L-E R L-E L-E L-ER R L-E L-E R R R R R L-E L-E L-E R R L-E R L-E R R R R L-E L-E L-E R RL-E R R L-E R R R L-E L-E L-E R R L-E R R R L-E- R R L-E L-E L-E R R L-ER R R R L-E R L-E L-E L-E R R R L-E L-E R R R R L-E L-E L-E R R R L-E RL-E R R R L-E L-E L-E R R R L-E R R L-E R R L-E L-E L-E R R R L-E R R RL-E R L-E L-E L-E R R R R L-E L-E R R R L-E L-E L-E R R R R L-E R L-E RR L-E L-E L-E R R R R L-E R R L-E R L-E L-E L-E R R R R R L-E L-E R RL-E L-E L-E R R R R R L-E R L-E R L-E L-E L-E R R R R R R L-E L-E R L-EL-E L-E R R R R R R R R L-E L-E L-E L-E R R L-E R R R R R L-E L-E L-EL-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-E R R R L-E L-E L-E L-ER R R R R L-E R R L-E L-E L-E L-E R R R R R R L-E R L-E L-E L-E L-E R RR R R R R L-E L-E L-E L-E L-E R R L-E L-E R R R R L-E L-E L-E L-E R RL-E R L-E R R R L-E L-E L-E L-E R R L-E R R L-E R R L-E L-E L-E L-E R RL-E R R R L-E R L-E L-E L-E L-E R R L-E R R R R L-E L-E L-E L-E L-E R RR L-E L-E R R R L-E L-E L-E L-E R R R L-E R L-E R R L-E L-E L-E L-E R RR L-E R R L-E R L-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R RR R L-E L-E R R L-E L-E L-E L-E R R R R L-E R L-E R L-E L-E L-E L-E R RR R L-E R R L-E L-E L-E L-E L-E R R R R R L-E L-E R L-E L-E L-E L-E R RR R R L-E R L-E L-E L-E L-E L-E R R R R R R L-E L-E L-E L-E L-E R L-E RR R R R R R R R L-E R L-E R L-E R R R R R R R L-E R L-E R R L-E R R R RR R L-E R L-E R R R L-E R R R R R L-E R L-E R R R R L-E R R R R L-E RL-E R R R R R L-E R R R L-E R L-E R R R R R R L-E R R L-E R L-E R L-EL-E R R R R R R L-E R L-E R L-E R L-E R R R R R L-E R L-E R L-E R R L-ER R R R L-E R L-E R L-E R R R L-E R R R L-E R L-E R L-E R R R R L-E R RL-E R L-E R R L-E L-E R R R R R L-E R L-E R R L-E R L-E R R R R L-E RL-E R R L-E R R L-E R R R L-E R L-E R R L-E R R R L-E R R L-E R L-E R RR L-E L-E R R R R L-E R L-E R R R L-E R L-E R R R L-E R L-E R R R L-E RR L-E R R L-E R L-E R R R R L-E L-E R R R L-E R L-E R R R R L-E R L-E RR L-E R L-E R R R R R L-E L-E R R L-E R L-E R R R R R R R L-E R L-E RL-E R L-E R R R R R L-E R L-E R L-E R R L-E R R R R L-E R L-E R L-E R RR L-E R R R L-E R L-E R L-E R R R R L-E R R L-E R L-E R L-E R R R R RL-E R L-E R L-E R L-E R R R R R R L-E L-E R L-E R L-E R L-E L-E R R R RL-E R L-E R L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R R L-E R R L-ER L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R L-E R R R R L-E L-E RL-E R L-E R R L-E L-E R R R L-E R L-E R L-E R R L-E R L-E R R L-E R L-ER L-E R R L-E R R L-E R L-E R L-E R L-E R R L-E R R R L-E L-E R L-E RL-E R R R L-E L-E R R L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R L-ER R R L-E R R L-E L-E R L-E R L-E R R R R L-E L-E R L-E R L-E R L-E R RR R L-E R L-E L-E R L-E R L-E R R R R R L-E L-E L-E R L-E R L-E R R R RR R R R L-E L-E R L-E R L-E R R R R R R L-E L-E R L-E R R L-E R R R R RL-E L-E R L-E R R R L-E R R R R L-E L-E R L-E R R R R L-E R R R L-E L-ER L-E R R R R R L-E R R L-E L-E R L-E R R R R R R L-E R L-E L-E R L-E RL-E L-E R R R R R L-E L-E R L-E R L-E R L-E R R R R L-E L-E R L-E R L-ER R L-E R R R L-E L-E R L-E R L-E R R R L-E R R L-E L-E R L-E R L-E R RR R L-E R L-E L-E R L-E R R L-E L-E R R R R L-E L-E R L-E R R L-E R L-ER R R L-E L-E R L-E R R L-E R R L-E R R L-E L-E R L-E R R L-E R R R L-ER L-E L-E R L-E R R R L-E L-E R R R L-E L-E R L-E R R R L-E R L-E R RL-E L-E R L-E R R R L-E R R L-E R L-E L-E R L-E R R R R L-E L-E R R L-EL-E R L-E R R R R L-E R L-E R L-E L-E R L-E R R R R R L-E L-E R L-E L-ER L-E R R R R R R R L-E L-E L-E R L-E R L-E R R R R R L-E L-E L-E R L-ER R L-E R R R R L-E L-E L-E R L-E R R R L-E R R R L-E L-E L-E R L-E R RR R L-E R R L-E L-E L-E R L-E R R R R R L-E R L-E L-E L-E R L-E R R R RR R L-E L-E L-E L-E R L-E R L-E L-E R R R R L-E L-E L-E R L-E R L-E RL-E R R R L-E L-E L-E R L-E R L-E R R L-E R R L-E L-E L-E R L-E R L-E RR R L-E R L-E L-E L-E R L-E R L-E R R R R L-E L-E L-E L-E R L-E R R L-EL-E R R R L-E L-E L-E R L-E R R L-E R L-E R R L-E L-E L-E R L-E R R L-ER R L-E R L-E L-E L-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R RL-E L-E R R L-E L-E L-E R L-E R R R L-E R L-E R L-E L-E L-E R L-E R R RL-E R R L-E L-E L-E L-E R L-E R R R R L-E L-E R L-E L-E L-E R L-E R R RR L-E R L-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-E L-E L-E R RR R R R R R R L-E L-E L-E R L-E R R R R R R R L-E L-E L-E R R L-E R R RR R R L-E L-E L-E R R R L-E R R R R R L-E L-E L-E R R R R L-E R R R RL-E L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R R L-E R R L-E L-EL-E R L-E L-E R R R R R R L-E L-E L-E R L-E R L-E R R R R R L-E L-E L-ER L-E R R L-E R R R R L-E L-E L-E R L-E R R R L-E R R R L-E L-E L-E RL-E R R R R L-E R R L-E L-E L-E R R L-E L-E R R R R R L-E L-E L-E R RL-E R L-E R R R R L-E L-E L-E R R L-E R R L-E R R R L-E L-E L-E R R L-ER R R L-E R R L-E L-E L-E R R R L-E L-E R R R R L-E L-E L-E R R R L-E RL-E R R R L-E L-E L-E R R R L-E R R L-E R R L-E L-E L-E R R R R L-E L-ER R R L-E L-E L-E R R R R L-E R L-E R R L-E L-E L-E R R R R R L-E L-E RR L-E L-E L-E R R R R R R R L-E R L-E L-E L-E R L-E R R R R R L-E R L-EL-E L-E R R L-E R R R R L-E R L-E L-E L-E R R R L-E R R R L-E R L-E L-EL-E R R R R L-E R R L-E R L-E L-E L-E R R R R R L-E R L-E R L-E L-E L-ER R R R R R L-E L-E R L-E L-E L-E R L-E L-E R R R R L-E R L-E L-E L-E RL-E R L-E R R R L-E R L-E L-E L-E R L-E R R L-E R R L-E R L-E L-E L-E RL-E R R R L-E R L-E R L-E L-E L-E R L-E R R R R L-E L-E R L-E L-E L-E RR L-E L-E R R R L-E R L-E L-E L-E R R L-E R L-E R R L-E R L-E L-E L-E RR L-E R R L-E R L-E R L-E L-E L-E R R L-E R R R L-E L-E R L-E L-E L-E RR R L-E L-E R R L-E R L-E L-E L-E R R R L-E R L-E R L-E R L-E L-E L-E RR R L-E R R L-E L-E R L-E L-E L-E R R R R L-E L-E R L-E R L-E L-E L-E RR R R L-E R L-E L-E R L-E L-E L-E R R R R R L-E L-E L-E R L-E L-E L-E RR R R R R R R L-E L-E L-E L-E R L-E R R R R R R L-E L-E L-E L-E R R L-ER R R R R L-E L-E L-E L-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-ER R R L-E L-E L-E L-E R R R R R L-E R R L-E L-E L-E L-E R R R R R R L-ER L-E L-E L-E L-E R L-E L-E R R R R R L-E L-E L-E L-E R L-E R L-E R R RR L-E L-E L-E L-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R R L-E RR L-E L-E L-E L-E R L-E R R R R L-E R L-E L-E L-E L-E R R L-E L-E R R RR L-E L-E L-E L-E R R L-E R L-E R R R L-E L-E L-E L-E R R L-E R R L-E RR L-E L-E L-E L-E R R L-E R R R L-E R L-E L-E L-E L-E R R R L-E L-E R RR L-E L-E L-E L-E R R R L-E R L-E R R L-E L-E L-E L-E R R R L-E R R L-ER L-E L-E L-E L-E R R R R L-E L-E R R L-E L-E L-E L-E R R R R L-E R L-ER L-E L-E L-E L-E R R R R R L-E L-E R L-E L-E L-E L-E R R R R R R R L-EL-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-E R R L-E R R R R L-EL-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R R R R L-E R R L-EL-E L-E L-E L-E R R R R R L-E R L-E L-E L-E L-E L-E R R R R R R L-E L-EL-E L-E L-E L-E R L-E L-E R R R R L-E L-E L-E L-E L-E R L-E R L-E R R RL-E L-E L-E L-E L-E R L-E R R L-E R R L-E L-E L-E L-E L-E R L-E R R RL-E R L-E L-E L-E L-E L-E R L-E R R R R L-E L-E L-E L-E L-E L-E R R L-EL-E R R R L-E L-E L-E L-E L-E R R L-E R L-E R R L-E L-E L-E L-E L-E R RL-E R R L-E R L-E L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-E L-E L-ER R R L-E L-E R R L-E L-E L-E L-E L-E R R R L-E R L-E R L-E L-E L-E L-EL-E R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R L-E L-E R L-E L-E L-EL-E L-E R R R R L-E R L-E L-E L-E L-E L-E L-E R R R R R L-E L-E L-E L-EL-E L-E L-E L-E R R R R R R R R L-E L-E L-E L-E L-E R R R R R R R L-EL-E L-E L-E R L-E R R R R R R L-E L-E L-E L-E R R L-E R R R R R L-E L-EL-E L-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-E R R R L-E L-E L-EL-E R R R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R R R L-E L-E L-EL-E L-E R L-E R R R R R L-E L-E L-E L-E L-E R R L-E R R R R L-E L-E L-EL-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R R R R L-E R R L-E L-E L-EL-E R L-E L-E R R R R R L-E L-E L-E L-E R L-E R L-E R R R R L-E L-E L-EL-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R R L-E R R L-E L-E L-EL-E R R L-E L-E R R R R L-E L-E L-E L-E R R L-E R L-E R R R L-E L-E L-EL-E R R L-E R R L-E R R L-E L-E L-E L-E R R R L-E L-E R R R L-E L-E L-EL-E R R R L-E R L-E R R L-E L-E L-E L-E R R R R L-E L-E R R L-E L-E L-EL-E R R R R R R L-E R L-E L-E L-E L-E L-E R R R R R L-E R L-E L-E L-EL-E R L-E R R R R L-E R L-E L-E L-E L-E R R L-E R R R L-E R L-E L-E L-EL-E R R R L-E R R L-E R L-E L-E L-E L-E R R R R L-E R L-E R L-E L-E L-EL-E R R R R R L-E L-E R L-E L-E L-E L-E L-E L-E R R R R L-E R L-E L-EL-E L-E L-E R L-E R R R L-E R L-E L-E L-E L-E L-E R R L-E R R L-E R L-EL-E L-E L-E L-E R R R L-E R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E RL-E L-E L-E L-E R L-E L-E R R R L-E R L-E L-E L-E L-E R L-E R L-E R RL-E R L-E L-E L-E L-E R L-E R R L-E R L-E R L-E L-E L-E L-E R L-E R R RL-E L-E R L-E L-E L-E L-E R R L-E L-E R R L-E R L-E L-E L-E L-E R R L-ER L-E R L-E R L-E L-E L-E L-E R R L-E R R L-E L-E R L-E L-E L-E L-E R RR L-E L-E R L-E R L-E L-E L-E L-E R R R L-E R L-E L-E R L-E L-E L-E L-ER R R R L-E L-E L-E R L-E L-E L-E L-E R R R R R R R L-E L-E L-E L-E L-EL-E R R R R R R L-E L-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-ER R L-E R R R R L-E L-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-ER R R R L-E R R L-E L-E L-E L-E L-E R R R R R L-E R L-E L-E L-E L-E L-EL-E L-E R R R R R L-E L-E L-E L-E L-E L-E R L-E R R R R L-E L-E L-E L-EL-E L-E R R L-E R R R L-E L-E L-E L-E L-E L-E R R R L-E R R L-E L-E L-EL-E L-E L-E R R R R L-E R L-E L-E L-E L-E L-E R L-E L-E R R R R L-E L-EL-E L-E L-E R L-E R L-E R R R L-E L-E L-E L-E L-E R L-E R R L-E R R L-EL-E L-E L-E L-E R L-E R R R L-E R L-E L-E L-E L-E L-E R R L-E L-E R R RL-E L-E L-E L-E L-E R R L-E R L-E R R L-E L-E L-E L-E L-E R R L-E R RL-E R L-E L-E L-E L-E L-E R R R L-E L-E R R L-E L-E L-E L-E L-E R R RL-E R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E R L-E L-E L-E L-E L-E RR R R R R L-E L-E L-E L-E L-E L-E L-E R R R R R L-E L-E L-E L-E L-E L-ER L-E R R R R L-E L-E L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-E L-EL-E R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R L-E R L-E L-E L-E L-EL-E L-E R R R R R L-E L-E L-E L-E L-E L-E L-E L-E L-E R R R R L-E L-EL-E L-E L-E L-E L-E R L-E R R R L-E L-E L-E L-E L-E L-E L-E R R L-E R RL-E L-E L-E L-E L-E L-E L-E R R R L-E R L-E L-E L-E L-E L-E L-E L-E R RR R L-E L-E L-E L-E L-E L-E L-E R L-E L-E R R R L-E L-E L-E L-E L-E L-ER L-E R L-E R R L-E L-E L-E L-E L-E L-E R L-E R R L-E R L-E L-E L-E L-EL-E L-E R L-E R R R L-E L-E L-E L-E L-E L-E L-E R R L-E L-E R R L-E L-EL-E L-E L-E L-E R R L-E R L-E R L-E L-E L-E L-E L-E L-E R R L-E R R L-EL-E L-E L-E L-E L-E L-E R R R L-E L-E R L-E L-E L-E L-E L-E L-E R R RL-E R L-E L-E L-E L-E L-E L-E L-E R R R R L-E L-E L-E L-E

Z₁ Z₂ Z₃ Z₄ Z₅ Z₆ Z₇ Z₈ Z₉ Z₁₀ Z₁₁ Z₁₂ R R R R R R R R R R R R R R R RL-E R R R R R R R R R R R R L-E R R R R R R R R R R R R L-E R R R R R RR R R R R R L-E R R R R R R R R R R R R L-E R R R R R R R R R R R R L-ER R R R R R L-E L-E R R R R R R R R R R L-E R L-E R R R R R R R R R L-ER R L-E R R R R R R R R L-E R R R L-E R R R R R R R L-E R R R R L-E R RR R R R R L-E L-E R R R R R R R R R R L-E R L-E R R R R R R R R R L-E RR L-E R R R R R R R R L-E R R R L-E R R R R R R R R L-E L-E R R R R R RR R R R L-E R L-E R R R R R R R R R L-E R R L-E R R R R R R R R R L-EL-E R R R R R R R R R R L-E R L-E R R R R R R R R R R L-E L-E R R R R RR R R R R R R L-E R R R R R L-E R R R R R L-E R R R R R R L-E R R R RL-E R R R R R R R L-E R R R L-E R R R R R R R R L-E R R L-E R R R R R RR R R L-E R L-E R R R R R R R R R R L-E L-E R R R R R L-E L-E R R R RL-E R R R R R L-E R L-E R R R L-E R R R R R L-E R R L-E R R L-E R R R RR L-E R R R L-E R L-E R R R R R L-E R R R R L-E L-E R R R R R R L-E L-ER R R L-E R R R R R R L-E R L-E R R L-E R R R R R R L-E R R L-E R L-E RR R R R R L-E R R R L-E L-E R R R R R R R L-E L-E R R L-E R R R R R R RL-E R L-E R L-E R R R R R R R L-E R R L-E L-E R R R R R R R R L-E L-E RL-E R R R R R R R R L-E R L-E L-E R R R R R R R R R L-E L-E L-E R R R RR R R R R R R R L-E R R R R L-E R R R R R R L-E R R R R R L-E R R R R RL-E R R R R R R L-E R R R R L-E R R R R R R R L-E R R R L-E R R R R R RR R L-E R R L-E R R R R R R R R R L-E R L-E R R R R L-E L-E R R R R RL-E R R R R L-E R L-E R R R R L-E R R R R L-E R R L-E R R R L-E R R R RL-E R R R L-E R R L-E R R R R L-E R R R R L-E R L-E R R R R R L-E L-E RR R R L-E R R R R R L-E R L-E R R R L-E R R R R R L-E R R L-E R R L-E RR R R R L-E R R R L-E R L-E R R R R R R L-E L-E R R R L-E R R R R R RL-E R L-E R R L-E R R R R R R L-E R R L-E R L-E R R R R R R R L-E L-E RR L-E R R R R R R R L-E R L-E R L-E R R R R R R R R L-E L-E R L-E R R RR R R R R R R L-E L-E R R R R L-E R R R R R L-E L-E R R R R R L-E R R RR L-E L-E R R R R R R L-E R R R L-E L-E R R R R R R R L-E R R L-E L-E RR R R R R R R L-E R L-E L-E R R R R R R R R R L-E L-E L-E R R R R L-EL-E R R R R L-E L-E R R R R L-E R L-E R R R L-E L-E R R R R L-E R R L-ER R L-E L-E R R R R L-E R R R L-E R L-E L-E R R R R L-E R R R R L-E L-EL-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E R L-E R R L-E L-E R RR R R L-E R R L-E R L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R RL-E L-E R R L-E L-E R R R R R R L-E R L-E R L-E L-E R R R R R R L-E R RL-E L-E L-E R R R R R R R L-E L-E R L-E L-E R R R R R R R L-E R L-E L-EL-E R R R R R R R R L-E L-E L-E L-E L-E R R R R R R R R R R R L-E R R RL-E R R R R R R R L-E R R R R L-E R R R R R R L-E R R R R R L-E R R R RR L-E R R R R R R L-E R R R R L-E R R R R R R R L-E R R R L-E R R R R RR R R L-E R R L-E R R R L-E L-E R R R R R R L-E R R R L-E R L-E R R R RR L-E R R R L-E R R L-E R R R R L-E R R R L-E R R R L-E R R R L-E R R RL-E R R R R L-E R R L-E R R R R L-E L-E R R R R R L-E R R R R L-E R L-ER R R R L-E R R R R L-E R R L-E R R R L-E R R R R L-E R R R L-E R R L-ER R R R R L-E L-E R R R R L-E R R R R R L-E R L-E R R R L-E R R R R RL-E R R L-E R R L-E R R R R R R L-E L-E R R R L-E R R R R R R L-E R L-ER R L-E R R R R R R R L-E L-E R R L-E R R R R R R R R R L-E R L-E R R RL-E R R R R R L-E R L-E R R R R L-E R R R R L-E R L-E R R R R R L-E R RR L-E R L-E R R R R R R L-E R R L-E R L-E R R R R R R R L-E R L-E R L-ER R R R R R R R L-E L-E R L-E R R R L-E L-E R R R R L-E R L-E R R R L-ER L-E R R R L-E R L-E R R R L-E R R L-E R R L-E R L-E R R R L-E R R RL-E R L-E R L-E R R R L-E R R R R L-E L-E R L-E R R R R L-E L-E R R RL-E R L-E R R R R L-E R L-E R R L-E R L-E R R R R L-E R R L-E R L-E RL-E R R R R L-E R R R L-E L-E R L-E R R R R R L-E L-E R R L-E R L-E R RR R R L-E R L-E R L-E R L-E R R R R R L-E R R L-E L-E R L-E R R R R R RL-E L-E R L-E R L-E R R R R R R L-E R L-E L-E R L-E R R R R R R R L-EL-E L-E R L-E R R R R R R R R R R L-E L-E R R R L-E R R R R R R L-E L-ER R R R L-E R R R R R L-E L-E R R R R R L-E R R R R L-E L-E R R R R R RL-E R R R L-E L-E R R R R R R R L-E R R L-E L-E R R R R R R R R L-E RL-E L-E R R R L-E L-E R R R R R L-E L-E R R R L-E R L-E R R R R L-E L-ER R R L-E R R L-E R R R L-E L-E R R R L-E R R R L-E R R L-E L-E R R RL-E R R R R L-E R L-E L-E R R R R L-E L-E R R R R L-E L-E R R R R L-E RL-E R R R L-E L-E R R R R L-E R R L-E R R L-E L-E R R R R L-E R R R L-ER L-E L-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E R L-E R R L-EL-E R R R R R L-E R R L-E R L-E L-E R R R R R R L-E L-E R R L-E L-E R RR R R R L-E R L-E R L-E L-E R R R R R R R L-E L-E R L-E L-E R R R R R RR R R L-E L-E L-E R R R L-E R R R R R L-E L-E L-E R R R R L-E R R R RL-E L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R R L-E R R L-E L-EL-E R R R R R R R L-E R L-E L-E L-E R R R R R R R R L-E L-E L-E L-E R RR L-E L-E R R R R L-E L-E L-E R R R L-E R L-E R R R L-E L-E L-E R R RL-E R R L-E R R L-E L-E L-E R R R L-E R R R L-E R L-E L-E L-E R R R L-ER R R R L-E L-E L-E L-E R R R R L-E L-E R R R L-E L-E L-E R R R R L-E RL-E R R L-E L-E L-E R R R R L-E R R L-E R L-E L-E L-E R R R R L-E R R RL-E L-E L-E L-E R R R R R L-E L-E R R L-E L-E L-E R R R R R L-E R L-E RL-E L-E L-E R R R R R L-E R R L-E L-E L-E L-E R R R R R R L-E L-E R L-EL-E L-E R R R R R R L-E R L-E L-E L-E L-E R R R R R R R L-E L-E L-E L-EL-E L-E R R R R R R R R R R L-E L-E R R L-E R R R R R R R L-E L-E R R RL-E R R R R R R L-E L-E R R R R L-E R R R R R L-E L-E R R R R R L-E R RR R L-E L-E R R R R R R L-E R R R L-E L-E R R R R R R R L-E R R L-E L-ER R L-E L-E R R R R R R L-E L-E R R L-E R L-E R R R R R L-E L-E R R L-ER R L-E R R R R L-E L-E R R L-E R R R L-E R R R L-E L-E R R L-E R R R RL-E R R L-E L-E R R R L-E L-E R R R R R L-E L-E R R R L-E R L-E R R R RL-E L-E R R R L-E R R L-E R R R L-E L-E R R R L-E R R R L-E R R L-E L-ER R R R L-E L-E R R R R L-E L-E R R R R L-E R L-E R R R L-E L-E R R R RL-E R R L-E R R L-E L-E R R R R R L-E L-E R R R L-E L-E R R R R R L-E RL-E R R L-E L-E R R R R R R L-E L-E R R L-E L-E R R R R R R R R L-E RL-E L-E R R L-E R R R R R L-E R L-E L-E R R R L-E R R R R L-E R L-E L-ER R R R L-E R R R L-E R L-E L-E R R R R R L-E R R L-E R L-E L-E R R R RR R L-E R L-E R L-E L-E R R R R R R R L-E L-E R L-E L-E R R L-E L-E R RR R L-E R L-E L-E R R L-E R L-E R R R L-E R L-E L-E R R L-E R R L-E R RL-E R L-E L-E R R L-E R R R L-E R L-E R L-E L-E R R L-E R R R R L-E L-ER L-E L-E R R R L-E L-E R R R L-E R L-E L-E R R R L-E R L-E R R L-E RL-E L-E R R R L-E R R L-E R L-E R L-E L-E R R R L-E R R R L-E L-E R L-EL-E R R R R L-E L-E R R L-E R L-E L-E R R R R L-E R L-E R L-E R L-E L-ER R R R L-E R R L-E L-E R L-E L-E R R R R R L-E L-E R L-E R L-E L-E R RR R R L-E R L-E L-E R L-E L-E R R R R R R L-E L-E L-E R L-E L-E R R R RR R R R R L-E L-E L-E R R L-E R R R R R R L-E L-E L-E R R R L-E R R R RR L-E L-E L-E R R R R L-E R R R R L-E L-E L-E R R R R R L-E R R R L-EL-E L-E R R R R R R L-E R R L-E L-E L-E R R R R R R R L-E R L-E L-E L-ER R L-E L-E R R R R R L-E L-E L-E R R L-E R L-E R R R R L-E L-E L-E R RL-E R R L-E R R R L-E L-E L-E R R L-E R R R L-E- R R L-E L-E L-E R R L-ER R R R L-E R L-E L-E L-E R R R L-E L-E R R R R L-E L-E L-E R R R L-E RL-E R R R L-E L-E L-E R R R L-E R R L-E R R L-E L-E L-E R R R L-E R R RL-E R L-E L-E L-E R R R R L-E L-E R R R L-E L-E L-E R R R R L-E R L-E RR L-E L-E L-E R R R R L-E R R L-E R L-E L-E L-E R R R R R L-E L-E R RL-E L-E L-E R R R R R L-E R L-E R L-E L-E L-E R R R R R R L-E L-E R L-EL-E L-E R R R R R R R R L-E L-E L-E L-E R R L-E R R R R R L-E L-E L-EL-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-E R R R L-E L-E L-E L-ER R R R R L-E R R L-E L-E L-E L-E R R R R R R L-E R L-E L-E L-E L-E R RR R R R R L-E L-E L-E L-E L-E R R L-E L-E R R R R L-E L-E L-E L-E R RL-E R L-E R R R L-E L-E L-E L-E R R L-E R R L-E R R L-E L-E L-E L-E R RL-E R R R L-E R L-E L-E L-E L-E R R L-E R R R R L-E L-E L-E L-E L-E R RR L-E L-E R R R L-E L-E L-E L-E R R R L-E R L-E R R L-E L-E L-E L-E R RR L-E R R L-E R L-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R RR R L-E L-E R R L-E L-E L-E L-E R R R R L-E R L-E R L-E L-E L-E L-E R RR R L-E R R L-E L-E L-E L-E L-E R R R R R L-E L-E R L-E L-E L-E L-E R RR R R L-E R L-E L-E L-E L-E L-E R R R R R R L-E L-E L-E L-E L-E R L-E RR R R R R R R R L-E R L-E R L-E R R R R R R R L-E R L-E R R L-E R R R RR R L-E R L-E R R R L-E R R R R R L-E R L-E R R R R L-E R R R R L-E RL-E R R R R R L-E R R R L-E R L-E R R R R R R L-E R R L-E R L-E R L-EL-E R R R R R R L-E R L-E R L-E R L-E R R R R R L-E R L-E R L-E R R L-ER R R R L-E R L-E R L-E R R R L-E R R R L-E R L-E R L-E R R R R L-E R RL-E R L-E R R L-E L-E R R R R R L-E R L-E R R L-E R L-E R R R R L-E RL-E R R L-E R R L-E R R R L-E R L-E R R L-E R R R L-E R R L-E R L-E R RR L-E L-E R R R R L-E R L-E R R R L-E R L-E R R R L-E R L-E R R R L-E RR L-E R R L-E R L-E R R R R L-E L-E R R R L-E R L-E R R R R L-E R L-E RR L-E R L-E R R R R R L-E L-E R R L-E R L-E R R R R R R R L-E R L-E RL-E R L-E R R R R R L-E R L-E R L-E R R L-E R R R R L-E R L-E R L-E R RR L-E R R R L-E R L-E R L-E R R R R L-E R R L-E R L-E R L-E R R R R RL-E R L-E R L-E R L-E R R R R R R L-E L-E R L-E R L-E R L-E L-E R R R RL-E R L-E R L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R R L-E R R L-ER L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R L-E R R R R L-E L-E RL-E R L-E R R L-E L-E R R R L-E R L-E R L-E R R L-E R L-E R R L-E R L-ER L-E R R L-E R R L-E R L-E R L-E R L-E R R L-E R R R L-E L-E R L-E RL-E R R R L-E L-E R R L-E R L-E R L-E R R R L-E R L-E R L-E R L-E R L-ER R R L-E R R L-E L-E R L-E R L-E R R R R L-E L-E R L-E R L-E R L-E R RR R L-E R L-E L-E R L-E R L-E R R R R R L-E L-E L-E R L-E R L-E R R R RR R R R L-E L-E R L-E R L-E R R R R R R L-E L-E R L-E R R L-E R R R R RL-E L-E R L-E R R R L-E R R R R L-E L-E R L-E R R R R L-E R R R L-E L-ER L-E R R R R R L-E R R L-E L-E R L-E R R R R R R L-E R L-E L-E R L-E RL-E L-E R R R R R L-E L-E R L-E R L-E R L-E R R R R L-E L-E R L-E R L-ER R L-E R R R L-E L-E R L-E R L-E R R R L-E R R L-E L-E R L-E R L-E R RR R L-E R L-E L-E R L-E R R L-E L-E R R R R L-E L-E R L-E R R L-E R L-ER R R L-E L-E R L-E R R L-E R R L-E R R L-E L-E R L-E R R L-E R R R L-ER L-E L-E R L-E R R R L-E L-E R R R L-E L-E R L-E R R R L-E R L-E R RL-E L-E R L-E R R R L-E R R L-E R L-E L-E R L-E R R R R L-E L-E R R L-EL-E R L-E R R R R L-E R L-E R L-E L-E R L-E R R R R R L-E L-E R L-E L-ER L-E R R R R R R R L-E L-E L-E R L-E R L-E R R R R R L-E L-E L-E R L-ER R L-E R R R R L-E L-E L-E R L-E R R R L-E R R R L-E L-E L-E R L-E R RR R L-E R R L-E L-E L-E R L-E R R R R R L-E R L-E L-E L-E R L-E R R R RR R L-E L-E L-E L-E R L-E R L-E L-E R R R R L-E L-E L-E R L-E R L-E RL-E R R R L-E L-E L-E R L-E R L-E R R L-E R R L-E L-E L-E R L-E R L-E RR R L-E R L-E L-E L-E R L-E R L-E R R R R L-E L-E L-E L-E R L-E R R L-EL-E R R R L-E L-E L-E R L-E R R L-E R L-E R R L-E L-E L-E R L-E R R L-ER R L-E R L-E L-E L-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R RL-E L-E R R L-E L-E L-E R L-E R R R L-E R L-E R L-E L-E L-E R L-E R R RL-E R R L-E L-E L-E L-E R L-E R R R R L-E L-E R L-E L-E L-E R L-E R R RR L-E R L-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-E L-E L-E R RR R R R R R R L-E L-E L-E R L-E R R R R R R R L-E L-E L-E R R L-E R R RR R R L-E L-E L-E R R R L-E R R R R R L-E L-E L-E R R R R L-E R R R RL-E L-E L-E R R R R R L-E R R R L-E L-E L-E R R R R R R L-E R R L-E L-EL-E R L-E L-E R R R R R R L-E L-E L-E R L-E R L-E R R R R R L-E L-E L-ER L-E R R L-E R R R R L-E L-E L-E R L-E R R R L-E R R R L-E L-E L-E RL-E R R R R L-E R R L-E L-E L-E R R L-E L-E R R R R R L-E L-E L-E R RL-E R L-E R R R R L-E L-E L-E R R L-E R R L-E R R R L-E L-E L-E R R L-ER R R L-E R R L-E L-E L-E R R R L-E L-E R R R R L-E L-E L-E R R R L-E RL-E R R R L-E L-E L-E R R R L-E R R L-E R R L-E L-E L-E R R R R L-E L-ER R R L-E L-E L-E R R R R L-E R L-E R R L-E L-E L-E R R R R R L-E L-E RR L-E L-E L-E R R R R R R R L-E R L-E L-E L-E R L-E R R R R R L-E R L-EL-E L-E R R L-E R R R R L-E R L-E L-E L-E R R R L-E R R R L-E R L-E L-EL-E R R R R L-E R R L-E R L-E L-E L-E R R R R R L-E R L-E R L-E L-E L-ER R R R R R L-E L-E R L-E L-E L-E R L-E L-E R R R R L-E R L-E L-E L-E RL-E R L-E R R R L-E R L-E L-E L-E R L-E R R L-E R R L-E R L-E L-E L-E RL-E R R R L-E R L-E R L-E L-E L-E R L-E R R R R L-E L-E R L-E L-E L-E RR L-E L-E R R R L-E R L-E L-E L-E R R L-E R L-E R R L-E R L-E L-E L-E RR L-E R R L-E R L-E R L-E L-E L-E R R L-E R R R L-E L-E R L-E L-E L-E RR R L-E L-E R R L-E R L-E L-E L-E R R R L-E R L-E R L-E R L-E L-E L-E RR R L-E R R L-E L-E R L-E L-E L-E R R R R L-E L-E R L-E R L-E L-E L-E RR R R L-E R L-E L-E R L-E L-E L-E R R R R R L-E L-E L-E R L-E L-E L-E RR R R R R R R L-E L-E L-E L-E R L-E R R R R R R L-E L-E L-E L-E R R L-ER R R R R L-E L-E L-E L-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-ER R R L-E L-E L-E L-E R R R R R L-E R R L-E L-E L-E L-E R R R R R R L-ER L-E L-E L-E L-E R L-E L-E R R R R R L-E L-E L-E L-E R L-E R L-E R R RR L-E L-E L-E L-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R R L-E RR L-E L-E L-E L-E R L-E R R R R L-E R L-E L-E L-E L-E R R L-E L-E R R RR L-E L-E L-E L-E R R L-E R L-E R R R L-E L-E L-E L-E R R L-E R R L-E RR L-E L-E L-E L-E R R L-E R R R L-E R L-E L-E L-E L-E R R R L-E L-E R RR L-E L-E L-E L-E R R R L-E R L-E R R L-E L-E L-E L-E R R R L-E R R L-ER L-E L-E L-E L-E R R R R L-E L-E R R L-E L-E L-E L-E R R R R L-E R L-ER L-E L-E L-E L-E R R R R R L-E L-E R L-E L-E L-E L-E R R R R R R R L-EL-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-E R R L-E R R R R L-EL-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R R R R L-E R R L-EL-E L-E L-E L-E R R R R R L-E R L-E L-E L-E L-E L-E R R R R R R L-E L-EL-E L-E L-E L-E R L-E L-E R R R R L-E L-E L-E L-E L-E R L-E R L-E R R RL-E L-E L-E L-E L-E R L-E R R L-E R R L-E L-E L-E L-E L-E R L-E R R RL-E R L-E L-E L-E L-E L-E R L-E R R R R L-E L-E L-E L-E L-E L-E R R L-EL-E R R R L-E L-E L-E L-E L-E R R L-E R L-E R R L-E L-E L-E L-E L-E R RL-E R R L-E R L-E L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-E L-E L-ER R R L-E L-E R R L-E L-E L-E L-E L-E R R R L-E R L-E R L-E L-E L-E L-EL-E R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R L-E L-E R L-E L-E L-EL-E L-E R R R R L-E R L-E L-E L-E L-E L-E L-E R R R R R L-E L-E L-E L-EL-E L-E L-E L-E R R R R R R R R L-E L-E L-E L-E L-E R R R R R R R L-EL-E L-E L-E R L-E R R R R R R L-E L-E L-E L-E R R L-E R R R R R L-E L-EL-E L-E R R R L-E R R R R L-E L-E L-E L-E R R R R L-E R R R L-E L-E L-EL-E R R R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R R R L-E L-E L-EL-E L-E R L-E R R R R R L-E L-E L-E L-E L-E R R L-E R R R R L-E L-E L-EL-E L-E R R R L-E R R R L-E L-E L-E L-E L-E R R R R L-E R R L-E L-E L-EL-E R L-E L-E R R R R R L-E L-E L-E L-E R L-E R L-E R R R R L-E L-E L-EL-E R L-E R R L-E R R R L-E L-E L-E L-E R L-E R R R L-E R R L-E L-E L-EL-E R R L-E L-E R R R R L-E L-E L-E L-E R R L-E R L-E R R R L-E L-E L-EL-E R R L-E R R L-E R R L-E L-E L-E L-E R R R L-E L-E R R R L-E L-E L-EL-E R R R L-E R L-E R R L-E L-E L-E L-E R R R R L-E L-E R R L-E L-E L-EL-E R R R R R R L-E R L-E L-E L-E L-E L-E R R R R R L-E R L-E L-E L-EL-E R L-E R R R R L-E R L-E L-E L-E L-E R R L-E R R R L-E R L-E L-E L-EL-E R R R L-E R R L-E R L-E L-E L-E L-E R R R R L-E R L-E R L-E L-E L-EL-E R R R R R L-E L-E R L-E L-E L-E L-E L-E L-E R R R R L-E R L-E L-EL-E L-E L-E R L-E R R R L-E R L-E L-E L-E L-E L-E R R L-E R R L-E R L-EL-E L-E L-E L-E R R R L-E R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E RL-E L-E L-E L-E R L-E L-E R R R L-E R L-E L-E L-E L-E R L-E R L-E R RL-E R L-E L-E L-E L-E R L-E R R L-E R L-E R L-E L-E L-E L-E R L-E R R RL-E L-E R L-E L-E L-E L-E R R L-E L-E R R L-E R L-E L-E L-E L-E R R L-ER L-E R L-E R L-E L-E L-E L-E R R L-E R R L-E L-E R L-E L-E L-E L-E R RR L-E L-E R L-E R L-E L-E L-E L-E R R R L-E R L-E L-E R L-E L-E L-E L-ER R R R L-E L-E L-E R L-E L-E L-E L-E R R R R R R R L-E L-E L-E L-E L-EL-E R R R R R R L-E L-E L-E L-E L-E R L-E R R R R R L-E L-E L-E L-E L-ER R L-E R R R R L-E L-E L-E L-E L-E R R R L-E R R R L-E L-E L-E L-E L-ER R R R L-E R R L-E L-E L-E L-E L-E R R R R R L-E R L-E L-E L-E L-E L-EL-E L-E R R R R R L-E L-E L-E L-E L-E L-E R L-E R R R R L-E L-E L-E L-EL-E L-E R R L-E R R R L-E L-E L-E L-E L-E L-E R R R L-E R R L-E L-E L-EL-E L-E L-E R R R R L-E R L-E L-E L-E L-E L-E R L-E L-E R R R R L-E L-EL-E L-E L-E R L-E R L-E R R R L-E L-E L-E L-E L-E R L-E R R L-E R R L-EL-E L-E L-E L-E R L-E R R R L-E R L-E L-E L-E L-E L-E R R L-E L-E R R RL-E L-E L-E L-E L-E R R L-E R L-E R R L-E L-E L-E L-E L-E R R L-E R RL-E R L-E L-E L-E L-E L-E R R R L-E L-E R R L-E L-E L-E L-E L-E R R RL-E R L-E R L-E L-E L-E L-E L-E R R R R L-E L-E R L-E L-E L-E L-E L-E RR R R R R L-E L-E L-E L-E L-E L-E L-E R R R R R L-E L-E L-E L-E L-E L-ER L-E R R R R L-E L-E L-E L-E L-E L-E R R L-E R R R L-E L-E L-E L-E L-EL-E R R R L-E R R L-E L-E L-E L-E L-E L-E R R R R L-E R L-E L-E L-E L-EL-E L-E R R R R R L-E L-E L-E L-E L-E L-E L-E L-E L-E R R R R L-E L-EL-E L-E L-E L-E L-E R L-E R R R L-E L-E L-E L-E L-E L-E L-E R R L-E R RL-E L-E L-E L-E L-E L-E L-E R R R L-E R L-E L-E L-E L-E L-E L-E L-E R RR R L-E L-E L-E L-E L-E L-E L-E R L-E L-E R R R L-E L-E L-E L-E L-E L-ER L-E R L-E R R L-E L-E L-E L-E L-E L-E R L-E R R L-E R L-E L-E L-E L-EL-E L-E R L-E R R R L-E L-E L-E L-E L-E L-E L-E R R L-E L-E R R L-E L-EL-E L-E L-E L-E R R L-E R L-E R L-E L-E L-E L-E L-E L-E R R L-E R R L-EL-E L-E L-E L-E L-E L-E R R R L-E L-E R L-E L-E L-E L-E L-E L-E R R RL-E R L-E L-E L-E L-E L-E L-E L-E R R R R L-E L-E L-E L-E

[0156] The following describes some preferred embodiments of theinvention with regard to drugs, active agents, etc., that can becoformulated with, coadministered with, copackaged with, etc, one ormore of the invention compounds described above. These formulations, etccan include any amount of invention compound(s) and drug(s), activeagent(s), etc, and preferably contain a therapeutic amount of the drug,etc, and a first pass effective amount of the invention compound(s).Some of the preferred materials are listed by name, etc, and others arelisted by the patent, published application, etc, in which they appear.Where references such as patents and applications are listed, all drugs,active agents, etc described therein are included herein. Allreferences, documents, patents, applications, publications, etc.mentioned above and below are specifically incorporated herein byreference.

[0157] Preferred drugs, active agents, etc include all those listed in:

[0158] Merck Index, Thirteenth Ed., Merck Research Laboratories,Whitehouse Station, N.J., 2001

[0159] “The Physicians Desk Reference,” 57th edition, 2003

[0160] “Goodman and Gilman's The Pharmacological Basis of Therapeutics”10th Edition (2001)

[0161] “The United States Pharmacopeia, The National Formulary”, USP26NF21 (2002), and further include those appearing below, listed such thatone of ordinary skill in the art can determine the drug, active agent,etc identified. In some cases there are more than one section devoted tothe same or similar indication.

[0162] Hepatitis Section:

[0163] BILN 2061, Boehringer Ingelheim; albuferon, Human GenomeSciences; HCV-AB68, XTL Biopharmaceuticals; ISIS 14803, ISISPharmaceutical/Elan Corporation; zadaxin (thymalfasin, thyrnosin),SciClone Pharmaceuticals; intron A (interferon alfa-2b),Schering-Plough; XTL 001, XTL Biopharm; theradigm, Epimmune; EHT 899,Enzo Biochem; HBV DNA vaccine, Powderject; bayherb, Bayer;anti-hepatitis B, Cangene; Nabi-H B, Nabi Biopharmaceuticals; adefovirdipivoxil (GS890), Gilead Sciences; heptazyme, RPI; VP 50406 series,Viropharma/Wyeth; HCV 371, Viropharmna/AHP; viramidine, Ribapharm;LY570310/VX950, Vertex Pharmaceuticals/Eli Lilly; NV08, IdenixPharmaceuticals; infergen (interferon alfacon-1), Intermune; multiferon,Viragen; rebif (interferon beta-1a), Ares-Serono; omega interferon,Biomedicine; oral interferon alpha, Amarillo Biosciences; interferongamma-1b, Intermune; interleukin-10, Schering-Plough; Plough; IP-501,Intemeuron; VX-497, Vertex Pharmaceuticals; amantadine (symmetrel), EndoLabs/Solvay; IDN-6556, Idun Pharmaceuticals; HEPX™-C (XTL-002), XTLBiopharm; HCV/MF59, Chiron Corporation; civacir, NabiBiopharmaceuticals; E-1, Innogenetics; cepelene, Maxim; JTK003, AKROSPharma (Japan Tabacco); rituximab (rituxam), Genetech/Idec; famvir(famciclovir), SmithKline Beecham; therapore, Avant; VX-944, VertexPharmaceuticals; adefovir dipivoxil, Bristol-Myers Squibb; alkovir,Thomas Jefferson University; AM 188, AMRAD; AM 365, AMRAD; AM 86, AMRAD;amdoxovir, Emory University; ANA 245, Anadys; ANA 246, ICN; BAY 414109,Bayer; celgosivir, Aventis; CKD 541, Chong Kun Dang; CpG 7909, ColeyPharmaceutical; CW 209292, Choongwae; DW 471, Dong Wha; emtricitabine,Emory University; entecavir, Bristol-Myers Squibb; FasTR, Human GenomeSciences; FLG prodrug, Medivir; HE 2000, Hollis Eden; helioxanthin,Achillion Pharmaceuticals; LB 05701-C, LG Chemical; levovirin, ICN; LY466700, Competitive Technologies; LY 570310, Eli Lilly; LY 582563,Mitsubishi Pharma; MB 6866, Metabasis Therapeutics;n-nonyl-deoxynojirimycin, Synergy; NP 77A, Choongwae; VIR 101, Aventis.U.S. Pat. No. 5,422,359; U.S. Pat. No. 5,858,389; U.S. Pat. No.5,872,206; U.S. Pat. No. 6,143,715; U.S. Pat. No. 6,194,430 B1; U.S.Pat. No. 6,245,789 B1; U.S. Pat. No. 6,258,831 B1; U.S. Pat. No.6,410,575 B2; U.S. Pat. No. 6,541,472; U.S. Pat. No. 6545170; U.S. Pat.No. 6545009; U.S. Pat. No. 6541224; U.S. Pat. No. 6541001; U.S. Pat. No.6537966; U.S. Pat. No. 6534631; U.S. Pat. No. 6534485; U.S. Pat. No.6534277; U.S. Pat. No. 6534067; U.S. Pat. No. 6531575; U.S. Pat. No.6527689; U.S. Pat. No. 6521453; U.S. Pat. No. 6518315; U.S. Pat. No.6518029; U.S. Pat. No. 6511833; U.S. Pat. No. 6506569; U.S. Pat. No.6503184; U.S. Pat. No. 6500652; U.S. Pat. No. 6495604; U.S. Pat. No.6495581; U.S. Pat. No. 6495544; U.S. Pat. No. 6495520; U.S. Pat. No.6495129; U.S. Pat. No. 6492390; U.S. Pat. No. 6489163; U.S. Pat. No.6482864; U.S. Pat. No. 6479652; U.S. Pat. No. 6479258; U.S. Pat. No.6476195; U.S. Pat. No. 6476031; U.S. Pat. No. 6475753; U.S. Pat. No.6472512; U.S. Pat. No. 6471959; U.S. Pat. No. 6468737; U.S. Pat. No.6465686; U.S. Pat. No. 6465518; U.S. Pat. No. 6458532; U.S. Pat. No.6455281; U.S. Pat. No. 6455280; U.S. Pat. No. 6455277; U.S. Pat. No.6455262; U.S. Pat. No. 6455040; U.S. Pat. No. 6451842; U.S. Pat. No.6451796; U.S. Pat. No. 6451305; U.S. Pat. No. 6444792; U.S. Pat. No.6444233; U.S. Pat. No. 6436675; U.S. Pat. No. 6436637; U.S. Pat. No.6433147; U.S. Pat. No. 6433145; U.S. Pat. No. 6428998; U.S. Pat. No.6428802; U.S. Pat. No. 6426224; U.S. Pat. No. 6423542; U.S. Pat. No.6420111; U.S. Pat. No. 6417324; U.S. Pat. No. 6413768; U.S. Pat. No.6410566; U.S. Pat. No. 6410267; U.S. Pat. No. 6407213; U.S. Pat. No.6406867; U.S. Pat. No. 6403830; U.S. Pat. No. 6403770; U.S. Pat. No.6403606; U.S. Pat. No. 6403337; U.S. Pat. No. 6403309; U.S. Pat. No.6399746; U.S. Pat. No. 6399639; U.S. Pat. No. 6399301; U.S. Pat. No.6399103; U.S. Pat. No. 6399076; U.S. Pat. No. 6399063; U.S. Pat. No.6395743; U.S. Pat. No. 6395275; U.S. Pat. No. 6392028; U.S. Pat. No.6391589; U.S. Pat. No. 6387371; U.S. Pat. No. 6376651; U.S. Pat. No.6376461; U.S. Pat. No. 6376246; U.S. Pat. No. 6369098; U.S. Pat. No.6368861; U.S. Pat. No. 6368591; U.S. Pat. No. 6365714; U.S. Pat. No.6365372; U.S. Pat. No. 6362177; U.S. Pat. No. 6358508; U.S. Pat. No.6355245; U.S. Pat. No. 6352982; U.S. Pat. No. 6337207; U.S. Pat. No.6335168; U.S. Pat. No. 6329505; U.S. Pat. No. 6329389; U.S. Pat. No.6326151; U.S. Pat. No. 6319714; U.S. Pat. No. 6310196; U.S. Pat. No.6300472; U.S. Pat. No. 6300120; U.S. Pat. No. 6279253; U.S. Pat. No.6294322; U.S. Pat. No. 6291702; U.S. Pat. No. 6291645; U.S. Pat. No.6291637; U.S. Pat. No. 6281334; U.S. Pat. No. 6277989; U.S. Pat. No.6277564; U.S. Pat. No. 6274720; U.S. Pat. No. 6271253; U.S. Pat. No.6271197; U.S. Pat. No. 6268192; U.S. Pat. No. 6268132; U.S. Pat. No.6267981; U.S. Pat. No. 6265565; U.S. Pat. No. 6264970; U.S. Pat. No.6261558; U.S. Pat. No. 6251926; U.S. Pat. No. 6248525; U.S. Pat. No.6242214; U.S. Pat. No. 6238666; U.S. Pat. No. 6235878; U.S. Pat. No.6235715; U.S. Pat. No. 6235521; U.S. Pat. No. 6235477; U.S. Pat. No.6231853; U.S. Pat. No. 6228991; U.S. Pat. No. 6222019; U.S. Pat. No.6221843; U.S. Pat. No. 6214838; U.S. Pat. No. 6214347; U.S. Pat. No.6210873; U.S. Pat. No. 6207876; U.S. Pat. No. 6204023; U.S. Pat. No.6204021; U.S. Pat. No. 6203979; U.S. Pat. No. 6201106; U.S. Pat. No.6197825; U.S. Pat. No. 6197350; U.S. Pat. No. 6194176; U.S. Pat. No.6194152; U.S. Pat. No. 6194141; U.S. Pat. No. 6190702; U.S. Pat. No.6183956; U.S. Pat. No. 6180342; U.S. Pat. No. 6171790; U.S. Pat. No.6165464; U.S. Pat. No. 6162828; U.S. Pat. No. 6136955; U.S. Pat. No.6135941; U.S. Pat. No. 6132964; U.S. Pat. No. 6130316; U.S. Pat. No.6130077; U.S. Pat. No. 6130064; U.S. Pat. No. 6127390; U.S. Pat. No.6127116; U.S. Pat. No. 6121019; U.S. Pat. No. 6121000; U.S. Pat. No.6117653; U.S. Pat. No. 6113905; U.S. Pat. No. 6110707; U.S. Pat. No.6110706; U.S. Pat. No. 6103469; U.S. Pat. No. 6100075; U.S. Pat. No.6100065; U.S. Pat. No. 6096527; U.S. Pat. No. 6093737; U.S. Pat. No.6093561; U.S. Pat. No. 6087384; U.S. Pat. No. 6087324; U.S. Pat. No.6087144; U.S. Pat. No. 6087129; U.S. Pat. No. 6084067; U.S. Pat. No.6083988; U.S. Pat. No. 6080847; U.S. Pat. No. 6080723; U.S. Pat. No.6077850; U.S. Pat. No. 6077693; U.S. Pat. No. 6077510; U.S. Pat. No.6072049; U.S. Pat. No. 6071704; U.S. Pat. No. 6071703; U.S. Pat. No.6060250; U.S. Pat. No. 6057427; U.S. Pat. No. 6057140; U.S. Pat. No.6057112; U.S. Pat. No. 6054297; U.S. Pat. No. 6051398; U.S. Pat. No.6051240; U.S. Pat. No. 6046189; U.S. Pat. No. 6046001; U.S. Pat. No.6039684; U.S. Pat. No. 6034256; U.S. Pat. No. 6030785; U.S. Pat. No.6027935; U.S. Pat. No. 6027914; U.S. Pat. No. 6022707; U.S. Pat. No.6022543; U.S. Pat. No. 6020474; U.S. Pat. No. 6020165; U.S. Pat. No.6020155; U.S. Pat. No. 6017744; U.S. Pat. No. 6015883; U.S. Pat. No.6015672; U.S. Pat. No. 6015660; U.S. Pat. No. 6013450; U.S. Pat. No.6013447; U.S. Pat. No. 6011046; U.S. Pat. No. 6004933; U.S. Pat. No.6004778; U.S. Pat. No. 6001621; U.S. Pat. No. 6001596; U.S. Pat. No.5998433; U.S. Pat. No. 5998383; U.S. Pat. No. 5998373; U.S. Pat. No.5998372; U.S. Pat. No. 5994081; U.S. Pat. No. 5989904; U.S. Pat. No.5989863; U.S. Pat. No. 5989860; U.S. Pat. No. 5989859; U.S. Pat. No.5986064; U.S. Pat. No. 5986057; U.S. Pat. No. 5981244; U.S. Pat. No.5981242; U.S. Pat. No. 5977338; U.S. Pat. No. 5977311; U.S. Pat. No.5976801; U.S. Pat. No. 5976800; U.S. Pat. No. 5972684; U.S. Pat. No.5972658; U.S. Pat. No. 5972653; U.S. Pat. No. 5965423; U.S. Pat. No.5965421; U.S. Pat. No. 5965395; U.S. Pat. No. 5965394; U.S. Pat. No.5962263; U.S. Pat. No. 5962232; U.S. Pat. No. 5958699; U.S. Pat. No.5955428; U.S. Pat. No. 5955278; U.S. Pat. No. 5948883; U.S. Pat. No.5945330; U.S. Pat. No. 5945306; U.S. Pat. No. 5942606; U.S. Pat. No.5942399; U.S. Pat. No. 5935931; U.S. Pat. No. 5932443; U.S. Pat. No.5932218; U.S. Pat. No. 5929033; U.S. Pat. No. 5928899; U.S. Pat. No.5928894; U.S. Pat. No. 5925640; U.S. Pat. No. 5922318; U.S. Pat. No.5919685; U.S. Pat. No. 5919657; U.S. Pat. No. 5916890; U.S. Pat. No.5914249; U.S. Pat. No. 5897867; U.S. Pat. No. 5897861; U.S. Pat. No.5895655; U.S. Pat. No. 5892012; U.S. Pat. No. 5885587; U.S. Pat. No.5885586; U.S. Pat. No. 5882894; U.S. Pat. No. 5887298; U.S. Pat. No.5877162; U.S. Pat. No. 5874247; U.S. Pat. No. 5874246; U.S. Pat. No.5872120; U.S. Pat. No. 5872012; U.S. Pat. No. 5871973; U.S. Pat. No.5871961; U.S. Pat. No. 5871960; U.S. Pat. No. 5871902; U.S. Pat. No.5869259; U.S. Pat. No. 5866119; U.S. Pat. No. 5859206; U.S. Pat. No.5858710; U.S. Pat. No. 5856110; U.S. Pat. No. 5854023; U.S. Pat. No.5853997; U.S. Pat. No. 5851987; U.S. Pat. No. 5849533; U.S. Pat. No.5846818; U.S. Pat. No. 5843440; U.S. Pat. No. 5840732; U.S. Pat. No.5840544; U.S. Pat. No. 5840535; U.S. Pat. No. 5840534; U.S. Pat. No.5840525; U.S. Pat. No. 5840502; U.S. Pat. No. 5837500; U.S. Pat. No.5834241; U.S. Pat. No. 5834229; U.S. Pat. No. 5830647; U.S. Pat. No.5821337; U.S. Pat. No. 5817494; U.S. Pat. No. 5814480; U.S. Pat. No.5804440; U.S. Pat. No. 5798358; U.S. Pat. No. 6545007; U.S. Pat. No.6525033; U.S. Pat. No. 6458773; U.S. Pat. No. 6407077; U.S. Pat. No.6245749; U.S. Pat. No. 5990093; U.S. Pat. No. 5750493; U.S. Pat. No.5723449; U.S. Pat. No. 5567689; U.S. Pat. No. 5464748; U.S. Pat. No.5159067; U.S. Pat. No. 5118672; U.S. Pat. No. 5007280; U.S. Pat. No.6538127; U.S. Pat. No. 6538119; U.S. Pat. No. 6531610; U.S. Pat. No.6511812; U.S. Pat. No. 6506766; U.S. Pat. No. 6465181; U.S. Pat. No.6455255; U.S. Pat. No. 6451578; U.S. Pat. No. 6444700; U.S. Pat. No.6413780; U.S. Pat. No. 6406841; U.S. Pat. No. 6395472; U.S. Pat. No.6391543; U.S. Pat. No. 6380207; U.S. Pat. No. 6368792; U.S. Pat. No.6350583; U.S. Pat. No. 6329386; U.S. Pat. No. 6294348; U.S. Pat. No.6255341; U.S. Pat. No. 6252047; U.S. Pat. No. 6251906; U.S. Pat. No.6232456; U.S. Pat. No. 6207642; U.S. Pat. No. 6207380; U.S. Pat. No.6190617; U.S. Pat. No. 6183952; U.S. Pat. No. 6177241; U.S. Pat. No.6172189; U.S. Pat. No. 6171787; U.S. Pat. No. 6166013; U.S. Pat. No.6160153; U.S. Pat. No. 6156495; U.S. Pat. No. 6153377; U.S. Pat. No.6150530; U.S. Pat. No. 6150113; U.S. Pat. No. 6130043; U.S. Pat. No.6121257; U.S. Pat. No. 6110675; U.S. Pat. No. 6096561; U.S. Pat. No.6074817; U.S. Pat. No. 6057429; U.S. Pat. No. 6051374; U.S. Pat. No.6033898; U.S. Pat. No. 6022712; U.S. Pat. No. 6020122; U.S. Pat. No.6017928; U.S. Pat. No. 6015815; U.S. Pat. No. 6015662; U.S. Pat. No.6010857; U.S. Pat. No. 5998224; U.S. Pat. No. 5994143; U.S. Pat. No.5990135; U.S. Pat. No. 5981172; U.S. Pat. No. 5981171; U.S. Pat. No.5960160; U.S. Pat. No. 5955598; U.S. Pat. No. 5955318; U.S. Pat. No.5952173; U.S. Pat. No. 5925512; U.S. Pat. No. 5919638; U.S. Pat. No.5905068; U.S. Pat. No. 5895750; U.S. Pat. No. 5892052; U.S. Pat. No.5888772; U.S. Pat. No. 5886036; U.S. Pat. No. 5859193; U.S. Pat. No.5858732; U.S. Pat. No. 5858652; U.S. Pat. No. 5858650; U.S. Pat. No.5856194; U.S. Pat. No. 5854001; U.S. Pat. No. 5846987; U.S. Pat. No.5846785; U.S. Pat. No. 5843450; U.S. Pat. No. 5837873; U.S. Pat. No.5834314; U.S. Pat. No. 5830636; U.S. Pat. No. 5814492; U.S. Pat. No.5807670; U.S. Pat. No. 5795784; U.S. Pat. No. 5789219; U.S. Pat. No.5785692; U.S. Pat. No. 5783699; U.S. Pat. No. 5773212; U.S. Pat. No.5762878; U.S. Pat. No. 5756298; U.S. Pat. No. 5753430; U.S. Pat. No.5741654; U.S. Pat. No. 5736624; U.S. Pat. No. 5736334; U.S. Pat. No.5731320; U.S. Pat. No. 5709997; U.S. Pat. No. 5708002; U.S. Pat. No.5707799; U.S. Pat. No. 5702953; U.S. Pat. No. 5700246; U.S. Pat. No.5696270; U.S. Pat. No. 5686272; U.S. Pat. No. 5681695; U.S. Pat. No.5679797; U.S. Pat. No. 6544796; U.S. Pat. No. 6531572; U.S. Pat. No.6524808; U.S. Pat. No. 6514736; U.S. Pat. No. 6503714; U.S. Pat. No.6489131; U.S. Pat. No. 6489129; U.S. Pat. No. 6482613; U.S. Pat. No.6447992; U.S. Pat. No. 6372883; U.S. Pat. No. 6306579; U.S. Pat. No.6270960; U.S. Pat. No. 6231815; U.S. Pat. No. 6214549; U.S. Pat. No.6197563; U.S. Pat. No. 6187905; U.S. Pat. No. 6187270; U.S. Pat. No.6183949; U.S. Pat. No. 6150118; U.S. Pat. No. 6136527; U.S. Pat. No.6127155; U.S. Pat. No. 6110696; U.S. Pat. No. 6096319; U.S. Pat. No.6066455; U.S. Pat. No. 6040166; U.S. Pat. No. 6020195; U.S. Pat. No.6018020; U.S. Pat. No. 6008057; U.S. Pat. No. 5986066; U.S. Pat. No.5981286; U.S. Pat. No. 5965378; U.S. Pat. No. 5958783; U.S. Pat. No.5955452; U.S. Pat. No. 5928636; U.S. Pat. No. 5902722; U.S. Pat. No.5866684; U.S. Pat. No. 5837442; U.S. Pat. No. 5750374; U.S. Pat. No.5747066; U.S. Pat. No. 5693517; U.S. Pat. No. 5580718; U.S. Pat. No.5571673; U.S. Pat. No. 5561058; U.S. Pat. No. 5527669; U.S. Pat. No.5501963; U.S. Pat. No. 5352600; U.S. Pat. No. 5333675; U.S. Pat. No.5232829; U.S. Pat. No. 5176995; U.S. Pat. No. 5070010; U.S. Pat. No.6413938; U.S. Pat. No. 6383498; U.S. Pat. No. 6337209; U.S. Pat. No.6329400; U.S. Pat. No. 6307043; U.S. Pat. No. 6300490; U.S. Pat. No.6294540; U.S. Pat. No. 6252055; U.S. Pat. No. 6210675; U.S. Pat. No.6204249; U.S. Pat. No. 6194546; U.S. Pat. No. 6191150; U.S. Pat. No.6172064; U.S. Pat. No. 6113920; U.S. Pat. No. 6107302; U.S. Pat. No.6096786; U.S. Pat. No. 6087501; U.S. Pat. No. 6077832; U.S. Pat. No.6004968; U.S. Pat. No. 5998605; U.S. Pat. No. 5958980; U.S. Pat. No.5919941; U.S. Pat. No. 5917042; U.S. Pat. No. 5912356; U.S. Pat. No.5885957; U.S. Pat. No. 5879706; U.S. Pat. No. 5876961; U.S. Pat. No.5872151; U.S. Pat. No. 5840990; U.S. Pat. No. 5840743; U.S. Pat. No.5830455; U.S. Pat. No. 5821080; U.S. Pat. No. 5808147; U.S. Pat. No.5700680; U.S. Pat. No. 5683700; U.S. Pat. No. 5663154; U.S. Pat. No.5643891; U.S. Pat. No. 5641889; U.S. Pat. No. 5637574; U.S. Pat. No.5607929; U.S. Pat. No. 5589474; U.S. Pat. No. 5589384; U.S. Pat. No.5559100; U.S. Pat. No. 6500662; U.S. Pat. No. 6448278; U.S. Pat. No.6443009; U.S. Pat. No. 6417202; U.S. Pat. No. 6403587; U.S. Pat. No.6372224; U.S. Pat. No. 6166064; U.S. Pat. No. 6057436; U.S. Pat. No.6048880; U.S. Pat. No. 5660844; U.S. Pat. No. 5643886; U.S. Pat. No.3992517; U.S. Pat. No. 6479284; U.S. Pat. No. 6410022; U.S. Pat. No.6261573; U.S. Pat. No. 6207171; U.S. Pat. No. 6015563; U.S. Pat. No.5958414; U.S. Pat. No. 5911703; U.S. Pat. No. 6544518; U.S. Pat. No.6514992; U.S. Pat. No. 6514953; U.S. Pat. No. 6506386; U.S. Pat. No.6500863; U.S. Pat. No. 6500432; U.S. Pat. No. 6488934; U.S. Pat. No.6482939; U.S. Pat. No. 6469160; U.S. Pat. No. 6455507; U.S. Pat. No.6455506; U.S. Pat. No. 6451320; U.S. Pat. No. 6448403; U.S. Pat. No.6432966; U.S. Pat. No. 6423318; U.S. Pat. No. 6413952; U.S. Pat. No.6403792; U.S. Pat. No. 6392085; U.S. Pat. No. 6391589; U.S. Pat. No.6375945; U.S. Pat. No. 6372227; U.S. Pat. No. 6358969; U.S. Pat. No.6355426; U.S. Pat. No. 6346405; U.S. Pat. No. 6340587; U.S. Pat. No.6306625; U.S. Pat. No. 6280959; U.S. Pat. No. 6228576; U.S. Pat. No.6214858; U.S. Pat. No. 6197793; U.S. Pat. No. 6174705; U.S. Pat. No.6169171; U.S. Pat. No. 6146632; U.S. Pat. No. 6114357; U.S. Pat. No.6113914; U.S. Pat. No. 6083944; U.S. Pat. No. 6077856; U.S. Pat. No.6077855; U.S. Pat. No. 6051584; U.S. Pat. No. 6036959; U.S. Pat. No.6030989; U.S. Pat. No. 6027730; U.S. Pat. No. 6013264; U.S. Pat. No.6010848; U.S. Pat. No. 5972346; U.S. Pat. No. 5942236; U.S. Pat. No.5928902; U.S. Pat. No. 5889168; U.S. Pat. No. 5869290; U.S. Pat. No.5830867; U.S. Pat. No. 5776900; U.S. Pat. No. 5776468; U.S. Pat. No.5750110; U.S. Pat. No. 5739292; U.S. Pat. No. 5733882; U.S. Pat. No.5723631; U.S. Pat. No. 5712129; U.S. Pat. No. 5652219; U.S. Pat. No.5620957; U.S. Pat. No. 5597715; U.S. Pat. No. 5591748; U.S. Pat. No.5583018; U.S. Pat. No. 5580720; U.S. Pat. No. 5547979; U.S. Pat. No.5491229; U.S. Pat. No. 6506383; U.S. Pat. No. 6440418; U.S. Pat. No.6413771; U.S. Pat. No. 6270769; U.S. Pat. No. 6197311; U.S. Pat. No.6136310; U.S. Pat. No. 6011138; U.S. Pat. No. 6001358; U.S. Pat. No.5958765; U.S. Pat. No. 5955364; U.S. Pat. No. 5939068; U.S. Pat. No.5866125; U.S. Pat. No. 5840298; U.S. Pat. No. 5811524; U.S. Pat. No.5756096; U.S. Pat. No. 5709860; U.S. Pat. No. 5695770; U.S. Pat. No.5585103; U.S. Pat. No. 6372453; U.S. Pat. No. 6342348; U.S. Pat. No.6165464; U.S. Pat. No. 6046048; U.S. Pat. No. 6030831; U.S. Pat. No.6001621; U.S. Pat. No. 5874543; U.S. Pat. No. 5869612; U.S. Pat. No.5849585; U.S. Pat. No. 5849533; U.S. Pat. No. 5821333; U.S. Pat. No.5702938; U.S. Pat. No. 5332671; U.S. Pat. No. 6462067; U.S. Pat. No.6407133; U.S. Pat. No. 6305380; U.S. Pat. No. 6242473; U.S. Pat. No.6221893; U.S. Pat. No. 6155266; U.S. Pat. No. 6071942; U.S. Pat. No.6003516; U.S. Pat. No. 5728378; U.S. Pat. No. 6528261; U.S. Pat. No.6521403; U.S. Pat. No. 6495670; U.S. Pat. No. 6482588; U.S. Pat. No.6440662; U.S. Pat. No. 6350860; U.S. Pat. No. 6331389; U.S. Pat. No.6329138; U.S. Pat. No. 6312903; U.S. Pat. No. 6287761; U.S. Pat. No.6245503; U.S. Pat. No. 6210903; U.S. Pat. No. 6180768; U.S. Pat. No.6171784; U.S. Pat. No. 6165730; U.S. Pat. No. 6150134; U.S. Pat. No.6126935; U.S. Pat. No. 6087093; U.S. Pat. No. 6051696; U.S. Pat. No.6025132; U.S. Pat. No. 6007982; U.S. Pat. No. 5922532; U.S. Pat. No.5910404; U.S. Pat. No. 5891640; U.S. Pat. No. 5846704; U.S. Pat. No.6544523; U.S. Pat. No. 6537745; U.S. Pat. No. 6534064; U.S. Pat. No.6531307; U.S. Pat. No. 6521423; U.S. Pat. No. 6521225; U.S. Pat. No.6514731; U.S. Pat. No. 6479284; U.S. Pat. No. 6472180; U.S. Pat. No.6468986; U.S. Pat. No. 6465634; U.S. Pat. No. 6458560; U.S. Pat. No.6458370; U.S. Pat. No. 6451592; U.S. Pat. No. 6451325; U.S. Pat. No.6436666; U.S. Pat. No. 6429001; U.S. Pat. No. 6428792; U.S. Pat. No.6426196; U.S. Pat. No. 6423544; U.S. Pat. No. 6416946; U.S. Pat. No.6416944; U.S. Pat. No. 6410326; U.S. Pat. No. 6391632; U.S. Pat. No.6391540; U.S. Pat. No. 6376236; U.S. Pat. No. 6355247; U.S. Pat. No.6346375; U.S. Pat. No. 6342372; U.S. Pat. No. 6333195; U.S. Pat. No.6326171; U.S. Pat. No. 6312889; U.S. Pat. No. 6306405; U.S. Pat. No.6303292; U.S. Pat. No. 6300056; U.S. Pat. No. 6299884; U.S. Pat. No.6297370; U.S. Pat. No. 6297048; U.S. Pat. No. 6277590; U.S. Pat. No.6274148; U.S. Pat. No. 6261764; U.S. Pat. No. 6251433; U.S. Pat. No.6241982; U.S. Pat. No. 6221646; U.S. Pat. No. 6214583; U.S. Pat. No.6194140; U.S. Pat. No. 6190864; U.S. Pat. No. 6190860; U.S. Pat. No.6188969; U.S. Pat. No. 6171782; U.S. Pat. No. 6150087; U.S. Pat. No.6133029; U.S. Pat. No. 6121020; U.S. Pat. No. 6100064; U.S. Pat. No.6096541; U.S. Pat. No. 6096505; U.S. Pat. No. 6086901; U.S. Pat. No.6074852; U.S. Pat. No. 6074846; U.S. Pat. No. 6074816; U.S. Pat. No.6074635; U.S. Pat. No. 6071693; U.S. Pat. No. 6071512; U.S. Pat. No.6069127; U.S. Pat. No. 6057093; U.S. Pat. No. 6054864; U.S. Pat. No.6034059; U.S. Pat. No. 6027729; U.S. Pat. No. 6022953; U.S. Pat. No.6015694; U.S. Pat. No. 6013517; U.S. Pat. No. 5997859; U.S. Pat. No.5997856; U.S. Pat. No. 5989905; U.S. Pat. No. 5989890; U.S. Pat. No.5986079; U.S. Pat. No. 5968775; U.S. Pat. No. 5965425; U.S. Pat. No.5965382; U.S. Pat. No. 5965140; U.S. Pat. No. 5959092; U.S. Pat. No.5942234; U.S. Pat. No. 5932219; U.S. Pat. No. 5922857; U.S. Pat. No.5889156; U.S. Pat. No. 5888814; U.S. Pat. No. 5885799; U.S. Pat. No.5874077; U.S. Pat. No. 5871903; U.S. Pat. No. 5866362; U.S. Pat. No.5863797; U.S. Pat. No. 5863756; U.S. Pat. No. 5863719; U.S. Pat. No.5860917; U.S. Pat. No. 5856437; U.S. Pat. No. 5856185; U.S. Pat. No.5853974; U.S. Pat. No. 5851759; U.S. Pat. No. 5849586; U.S. Pat. No.5849481; U.S. Pat. No. 5843723; U.S. Pat. No. 5834307; U.S. Pat. No.5830684; U.S. Pat. No. 5827648; U.S. Pat. No. 5821055; U.S. Pat. No.5814485; U.S. Pat. No. 5795579; U.S. Pat. No. 5792463; U.S. Pat. No.5789245; U.S. Pat. No. 5783674; U.S. Pat. No. 5770714; U.S. Pat. No.5767250; U.S. Pat. No. 5766845; U.S. Pat. No. 5756312; U.S. Pat. No.5750350; U.S. Pat. No. 5750114; U.S. Pat. No. 5747248; U.S. Pat. No.5747044; U.S. Pat. No. 5747039; U.S. Pat. No. 5736340; U.S. Pat. No.5736327; U.S. Pat. No. 5736316; U.S. Pat. No. 5730969; U.S. Pat. No.5728520; U.S. Pat. No. RE35749; U.S. Pat. No. 5714596; U.S. Pat. No.5714152; U.S. Pat. No. 5712145; U.S. Pat. No. 5712088; U.S. Pat. No.5712087; U.S. Pat. No. 5710264; U.S. Pat. No. 5709879; U.S. Pat. No.5702891; U.S. Pat. No. 5702697; U.S. Pat. No. 5698446; U.S. Pat. No.5698390; U.S. Pat. No. 5696238; U.S. Pat. No. 5683864; U.S. Pat. No.5681702; U.S. Pat. No. 5681697; U.S. Pat. No. 5679342; U.S. Pat. No.5670153; U.S. Pat. No. 5670152; U.S. Pat. No. 5667776; U.S. Pat. No.5663306; U.S. Pat. No. 5656731; U.S. Pat. No. 5653985; U.S. Pat. No.5652130; U.S. Pat. No. 5644035; U.S. Pat. No. 5635399; U.S. Pat. No.6544951; U.S. Pat. No. 6531467; U.S. Pat. No. 6528506; U.S. Pat. No.6525024; U.S. Pat. No. 6515173; U.S. Pat. No. 6489353; U.S. Pat. No.6444663; U.S. Pat. No. 6200969; U.S. Pat. No. 6197750; U.S. Pat. No.6187771; U.S. Pat. No. 6184244; U.S. Pat. No. 5968927; U.S. Pat. No.5869519; U.S. Pat. No. 6251404; U.S. Pat. No. 6110467; U.S. Pat. No.5874267; U.S. Pat. No. 5695766; U.S. Pat. No. 6093536; U.S. Pat. No.5830766; U.S. Pat. No. 5312729; U.S. Pat. No. 6433144; U.S. Pat. No.6350589; U.S. Pat. No. RE37806; U.S. Pat. No. 6395509; U.S. Pat. No.RE37720; U.S. Pat. No. 6358971; U.S. Pat. No. 6344197; U.S. Pat. No.6303610; U.S. Pat. No. 6291446; U.S. Pat. No. 6242192; U.S. Pat. No.6221838; U.S. Pat. No. 6180816; U.S. Pat. No. 6180815; U.S. Pat. No.6175034; U.S. Pat. No. 6156924; U.S. Pat. No. 6127422; U.S. Pat. No.6124494; U.S. Pat. No. 6114327; U.S. Pat. No. 6103923; U.S. Pat. No.6103922; U.S. Pat. No. 6100426; U.S. Pat. No. 6096917; U.S. Pat. No.6087374; U.S. Pat. No. 6060484; U.S. Pat. No. 6057130; U.S. Pat. No.6037348; U.S. Pat. No. 5922678; U.S. Pat. No. 5891874; U.S. Pat. No.5879919; U.S. Pat. No. 5858704; U.S. Pat. No. 5851995; U.S. Pat. No.5846974; U.S. Pat. No. 5831017; U.S. Pat. No. 5821242; U.S. Pat. No.5816260; U.S. Pat. No. 5770397; U.S. Pat. No. 5756461; U.S. Pat. No.5732717; U.S. Pat. No. 5719266; U.S. Pat. No. 5691309; U.S. Pat. No.5686467; U.S. Pat. No. 5681932; U.S. Pat. No. 5672496; U.S. Pat. No.5605886; U.S. Pat. No. 5594104; U.S. Pat. No. 5594101; U.S. Pat. No.5580954; U.S. Pat. No. 5578465; U.S. Pat. No. 5574133; U.S. Pat. No.5574047; U.S. Pat. No. 5573928; U.S. Pat. No. 5569744; U.S. Pat. No.6541496; U.S. Pat. No. 6531474; U.S. Pat. No. 6528508; U.S. Pat. No.6528276; U.S. Pat. No. 6518291; U.S. Pat. No. 6509363; U.S. Pat. No.6498178; U.S. Pat. No. 6426413; U.S. Pat. No. 6423840; U.S. Pat. No.6420522; U.S. Pat. No. 6407080; U.S. Pat. No. 6350741; U.S. Pat. No.6344465; U.S. Pat. No. 6329365; U.S. Pat. No. 6303287; U.S. Pat. No.6265380; U.S. Pat. No. 6258948; U.S. Pat. No. 6204261; U.S. Pat. No.6183121; U.S. Pat. No. 6162800; U.S. Pat. No. 6162790; U.S. Pat. No.6153579; U.S. Pat. No. 6147080; U.S. Pat. No. 6128582; U.S. Pat. No.6121266; U.S. Pat. No. 6117639; U.S. Pat. No. 6103711; U.S. Pat. No.6093742; U.S. Pat. No. 6054472; U.S. Pat. No. 6025147; U.S. Pat. No.6008217; U.S. Pat. No. 5985863; U.S. Pat. No. 5985838; U.S. Pat. No.5978740; U.S. Pat. No. 5973111; U.S. Pat. No. 5945418; U.S. Pat. No.5932600; U.S. Pat. No. 5874424; U.S. Pat. No. 5861267; U.S. Pat. No.5847135; U.S. Pat. No. 5843905; U.S. Pat. No. 5843904; U.S. Pat. No.5834514; U.S. Pat. No. 5756466; U.S. Pat. No. 5723459; U.S. Pat. No.5716929; U.S. Pat. No. 5656627; U.S. Pat. No. 5622970; U.S. Pat. No.5620971; U.S. Pat. No. 5516797; U.S. Pat. No. 6525039; U.S. Pat. No.6458778; U.S. Pat. No. 6429214; U.S. Pat. No. 6423308; U.S. Pat. No.6541472; U.S. Pat. No. 6440985; U.S. Pat. No. 6316492; U.S. Pat. No.6127384; U.S. Pat. No. 5830905; U.S. Pat. No. 5830894; U.S. Pat. No.5633388; U.S. Pat. No. 6451340; U.S. Pat. No. 6225460; U.S. Pat. No.5886179; U.S. Pat. No. 5798340; U.S. Pat. No. 5767100; U.S. Pat. No.5756486; U.S. Pat. No. 5756291; U.S. Pat. No. 5717095; U.S. Pat. No.5693771; U.S. Pat. No. 5659023; U.S. Pat. No. 5656745; U.S. Pat. No.5591851; U.S. Pat. No. 6355625; U.S. Pat. No. 5843912; U.S. Pat. No.5641663; U.S. Pat. No. 5514590; U.S. Pat. No. 6504019; U.S. Pat. No.6503913; U.S. Pat. No. 6500817; U.S. Pat. No. 6465175; U.S. Pat. No.6437102; U.S. Pat. No. 6436943; U.S. Pat. No. 6436721; U.S. Pat. No.6429211; U.S. Pat. No. 6344476; U.S. Pat. No. 6288063; U.S. Pat. No.6235465; U.S. Pat. No. 6232462; U.S. Pat. No. 6194408; U.S. Pat. No.6187538; U.S. Pat. No. 6180380; U.S. Pat. No. 6171825; U.S. Pat. No.6150361; U.S. Pat. No. 6008259; U.S. Pat. No. 5866424; U.S. Pat. No.5837519; U.S. Pat. No. 5808076; U.S. Pat. No. 5804420; U.S. Pat. No.5786458; U.S. Pat. No. 5696170; U.S. Pat. No. 5646032; U.S. Pat. No.5561108; U.S. Pat. No. 6168587; U.S. Pat. No. 5899880; U.S. Pat. No.6534482; U.S. Pat. No. 6464980; U.S. Pat. No. 6419931; U.S. Pat. No.6413935; U.S. Pat. No. 6413517; U.S. Pat. No. 6322789; U.S. Pat. No.6037135; U.S. Pat. No. 6451319; U.S. Pat. No. 6410311; U.S. Pat. No.6294176; U.S. Pat. No. 6183753; U.S. Pat. No. 6495521; U.S. Pat. No.6288033; U.S. Pat. No. 6200952; U.S. Pat. No. 6001799; U.S. Pat. No.5939423; U.S. Pat. No. 5849696; U.S. Pat. No. 5308833; U.S. Pat. No.6545003; U.S. Pat. No. 6492372; U.S. Pat. No. 6479492; U.S. Pat. No.6465513; U.S. Pat. No. 6451828; U.S. Pat. No. 6537973; U.S. Pat. No.6525031; U.S. Pat. No. 6492111; U.S. Pat. No. 6433159; U.S. Pat. No.6423489; U.S. Pat. No. 6391542; U.S. Pat. No. 6379960; U.S. Pat. No.6339066; U.S. Pat. No. 6320040; U.S. Pat. No. 6303319; U.S. Pat. No.6284458; U.S. Pat. No. 6277982; U.S. Pat. No. 6271358; U.S. Pat. No.6258790; U.S. Pat. No. 6235723; U.S. Pat. No. 6228642; U.S. Pat. No.6204055; U.S. Pat. No. 6180403; U.S. Pat. No. 6177246; U.S. Pat. No.6174868; U.S. Pat. No. 6172209; U.S. Pat. No. 6147200; U.S. Pat. No.6133031; U.S. Pat. No. 6127533; U.S. Pat. No. 6111094; U.S. Pat. No.6096722; U.S. Pat. No. 6080580; U.S. Pat. No. 6045995; U.S. Pat. No.6043352; U.S. Pat. No. 6022691; U.S. Pat. No. 5998603; U.S. Pat. No.5985662; U.S. Pat. No. 5968826; U.S. Pat. No. 5955443; U.S. Pat. No.5914396; U.S. Pat. No. 5837449; U.S. Pat. No. 5698391; U.S. Pat. No.5688941; U.S. Pat. No. 5686242; U.S. Pat. No. 5661134; U.S. Pat. No.5654284; U.S. Pat. No. 5643780; U.S. Pat. No. 5620963; U.S. Pat. No.5608046; U.S. Pat. No. 5607923; U.S. Pat. No. 5599797; U.S. Pat. No.5587361; U.S. Pat. No. 5576302; U.S. Pat. No. 6254867; U.S. Pat. No.6146629; U.S. Pat. No. 6541224; U.S. Pat. No. 6537966; U.S. Pat. No.6534631; U.S. Pat. No. 6534485; U.S. Pat. No. 6531447; U.S. Pat. No.6525174; U.S. Pat. No. 6521441; U.S. Pat. No. 6509173; U.S. Pat. No.6506569; U.S. Pat. No. 6503184; U.S. Pat. No. 6495520; U.S. Pat. No.6495129; U.S. Pat. No. 6495128; U.S. Pat. No. 6488925; U.S. Pat. No.6486301; U.S. Pat. No. 6485719; U.S. Pat. No. 6482923; U.S. Pat. No.6476195; U.S. Pat. No. 6475753; U.S. Pat. No. 6472512; U.S. Pat. No.6455040; U.S. Pat. No. 6451562; U.S. Pat. No. 6448230; U.S. Pat. No.6448043; U.S. Pat. No. 6444440; U.S. Pat. No. 6433147; U.S. Pat. No.6433145; U.S. Pat. No. 6433139; U.S. Pat. No. 6420526; U.S. Pat. No.6416989; U.S. Pat. No. 6410709; U.S. Pat. No. 6406867; U.S. Pat. No.6403770; U.S. Pat. No. 6403337; U.S. Pat. No. 6395538; U.S. Pat. No.6391589; U.S. Pat. No. 6372473; U.S. Pat. No. 6365369; U.S. Pat. No.6358508; U.S. Pat. No. 6342581; U.S. Pat. No. 6333182; U.S. Pat. No.6316225; U.S. Pat. No. 6303338; U.S. Pat. No. 6222019; U.S. Pat. No.6171816; U.S. Pat. No. 6139832; U.S. Pat. No. 6120999; U.S. Pat. No.6114145; U.S. Pat. No. 6093795; U.S. Pat. No. 6077692; U.S. Pat. No.6040157; U.S. Pat. No. 6001606; U.S. Pat. No. 5965421; U.S. Pat. No.5861272; U.S. Pat. No. 6534523; U.S. Pat. No. 6525046; U.S. Pat. No.6506748; U.S. Pat. No. 6498008; U.S. Pat. No. 6492529; U.S. Pat. No.6492393; U.S. Pat. No. 6479508; U.S. Pat. No. 6448281; U.S. Pat. No.6432995; U.S. Pat. No. 6420380; U.S. Pat. No. 6420359; U.S. Pat. No.6410531; U.S. Pat. No. 6372773; U.S. Pat. No. 6358945; U.S. Pat. No.6335016; U.S. Pat. No. 6329417; U.S. Pat. No. 6329415; U.S. Pat. No.6329379; U.S. Pat. No. 6323180; U.S. Pat. No. 6297381; U.S. Pat. No.6268207; U.S. Pat. No. 6242453; U.S. Pat. No. 6241990; U.S. Pat. No.6228881; U.S. Pat. No. 6180385; U.S. Pat. No. 6143715; U.S. Pat. No.6080763; U.S. Pat. No. 6080570; U.S. Pat. No. 5846805; U.S. Pat. No.5840563; U.S. Pat. No. 5789230; U.S. Pat. No. 5753647; U.S. Pat. No.5693509.

[0164] U.S. Patent Application Publication 2001/0031773 A1; U.S. PatentApplication Publication 2002/0111313 A1; U.S. Patent ApplicationPublication 2002/0177725 A1; U.S. Patent Application Publication20030060645; U.S. Patent Application Publication 20020111495; U.S.Patent Application Publication 20030049268; U.S. Patent ApplicationPublication 20030022304; U.S. Patent Application Publication20030013697; U.S. Patent Application Publication 20020192224; U.S.Patent Application Publication 20020054884; U.S. Patent ApplicationPublication 20020028209; U.S. Patent Application Publication20010053365; U.S. Patent Application Publication 20010014331; U.S.Patent Application Publication 20030059424; U.S. Patent ApplicationPublication 20030003097; U.S. Patent Application Publication20020150580; U.S. Patent Application Publication 20020044930; U.S.Patent Application Publication 20020001798; U.S. Patent ApplicationPublication 20010019715; U.S. Patent Application Publication20010018054; U.S. Patent Application Publication 20030044774; U.S.Patent Application Publication 20020141971; U.S. Patent ApplicationPublication 20020068354; U.S. Patent Application Publication20020058325; U.S. Patent Application Publication 20020025329; U.S.Patent Application Publication 20010043915; U.S. Patent ApplicationPublication 20030060416; U.S. Patent Application Publication20020197702; U.S. Patent Application Publication 20020155579; U.S.Patent Application Publication 20020147171; U.S. Patent ApplicationPublication 20020128306; U.S. Patent Application Publication20020123522; U.S. Patent Application Publication 20020042046; U.S.Patent Application Publication 200 20183310; U.S. Patent ApplicationPublication 20020173499; U.S. Patent Application Publication20020169150; U.S. Patent Application Publication 20020151532; U.S.Patent Application Publication 20010041794; U.S. Patent ApplicationPublication 20010012830; U.S. Patent Application Publication20030068627; U.S. Patent Application Publication 20030065151; U.S.Patent Application Publication 20030059908; U.S. Patent ApplicationPublication 20030059875; U.S. Patent Application Publication20030054420; U.S. Patent Application Publication 20030054379; U.S.Patent Application Publication 20030054377; U.S. Patent ApplicationPublication 20030054375; U.S. Patent Application Publication20030054373; U.S. Patent Application Publication 20030054368; U.S.Patent Application Publication 20030050443; U.S. Patent ApplicationPublication 20030050442; U.S. Patent Application Publication20030049703; U.S. Patent Application Publication 20030049652; U.S.Patent Application Publication 20030049650; U.S. Patent ApplicationPublication 20030044907; U.S. Patent Application Publication20030044905; U.S. Patent Application Publication 20030044904; U.S.Patent Application Publication 20030044851; U.S. Patent ApplicationPublication 20030040088; U.S. Patent Application Publication20030039994; U.S. Patent Application Publication 20030039993; U.S.Patent Application Publication 20030036505; U.S. Patent ApplicationPublication 20030023070; U.S. Patent Application Publication20030023068; U.S. Patent Application Publication 20030022345; U.S.Patent Application Publication 20030022338; U.S. Patent ApplicationPublication 20030022314; U.S. Patent Application Publication20030022289; U.S. Patent Application Publication 20030017500; U.S.Patent Application Publication 20030013161; U.S. Patent ApplicationPublication 20020197701; U.S. Patent Application Publication20020187526; U.S. Patent Application Publication 20020183503; U.S.Patent Application Publication 20020177213; U.S. Patent ApplicationPublication 20020173640; U.S. Patent Application Publication20020168729; U.S. Patent Application Publication 20020168359; U.S.Patent Application Publication 20020165384; U.S. Patent ApplicationPublication 20020165137; U.S. Patent Application Publication20020164694; U.S. Patent Application Publication 20020164693; U.S.Patent Application Publication 20020155541; U.S. Patent ApplicationPublication 20020155539; U.S. Patent Application Publication20020151009; U.S. Patent Application Publication 20020150583; U.S.Patent Application Publication 20020146738; U.S. Patent ApplicationPublication 20020143165; U.S. Patent Application Publication20020127640; U.S. Patent Application Publication 20020115112; U.S.Patent Application Publication 20020106736; U.S. Patent ApplicationPublication 20020103122; U.S. Patent Application Publication20020098525; U.S. Patent Application Publication 20020098163; U.S.Patent Application Publication 20020081647; U.S. Patent ApplicationPublication 20020072091; U.S. Patent Application Publication20020064829; U.S. Patent Application Publication 20020061551; U.S.Patent Application Publication 20020055142; U.S. Patent ApplicationPublication 20020052024; U.S. Patent Application Publication20020045737; U.S. Patent Application Publication 20020042372; U.S.Patent Application Publication 20010036650; U.S. Patent ApplicationPublication 20030064032; U.S. Patent Application Publication20010021383; U.S. Patent Application Publication 20030060400; U.S.Patent Application Publication 20030050229; U.S. Patent ApplicationPublication 20060036528; U.S. Patent Application Publication20030008887; U.S. Patent Application Publication 20020193415; U.S.Patent Application Publication 20020120130; U.S. Patent ApplicationPublication 20020107221; U.S. Patent Application Publication20020035085.

[0165] HIV Section:

[0166] Nelfinavir, Pfizer; amprenavir, VertexPharmaceuticals/GlaxoSmithKline; saquinavir, Hoffman LaRoche; lopinavir,Abbott; indinavir, Merck & Co; ritonavir, Abbott; TAK 449, TakedaChemical Industries; AMD 8664, Anormed; TAK 779, Takeda ChemicalIndustries; PEHRG214, Probe Australasia; HIV NCp7, AchillionPharmaceuticals; SPD-756 (BCH-13520), Shire Pharmaceuticals; 5-Helix,Howard Hughes Medical Institute; T-649, Trimeris/Hoffinan LaRoche;mozenavir (DMP-450), Dupont Pharmaceuticals/Triangle Pharmaceuticals;AOP-Pantes, Gryphon Sciences; tipranavir (PNU-140690), PharmaciaCorporation/Boehringer Ingelheim; atazanavir (BMS-232,632, zrivada),Bristol-Myers Squibb; TMC114, Tibotec; enfuvirtide (fuzeon, T-20,pentfuside), Trimeris/Hoffmann-LaRoche; PRO 542 (CD4-IgG2), ProgenicsPharmaceuticals; SCH—C (Schering C), Schering-Plough; S-1360 (GW810781),Shinogi Pharmaceuticals/ GlaxoSmithKline; L-870,812, Merck & Co.;L-870,810, Merck & Co.; ACH-0100703, Achillion Pharmaceuticals;GW433908/VX175, GlaxoSmithKline/Vertex Pharmaceuticals; L-756,423, Merck& Co.; RO033-4649, Hoffinan LaRoche; Interleukin-2 (IL-2, aldesleukin,proleukin), Chiron Corporation; multikine, Cel-Sci Corporation; HRG214,Vironyx; remune, Immune Response Corporation; ampligen, HemispherxBiopharma; reticulose, Advanced Viral Research Corporation; AIDS GeneTherapy, Cell Genesys; murabutide, ??????????????; resveratrol,Pharmascience; FP21399, Fuji Pharmaceuticals; TNX-355, Tanox;UK-427,857, Pfizer; azodicarbonamide (ADA), Hubriphar; HGTV43, EnzoTherapeutics; BMS-806, Bristol- Myers Squibb; PRO-140, ProgenicsPharmaceuticals; SCH-D, Schering-Plough; AMD-3100, Anormed; VMIP-II,GlaxoSmithKline; SJ-3366, Samjin; GPG-NH2, Triper; AXD-455, Axxima;PA-457, Panaco; zerit XR, Bristol-Myers Squibb; fosamprenavir (908),GlaxoSmithKline; covracil (FTC, emtricitabine), TrianglePharmaceuticals; AMD-3465, Anormed; AMD-8445, Anormed; DEHSPM, Sunpharm;DPC 681, Dupont Pharmaceuticals; DPC 684, Dupont Pharmaceuticals; HU5A8,Tanox; hydroxyurea, Bristol-Myers Squibb; LB-71350, LG Chemical;mycophenlate, Hoffman-LaRoche; peldesine, BioCryst; PRO 367, ProgenicsPharmaceuticals; ONO-4128, ONO Pharmaceutical/GlaxoSmithKline; VX-385,Vertex Pharmaceuticals/GlaxoSmithKline; A 74704, Abbott; A 75912,Abbott; A 77003, Abbott; A 78624, Abbott; A 80164, Abbott; A 80987,Abbott; AG 1026, Agouron; AG 1157, Agouron; AG 1284, Agouron; AG 1350,Agouron; arecathannin B1, National Cancer Research Institute; atazanavirsulfate, Novartis; BMS 182193, Bristol-Myers Squibb; BMS 186318,Bristol-Myers Squibb; CGP 53437, Novartis; CGP 56603, Novartis; CGP57813, Novartis; CI 1029, Pfizer; compound K, Merck & Co; DMP 850,Bristol-Myers Squibb; DMP 851, Bristol-Myers Squibb; DPC 681,Bristol-Myers Squibb; droxinavir, Pharmacia Corporation; EMD 58608,Merck KgaA; GS 2992, Gilead Sciences; GS 3333, Gilead Sciences; HBY 793,Aventis; JE 2147, Japan Energy Corporation; KH 164, Eli Lilly;kynostatin, Japan Energy Corporation; kynostatin 227, Nippon Mining; L694746, Merck & Co; L 696474, Merck & Co; lasinavir, Novartis; LB 71112,LG Chemical; LB 71116, LG Chemical; LB 71119; LG Chemical; LB 71262; LGChemical; lithium gammalinolenate; Scotia; lopinavir+ritonavir, Abbott;LY 289612, Eli Lilly; LY 294779, Eli Lilly; LY 326620, Eli Lilly; M 163,Medivir; MK 944, Merck & Co; MK 944 +indinavir, Merck & Co; palinavir,Bio-Mega; PD 153103, Pfizer; PD 173606, Pfizer; PD 177298, Pfizer; PD178390, Pfizer; PD 178392, Pfizer; PNU 140135, Pfizer; R 944, HoffmanLaRoche; RP 71955, Aventis; SB 206343, GlaxoSmithKline; SC 55099,Pharmacia Corporation; SDZ PRI 053, Novartis; SKF 108922,GlaxoSmithKline; telinavir, Pharmacia Corporation; TMC 126, Tibotec; U103017, Pharmacia Corporation; U 75875, Pharmacia Corporation; U 81749,Pharmacia Corporation; U 96988, Pharmacia Corporation; UK 88947, Pfizer;VB 10411, Vertex Pharmaceuticals; VX 10307, Vertex Pharmaceuticals; VX10318, Vertex Pharmaceuticals; VX 10411 Vertex Pharmaceuticals; VX11106, Vertex Pharmaceuticals; XM 323, Bristol-Myers Squibb; XM 412,Merck & Co. U.S. Pat. No. 6,313,345 B1; U.S. Pat. No. 6,316,449 B1; U.S.Pat. No. 6,316,496 B1; U.S. Pat. No. 6,333,323 B1; U.S. Pat. No.6,335,460 B1; U.S. Pat. No. 6,362,207 B1; U.S. Pat. No. 6,319,946 B1;U.S. Pat. No. 6,329,502 B1; U.S. Pat. No. 6,329,524 B1; U.S. Pat. No.6,376,536 B1; U.S. Pat. No. 6,380,188 B1; U.S. Pat. No. 6,380,249 B1;U.S. Pat. No. 6,384,036 B1; U.S. Pat. No. 6,387,930 B1; U.S. Pat. No.6,388,132 B1; U.S. Pat. No. 6,391,865 B1; U.S. Pat. No. 6,391,919 B1;U.S. Pat. No. 6,392,046 B1; U.S. Pat. No. 6,392,067 B1; U.S. Pat. No.6,395,743 B1; U.S. Pat. No. 6,403,347 B1; U.S. Pat. No. 6,403,585 B1;U.S. Pat. No. 6,372,778 B1; U.S. Pat. No. 6,407,134 B1; U.S. Pat. No.6,410,575 B2; U.S. Pat. No. 6,417,387 B1; U.S. Pat. No. 6,451,999 B2;U.S. Pat. No. 6,452,000 B2; U.S. Pat. No. 6,455,581 B1; U.S. Pat. No.6,455,587 B1; U.S. Pat. No. 6,458,785 B1; U.S. Pat. No. 6,469,006 B1;U.S. Pat. No. 6,469,207 B2; U.S. Pat. No. 6,472,407 B1; U.S. Pat. No.6,476,034 B2; U.S. Pat. No. 6,479,526 B1; U.S. Pat. No. 6,482,412 B1;U.S. Pat. No. 6,489,364 B2; U.S. Pat. No. 6,500,832 B1; U.S. Pat. No.6,506,759 B1; U.S. Pat. No. 6,506,787 B2; U.S. Pat. No. 6,511,994 B2;U.S. Pat. No. 6,512,135 B2; U.S. Pat. No. 6,528,510 B1; U.S. Pat. No.6,528,532 B1; U.S. Pat. No. 6,531,476 B1; U.S. Pat. No. 6,531,484 B2;U.S. Pat. No. 6,534,493 B1; U.S. Pat. No. 6,313,177 B1; U.S. Pat. No.6,313,110 B1; U.S. Pat. No. 6,310,080 B1; U.S. Pat. No. 6,306,891 B1;U.S. Pat. No. 6,303,786 B1; U.S. Pat. No. 6,291,687 B1; U.S. Pat. No.6,291,432 B1; U.S. Pat. No. 6,271,402 B1; U.S. Pat. No. 6,271,235 B1;U.S. Pat. No. 6,270,957 B1; U.S. Pat. No. 6,265,583 B1; U.S. Pat. No.6,262,055 B1; U.S. Pat. No. 6,258,932 B1; U.S. Pat. No. 6,258,831 B1;U.S. Pat. No. 6,248,775 B1; U.S. Pat. No. 6,245,806 B1; U.S. Pat. No.6,245,789 B1; U.S. Pat. No. 6,235,771 B1; U.S. Pat. No. 6,222,043 B1;U.S. Pat. No. 6,218,534 B1; U.S. Pat. No. 6,218,386 B1; U.S. Pat. No.6,214,861 B1; U.S. Pat. No. 6,211,176 B1; U.S. Pat. No. 6,194,430 B1;U.S. Pat. No. 6,184,241 B1; U.S. Pat. No. 6,180,646 B1; U.S. Pat. No.6,180,634 B1; U.S. Pat. No. 6,172,101 B1; U.S. Pat. No. 6,172,082 B1;U.S. Pat. No. 6,169,085 B1; U.S. Pat. No. 6,162,812; U.S. Pat. No.6,150,556; U.S. Pat. No. 6,147,117; U.S. Pat. No. 6,143,788; U.S. Pat.No. 6,143,747; U.S. Pat. No. 6,127,372; U.S. Pat. No. 6,124,327; U.S.Pat. No. 6,110,716; U.S. Pat. No. 6,100,277; U.S. Pat. No. 6,096,780;U.S. Pat. No. 6,087,383; U.S. Pat. No. 6,083,958; U.S. Pat. No.6,077,963; U.S. Pat. No. 6,071,916; U.S. Pat. No. 6,063,795; U.S. Pat.No. 6,060,476; U.S. Pat. No. 6,054,597; U.S. Pat. No. 6,043,357; U.S.Pat. No. 6,022,994; U.S. Pat. No. 6,022,872; U.S. Pat. No. 6,017,880;U.S. Pat. No. 6544761; U.S. Pat. No. 6541224; U.S. Pat. No. 6541013;U.S. Pat. No. 6541011; U.S. Pat. No. 6537966; U.S. Pat. No. 6534631;U.S. Pat. No. 6534485; U.S. Pat. No. 6534067; U.S. Pat. No. 6531484;U.S. Pat. No. 6531305; U.S. Pat. No. 6531125; U.S. Pat. No. 6528308;U.S. Pat. No. 6524582; U.S. Pat. No. 6521614; U.S. Pat. No. 6521453;U.S. Pat. No. 6521228; U.S. Pat. No. 6511994; U.S. Pat. No. 6511833;U.S. Pat. No. 6506569; U.S. Pat. No. 6503184; U.S. Pat. No. 6500927;U.S. Pat. No. 6500856; U.S. Pat. No. 6500652; U.S. Pat. No. 6495604;U.S. Pat. No. 6495520; U.S. Pat. No. 6495129; U.S. Pat. No. 6492390;U.S. Pat. No. 6492324; U.S. Pat. No. 6490588; U.S. Pat. No. 6489163;U.S. Pat. No. 6488929; U.S. Pat. No. 6486186; U.S. Pat. No. 6486148;U.S. Pat. No. 6479652; U.S. Pat. No. 6479258; U.S. Pat. No. 6479254;U.S. Pat. No. 6476195; U.S. Pat. No. 6476188; U.S. Pat. No. 6476031;U.S. Pat. No. 6475753; U.S. Pat. No. 6475521; U.S. Pat. No. 6472512;U.S. Pat. No. 6471956; U.S. Pat. No. 6468768; U.S. Pat. No. 6468737;U.S. Pat. No. 6465633; U.S. Pat. No. 6465431; U.S. Pat. No. 6458787;U.S. Pat. No. 6458575; U.S. Pat. No. 6455685; U.S. Pat. No. 6455587;U.S. Pat. No. 6455562; U.S. Pat. No. 6455280; U.S. Pat. No. 6455040;U.S. Pat. No. 6453241; U.S. Pat. No. 6451796; U.S. Pat. No. 6444870;U.S. Pat. No. 6444671; U.S. Pat. No. 6441135; U.S. Pat. No. 6440946;U.S. Pat. No. 6436675; U.S. Pat. No. 6436628; U.S. Pat. No. 6433147;U.S. Pat. No. 6433145; U.S. Pat. No. 6432915; U.S. Pat. No. 6429290;U.S. Pat. No. 6426224; U.S. Pat. No. 6423710; U.S. Pat. No. 6423542;U.S. Pat. No. 6420111; U.S. Pat. No. 6416991; U.S. Pat. No. 6414117;U.S. Pat. No. 6413947; U.S. Pat. No. 6410689; U.S. Pat. No. 6407213;U.S. Pat. No. 6406867; U.S. Pat. No. 6403770; U.S. Pat. No. 6403337;U.S. Pat. No. 6403090; U.S. Pat. No. 6399298; U.S. Pat. No. 6399067;U.S. Pat. No. 6395743; U.S. Pat. No. 6395541; U.S. Pat. No. 6395468;U.S. Pat. No. 6395275; U.S. Pat. No. 6392028; U.S. Pat. No. 6391865;U.S. Pat. No. 6391589; U.S. Pat. No. 6391587; U.S. Pat. No. 6391567;U.S. Pat. No. 6389378; U.S. Pat. No. 6387930; U.S. Pat. No. 6380171;U.S. Pat. No. 6376536; U.S. Pat. No. 6376246; U.S. Pat. No. 6372777;U.S. Pat. No. 6370478; U.S. Pat. No. 6369098; U.S. Pat. No. 6369057;U.S. Pat. No. 6368861; U.S. Pat. No. 6368828; U.S. Pat. No. 6365712;U.S. Pat. No. 6365372; U.S. Pat. No. 6362213; U.S. Pat. No. 6358508;U.S. Pat. No. 6353024; U.S. Pat. No. 6350738; U.S. Pat. No. 6350730;U.S. Pat. No. 6348602; U.S. Pat. No. 6346411; U.S. Pat. No. 6346246;U.S. Pat. No. 6338945; U.S. Pat. No. 6337207; U.S. Pat. No. 6335168;U.S. Pat. No. 6333303; U.S. Pat. No. 6326154; U.S. Pat. No. 6326151;U.S. Pat. No. 6319714; U.S. Pat. No. 6313156; U.S. Pat. No. 6312887;U.S. Pat. No. 6310196; U.S. Pat. No. 6310048; U.S. Pat. No. 6309853;U.S. Pat. No. 6309642; U.S. Pat. No. 6307021; U.S. Pat. No. 6300472;U.S. Pat. No. 3297253; U.S. Pat. No. 6294561; U.S. Pat. No. 6294322;U.S. Pat. No. 6291645; U.S. Pat. No. 6290839; U.S. Pat. No. 6288218;U.S. Pat. No. 6284236; U.S. Pat. No. 6277989; U.S. Pat. No. 6277974;U.S. Pat. No. 6277377; U.S. Pat. No. 6271253; U.S. Pat. No. 6268354;U.S. Pat. No. 6265551; U.S. Pat. No. 6264825; U.S. Pat. No. 6261760;U.S. Pat. No. 6261558; U.S. Pat. No. 6258833; U.S. Pat. No. 6258527;U.S. Pat. No. 6255456; U.S. Pat. No. 6251582; U.S. Pat. No. 6248516;U.S. Pat. No. 6242178; U.S. Pat. No. 6238903; U.S. Pat. No. 6235771;U.S. Pat. No. 6235477; U.S. Pat. No. 6228991; U.S. Pat. No. 6222019;U.S. Pat. No. 6218162; U.S. Pat. No. 6217867; U.S. Pat. No. 6214347;U.S. Pat. No. 6211215; U.S. Pat. No. 6210942; U.S. Pat. No. 6210873;U.S. Pat. No. 6207386; U.S. Pat. No. 6204415; U.S. Pat. No. 6204371;U.S. Pat. No. 6197982; U.S. Pat. No. 6194592; U.S. Pat. No. 6194176;U.S. Pat. No. 6190909; U.S. Pat. No. 6190871; U.S. Pat. No. 6187559;U.S. Pat. No. 6184396; U.S. Pat. No. 6184226; U.S. Pat. No. 6183956;U.S. Pat. No. 6172266; U.S. Pat. No. 6172199; U.S. Pat. No. 6172190;U.S. Pat. No. 6172061; U.S. Pat. No. 6166006; U.S. Pat. No. 6165470;U.S. Pat. No. 6162627; U.S. Pat. No. 6160092; U.S. Pat. No. 6159461;U.S. Pat. No. 6156887; U.S. Pat. No. 6146827; U.S. Pat. No. 6136955;U.S. Pat. No. 6135941; U.S. Pat. No. 6133502; U.S. Pat. No. 6133028;U.S. Pat. No. 6130316; U.S. Pat. No. 6127116; U.S. Pat. No. 6124448;U.S. Pat. No. 6124439; U.S. Pat. No. 6124132; U.S. Pat. No. 6124123;U.S. Pat. No. 3124116; U.S. Pat. No. 6121000; U.S. Pat. No. 6117653;U.S. Pat. No. 6114127; U.S. Pat. No. 6113905; U.S. Pat. No. 6113904;U.S. Pat. No. 6110707; U.S. Pat. No. 6110706; U.S. Pat. No. 6110686;U.S. Pat. No. 6107289; U.S. Pat. No. 6103878; U.S. Pat. No. 6100065;U.S. Pat. No. 6100042; U.S. Pat. No. 6100037; U.S. Pat. No. 6096780;U.S. Pat. No. 6096300; U.S. Pat. No. 6090377; U.S. Pat. No. 6087478;U.S. Pat. No. 6087129; U.S. Pat. No. 6084083; U.S. Pat. No. 6084067;U.S. Pat. No. 6083968; U.S. Pat. No. 6080723; U.S. Pat. No. 6080548;U.S. Pat. No. 6077850; U.S. Pat. No. 6077682; U.S. Pat. No. 6077510;U.S. Pat. No. 6072049; U.S. Pat. No. 6066498; U.S. Pat. No. 6066322;U.S. Pat. No. 6063945; U.S. Pat. No. 6060600; U.S. Pat. No. 6057129;U.S. Pat. No. 6057112; U.S. Pat. No. 6057102; U.S. Pat. No. 6054297;U.S. Pat. No. 6054284; U.S. Pat. No. 6054121; U.S. Pat. No. 6048850;U.S. Pat. No. 6048837; U.S. Pat. No. 6046001; U.S. Pat. No. 6043346;U.S. Pat. No. 6043086; U.S. Pat. No. 6040325; U.S. Pat. No. 6040174;U.S. Pat. No. 6039684; U.S. Pat. No. 6034212; U.S. Pat. No. 6033855;U.S. Pat. No. 6030825; U.S. Pat. No. 6030785; U.S. Pat. No. 6027916;U.S. Pat. No. 6022863; U.S. Pat. No. 6022709; U.S. Pat. No. 6022543;U.S. Pat. No. 6020166; U.S. Pat. No. 6020142; U.S. Pat. No. 6018021;U.S. Pat. No. 6017958; U.S. Pat. No. 6017744; U.S. Pat. No. 6015660;U.S. Pat. No. 6013257; U.S. Pat. No. 6010879; U.S. Pat. No. 6010859;U.S. Pat. No. 6008239; U.S. Pat. No. 6004933; U.S. Pat. No. 6002028;U.S. Pat. No. 6001968; U.S. Pat. No. 6001803; U.S. Pat. No. 6001596;U.S. Pat. No. 5998383; U.S. Pat. No. 5997869; U.S. Pat. No. 5994054;U.S. Pat. No. 5989883; U.S. Pat. No. 5986144; U.S. Pat. No. 5986069;U.S. Pat. No. 5986057; U.S. Pat. No. 5981583; U.S. Pat. No. 5981279;U.S. Pat. No. 5981223; U.S. Pat. No. 5977169; U.S. Pat. No. 5976801;U.S. Pat. No. 5972643; U.S. Pat. No. 5968742; U.S. Pat. No. 5965421;U.S. Pat. No. 5965394; U.S. Pat. No. 5958912; U.S. Pat. No. 5955429;U.S. Pat. No. 5955303; U.S. Pat. No. 5945438; U.S. Pat. No. 5942606;U.S. Pat. No. 5939448; U.S. Pat. No. 5939320; U.S. Pat. No. 5939074;U.S. Pat. No. 5935817; U.S. Pat. No. 5935810; U.S. Pat. No. 5932423;U.S. Pat. No. 5932218; U.S. Pat. No. 5928894; U.S. Pat. No. 5925640;U.S. Pat. No. 5925635; U.S. Pat. No. 5925542; U.S. Pat. No. 5922595;U.S. Pat. No. 5922325; U.S. Pat. No. 5922318; U.S. Pat. No. 5919657;U.S. Pat. No. 5917019; U.S. Pat. No. 5916890; U.S. Pat. No. 5916772;U.S. Pat. No. 5916764; U.S. Pat. No. 5897989; U.S. Pat. No. 5897861;U.S. Pat. No. 5892012; U.S. Pat. No. 5891924; U.S. Pat. No. 5886177;U.S. Pat. No. 5886151; U.S. Pat. No. 5885798; U.S. Pat. No. 5879909;U.S. Pat. No. 5876951; U.S. Pat. No. 5876926; U.S. Pat. No. 5876919;U.S. Pat. No. 5876692; U.S. Pat. No. 5872120; U.S. Pat. No. 5872012;U.S. Pat. No. 5871931; U.S. Pat. No. 5871902; U.S. Pat. No. 5869622;U.S. Pat. No. 5869291; U.S. Pat. No. 5866332; U.S. Pat. No. 5861490;U.S. Pat. No. 5861239; U.S. Pat. No. 5859183; U.S. Pat. No. 5858715;U.S. Pat. No. 5858675; U.S. Pat. No. 5854414; U.S. Pat. No. 5854023;U.S. Pat. No. 5849533; U.S. Pat. No. 5847094; U.S. Pat. No. 5847093;U.S. Pat. No. 5846780; U.S. Pat. No. 5843717; U.S. Pat. No. 5843440;U.S. Pat. No. 5840866; U.S. Pat. No. 5840534; U.S. Pat. No. 5840502;U.S. Pat. No. 5837837; U.S. Pat. No. 5837500; U.S. Pat. No. 5837479;U.S. Pat. No. 5834241; U.S. Pat. No. 5830647; U.S. Pat. No. 5821337;U.S. Pat. No. 5821331; U.S. Pat. No. 5821086; U.S. Pat. No. 5817762;U.S. Pat. No. 5817494; U.S. Pat. No. 6538127; U.S. Pat. No. 6531610;U.S. Pat. No. 6521651; U.S. Pat. No. 6511812; U.S. Pat. No. 6506766;U.S. Pat. No. 6472529; U.S. Pat. No. 6458818; U.S. Pat. No. 6444700;U.S. Pat. No. 6440470; U.S. Pat. No. 6413780; U.S. Pat. No. 6406841;U.S. Pat. No. 6399312; U.S. Pat. No. 6395472; U.S. Pat. No. 6391544;U.S. Pat. No. 6380207; U.S. Pat. No. 6372905; U.S. Pat. No. 6326500;U.S. Pat. No. 6313296; U.S. Pat. No. 6294326; U.S. Pat. No. 6287760;U.S. Pat. No. 6284882; U.S. Pat. No. 6284767; U.S. Pat. No. 6258387;U.S. Pat. No. 6255341; U.S. Pat. No. 6251906; U.S. Pat. No. 6245803;U.S. Pat. No. 6232455; U.S. Pat. No. 6232333; U.S. Pat. No. 6210898;U.S. Pat. No. 6203974; U.S. Pat. No. 6194379; U.S. Pat. No. 6190617;U.S. Pat. No. 6177241; U.S. Pat. No. 6172189; U.S. Pat. No. 6166013;U.S. Pat. No. 6160122; U.S. Pat. No. 6153377; U.S. Pat. No. 6150530;U.S. Pat. No. 6143749; U.S. Pat. No. 6139781; U.S. Pat. No. 6136855;U.S. Pat. No. 6130244; U.S. Pat. No. 6100099; U.S. Pat. No. 6096561;U.S. Pat. No. 6074817; U.S. Pat. No. 6037157; U.S. Pat. No. 6033898;U.S. Pat. No. 6030969; U.S. Pat. No. 6022989; U.S. Pat. No. 6022746;U.S. Pat. No. 6022712; U.S. Pat. No. 6020122; U.S. Pat. No. 6017928;U.S. Pat. No. 6015662; U.S. Pat. No. 6010857; U.S. Pat. No. 6001659;U.S. Pat. No. 6001561; U.S. Pat. No. 5998593; U.S. Pat. No. 5994143;U.S. Pat. No. 5990135; U.S. Pat. No. 5981587; U.S. Pat. No. 5981171;U.S. Pat. No. 5962665; U.S. Pat. No. 5960160; U.S. Pat. No. 5959118;U.S. Pat. No. 5955598; U.S. Pat. No. 5955268; U.S. Pat. No. 5952173;U.S. Pat. No. 5948436; U.S. Pat. No. 5942632; U.S. Pat. No. 5939326;U.S. Pat. No. 5932766; U.S. Pat. No. 5925512; U.S. Pat. No. 5922533;U.S. Pat. No. 5914332; U.S. Pat. No. 5912372; U.S. Pat. No. 5905068;U.S. Pat. No. 5892052; U.S. Pat. No. 5891734; U.S. Pat. No. 5886036;U.S. Pat. No. 5877334; U.S. Pat. No. 5876749; U.S. Pat. No. 5869252;U.S. Pat. No. 5866606; U.S. Pat. No. 5866322; U.S. Pat. No. 5861294;U.S. Pat. No. 5859193; U.S. Pat. No. 5858732; U.S. Pat. No. 5858356;U.S. Pat. No. 5856194; U.S. Pat. No. 5846987; U.S. Pat. No. 5846785;U.S. Pat. No. 5843634; U.S. Pat. No. 5837873; U.S. Pat. No. 5830636;U.S. Pat. No. 5814492; U.S. Pat. No. 5812419; U.S. Pat. No. 5811425;U.S. Pat. No. 5800983; U.S. Pat. No. 5795784; U.S. Pat. No. 6545143;U.S. Pat. No. 6544796; U.S. Pat. No. 6538015; U.S. Pat. No. 6534017;U.S. Pat. No. 6531572; U.S. Pat. No. 6528284; U.S. Pat. No. 6524808;U.S. Pat. No. 6518293; U.S. Pat. No. 6514736; U.S. Pat. No. 6509157;U.S. Pat. No. 6489479; U.S. Pat. No. 6489131; U.S. Pat. No. 6489129;U.S. Pat. No. 6472404; U.S. Pat. No. 6468775; U.S. Pat. No. 6447999;U.S. Pat. No. 6447992; U.S. Pat. No. 6437134; U.S. Pat. No. 6437095;U.S. Pat. No. 6410235; U.S. Pat. No. 6352717; U.S. Pat. No. 6329346;U.S. Pat. No. 6284484; U.S. Pat. No. 6270988; U.S. Pat. No. 6248522;U.S. Pat. No. 6239296; U.S. Pat. No. 6231815; U.S. Pat. No. 6229041;U.S. Pat. No. 6221584; U.S. Pat. No. 6214979; U.S. Pat. No. 6211158;U.S. Pat. No. 6210901; U.S. Pat. No. 6207144; U.S. Pat. No. 6197563;U.S. Pat. No. 6194561; U.S. Pat. No. 6171785; U.S. Pat. No. 6153393;U.S. Pat. No. 6136969; U.S. Pat. No. 6130348; U.S. Pat. No. 6127155;U.S. Pat. No. 6093546; U.S. Pat. No. 6081734; U.S. Pat. No. 6080734;U.S. Pat. No. 6040166; U.S. Pat. No. 6039975; U.S. Pat. No. 6027885;U.S. Pat. No. 6025343; U.S. Pat. No. 6008228; U.S. Pat. No. 6001611;U.S. Pat. No. 5998157; U.S. Pat. No. 5994056; U.S. Pat. No. 5985544;U.S. Pat. No. 5981286; U.S. Pat. No. 5977388; U.S. Pat. No. 5972720;U.S. Pat. No. 5965733; U.S. Pat. No. 5958783; U.S. Pat. No. 5955452;U.S. Pat. No. 5928636; U.S. Pat. No. 5919949; U.S. Pat. No. 5914406;U.S. Pat. No. 5914404; U.S. Pat. No. 5912117; U.S. Pat. No. 5908743;U.S. Pat. No. 5907038; U.S. Pat. No. 5784533; U.S. Pat. No. 5859248;U.S. Pat. No. 5853721; U.S. Pat. No. 5847144; U.S. Pat. No. 5837818;U.S. Pat. No. 5830920; U.S. Pat. No. 5808029; U.S. Pat. No. 5804375;U.S. Pat. No. 5780607; U.S. Pat. No. 5780038; U.S. Pat. No. 5773258;U.S. Pat. No. 5767268; U.S. Pat. No. 5750706; U.S. Pat. No. 5750374;U.S. Pat. No. 5712121; U.S. Pat. No. 5702918; U.S. Pat. No. 5698698;U.S. Pat. No. 5693755; U.S. Pat. No. 5693517; U.S. Pat. No. 5684176;U.S. Pat. No. 5677152; U.S. Pat. No. 5670653; U.S. Pat. No. 5668256;U.S. Pat. No. 5665548; U.S. Pat. No. 5652369; U.S. Pat. No. 5643723;U.S. Pat. No. 5641886; U.S. Pat. No. 5641864; U.S. Pat. No. 5635348;U.S. Pat. No. 5620987; U.S. Pat. No. 5620847; U.S. Pat. No. 5618703;U.S. Pat. No. 5610279; U.S. Pat. No. 5599662; U.S. Pat. No. 5594123;U.S. Pat. No. RE37918; U.S. Pat. No. 6383498; U.S. Pat. No. 6329400;U.S. Pat. No. 6319702; U.S. Pat. No. RE7438; U.S. Pat. No. 6294540; U.S.Pat. No. 6281367; U.S. Pat. No. 6221852; U.S. Pat. No. 6191150; U.S.Pat. No. 6177436; U.S. Pat. No. 6177435; U.S. Pat. No. 6172064; U.S.Pat. No. 6147254; U.S. Pat. No. 6140100; U.S. Pat. No. 6113920; U.S.Pat. No. 6107302; U.S. Pat. No. 6096786; U.S. Pat. No. 6087501; U.S.Pat. No. 6004968; U.S. Pat. No. 5958980; U.S. Pat. No. 5955488; U.S.Pat. No. 5917042; U.S. Pat. No. 5917041; U.S. Pat. No. 5879706; U.S.Pat. No. 5877163; U.S. Pat. No. 5876961; U.S. Pat. No. 5872151; U.S.Pat. No. 5866612; U.S. Pat. No. 5856362; U.S. Pat. No. 5854270; U.S.Pat. No. 5840743; U.S. Pat. No. 5830455; U.S. Pat. No. 5776940; U.S.Pat. No. 5741806; U.S. Pat. No. 5723452; U.S. Pat. No. 5683990; U.S.Pat. No. 5683700; U.S. Pat. No. 5665754; U.S. Pat. No. 5663154; U.S.Pat. No. 5643913; U.S. Pat. No. 5607929; U.S. Pat. No. 5589474; U.S.Pat. No. 5589384; U.S. Pat. No. 6100277; U.S. Pat. No. 6417191; U.S.Pat. No. 6369272; U.S. Pat. No. 6525067; U.S. Pat. No. 6509337; U.S.Pat. No. 6506780; U.S. Pat. No. 6497899; U.S. Pat. No. 6492520; U.S.Pat. No. 6475784; U.S. Pat. No. 6462254; U.S. Pat. No. 6448265; U.S.Pat. No. 6444826; U.S. Pat. No. 6441018; U.S. Pat. No. 6441015; U.S.Pat. No. 6410297; U.S. Pat. No. 6403611; U.S. Pat. No. 6403587; U.S.Pat. No. 6399601; U.S. Pat. No. 6391872; U.S. Pat. No. 6380223; U.S.Pat. No. 6380219; U.S. Pat. No. 6355825; U.S. Pat. No. 6355670; U.S.Pat. No. 6316631; U.S. Pat. No. 6303636; U.S. Pat. No. 6288242; U.S.Pat. No. 6280974; U.S. Pat. No. 6274618; U.S. Pat. No. 6262040; U.S.Pat. No. 6248753; U.S. Pat. No. 6245766; U.S. Pat. No. 6242461; U.S.Pat. No. 6218397; U.S. Pat. No. 6214872; U.S. Pat. No. 6211222; U.S.Pat. No. 6153609; U.S. Pat. No. 6147074; U.S. Pat. No. 6147061; U.S.Pat. No. 6127398; U.S. Pat. No. 6107337; U.S. Pat. No. 6107331; U.S.Pat. No. 6103900; U.S. Pat. No. 6096906; U.S. Pat. No. 6077864; U.S.Pat. No. 6051578; U.S. Pat. No. 6040329; U.S. Pat. No. 6022978; U.S.Pat. No. 5994351; U.S. Pat. No. 5968944; U.S. Pat. No. 5962479; U.S.Pat. No. 5958953; U.S. Pat. No. 5958948; U.S. Pat. No. 5883131; U.S.Pat. No. 5863949; U.S. Pat. No. 5861510; U.S. Pat. No. 5854275; U.S.Pat. No. 5712303; U.S. Pat. No. 5705646; U.S. Pat. No. 5668145; U.S.Pat. No. 5603953; U.S. Pat. No. 6479284; U.S. Pat. No. 6410022; U.S.Pat. No. 6316604; U.S. Pat. No. 6261573; U.S. Pat. No. 6207171; U.S.Pat. No. 6193979; U.S. Pat. No. 6169068; U.S. Pat. No. 6015563; U.S.Pat. No. 5981481; U.S. Pat. No. 5911703; U.S. Pat. No. 6544961; U.S.Pat. No. 6544518; U.S. Pat. No. 6528512; U.S. Pat. No. 6518306; U.S.Pat. No. 6515027; U.S. Pat. No. 6514992; U.S. Pat. No. 6514953; U.S.Pat. No. 6506878; U.S. Pat. No. 6506790; U.S. Pat. No. 6506758; U.S.Pat. No. 6506386; U.S. Pat. No. 6500863; U.S. Pat. No. 6500432; U.S.Pat. No. 6498166; U.S. Pat. No. 6495606; U.S. Pat. No. 6492425; U.S.Pat. No. 6489325; U.S. Pat. No. 6486136; U.S. Pat. No. 6476028; U.S.Pat. No. 6469018; U.S. Pat. No. 6465493; U.S. Pat. No. 6461836; U.S.Pat. No. 6455507; U.S. Pat. No. 6455506; U.S. Pat. No. 6451794; U.S.Pat. No. 6451320; U.S. Pat. No. 6440993; U.S. Pat. No. 6436927; U.S.Pat. No. 6433156; U.S. Pat. No. 6428982; U.S. Pat. No. 6423508; U.S.Pat. No. 6414150; U.S. Pat. No. 6410529; U.S. Pat. No. 6403792; U.S.Pat. No. 6399656; U.S. Pat. No. 6391589; U.S. Pat. No. 6388055; U.S.Pat. No. 6387703; U.S. Pat. No. 6375945; U.S. Pat. No. 6372757; U.S.Pat. No. 6372227; U.S. Pat. No. 6369068; U.S. Pat. No. 6365389; U.S.Pat. No. 6362326; U.S. Pat. No. 6362193; U.S. Pat. No. 6361967; U.S.Pat. No. 6361773; U.S. Pat. No. 6358695; U.S. Pat. No. 6355689; U.S.Pat. No. 6355465; U.S. Pat. No. 6355452; U.S. Pat. No. 6355426; U.S.Pat. No. 6346388; U.S. Pat. No. 6344542; U.S. Pat. No. 6344342; U.S.Pat. No. 6340587; U.S. Pat. No. 6335352; U.S. Pat. No. 6335340; U.S.Pat. No. 6331542; U.S. Pat. No. 6329526; U.S. Pat. No. 6323333; U.S.Pat. No. 6323318; U.S. Pat. No. 6316478; U.S. Pat. No. 6313269; U.S.Pat. No. 6309854; U.S. Pat. No. 6306883; U.S. Pat. No. 6306625; U.S.Pat. No. 6300372; U.S. Pat. No. 6300325; U.S. Pat. No. 6297265; U.S.Pat. No. 6297036; U.S. Pat. No. 6288062; U.S. Pat. No. 6287801; U.S.Pat. No. 6284777; U.S. Pat. No. 6277977; U.S. Pat. No. 6277960; U.S.Pat. No. 6271261; U.S. Pat. No. 6268370; U.S. Pat. No. 6251914; U.S.Pat. No. 6248785; U.S. Pat. No. 6242572; U.S. Pat. No. 6242459; U.S.Pat. No. 6238873; U.S. Pat. No. 6232342; U.S. Pat. No. 6232084; U.S.Pat. No. 6222036; U.S. Pat. No. 6221889; U.S. Pat. No. 6221627; U.S.Pat. No. 6218539; U.S. Pat. No. 6218537; U.S. Pat. No. 6218136; U.S.Pat. No. 6214881; U.S. Pat. No. 6214858; U.S. Pat. No. 6214844; U.S.Pat. No. 6204294; U.S. Pat. No. 6200775; U.S. Pat. No. 6197069; U.S.Pat. No. 6180365; U.S. Pat. No. 6177448; U.S. Pat. No. 6174994; U.S.Pat. No. 6172118; U.S. Pat. No. 6166182; U.S. Pat. No. 6166055; U.S.Pat. No. 6165766; U.S. Pat. No. 6162899; U.S. Pat. No. 6159716; U.S.Pat. No. 6159700; U.S. Pat. No. 6153441; U.S. Pat. No. 6150557; U.S.Pat. No. 6146632; U.S. Pat. No. 6143521; U.S. Pat. No. 6133420; U.S.Pat. No. 6133319; U.S. Pat. No. 6133006; U.S. Pat. No. 6130067; U.S.Pat. No. 6124304; U.S. Pat. No. 6118017; U.S. Pat. No. 6114127; U.S.Pat. No. 6103936; U.S. Pat. No. 6096868; U.S. Pat. No. 6096748; U.S.Pat. No. 6074845; U.S. Pat. No. 6071722; U.S. Pat. No. 6071719; U.S.Pat. No. 6057362; U.S. Pat. No. 6057327; U.S. Pat. No. 6051579; U.S.Pat. No. 6046208; U.S. Pat. No. 6046025; U.S. Pat. No. 6043374; U.S.Pat. No. 6043054; U.S. Pat. No. 6043052; U.S. Pat. No. 6037367; U.S.Pat. No. 6037146; U.S. Pat. No. 6036959; U.S. Pat. No. 6033872; U.S.Pat. No. 6031090; U.S. Pat. No. 6025390; U.S. Pat. No. 6020157; U.S.Pat. No. 6015908; U.S. Pat. No. 6013827; U.S. Pat. No. 6010877; U.S.Pat. No. 6008235; U.S. Pat. No. 6008050; U.S. Pat. No. 6005074; U.S.Pat. No. 6001972; U.S. Pat. No. 6001963; U.S. Pat. No. 6001623; U.S.Pat. No. 5998470; U.S. Pat. No. 5998425; U.S. Pat. No. 5994098; U.S.Pat. No. 5990119; U.S. Pat. No. 5981525; U.S. Pat. No. 5981223; U.S.Pat. No. 5977122; U.S. Pat. No. 5977103; U.S. Pat. No. 5976834; U.S.Pat. No. 5972606; U.S. Pat. No. 5969184; U.S. Pat. No. 5965420; U.S.Pat. No. 5955366; U.S. Pat. No. 5955309; U.S. Pat. No. 5955308; U.S.Pat. No. 5942416; U.S. Pat. No. 5935814; U.S. Pat. No. 5929250; U.S.Pat. No. 5929076; U.S. Pat. No. 5916891; U.S. Pat. No. 5912335; U.S.Pat. No. 5910430; U.S. Pat. No. 5900417; U.S. Pat. No. 5892098; U.S.Pat. No. 5891883; U.S. Pat. No. 5889168; U.S. Pat. No. 5874252; U.S.Pat. No. 5874243; U.S. Pat. No. 5871967; U.S. Pat. No. 5871934; U.S.Pat. No. 5869677; U.S. Pat. No. 5869660; U.S. Pat. No. 5866616; U.S.Pat. No. 5866581; U.S. Pat. No. 5864036; U.S. Pat. No. 5863926; U.S.Pat. No. 5861421; U.S. Pat. No. 5858716; U.S. Pat. No. 5851798; U.S.Pat. No. 5834587; U.S. Pat. No. 5811549; U.S. Pat. No. 5811455; U.S.Pat. No. 5795918; U.S. Pat. No. 5783664; U.S. Pat. No. 5780667; U.S.Pat. No. 5777176; U.S. Pat. No. 5777160; U.S. Pat. No. 5777097; U.S.Pat. No. 5776468; U.S. Pat. No. 5767151; U.S. Pat. No. 5756499; U.S.Pat. No. 6455043; U.S. Pat. No. 6413771; U.S. Pat. No. 6270769; U.S.Pat. No. 6197311; U.S. Pat. No. 6136310; U.S. Pat. No. 5958765; U.S.Pat. No. 5955364; U.S. Pat. No. 5939068; U.S. Pat. No. 5866125; U.S.Pat. No. 5840298; U.S. Pat. No. 5811524; U.S. Pat. No. 5709860; U.S.Pat. No. 5695770; U.S. Pat. No. 5585103; U.S. Pat. No. 6420518; U.S.Pat. No. 6372453; U.S. Pat. No. 6342348; U.S. Pat. No. 6124435; U.S.Pat. No. 6066719; U.S. Pat. No. 6046048; U.S. Pat. No. 6030831; U.S.Pat. No. 6022735; U.S. Pat. No. 5869612; U.S. Pat. No. 5849533; U.S.Pat. No. 5821333; U.S. Pat. No. 5580723; U.S. Pat. No. 6221893; U.S.Pat. No. 6071942; U.S. Pat. No. 5670311; U.S. Pat. No. 6511801; U.S.Pat. No. 6495670; U.S. Pat. No. 6440662; U.S. Pat. No. 6331389; U.S.Pat. No. 6287761; U.S. Pat. No. 6265200; U.S. Pat. No. 6245503; U.S.Pat. No. 6210903; U.S. Pat. No. 6171784; U.S. Pat. No. 6165730; U.S.Pat. No. 6150134; U.S. Pat. No. 6087093; U.S. Pat. No. 6051696; U.S.Pat. No. 6013484; U.S. Pat. No. 6007982; U.S. Pat. No. 5992532; U.S.Pat. No. 5910404; U.S. Pat. No. 5981640; U.S. Pat. No. 5858647; U.S.Pat. No. 5846704; U.S. Pat. No. 5798743; U.S. Pat. No. 5736524; U.S.Pat. No. 5624795; U.S. Pat. No. 5567603; U.S. Pat. No. 5304466; U.S.Pat. No. 6537745; U.S. Pat. No. 6534064; U.S. Pat. No. 6531307; U.S.Pat. No. 6531276; U.S. Pat. No. 6525102; U.S. Pat. No. 6521225; U.S.Pat. No. 6512102; U.S. Pat. No. 6479284; U.S. Pat. No. 6476207; U.S.Pat. No. 6468986; U.S. Pat. No. 6465634; U.S. Pat. No. 6458560; U.S.Pat. No. 6458527; U.S. Pat. No. 6458370; U.S. Pat. No. 6451592; U.S.Pat. No. 6451539; U.S. Pat. No. 6451325; U.S. Pat. No. 6436666; U.S.Pat. No. 6428792; U.S. Pat. No. 6426196; U.S. Pat. No. 6423544; U.S.Pat. No. 6410326; U.S. Pat. No. 6410316; U.S. Pat. No. 6391632; U.S.Pat. No. 6376236; U.S. Pat. No. 6355247; U.S. Pat. No. 6346375; U.S.Pat. No. 6342372; U.S. Pat. No. 6333195; U.S. Pat. No. 6323326; U.S.Pat. No. 6319896; U.S. Pat. No. 6316253; U.S. Pat. No. 6310045; U.S.Pat. No. 6306405; U.S. Pat. No. 6303292; U.S. Pat. No. 6300484; U.S.Pat. No. 6300056; U.S. Pat. No. 6299884; U.S. Pat. No. 6297048; U.S.Pat. No. 6277590; U.S. Pat. No. 6261764; U.S. Pat. No. 6251433; U.S.Pat. No. 6241982; U.S. Pat. No. 6228620; U.S. Pat. No. 6190860; U.S.Pat. No. 6188969; U.S. Pat. No. 6183985; U.S. Pat. No. 6171782; U.S.Pat. No. 6150087; U.S. Pat. No. 6133029; U.S. Pat. No. 6114113; U.S.Pat. No. 6100064; U.S. Pat. No. 6097831; U.S. Pat. No. 6096541; U.S.Pat. No. 6096505; U.S. Pat. No. 6090621; U.S. Pat. No. 6087178; U.S.Pat. No. 6086901; U.S. Pat. No. 6074816; U.S. Pat. No. 6074635; U.S.Pat. No. 6069127; U.S. Pat. No. 6068994; U.S. Pat. No. 6060447; U.S.Pat. No. 6027729; U.S. Pat. No. 6022953; U.S. Pat. No. 6015694; U.S.Pat. No. 6013517; U.S. Pat. No. 6013432; U.S. Pat. No. 5997859; U.S.Pat. No. 5997856; U.S. Pat. No. 5989890; U.S. Pat. No. 5986079; U.S.Pat. No. 5965425; U.S. Pat. No. 5965382; U.S. Pat. No. 5965354; U.S.Pat. No. 5948640; U.S. Pat. No. 5932537; U.S. Pat. No. 5932467; U.S.Pat. No. 5914266; U.S. Pat. No. 5885799; U.S. Pat. No. 5872095; U.S.Pat. No. 5866362; U.S. Pat. No. 5863756; U.S. Pat. No. 5860917; U.S.Pat. No. 5856185; U.S. Pat. No. 5853974; U.S. Pat. No. 5853739; U.S.Pat. No. 5851759; U.S. Pat. No. 5849481; U.S. Pat. No. 5843723; U.S.Pat. No. 5843693; U.S. Pat. No. 5840496; U.S. Pat. No. 5837816; U.S.Pat. No. 5834307; U.S. Pat. No. 5830684; U.S. Pat. No. 5827648; U.S.Pat. No. 5824549; U.S. Pat. No. 5817792; U.S. Pat. No. 5817306; U.S.Pat. No. 5814485; U.S. Pat. No. 5814469; U.S. Pat. No. 5814458; U.S.Pat. No. 5792459; U.S. Pat. No. 5789245; U.S. Pat. No. 5789203; U.S.Pat. No. 5783674; U.S. Pat. No. 5767250; U.S. Pat. No. 5766845; U.S.Pat. No. 5763573; U.S. Pat. No. 5760203; U.S. Pat. No. 5756312; U.S.Pat. No. 5747444; U.S. Pat. No. 5747338; U.S. Pat. No. 5747248; U.S.Pat. No. 5736340; U.S. Pat. No. 5736327; U.S. Pat. No. 5730969; U.S.Pat. No. 5728520; U.S. Pat. No. 5712145; U.S. Pat. No. 5710264; U.S.Pat. No. 5709879; U.S. Pat. No. 5698446; U.S. Pat. No. 5698390; U.S.Pat. No. 5696238; U.S. Pat. No. 5688688; U.S. Pat. No. 5681702; U.S.Pat. No. 5681697; U.S. Pat. No. 5674706; U.S. Pat. No. 5670153; U.S.Pat. No. 5670152; U.S. Pat. No. 5656458; U.S. Pat. No. 5653985; U.S.Pat. No. 5644035; U.S. Pat. No. 5635352; U.S. Pat. No. 5631148; U.S.Pat. No. 5629203; U.S. Pat. No. 5629153; U.S. Pat. No. 5624802; U.S.Pat. No. 5620853; U.S. Pat. No. 5614362; U.S. Pat. No. 5605816; U.S.Pat. No. 5597909; U.S. Pat. No. 5597691; U.S. Pat. No. 5595886; U.S.Pat. No. 5594118; U.S. Pat. No. 5594117; U.S. Pat. No. 5585258; U.S.Pat. No. 5580790; U.S. Pat. No. 5571670; U.S. Pat. No. 6545027; U.S.Pat. No. 6521755; U.S. Pat. No. 6514976; U.S. Pat. No. 6465453; U.S.Pat. No. 6436964; U.S. Pat. No. 6358958; U.S. Pat. No. 6353008; U.S.Pat. No. 6303627; U.S. Pat. No. 6239135; U.S. Pat. No. 6172073; U.S.Pat. No. 6469105; U.S. Pat. No. 6107327; U.S. Pat. No. 6107307; U.S.Pat. No. 6046215; U.S. Pat. No. 6001810; U.S. Pat. No. 5958429; U.S.Pat. No. 5942387; U.S. Pat. No. 5912256; U.S. Pat. No. 5905077; U.S.Pat. No. 5846982; U.S. Pat. No. 5846974; U.S. Pat. No. 5821331; U.S.Pat. No. 5816260; U.S. Pat. No. 5789402; U.S. Pat. No. 5741789; U.S.Pat. No. 5734057; U.S. Pat. No. 5733906; U.S. Pat. No. 5732717; U.S.Pat. No. 5719287; U.S. Pat. No. 5672610; U.S. Pat. No. 5672496; U.S.Pat. No. 5627196; U.S. Pat. No. 5624734; U.S. Pat. No. 5614523; U.S.Pat. No. 5578608; U.S. Pat. No. 5576321; U.S. Pat. No. 5554653; U.S.Pat. No. 5552429; U.S. Pat. No. 5538992; U.S. Pat. No. 5532268; U.S.Pat. No. 5532264; U.S. Pat. No. 5532250; U.S. Pat. No. 5532244; U.S.Pat. No. 5514802; U.S. Pat. No. 5514778; U.S. Pat. No. 5508407; U.S.Pat. No. 5506118; U.S. Pat. No. 5502061; U.S. Pat. No. 6541496; U.S.Pat. No. 6531474; U.S. Pat. No. 6528508; U.S. Pat. No. 6528276; U.S.Pat. No. 6518291; U.S. Pat. No. 6514687; U.S. Pat. No. 6509363; U.S.Pat. No. 6498178; U.S. Pat. No. 6436989; U.S. Pat. No. 6426413; U.S.Pat. No. 6423840; U.S. Pat. No. 6395763; U.S. Pat. No. 6392046; U.S.Pat. No. 6372778; U.S. Pat. No. 6350741; U.S. Pat. No. 6344465; U.S.Pat. No. 6329365; U.S. Pat. No. 6319946; U.S. Pat. No. 6265380; U.S.Pat. No. 6258948; U.S. Pat. No. 6204261; U.S. Pat. No. 6462790; U.S.Pat. No. 6147080; U.S. Pat. No. 6128582; U.S. Pat. No. 6127372; U.S.Pat. No. 6117639; U.S. Pat. No. 6093742; U.S. Pat. No. 6054472; U.S.Pat. No. 6008217; U.S. Pat. No. 6004957; U.S. Pat. No. 5990155; U.S.Pat. No. 5978780; U.S. Pat. No. 5977137; U.S. Pat. No. 5945418; U.S.Pat. No. 5945413; U.S. Pat. No. 5932600; U.S. Pat. No. 5883252; U.S.Pat. No. 5874424; U.S. Pat. No. 5861267; U.S. Pat. No. 5856353; U.S.Pat. No. 5843904; U.S. Pat. No. 5807876; U.S. Pat. No. 5783701; U.S.Pat. No. 5723490; U.S. Pat. No. 5723459; U.S. Pat. No. 5693847; U.S.Pat. No. 5691372; U.S. Pat. No. 5646180; U.S. Pat. No. 5620971; U.S.Pat. No. 5585397; U.S. Pat. No. 5516797; U.S. Pat. No. 6482804; U.S.Pat. No. 6465508; U.S. Pat. No. 6462055; U.S. Pat. No. 6444668; U.S.Pat. No. 6436929; U.S. Pat. No. 6429214; U.S. Pat. No. 6423308; U.S.Pat. No. 6399593; U.S. Pat. No. 6541472; U.S. Pat. No. 5830894; U.S.Pat. No. 6531286; U.S. Pat. No. 6465649; U.S. Pat. No. 6465188; U.S.Pat. No. 6451340; U.S. Pat. No. 6441161; U.S. Pat. No. 6432631; U.S.Pat. No. 6426335; U.S. Pat. No. 6395888; U.S. Pat. No. 6387635; U.S.Pat. No. 6387620; U.S. Pat. No. 6376474; U.S. Pat. No. 6346611; U.S.Pat. No. 6344321; U.S. Pat. No. 6344318; U.S. Pat. No. 6331398; U.S.Pat. No. 6331394; U.S. Pat. No. 6300074; U.S. Pat. No. 6280943; U.S.Pat. No. 6280932; U.S. Pat. No. 6261783; U.S. Pat. No. 6261774; U.S.Pat. No. 6232071; U.S. Pat. No. 6225460; U.S. Pat. No. 6069249; U.S.Pat. No. 6043230; U.S. Pat. No. 6034118; U.S. Pat. No. 5977089; U.S.Pat. No. 5935946; U.S. Pat. No. 5922695; U.S. Pat. No. 5886179; U.S.Pat. No. 5830653; U.S. Pat. No. 5815781; U.S. Pat. No. 5811450; U.S.Pat. No. 5798340; U.S. Pat. No. 5792608; U.S. Pat. No. 5767100; U.S.Pat. No. 5763208; U.S. Pat. No. 5756486; U.S. Pat. No. 5756291; U.S.Pat. No. 5717095; U.S. Pat. No. 5705524; U.S. Pat. No. 5693771; U.S.Pat. No. 5659023; U.S. Pat. No. 5656745; U.S. Pat. No. 5645985; U.S.Pat. No. 5633360; U.S. Pat. No. 5594121; U.S. Pat. No. 5591851; U.S.Pat. No. 5565555; U.S. Pat. No. 5993812; U.S. Pat. No. 6518274; U.S.Pat. No. 6514936; U.S. Pat. No. 6504019; U.S. Pat. No. 6465175; U.S.Pat. No. 6462180; U.S. Pat. No. 6437102; U.S. Pat. No. 6433157; U.S.Pat. No. 6420393; U.S. Pat. No. 6399657; U.S. Pat. No. 6348192; U.S.Pat. No. 6344476; U.S. Pat. No. 6335426; U.S. Pat. No. 6326004; U.S.Pat. No. 6288063; U.S. Pat. No. 6262334; U.S. Pat. No. 6262333; U.S.Pat. No. 6239155; U.S. Pat. No. 6232462; U.S. Pat. No. 6194428; U.S.Pat. No. 6187538; U.S. Pat. No. 6180777; U.S. Pat. No. 6180339; U.S.Pat. No. 6174897; U.S. Pat. No. 6147087; U.S. Pat. No. 6046836; U.S.Pat. No. 6143298; U.S. Pat. No. 6130202; U.S. Pat. No. 6121284; U.S.Pat. No. 6107461; U.S. Pat. No. 6103925; U.S. Pat. No. 6066655; U.S.Pat. No. 6008259; U.S. Pat. No. 6001857; U.S. Pat. No. 5990121; U.S.Pat. No. 5986059; U.S. Pat. No. 5958693; U.S. Pat. No. 5955482; U.S.Pat. No. 5942526; U.S. Pat. No. 5874462; U.S. Pat. No. 5874438; U.S.Pat. No. 5871733; U.S. Pat. No. 5866562; U.S. Pat. No. 5861394; U.S.Pat. No. 5849893; U.S. Pat. No. 5837519; U.S. Pat. No. 5833946; U.S.Pat. No. 5798265; U.S. Pat. No. 5760230; U.S. Pat. No. 5760073; U.S.Pat. No. 5756517; U.S. Pat. No. 6534482; U.S. Pat. No. 6419931; U.S.Pat. No. 6413935; U.S. Pat. No. 6413517; U.S. Pat. No. 6322789; U.S.Pat. No. 6037135; U.S. Pat. No. 6495521; U.S. Pat. No. 6288033; U.S.Pat. No. 6200952; U.S. Pat. No. 6001799; U.S. Pat. No. 5939423; U.S.Pat. No. 5849696; U.S. Pat. No. 5308833; U.S. Pat. No. 6541486; U.S.Pat. No. 6451828; U.S. Pat. No. 6379882; U.S. Pat. No. 6375986; U.S.Pat. No. 6221400; U.S. Pat. No. 6140484; U.S. Pat. No. 6068858; U.S.Pat. No. 6045829; U.S. Pat. No. 6537973; U.S. Pat. No. 6531584; U.S.Pat. No. 6528631; U.S. Pat. No. 6525031; U.S. Pat. No. 6500945; U.S.Pat. No. 6495671; U.S. Pat. No. 6486312; U.S. Pat. No. 6451991; U.S.Pat. No. 6451968; U.S. Pat. No. 6448373; U.S. Pat. No. 6448079; U.S.Pat. No. 6441130; U.S. Pat. No. 6440943; U.S. Pat. No. 6423489; U.S.Pat. No. 6410702; U.S. Pat. No. 6403779; U.S. Pat. No. 6399754; U.S.Pat. No. 6399589; U.S. Pat. No. 6399376; U.S. Pat. No. 6395492; U.S.Pat. No. 6391542; U.S. Pat. No. 6380368; U.S. Pat. No. 6380169; U.S.Pat. No. 6369209; U.S. Pat. No. 6368863; U.S. Pat. No. 6359061; U.S.Pat. No. 6358931; U.S. Pat. No. 6339066; U.S. Pat. No. 6335434; U.S.Pat. No. 6335194; U.S. Pat. No. 6329523; U.S. Pat. No. 6326358; U.S.Pat. No. 6320040; U.S. Pat. No. 6319906; U.S. Pat. No. 6316626; U.S.Pat. No. 6316623; U.S. Pat. No. 6312900; U.S. Pat. No. 6307040; U.S.Pat. No. 6300319; U.S. Pat. No. 6294664; U.S. Pat. No. 6277982; U.S.Pat. No. 6277967; U.S. Pat. No. 6277334; U.S. Pat. No. 6271357; U.S.Pat. No. 6262241; U.S. Pat. No. 6242589; U.S. Pat. No. 6239265; U.S.Pat. No. 6235887; U.S. Pat. No. 6235886; U.S. Pat. No. 6232463; U.S.Pat. No. 6222025; U.S. Pat. No. 6221850; U.S. Pat. No. 6214551; U.S.Pat. No. 6211350; U.S. Pat. No. 6204055; U.S. Pat. No. 6197965; U.S.Pat. No. 6197584; U.S. Pat. No. 6194598; U.S. Pat. No. 6191273; U.S.Pat. No. 6177246; U.S. Pat. No. 6174868; U.S. Pat. No. 6172209; U.S.Pat. No. 6166197; U.S. Pat. No. 6165788; U.S. Pat. No. 6156758; U.S.Pat. No. 6153737; U.S. Pat. No. 6153595; U.S. Pat. No. 6150129; U.S.Pat. No. 6147200; U.S. Pat. No. 6140124; U.S. Pat. No. 6133246; U.S.Pat. No. 6127533; U.S. Pat. No. 6124450; U.S. Pat. No. 6111094; U.S.Pat. No. 6096722; U.S. Pat. No. 6090626; U.S. Pat. No. 6077954; U.S.Pat. No. 6077833; U.S. Pat. No. 6077709; U.S. Pat. No. 6077672; U.S.Pat. No. 6045995; U.S. Pat. No. 6034233; U.S. Pat. No. 6033910; U.S.Pat. No. 6030786; U.S. Pat. No. 6025482; U.S. Pat. No. 6022691; U.S.Pat. No. 6020198; U.S. Pat. No. 6007995; U.S. Pat. No. 6005087; U.S.Pat. No. 6004814; U.S. Pat. No. 6001991; U.S. Pat. No. 6001982; U.S.Pat. No. 6001841; U.S. Pat. No. 6001652; U.S. Pat. No. 6001651; U.S.Pat. No. 5998603; U.S. Pat. No. 5998419; U.S. Pat. No. 5986053; U.S.Pat. No. 5985663; U.S. Pat. No. 5985662; U.S. Pat. No. 5985558; U.S.Pat. No. 5969118; U.S. Pat. No. 5965721; U.S. Pat. No. 5965370; U.S.Pat. No. 5962672; U.S. Pat. No. 5962671; U.S. Pat. No. 5959096; U.S.Pat. No. 5955589; U.S. Pat. No. 5955443; U.S. Pat. No. 5952490; U.S.Pat. No. 5952229; U.S. Pat. No. 5945290; U.S. Pat. No. 5945290; U.S.Pat. No. 5925732; U.S. Pat. No. 5922872; U.S. Pat. No. 5922686; U.S.Pat. No. 5919773; U.S. Pat. No. 5916807; U.S. Pat. No. 5886177; U.S.Pat. No. 5885970; U.S. Pat. No. 5882927; U.S. Pat. No. 5877309; U.S.Pat. No. 5874564; U.S. Pat. No. 5872232; U.S. Pat. No. 5866698; U.S.Pat. No. 5859221; U.S. Pat. No. 5856099; U.S. Pat. No. 5852188; U.S.Pat. No. 5847106; U.S. Pat. No. 5837449; U.S. Pat. No. 5834607; U.S.Pat. No. 5817489; U.S. Pat. No. 5811534; U.S. Pat. No. 5808023; U.S.Pat. No. 5807838; U.S. Pat. No. 5798360; U.S. Pat. No. 5792844; U.S.Pat. No. 5783682; U.S. Pat. No. 5780241; U.S. Pat. No. 5767102; U.S.Pat. No. 5747253; U.S. Pat. No. 5744362; U.S. Pat. No. 5736294; U.S.Pat. No. 5731438; U.S. Pat. No. 5723335; U.S. Pat. No. 5717083; U.S.Pat. No. 5698391; U.S. Pat. No. 5688941; U.S. Pat. No. 5686242; U.S.Pat. No. 6544761; U.S. Pat. No. 6541452; U.S. Pat. No. 6541249; U.S.Pat. No. 6541224; U.S. Pat. No. 6538121; U.S. Pat. No. 6537966; U.S.Pat. No. 6534631; U.S. Pat. No. 6534485; U.S. Pat. No. 6531447; U.S.Pat. No. 6525174; U.S. Pat. No. 6524826; U.S. Pat. No. 6521742; U.S.Pat. No. 6521441; U.S. Pat. No. 6509173; U.S. Pat. No. 6509170; U.S.Pat. No. 6506882; U.S. Pat. No. 6506569; U.S. Pat. No. 6503184; U.S.Pat. No. 6500638; U.S. Pat. No. 6495520; U.S. Pat. No. 6495519; U.S.Pat. No. 6495322; U.S. Pat. No. 6495129; U.S. Pat. No. 6495128; U.S.Pat. No. 6489138; U.S. Pat. No. 6488925; U.S. Pat. No. 6486301; U.S.Pat. No. 6485719; U.S. Pat. No. 6482923; U.S. Pat. No. 6479254; U.S.Pat. No. 6476195; U.S. Pat. No. 6475753; U.S. Pat. No. 6472512; U.S.Pat. No. 6468768; U.S. Pat. No. 6461823; U.S. Pat. No. 6455040; U.S.Pat. No. 6451562; U.S. Pat. No. 6448230; U.S. Pat. No. 6448044; U.S.Pat. No. 6448043; U.S. Pat. No. 6444440; U.S. Pat. No. 6433147; U.S.Pat. No. 6433145; U.S. Pat. No. 6433139; U.S. Pat. No. 6420526; U.S.Pat. No. 6420116; U.S. Pat. No. 6416989; U.S. Pat. No. 6413933; U.S.Pat. No. 6413726; U.S. Pat. No. 6410709; U.S. Pat. No. 6406867; U.S.Pat. No. 6403770; U.S. Pat. No. 6403557; U.S. Pat. No. 6403337; U.S.Pat. No. 6395514; U.S. Pat. No. 6391589; U.S. Pat. No. 6379926; U.S.Pat. No. 6379923; U.S. Pat. No. 6372473; U.S. Pat. No. 6372456; U.S.Pat. No. 6372454; U.S. Pat. No. 6358508; U.S. Pat. No. 6346246; U.S.Pat. No. 6342581; U.S. Pat. No. 6342363; U.S. Pat. No. 6333182; U.S.Pat. No. 6316609; U.S. Pat. No. 6316225; U.S. Pat. No. 6312937; U.S.Pat. No. 6303338; U.S. Pat. No. 6300477; U.S. Pat. No. 6294164; U.S.Pat. No. 6284486; U.S. Pat. No. 6262233; U.S. Pat. No. 6255079; U.S.Pat. No. 6232291; U.S. Pat. No. 6232100; U.S. Pat. No. 6222019; U.S.Pat. No. 6214580; U.S. Pat. No. 6191260; U.S. Pat. No. 6171816; U.S.Pat. No. 6153402; U.S. Pat. No. 6143498; U.S. Pat. No. 6139832; U.S.Pat. No. 6130079; U.S. Pat. No. 6120999; U.S. Pat. No. 6114503; U.S.Pat. No. 6114145; U.S. Pat. No. 6093795; U.S. Pat. No. 6087150; U.S.Pat. No. 6077692; U.S. Pat. No. 6066617; U.S. Pat. No. 6046035; U.S.Pat. No. 6046031; U.S. Pat. No. 6040157; U.S. Pat. No. 6028169; U.S.Pat. No. 6027916; U.S. Pat. No. 6011012; U.S. Pat. No. 6008020; U.S.Pat. No. 6008018; U.S. Pat. No. 6004780; U.S. Pat. No. 6001606; U.S.Pat. No. 5998171; U.S. Pat. No. 5994302; U.S. Pat. No. 5994102; U.S.Pat. No. 5986069; U.S. Pat. No. 5985614; U.S. Pat. No. 5981215; U.S.Pat. No. 5968780; U.S. Pat. No. 5965421; U.S. Pat. No. 5962411; U.S.Pat. No. 5958400; U.S. Pat. No. 5945309; U.S. Pat. No. 5919658; U.S.Pat. No. 5874240; U.S. Pat. No. 5780263; U.S. Pat. No. 5747280; U.S.Pat. No. 5721113; U.S. Pat. No. 5641657; U.S. Pat. No. 5597709; U.S.Pat. No. 6545035; U.S. Pat. No. 6534523; U.S. Pat. No. 6525046; U.S.Pat. No. 6506748; U.S. Pat. No. 6500963; U.S. Pat. No. 6492529; U.S.Pat. No. 6492393; U.S. Pat. No. 6432995; U.S. Pat. No. 6420380; U.S.Pat. No. 6420359; U.S. Pat. No. 6410531; U.S. Pat. No. 6399781; U.S.Pat. No. 6372773; U.S. Pat. No. 6358945; U.S. Pat. No. 6335016; U.S.Pat. No. 6333325; U.S. Pat. No. 6329417; U.S. Pat. No. 6329415; U.S.Pat. No. 6329379; U.S. Pat. No. 6323180; U.S. Pat. No. 6319918; U.S.Pat. No. 6297381; U.S. Pat. No. 6297028; U.S. Pat. No. 6284880; U.S.Pat. No. 6274322; U.S. Pat. No. 6268207; U.S. Pat. No. 6255481; U.S.Pat. No. 6242453; U.S. Pat. No. 6228881; U.S. Pat. No. 6180385; U.S.Pat. No. 6172059; U.S. Pat. No. 6169106; U.S. Pat. No. 6143715; U.S.Pat. No. 6136982; U.S. Pat. No. 6111112; U.S. Pat. No. 6090542; U.S.Pat. No. 6080763; U.S. Pat. No. 6077663; U.S. Pat. No. 6043254; U.S.Pat. No. 6022735; U.S. Pat. No. 5981273; U.S. Pat. No. 5922859; U.S.Pat. No. 5919779; U.S. Pat. No. 5908841; U.S. Pat. No. 5869482; U.S.Pat. No. 5847169; U.S. Pat. No. 5837704; U.S. Pat. No. 5807870; U.S.Pat. No. 5792645; U.S. Pat. No. 5789230.

[0167] U.S. Patent Application Publication 2003/0055071 A1; U.S. PatentApplication Publication 2002/0193415 A1; U.S. Patent Application2002/0198247 A1; U.S. Patent Application Publication 2002/0198378 A1;U.S. Patent Application Publication 2002/0198388 A1; U.S. PatentApplication Publication 2003/0004185 A1; U.S. Patent ApplicationPublication 2003/0008877 A1; U.S. Patent Application Publication2003/0013751 A1; U.S. Patent Application Publication 2003/0040633 A1;U.S. Patent Application Publication 2002/0068749 A1; U.S. PatentApplication Publication 2002/0072606 A1; U.S. Patent ApplicationPublication 2002/0077338 A1; U.S. Patent Application Publication2002/0082249 A1; U.S. Patent Application Publication 2002/0107261 A1;U.S. Patent Application Publication 2002/0107264 A1; U.S. PatentApplication Publication 2002/0111368 A1; U.S. Patent ApplicationPublication 2002/0061892 A1; U.S. Patent Application Publication2002/0061836 A1; U.S. Patent Application Publication 2002/0052399 A1;U.S. Patent Application Publication 2002/0049201 A1; U.S. PatentApplication Publication 2002/0049165 A1; U.S. Patent ApplicationPublication 2002/0045658 A1; U.S. Patent Application Publication2002/0028791 A1; U.S. Patent Application Publication 2002/0022742 A1;U.S. Patent Application Publication 2002/0022659 A1; U.S. PatentApplication Publication 2002/0019434 A1; U.S. Patent ApplicationPublication 2001/0051635 A1; U.S. Patent Application Publication2001/0044547 A1; U.S. Patent Application Publication 2001/0031773 A1;U.S. Patent Application Publication 2001/0020093 A1; U.S. PatentApplication Publication 2001/0011088 A1; U.S. Patent ApplicationPublication 2002/0137942 A1. U.S. Patent Application Publication20030060645; U.S. Patent Application Publication 20020006417; U.S.Patent Application Publication 20020111495; U.S. Patent ApplicationPublication 20030064997; U.S. Patent Application Publication20020169173; U.S. Patent Application Publication 20020107196; U.S.Patent Application Publication 20020107195; U.S. Patent ApplicationPublication 20020082202; U.S. Patent Application Publication20020064852; U.S. Patent Application Publication 20010053365; U.S.Patent Application Publication 20030026804; U.S. Patent ApplicationPublication 20030003097; U.S. Patent Application Publication20020187146; U.S. Patent Application Publication 20020044930; U.S.Patent Application Publication 20020039582; U.S. Patent ApplicationPublication 20020009444; U.S. Patent Application Publication20020006404; U.S. Patent Application Publication 20010019715; U.S.Patent Application Publication 20010018054; U.S. Patent ApplicationPublication 20030017508; U.S. Patent Application Publication20030013130; U.S. Patent Application Publication 20020192699; U.S.Patent Application Publication 20020172661; U.S. Patent ApplicationPublication 20020141971; U.S. Patent Application Publication20020068354; U.S. Patent Application Publication 20020055125; U.S.Patent Application Publication 20020025329; U.S. Patent ApplicationPublication 20020015707; U.S. Patent Application Publication20010043915; U.S. Patent Application Publication 20010024807; U.S.Patent Application Publication 20020197702; U.S. Patent ApplicationPublication 20020155579; U.S. Patent Application Publication20020128306; U.S. Patent Application Publication 20030069222; U.S.Patent Application Publication 20030064977; U.S. Patent ApplicationPublication 20020198388; U.S. Patent Application Publication20030035332; U.S. Patent Application Publication 20030013732; U.S.Patent Application Publication 20030049644; U.S. Patent ApplicationPublication 20030003461; U.S. Patent Application Publication20020172962; U.S. Patent Application Publication 20020150536; U.S.Patent Application Publication 20020119443; U.S. Patent ApplicationPublication 20020102599; U.S. Patent Application Publication20020055113; U.S. Patent Application Publication 20020034506; U.S.Patent Application Publication 20010041794; U.S. Patent ApplicationPublication 20030059918; U.S. Patent Application Publication20020177150; U.S. Patent Application Publication 20030069409; U.S.Patent Application Publication 20030069408; U.S. Patent ApplicationPublication 20030068627; U.S. Patent Application Publication20030065151; U.S. Patent Application Publication 20030059908; U.S.Patent Application Publication 20030059875; U.S. Patent ApplicationPublication 20030059874; U.S. Patent Application Publication20030059431; U.S. Patent Application Publication 20030054420; U.S.Patent Application Publication 20030054379; U.S. Patent ApplicationPublication 20030054377; U.S. Patent Application Publication20030054375; U.S. Patent Application Publication 20030054373; U.S.Patent Application Publication 20030054368; U.S. Patent ApplicationPublication 20030050443; U.S. Patent Application Publication20030050442; U.S. Patent Application Publication 20030049703; U.S.Patent Application Publication 20030049652; U.S. Patent ApplicationPublication 20030049650; U.S. Patent Application Publication20030044907; U.S. Patent Application Publication 20030044905; U.S.Patent Application Publication 20030044904; U.S. Patent ApplicationPublication 20030044851; U.S. Patent Application Publication20030040088; U.S. Patent Application Publication 20030040081; U.S.Patent Application Publication 20030039994; U.S. Patent ApplicationPublication 20030039993; U.S. Patent Application Publication20030036505; U.S. Patent Application Publication 20030036168; U.S.Patent Application Publication 20030023070; U.S. Patent ApplicationPublication 20030023068; U.S. Patent Application Publication20030022345; U.S. Patent Application Publication 20030022338; U.S.Patent Application Publication 20030022314; U.S. Patent ApplicationPublication 20030022289; U.S. Patent Application Publication20030017500; U.S. Patent Application Publication 20030017495; U.S.Patent Application Publication 20030004327; U.S. Patent ApplicationPublication 20020197701; U.S. Patent Application Publication20020187526; U.S. Patent Application Publication 20020183503; U.S.Patent Application Publication 20020177213; U.S. Patent ApplicationPublication 20020173640; U.S. Patent Application Publication20020168729; U.S. Patent Application Publication 20020168359; U.S.Patent Application Publication 20020165384; U.S. Patent ApplicationPublication 20020165137; U.S. Patent Application Publication20020164768; U.S. Patent Application Publication 20020164714; U.S.Patent Application Publication 20020164694; U.S. Patent ApplicationPublication 20020098550; U.S. Patent Application Publication20020098525; U.S. Patent Application Publication 20020098163; U.S.Patent Application Publication 20020081647; U.S. Patent ApplicationPublication 20020072595; U.S. Patent Application Publication20020072091; U.S. Patent Application Publication 20020064869; U.S.Patent Application Publication 20020064829; U.S. Patent ApplicationPublication 20020061551; U.S. Patent Application Publication20020055142; U.S. Patent Application Publication 20020052476; U.S.Patent Application Publication 20020052024; U.S. Patent ApplicationPublication 20020045737; U.S. Patent Application Publication20020042372; U.S. Patent Application Publication 20020042119; U.S.Patent Application Publication 20020009773; U.S. Patent ApplicationPublication 20010029034; U.S. Patent Application Publication20010021516.

[0168] Cancer Section:

[0169] A 84441, Abbott; AD 143, Sidney Farber Cancer Institute; AD 198,Tennessee University; AGM 1470, Harvard University; amrubicin, Sumitomo;antibiotic SO 75R1, Hokkaido University; azamitosenes, Arizona StateUniversity; betaclamycin B, Institute of Microbial Chemistry; breflate,National Cancer Institute; C 1027, Taiho; clavalanine, NAEJA; CNF 101,Conforma; cordycepin, National Cancer Institute; D 26232, Baxter; D2A21,Demegen; daunoform, University of Colorado; dioxamycin, Institute ofMicrobial Chemistry; doxoform, University of Colorado; duocarmycin B2,Kyowa Hakko; E 7010, Eisai; elsamitrucin, Bristol-Myers Squibb;epidoxoform, University of Colorado; ER 34410, Eisai; ER 35744, Eisai;FCE 21424, Pharmacia Corporation; FCE 24366; Pharmacia Corporation; FCE24367, Pharmacia Corporation; fluorodaunorubicin hydrochloride, SagamiChemical Research Center; galarubicin, Dong-A; GPX 100, Gem;hatomamicin, Yamanouchi; HMN 214, Nippon Shinyaku; hyrubicin, II Dong;IC 101, Microbial Chemistry Research Foundation; iododoxorubicin,Pharmacia Corporation; IST 622, Ishihara Sangyo; JSM ASB001, Josman; JSMBCYL001, Josman; JSM BIAS001, Josman; L 377202, Merck & Co;leptolstatin, Tokyo University; MEN 10755, Bristol-Myers Squibb;menogaril, Pharmacia Corporation; nemorubicin, Pharmacia Corporation;nisamycin, Osaka University; oxaunomycin, Sanraku; phenazinomycin,Kitasato University; pibrozelesin, Kyowa Hakko; placetin A, Yamanouchi;placetin B, Yamanouchi; reveromycin A, Snow Brand Milk Products;rhizoxin, National Institute of Agro-Environmental Sciences; RK 1409B,Saitama Cancer Center Research Institute; ruboxyl, Russian Academy ofSciences; SP 1049C, Supratek; SYN 1127, NAEJA; SYN 1932, Taiho;tetrazomine, Yamanouchi; Y 05460MA, Yamanouchi; A 316023, Abbott; AE941, Aetema; AG 13925, Agouron; atrasentan, Abbott; B 201, University ofColorado; BIM 46228, Biomeasure; BMS 214662, Bristol-Myers Squibb; BMS247550, Bristol-Myers Squibb; BMS 275291, Celltech Group; BN 80927,Biomeasure; canertinib dihydrochloride, Pfizer; carbendazim, Procter &Gamble; CDC 394, Rockefeller University; CDC 501, Celgene; CEP 7055,Cephalon; CHIR 200131, Chiron Corporation; CI 1040, Agouron;clofarabine, Southern Research Institute; CMT 3, New York StateUniversity Research Foundation; CP 461, Cell Pathways; CP 547632, OSI; D24851, Baxter; DRF 1042, Dr Reddys Research Foundation; EKB 569, Wyeth,elacridar, GlaxoSmithKline; ER 6820300, Eisai; erlotinib, Pfizer;exizulind, Cell Pathways; fenretinide, McNeil; flurbiprofen, R-, Encore;GW 2286, GlaxoSmithKline; GW 572016, GlaxoSmithKline; halofuginone,Collgard; HTI 286, Wyeth; ILX 237553, Hoffinan LaRoche; ILX 651, BASF;KP 0201448, Kinetix; KRN 633, Kirin Brewery; lonafarnib,Schering-Plough; LY 293111, Eli Lilly; LY 317615, Eli Lilly; marimastat,British Biotech; midostaurin, Novartis; miglustat, Oxford University;minodronic acid, Yamanouchi; MLN 518, Millenium; MS 209,Schering-Plough; MS 275, Mitsui; NC 381, Ion; NM 3, Microbial ChemistryResearch Foundation; NSC 639829, National Cancer Institute; OC 144093,Ontogen; OCX 191, Yale University; ONYX 015, Onyx; PC 4071, SignatureBioScience; perlifosine, Baxter; prinomastat, Agouron; R 440, HoffinanLaRoche; R(+)XK 469, Wayne State University; reminertant,Sanofi-Synthelabo; Ro 317453, Hoffman LaRoche; S 247, PharmaciaCorporation; SC 77964, Pharmacia Corporation; SCH 226374,Schering-Plough; SG 292, SignalGene; solimastat, British Biotech; SR271425, Sanofi-Synthelabo; SU 6668, SUGEN; TAK 165, Takeda ChemicalIndustries; tariquidar, Xenova; thalidomide, Boston Childrens Hospital;tilmacoxib, Japan Tobacco; timcodar, Vertex Pharmaceuticals; tipifarnib,Janssen Cilag; XR 11576, Xenova; XR 11612, Xenova; XR 5944, Xenova; XV454, Bristol-Myers Squibb; YM 598, Yamanouchi; ZD 0473, Johnson Matthey;ZD 6474, AstraZeneca; zosuquidar trihydrochloride, Roche Bioscience; (−)BRT 216, Elan Corporation; 109881, Aventis; 9-aminocamptothecin,Research Triangle Institute; andrographolide, Paracelsian;anhydrovinblastine, Prescient NeuroPharma; annonaceous acetogenins,Purdue University; ANVIRZEL, Ozelle; ARGLABIN, NuOncology; baccatin IIIderivatives, Indena; beta lapachone, Dana Farber Cancer Institute;betulinic acid, Illinois University; BMS 184476, Bristol-Myers Squibb;BMS 275183, Bristol-Myers Squibb; BP 179, Biophysica; bromotaxol,Liposome Company; camptothecin analogues, Bristol-Myers Squibb;camptothecin derivatives, Daiichi; CIDI, IDI; CKD 602, Chong Kun Dang;CP 55940, Pfizer; CUR 61414, Johns Hopkins University; DB 67, NationalCancer Institute; DHA-paclitaxel, Protarga; diflomotecan, Beafour Ipsen;dihydrotaxol,9-, Abbott; DJ 927, Daiichi; docetaxel, Aventis; exatecanmesylate, Daiichi; gambogic acid, Maxim; GPO 1986, GovernmentPharmaceutical Organization; HAR 7, Glycosyn; IDN 5109, Indena; IDN5390, Indena; irinotecan, Yakult; karenitecin, BioNumerik;kaurenil-O-glucopiranose, Lisandro Alvarado Central Western University;lurtotecan, GlaxoSmithKline; maitansine, Takeda Chemical Industries; P54, Phytochemindo; paclitaxel, National Cancer Institute; perillylalcohol, Wisconsin Alumni Research Foundation; PN 271, Paracelsian; PN272, Paracelsian; PN 273, Paracelsian; PN 274, Paracelsian; PN 275,Paracelsian; polyethylene glycol paclitaxel, Enzon; polyethyleneglycol-camptothecin, Enzon; RPR 116258A, Aventis; rubitecan, ClaytonFoundation for Research; salvianolic acid A, Chinese Academy of MedicalSciences; SP 0110C, Supratek; T4GEN, University of Southern California;tafluposide, Fabre; tanshinone II A, West China University of MedicalSciences; TOP 53, Taiho; topotecan, GlaxoSmithKline; tridolgosir, MountSinai Hospital Research Institute; TXD 258, Aventis; TZ 93, Tsumura;vinflunine, Fabre; vinorelbine, ANVAR; vinxaltine, Servier; ZYN-LINKERconjugated paclitaxel, Phanos. U.S. Pat. No. 6545170; U.S. Pat. No.6545129; U.S. Pat. No. 6545009; U.S. Pat. No. 6544768; U.S. Pat. No.6544761; U.S. Pat. No. RE38073; U.S. Pat. No. 6541252; U.S. Pat. No.6541224; U.S. Pat. No. 6541013; U.S. Pat. No. 6541011; U.S. Pat. No.6540980; U.S. Pat. No. 6538107; U.S. Pat. No. 6537966; U.S. Pat. No.6534641; U.S. Pat. No. 6534631; U.S. Pat. No. 6534486; U.S. Pat. No.6534485; U.S. Pat. No. 6534298; U.S. Pat. No. 6534277; U.S. Pat. No.6534067; U.S. Pat. No. 6531604; U.S. Pat. No. 6531575; U.S. Pat. No.6531484; U.S. Pat. No. 6531316; U.S. Pat. No. 6531309; U.S. Pat. No.6531305; U.S. Pat. No. 6531125; U.S. Pat. No. 6528308; U.S. Pat. No.6528270; U.S. Pat. No. 6528093; U.S. Pat. No. 6528060; U.S. Pat. No.6527689; U.S. Pat. No. 6524841; U.S. Pat. No. 6524840; U.S. Pat. No.6524838; U.S. Pat. No. 6524806; U.S. Pat. No. 6524792; U.S. Pat. No.6524582; U.S. Pat. No. 6524579; U.S. Pat. No. 6521448; U.S. Pat. No.6521412; U.S. Pat. No. 6521228; U.S. Pat. No. 6518402; U.S. Pat. No.6518315; U.S. Pat. No. 6518298; U.S. Pat. No. 6518268; U.S. Pat. No.6518257; U.S. Pat. No. 6518035; U.S. Pat. No. 3518029; U.S. Pat. No.6515117; U.S. Pat. No. 6515109; U.S. Pat. No. 6514988; U.S. Pat. No.6514939; U.S. Pat. No. 6514726; U.S. Pat. No. 6514725; U.S. Pat. No.6514715; U.S. Pat. No. 6512279; U.S. Pat. No. 6511994; U.S. Pat. No.6511990; U.S. Pat. No. 6511840; U.S. Pat. No. 6511833; U.S. Pat. No.6509456; U.S. Pat. No. 6509189; U.S. Pat. No. 6506884; U.S. Pat. No.6506877; U.S. Pat. No. 6506750; U.S. Pat. No. 6506607; U.S. Pat. No.6506587; U.S. Pat. No. 6506578; U.S. Pat. No. 6506571; U.S. Pat. No.6506569; U.S. Pat. No. 6506410; U.S. Pat. No. 6503733; U.S. Pat. No.6503718; U.S. Pat. No. 6503708; U.S. Pat. No. 6503184; U.S. Pat. No.6500927; U.S. Pat. No. 6500856; U.S. Pat. No. 6500639; U.S. Pat. No.6500428; U.S. Pat. No. 6498196; U.S. Pat. No. 6498019; U.S. Pat. No.6498013; U.S. Pat. No. 6498012; U.S. Pat. No. 6495674; U.S. Pat. No.6495667; U.S. Pat. No. 6495666; U.S. Pat. No. 6495604; U.S. Pat. No.6495581; U.S. Pat. No. 6495544; U.S. Pat. No. 6495520; U.S. Pat. No.6495139; U.S. Pat. No. 6495129; U.S. Pat. No. 6492507; U.S. Pat. No.6492499; U.S. Pat. No. 6492390; U.S. Pat. No. 6492324; U.S. Pat. No.6492129; U.S. Pat. No. 6492126; U.S. Pat. No. 6492108; U.S. Pat. No.6491918; U.S. Pat. No. 9489444; U.S. Pat. No. 6489351; U.S. Pat. No.6489306; U.S. Pat. No. 6489163; U.S. Pat. No. 6489134; U.S. Pat. No.6486300; U.S. Pat. No. 6486299; U.S. Pat. No. 6486186; U.S. Pat. No.6485933; U.S. Pat. No. 6485925; U.S. Pat. No. 6482927; U.S. Pat. No.6482926; U.S. Pat. No. 6482864; U.S. Pat. No. 6482821; U.S. Pat. No.6482595; U.S. Pat. No. 6482586; U.S. Pat. No. 6479634; U.S. Pat. No.6479258; U.S. Pat. No. 6479254; U.S. Pat. No. 6479064; U.S. Pat. No.6479054; U.S. Pat. No. 6476867; U.S. Pat. No. 6476210; U.S. Pat. No.6476195; U.S. Pat. No. 6476188; U.S. Pat. No. 6476031; U.S. Pat. No.6475753; U.S. Pat. No. 6475738; U.S. Pat. No. 6475485; U.S. Pat. No.6472512; U.S. Pat. No. 6472508; U.S. Pat. No. 6472377; U.S. Pat. No.6472376; U.S. Pat. No. 6472195; U.S. Pat. No. 6472172; U.S. Pat. No.6472142; U.S. Pat. No. 6471959; U.S. Pat. No. 6471956; U.S. Pat. No.6469045; U.S. Pat. No. 6469040; U.S. Pat. No. 6468770; U.S. Pat. No.6468768; U.S. Pat. No. 6468737; U.S. Pat. No. 6468476; U.S. Pat. No.6467333; U.S. Pat. No. 6465687; U.S. Pat. No. 6465686; U.S. Pat. No.6465633; U.S. Pat. No. 6465632; U.S. Pat. No. 6465619; U.S. Pat. No.6465518; U.S. Pat. No. 6465210; U.S. Pat. No. 6465198; U.S. Pat. No.6462186; U.S. Pat. No. 6462058; U.S. Pat. No. 6461826; U.S. Pat. No.6461807; U.S. Pat. No. 6458939; U.S. Pat. No. 6458787; U.S. Pat. No.6458575; U.S. Pat. No. 6458534; U.S. Pat. No. 6455685; U.S. Pat. No.6455672; U.S. Pat. No. 6455562; U.S. Pat. No. 6455281; U.S. Pat. No.6455280; U.S. Pat. No. 6455277; U.S. Pat. No. 6455262; U.S. Pat. No.6455040; U.S. Pat. No. 6455035; U.S. Pat. No. 6453241; U.S. Pat. No.6452014; U.S. Pat. No. 6451546; U.S. Pat. No. 6451305; U.S. Pat. No.6448388; U.S. Pat. No. 6448224; U.S. Pat. No. 6448075; U.S. Pat. No.6444804; U.S. Pat. No. 6444792; U.S. Pat. No. 6444790; U.S. Pat. No.6444671; U.S. Pat. No. 6444456; U.S. Pat. No. 6444233; U.S. Pat. No.6441270; U.S. Pat. No. 6441154; U.S. Pat. No. 6441153; U.S. Pat. No.6441137; U.S. Pat. No. 6441135; U.S. Pat. No. 6440946; U.S. Pat. No.6437132; U.S. Pat. No. 6437108; U.S. Pat. No. 6437098; U.S. Pat. No.6436683; U.S. Pat. No. 6436637; U.S. Pat. No. 6436628; U.S. Pat. No.6433153; U.S. Pat. No. 6433147; U.S. Pat. No. 6433145; U.S. Pat. No.6433143; U.S. Pat. No. 6433012; U.S. Pat. No. 6432915; U.S. Pat. No.6432690; U.S. Pat. No. 6432687; U.S. Pat. No. 6432667; U.S. Pat. No.6429304; U.S. Pat. No. 6429290; U.S. Pat. No. 6428998; U.S. Pat. No.6428983; U.S. Pat. No. 6428964; U.S. Pat. No. 6428949; U.S. Pat. No.6428813; U.S. Pat. No. 6428802; U.S. Pat. No. 6423869; U.S. Pat. No.6423829; U.S. Pat. No. 6423710; U.S. Pat. No. 6423511; U.S. Pat. No.6423056; U.S. Pat. No. 6420415; U.S. Pat. No. 6420414; U.S. Pat. No.6420375; U.S. Pat. No. 6420137; U.S. Pat. No. 6420111; U.S. Pat. No.6419961; U.S. Pat. No. 6417329; U.S. Pat. No. 6417324; U.S. Pat. No.6416991; U.S. Pat. No. 6416974; U.S. Pat. No. 6416755; U.S. Pat. No.6414126; U.S. Pat. No. 6414117; U.S. Pat. No. 6414018; U.S. Pat. No.6414003; U.S. Pat. No. 6414002; U.S. Pat. No. 6413972; U.S. Pat. No.6413947; U.S. Pat. No. 6413773; U.S. Pat. No. 6413768; U.S. Pat. No.6413740; U.S. Pat. No. 6410693; U.S. Pat. No. 6410689; U.S. Pat. No.6410687; U.S. Pat. No. 6410267; U.S. Pat. No. 6407213; U.S. Pat. No.6407117; U.S. Pat. No. 6407116; U.S. Pat. No. 6406867; U.S. Pat. No.6406857; U.S. Pat. No. 6403830; U.S. Pat. No. 6403784; U.S. Pat. No.6403770; U.S. Pat. No. 6403606; U.S. Pat. No. 6403595; U.S. Pat. No.6403559; U.S. Pat. No. 6403558; U.S. Pat. No. 6403552; U.S. Pat. No.6403337; U.S. Pat. No. 6403309; U.S. Pat. No. 6399762; U.S. Pat. No.6399746; U.S. Pat. No. 6399350; U.S. Pat. No. 6399345; U.S. Pat. No.6399337; U.S. Pat. No. 6399328; U.S. Pat. No. 6399301; U.S. Pat. No.6399298; U.S. Pat. No. 6399103; U.S. Pat. No. 6399067; U.S. Pat. No.6399063; U.S. Pat. No. 6395784; U.S. Pat. No. 6395743; U.S. Pat. No.6395740; U.S. Pat. No. 6395498; U.S. Pat. No. 6395482; U.S. Pat. No.6395468; U.S. Pat. No. 6395282; U.S. Pat. No. 6392028; U.S. Pat. No.6391905; U.S. Pat. No. 6391589; U.S. Pat. No. 6391580; U.S. Pat. No.6391567; U.S. Pat. No. 6388173; U.S. Pat. No. 6387895; U.S. Pat. No.6387613; U.S. Pat. No. 6387371; U.S. Pat. No. 6387366; U.S. Pat. No.6383744; U.S. Pat. No. 6380363; U.S. Pat. No. 6379913; U.S. Pat. No.6379904; U.S. Pat. No. 6379722; U.S. Pat. No. RE7686; U.S. Pat. No.6376651; U.S. Pat. No. 6376528; U.S. Pat. No. 6376497; U.S. Pat. No.6376464; U.S. Pat. No. 6376461; U.S. Pat. No. 6375950; U.S. Pat. No.6372896; U.S. Pat. No. 6372777; U.S. Pat. No. 6372742; U.S. Pat. No.6372444; U.S. Pat. No. 6370478; U.S. Pat. No. 6369098; U.S. Pat. No.6368828; U.S. Pat. No. 6368810; U.S. Pat. No. 6368591; U.S. Pat. No.6365725; U.S. Pat. No. 6365714; U.S. Pat. No. 6365607; U.S. Pat. No.6365577; U.S. Pat. No. 6365386; U.S. Pat. No. 6365372; U.S. Pat. No.6365371; U.S. Pat. No. 6365358; U.S. Pat. No. 6362213; U.S. Pat. No.6361984; U.S. Pat. No. 6361772; U.S. Pat. No. 6359194; U.S. Pat. No.6359193; U.S. Pat. No. 6359134; U.S. Pat. No. 6359123; U.S. Pat. No.6358923; U.S. Pat. No. 6358732; U.S. Pat. No. 6358711; U.S. Pat. No.6358508; U.S. Pat. No. 6355672; U.S. Pat. No. 6355245; U.S. Pat. No.6355237; U.S. Pat. No. 6353024; U.S. Pat. No. 6352982; U.S. Pat. No.6350749; U.S. Pat. No. 6350730; U.S. Pat. No. 6350581; U.S. Pat. No.6350473; U.S. Pat. No. 6350448; U.S. Pat. No. 6348602; U.S. Pat. No.6348576; U.S. Pat. No. 6348485; U.S. Pat. No. 6346411; U.S. Pat. No.6346374; U.S. Pat. No. 6346246; U.S. Pat. No. 6344209; U.S. Pat. No.6342382; U.S. Pat. No. 6342351; U.S. Pat. No. 6340704; U.S. Pat. No.6340703; U.S. Pat. No. 6340686; U.S. Pat. No. 6340575; U.S. Pat. No.6338945; U.S. Pat. No. 6337207; U.S. Pat. No. 6337070; U.S. Pat. No.6335432; U.S. Pat. No. 6335180; U.S. Pat. No. 6335168; U.S. Pat. No.6335157; U.S. Pat. No. 6333303; U.S. Pat. No. 6332017; U.S. Pat. No.6331407; U.S. Pat. No. 6329505; U.S. Pat. No. 6329428; U.S. Pat. No.6329389; U.S. Pat. No. 6329388; U.S. Pat. No. 6329341; U.S. Pat. No.6329170; U.S. Pat. No. 6328964; U.S. Pat. No. 6326469; U.S. Pat. No.6326369; U.S. Pat. No. 6326207; U.S. Pat. No. 6326158; U.S. Pat. No.6326151; U.S. Pat. No. 6324479; U.S. Pat. No. 6323328; U.S. Pat. No.6323244; U.S. Pat. No. 6323179; U.S. Pat. No. 6323027; U.S. Pat. No.6322982; U.S. Pat. No. 6319724; U.S. Pat. No. 6319704; U.S. Pat. No.6319701; U.S. Pat. No. 6316689; U.S. Pat. No. 6316497; U.S. Pat. No.6316222; U.S. Pat. No. 6316206; U.S. Pat. No. 6316204; U.S. Pat. No.6313301; U.S. Pat. No. 6313271; U.S. Pat. No. 6313266; U.S. Pat. No.6313156; U.S. Pat. No. 6312909; U.S. Pat. No. 6312895; U.S. Pat. No.6312887; U.S. Pat. No. 6312692; U.S. Pat. No. 6310182; U.S. Pat. No.6310048; U.S. Pat. No. 6309859; U.S. Pat. No. 6309858; U.S. Pat. No.6309853; U.S. Pat. No. 6309821; U.S. Pat. No. 6309637; U.S. Pat. No.6307021; U.S. Pat. No. 6306819; U.S. Pat. No. 6306648; U.S. Pat. No.6306624; U.S. Pat. No. 6306575; U.S. Pat. No. 6303772; U.S. Pat. No.6303765; U.S. Pat. No. 6303628; U.S. Pat. No. 6303358; U.S. Pat. No.6303304; U.S. Pat. No. 6302685; U.S. Pat. No. 6300482; U.S. Pat. No.6300479; U.S. Pat. No. 6300473; U.S. Pat. No. 6300472; U.S. Pat. No.6300077; U.S. Pat. No. 6297493; U.S. Pat. No. 6297379; U.S. Pat. No.6297255; U.S. Pat. No. 6297035; U.S. Pat. No. 6294660; U.S. Pat. No.6294561; U.S. Pat. No. 6294558; U.S. Pat. No. 6294173; U.S. Pat. No.6291702; U.S. Pat. No. 6291645; U.S. Pat. No. 6290839; U.S. Pat. No.6288218; U.S. Pat. No. 6288078; U.S. Pat. No. 6287854; U.S. Pat. No.6287806; U.S. Pat. No. 6287782; U.S. Pat. No. 6287763; U.S. Pat. No.6284910; U.S. Pat. No. 6284732; U.S. Pat. No. 6284236; U.S. Pat. No.6281334; U.S. Pat. No. 6281333; U.S. Pat. No. 6281190; U.S. Pat. No.6280963; U.S. Pat. No. 6280947; U.S. Pat. No. 6280733; U.S. Pat. No.6279611; U.S. Pat. No. 6277989; U.S. Pat. No. 6277974; U.S. Pat. No.6277963; U.S. Pat. No. 6277878; U.S. Pat. No. 6277619; U.S. Pat. No.6277613; U.S. Pat. No. 6277572; U.S. Pat. No. 6277568; U.S. Pat. No.6277565; U.S. Pat. No. 6277564; U.S. Pat. No. 6277377; U.S. Pat. No.6277373; U.S. Pat. No. 6274720; U.S. Pat. No. 6274339; U.S. Pat. No.6274138; U.S. Pat. No. 6271253; U.S. Pat. No. 6271209; U.S. Pat. No.6271197; U.S. Pat. No. 6268470; U.S. Pat. No. 6268192; U.S. Pat. No.6268164; U.S. Pat. No. 6268156; U.S. Pat. No. 6268136; U.S. Pat. No.6268132; U.S. Pat. No. 6267981; U.S. Pat. No. 6265565; U.S. Pat. No.6265564; U.S. Pat. No. 6265551; U.S. Pat. No. 6265550; U.S. Pat. No.6265547; U.S. Pat. No. 6265535; U.S. Pat. No. 6265377; U.S. Pat. No.6264970; U.S. Pat. No. 6264949; U.S. Pat. No. 6264947; U.S. Pat. No.6264825; U.S. Pat. No. 6262267; U.S. Pat. No. 6262025; U.S. Pat. No.6261760; U.S. Pat. No. 6261596; U.S. Pat. No. 6261548; U.S. Pat. No.6258929; U.S. Pat. No. 6258833; U.S. Pat. No. 6258561; U.S. Pat. No.6258527; U.S. Pat. No. 6255456; U.S. Pat. No. 6251926; U.S. Pat. No.6251597; U.S. Pat. No. 6251582; U.S. Pat. No. 6251389; U.S. Pat. No.6248594; U.S. Pat. No. 6248549; U.S. Pat. No. 6248528; U.S. Pat. No.6248525; U.S. Pat. No. 6248520; U.S. Pat. No. 6248516; U.S. Pat. No.6248325; U.S. Pat. No. 6245755; U.S. Pat. No. 6245351; U.S. Pat. No.3245335; U.S. Pat. No. 3244096; U.S. Pat. No. 6242481; U.S. Pat. No.6242471; U.S. Pat. No. 6242214; U.S. Pat. No. 6242212; U.S. Pat. No.6242179; U.S. Pat. No. 6242178; U.S. Pat. No. 6238903; U.S. Pat. No.6238894; U.S. Pat. No. 6238666; U.S. Pat. No. 6235880; U.S. Pat. No.6235878; U.S. Pat. No. 6235873; U.S. Pat. No. 6235789; U.S. Pat. No.6235756; U.S. Pat. No. 6235715; U.S. Pat. No. 6235712; U.S. Pat. No.6235477; U.S. Pat. No. 6235470; U.S. Pat. No. 6232459; U.S. Pat. No.6262454; U.S. Pat. No. 6232440; U.S. Pat. No. 6232288; U.S. Pat. No.6232077; U.S. Pat. No. 6232068; U.S. Pat. No. 6231853; U.S. Pat. No.6230501; U.S. Pat. No. 6228991; U.S. Pat. No. 6228984; U.S. Pat. No.6228879; U.S. Pat. No. 6228867; U.S. Pat. No. 6228616; U.S. Pat. No.6225084; U.S. Pat. No. 6224901; U.S. Pat. No. 6221843; U.S. Pat. No.6221628; U.S. Pat. No. 6218510; U.S. Pat. No. 6218429; U.S. Pat. No.6218387; U.S. Pat. No. 6218162; U.S. Pat. No. 6218113; U.S. Pat. No.6217867; U.S. Pat. No. 6214985; U.S. Pat. No. 6214838; U.S. Pat. No.6211224; U.S. Pat. No. 6211215; U.S. Pat. No. 6210890; U.S. Pat. No.6210873; U.S. Pat. No. 6207876; U.S. Pat. No. 6207663; U.S. Pat. No.6207413; U.S. Pat. No. 6207403; U.S. Pat. No. 6207386; U.S. Pat. No.6207148; U.S. Pat. No. 6204372; U.S. Pat. No. 6204371; U.S. Pat. No.6204023; U.S. Pat. No. 6204021; U.S. Pat. No. 6203993; U.S. Pat. No.6203987; U.S. Pat. No. 6203979; U.S. Pat. No. 3201106; U.S. Pat. No.6200957; U.S. Pat. No. 6200790; U.S. Pat. No. 6197982; U.S. Pat. No.6197975; U.S. Pat. No. 6197825; U.S. Pat. No. 6197543; U.S. Pat. No.6197512; U.S. Pat. No. 6197511; U.S. Pat. No. 6197502; U.S. Pat. No.6197350; U.S. Pat. No. 6197299; U.S. Pat. No. 6194549; U.S. Pat. No.6194419; U.S. Pat. No. 6194385; U.S. Pat. No. 6194186; U.S. Pat. No.6194176; U.S. Pat. No. 6194152; U.S. Pat. No. 6193967; U.S. Pat. No.6190909; U.S. Pat. No. 6190876; U.S. Pat. No. 6190702; U.S. Pat. No.6190700; U.S. Pat. No. 6190695; U.S. Pat. No. 6190659; U.S. Pat. No.6190658; U.S. Pat. No. 6187788; U.S. Pat. No. 6187593; U.S. Pat. No.6187559; U.S. Pat. No. 6184357; U.S. Pat. No. 6184226; U.S. Pat. No.6184027; U.S. Pat. No. 6183971; U.S. Pat. No. 6180792; U.S. Pat. No.6180763; U.S. Pat. No. 6180642; U.S. Pat. No. 6180370; U.S. Pat. No.6180342; U.S. Pat. No. 6177546; U.S. Pat. No. 6177401; U.S. Pat. No.6174702; U.S. Pat. No. 6174526; U.S. Pat. No. 6172199; U.S. Pat. No.6172190; U.S. Pat. No. 6172080; U.S. Pat. No. 6171843; U.S. Pat. No.6171815; U.S. Pat. No. 6171799; U.S. Pat. No. 6171790; U.S. Pat. No.6169104; U.S. Pat. No. 6169102; U.S. Pat. No. 6168920; U.S. Pat. No.9166185; U.S. Pat. No. 6166006; U.S. Pat. No. 6165767; U.S. Pat. No.6165709; U.S. Pat. No. 6465470; U.S. Pat. No. 6165464; U.S. Pat. No.6462901; U.S. Pat. No. 6162900; U.S. Pat. No. 6162813; U.S. Pat. No.6162627; U.S. Pat. No. 6162601; U.S. Pat. No. 6162431; U.S. Pat. No.6160092; U.S. Pat. No. 6159989; U.S. Pat. No. 6159975; U.S. Pat. No.6159964; U.S. Pat. No. 6159719; U.S. Pat. No. 6159461; U.S. Pat. No.6156887; U.S. Pat. No. 6156772; U.S. Pat. No. 6156767; U.S. Pat. No.6156523; U.S. Pat. No. 6156500; U.S. Pat. No. 6153423; U.S. Pat. No.6150522; U.S. Pat. No. 6150407; U.S. Pat. No. 6150352; U.S. Pat. No.6150347; U.S. Pat. No. 6150131; U.S. Pat. No. 6149945; U.S. Pat. No.6147088; U.S. Pat. No. 6146828; U.S. Pat. No. 6146827; U.S. Pat. No.6146624; U.S. Pat. No. 6143883; U.S. Pat. No. 6143871; U.S. Pat. No.6143867; U.S. Pat. No. 6143737; U.S. Pat. No. 6143544; U.S. Pat. No.6141589; U.S. Pat. No. 6140467; U.S. Pat. No. 6140066; U.S. Pat. No.6139837; U.S. Pat. No. 6136955; U.S. Pat. No. 6136839; U.S. Pat. No.6136839; U.S. Pat. No. 6136781; U.S. Pat. No. 6136547; U.S. Pat. No.6136314; U.S. Pat. No. 6135942; U.S. Pat. No. 6135941; U.S. Pat. No.6133502; U.S. Pat. No. 6133423; U.S. Pat. No. 6133281; U.S. Pat. No.6133278; U.S. Pat. No. 6133028; U.S. Pat. No. 6132973; U.S. Pat. No.6132969; U.S. Pat. No. 6132964; U.S. Pat. No. 6132714; U.S. Pat. No.6130325; U.S. Pat. No. 6130316; U.S. Pat. No. 6130077; U.S. Pat. No.6130065; U.S. Pat. No. 6130064; U.S. Pat. No. 6130039; U.S. Pat. No.6127523; U.S. Pat. No. 6127410; U.S. Pat. No. 6127390; U.S. Pat. No.6127166; U.S. Pat. No. 6127146; U.S. Pat. No. 6127116; U.S. Pat. No.6126943; U.S. Pat. No. 6124448; U.S. Pat. No. 6124446; U.S. Pat. No.6124439; U.S. Pat. No. 6124436; U.S. Pat. No. 6124433; U.S. Pat. No.6124299; U.S. Pat. No. 6124261; U.S. Pat. No. 6124123; U.S. Pat. No.6124116; U.S. Pat. No. 6124095; U.S. Pat. No. 6121019; U.S. Pat. No.6121017; U.S. Pat. No. 6121004; U.S. Pat. No. 6121000; U.S. Pat. No.6120767; U.S. Pat. No. 6118851; U.S. Pat. No. 6117989; U.S. Pat. No.6117985; U.S. Pat. No. 6117645; U.S. Pat. No. 6117641; U.S. Pat. No.6114355; U.S. Pat. No. 6114139; U.S. Pat. No. 6114129; U.S. Pat. No.6114127; U.S. Pat. No. 6113943; U.S. Pat. No. 6113905; U.S. Pat. No.6113904; U.S. Pat. No. 6111090; U.S. Pat. No. 6111076; U.S. Pat. No.6110948; U.S. Pat. No. 6110931; U.S. Pat. No. 6110722; U.S. Pat. No.6110707; U.S. Pat. No. 6110697; U.S. Pat. No. 6110686; U.S. Pat. No.6110507; U.S. Pat. No. 6107289; U.S. Pat. No. 6103882; U.S. Pat. No.6103874; U.S. Pat. No. 6103497; U.S. Pat. No. 6103477; U.S. Pat. No.6103471; U.S. Pat. No. 6103469; U.S. Pat. No. 6103466; U.S. Pat. No.6103232; U.S. Pat. No. 6101412; U.S. Pat. No. 6100075; U.S. Pat. No.6100042; U.S. Pat. No. 6100037; U.S. Pat. No. 6100036; U.S. Pat. No.6100031; U.S. Pat. No. 6099823; U.S. Pat. No. 6096537; U.S. Pat. No.6096527; U.S. Pat. No. 6096526; U.S. Pat. No. 6096308; U.S. Pat. No.6093737; U.S. Pat. No. 6093565; U.S. Pat. No. 6093561; U.S. Pat. No.6090912; U.S. Pat. No. 6090577; U.S. Pat. No. 6090573; U.S. Pat. No.6090564; U.S. Pat. No. 6090377; U.S. Pat. No. 6087503; U.S. Pat. No.6087485; U.S. Pat. No. 6087478; U.S. Pat. No. 6087477; U.S. Pat. No.6087394; U.S. Pat. No. 6087367; U.S. Pat. No. 6087333; U.S. Pat. No.6087324; U.S. Pat. No. 6087144; U.S. Pat. No. 6087129; U.S. Pat. No.6087125; U.S. Pat. No. 6087108; U.S. Pat. No. 6087105; U.S. Pat. No.6086865; U.S. Pat. No. 6084083; U.S. Pat. No. 6084070; U.S. Pat. No.6084067; U.S. Pat. No. 6083988; U.S. Pat. No. 6083916; U.S. Pat. No.6083713; U.S. Pat. No. 6083704; U.S. Pat. No. 6083700; U.S. Pat. No.6080848; U.S. Pat. No. 6080847; U.S. Pat. No. 6080842; U.S. Pat. No.6080841; U.S. Pat. No. 6080723; U.S. Pat. No. 6080558; U.S. Pat. No.6080548; U.S. Pat. No. 6080407; U.S. Pat. No. 6077858; U.S. Pat. No.6077850; U.S. Pat. No. 6077847; U.S. Pat. No. 6077693; U.S. Pat. No.6077688; U.S. Pat. No. 6077686; U.S. Pat. No. 6077682; U.S. Pat. No.6077510; U.S. Pat. No. 6077508; U.S. Pat. No. 6075256; U.S. Pat. No.6075136; U.S. Pat. No. 6075123; U.S. Pat. No. 6074844; U.S. Pat. No.6074843; U.S. Pat. No. 6074841; U.S. Pat. No. 6071948; U.S. Pat. No.6071874; U.S. Pat. No. 6071721; U.S. Pat. No. 6071720; U.S. Pat. No.6071704; U.S. Pat. No. 6071703; U.S. Pat. No. 6071700; U.S. Pat. No.6071513; U.S. Pat. No. 6068990; U.S. Pat. No. 6068987; U.S. Pat. No.6068850; U.S. Pat. No. 6066658; U.S. Pat. No. 6066619; U.S. Pat. No.6066498; U.S. Pat. No. 6066485; U.S. Pat. No. 6066470; U.S. Pat. No.6066463; U.S. Pat. No. 6066322; U.S. Pat. No. 6063767; U.S. Pat. No.6063621; U.S. Pat. No. 6063596; U.S. Pat. No. 6063594; U.S. Pat. No.6063377; U.S. Pat. No. 6060454; U.S. Pat. No. 6060297; U.S. Pat. No.6060284; U.S. Pat. No. 6060276; U.S. Pat. No. 6060250; U.S. Pat. No.6060154; U.S. Pat. No. 6057427; U.S. Pat. No. 6057140; U.S. Pat. No.6057129; U.S. Pat. No. 6057112; U.S. Pat. No. 6057110; U.S. Pat. No.6057109; U.S. Pat. No. 6057102; U.S. Pat. No. 6054558; U.S. Pat. No.6054297; U.S. Pat. No. 6054292; U.S. Pat. No. 6054290; U.S. Pat. No.6054280; U.S. Pat. No. 6054121; U.S. Pat. No. 6051692; U.S. Pat. No.6051398; U.S. Pat. No. 6051397; U.S. Pat. No. 6048970; U.S. Pat. No.6048863; U.S. Pat. No. 6048850; U.S. Pat. No. 6048837; U.S. Pat. No.6048718; U.S. Pat. No. 6048711; U.S. Pat. No. 6048709; U.S. Pat. No.6048526; U.S. Pat. No. 6046315; U.S. Pat. No. 6046189; U.S. Pat. No.6046166; U.S. Pat. No. 6046044; U.S. Pat. No. 6046029; U.S. Pat. No.6046027; U.S. Pat. No. 6046001; U.S. Pat. No. 6045830; U.S. Pat. No.6045797; U.S. Pat. No. 6045792; U.S. Pat. No. 6043346; U.S. Pat. No.6043343; U.S. Pat. No. 6043273; U.S. Pat. No. 6043222; U.S. Pat. No.6043086; U.S. Pat. No. 6043083; U.S. Pat. No. 6043056; U.S. Pat. No.6043033; U.S. Pat. No. 6042828; U.S. Pat. No. 6040174; U.S. Pat. No.6039684; U.S. Pat. No. 6037449; U.S. Pat. No. 6037446; U.S. Pat. No.6037323; U.S. Pat. No. 6037164; U.S. Pat. No. 6037163; U.S. Pat. No.6037134; U.S. Pat. No. 6037132; U.S. Pat. No. 6036976; U.S. Pat. No.6036954; U.S. Pat. No. 6034256; U.S. Pat. No. 6034239; U.S. Pat. No.6034219; U.S. Pat. No. 6034212; U.S. Pat. No. 6034175; U.S. Pat. No.6034089; U.S. Pat. No. 6034063; U.S. Pat. No. 6033893; U.S. Pat. No.6033870; U.S. Pat. No. 6033869; U.S. Pat. No. 6033855; U.S. Pat. No.6030967; U.S. Pat. No. 6030826; U.S. Pat. No. 6030825; U.S. Pat. No.6030824; U.S. Pat. No. 6030822; U.S. Pat. No. 6030809; U.S. Pat. No.6030801; U.S. Pat. No. 6030785; U.S. Pat. No. 6030780; U.S. Pat. No.6030615; U.S. Pat. No. 6027935; U.S. Pat. No. 6027916; U.S. Pat. No.6027914; U.S. Pat. No. 6025473; U.S. Pat. No. 6025464; U.S. Pat. No.6025366; U.S. Pat. No. 6025353; U.S. Pat. No. 6025333; U.S. Pat. No.6025331; U.S. Pat. No. 6025137; U.S. Pat. No. 6025123; U.S. Pat. No.6022863; U.S. Pat. No. 6022740; U.S. Pat. No. 6022709; U.S. Pat. No.6022707; U.S. Pat. No. 6020478; U.S. Pat. No. 6020474; U.S. Pat. No.6020463; U.S. Pat. No. 6020179; U.S. Pat. No. 6020166; U.S. Pat. No.6020165; U.S. Pat. No. 6020164; U.S. Pat. No. 6020155; U.S. Pat. No.6020142; U.S. Pat. No. 6020140; U.S. Pat. No. 6020137; U.S. Pat. No.6019970; U.S. Pat. No. 6018413; U.S. Pat. No. 6018028; U.S. Pat. No.6018025; U.S. Pat. No. 6018021; U.S. Pat. No. 6017958; U.S. Pat. No.6017954; U.S. Pat. No. 6017944; U.S. Pat. No. 6017763; U.S. Pat. No.6017744; U.S. Pat. No. 6017717; U.S. Pat. No. 6017529; U.S. Pat. No.6015883; U.S. Pat. No. 6015789; U.S. Pat. No. 6015788; U.S. Pat. No.6015702; U.S. Pat. No. 6015678; U.S. Pat. No. 6015672; U.S. Pat. No.6015660; U.S. Pat. No. 6015561; U.S. Pat. No. 6013762; U.S. Pat. No.6013630; U.S. Pat. No. 6013519; U.S. Pat. No. 6013479; U.S. Pat. No.6013455; U.S. Pat. No. 6013454; U.S. Pat. No. 6013450; U.S. Pat. No.6013441; U.S. Pat. No. 6013257; U.S. Pat. No. 6011045; U.S. Pat. No.6010879; U.S. Pat. No. 6010859; U.S. Pat. No. 6010852; U.S. Pat. No.6008337; U.S. Pat. No. 6008194; U.S. Pat. No. 6005080; U.S. Pat. No.6004984; U.S. Pat. No. 6004933; U.S. Pat. No. 6004925; U.S. Pat. No.6004924; U.S. Pat. No. 6004792; U.S. Pat. No. 6004778; U.S. Pat. No.6004753; U.S. Pat. No. 6001971; U.S. Pat. No. 6001968; U.S. Pat. No.6001850; U.S. Pat. No. 6001803; U.S. Pat. No. 6001632; U.S. Pat. No.6001629; U.S. Pat. No. 6001624; U.S. Pat. No. 6001621; U.S. Pat. No.6001620; U.S. Pat. No. 6001607; U.S. Pat. No. 6001598; U.S. Pat. No.6001596; U.S. Pat. No. 6001594; U.S. Pat. No. 6001593; U.S. Pat. No.6001583; U.S. Pat. No. 6001580; U.S. Pat. No. 6001563; U.S. Pat. No.5998432; U.S. Pat. No. 5998383; U.S. Pat. No. 5998373; U.S. Pat. No.5998372; U.S. Pat. No. 5998371; U.S. Pat. No. 5998165; U.S. Pat. No.5998136; U.S. Pat. No. 5997869; U.S. Pat. No. 5997858; U.S. Pat. No.5994503; U.S. Pat. No. 5994388; U.S. Pat. No. 5994112; U.S. Pat. No.6538127; U.S. Pat. No. 6538119; U.S. Pat. No. 6525053; U.S. Pat. No.6521658; U.S. Pat. No. 6515013; U.S. Pat. No. 6509341; U.S. Pat. No.6506766; U.S. Pat. No. 6495562; U.S. Pat. No. 6489289; U.S. Pat. No.6482832; U.S. Pat. No. 6472545; U.S. Pat. No. 6472416; U.S. Pat. No.6469056; U.S. Pat. No. 6465181; U.S. Pat. No. 6462194; U.S. Pat. No.6448254; U.S. Pat. No. 6448248; U.S. Pat. No. 6444700; U.S. Pat. No.6441189; U.S. Pat. No. 6436949; U.S. Pat. No. 6436925; U.S. Pat. No.6432684; U.S. Pat. No. 6428990; U.S. Pat. No. 6413780; U.S. Pat. No.6410288; U.S. Pat. No. 6403575; U.S. Pat. No. 6403349; U.S. Pat. No.6399371; U.S. Pat. No. 6399312; U.S. Pat. No. 6391543; U.S. Pat. No.6387885; U.S. Pat. No. 6387883; U.S. Pat. No. 6380241; U.S. Pat. No.6380220; U.S. Pat. No. 6380207; U.S. Pat. No. 6379671; U.S. Pat. No.6372782; U.S. Pat. No. 6368792; U.S. Pat. No. 6358983; U.S. Pat. No.6350583; U.S. Pat. No. 6329386; U.S. Pat. No. 6326355; U.S. Pat. No.6323228; U.S. Pat. No. 6316497; U.S. Pat. No. 6316475; U.S. Pat. No.6307047; U.S. Pat. No. 6297354; U.S. Pat. No. 6297021; U.S. Pat. No.6294573; U.S. Pat. No. 6288261; U.S. Pat. No. 6288228; U.S. Pat. No.6284882; U.S. Pat. No. 6284796; U.S. Pat. No. 6277871; U.S. Pat. No.6265154; U.S. Pat. No. 6258822; U.S. Pat. No. 6255341; U.S. Pat. No.6252047; U.S. Pat. No. 6251867; U.S. Pat. No. 6248919; U.S. Pat. No.6245803; U.S. Pat. No. 6242494; U.S. Pat. No. 6242216; U.S. Pat. No.6235786; U.S. Pat. No. 6232456; U.S. Pat. No. 6228886; U.S. Pat. No.6228868; U.S. Pat. No. 6214581; U.S. Pat. No. 6211164; U.S. Pat. No.6207701; U.S. Pat. No. 6207642; U.S. Pat. No. 6207380; U.S. Pat. No.6204431; U.S. Pat. No. 6203992; U.S. Pat. No. 6203974; U.S. Pat. No.6201001; U.S. Pat. No. 6191115; U.S. Pat. No. 9183952; U.S. Pat. No.6171787; U.S. Pat. No. 6166013; U.S. Pat. No. 6162927; U.S. Pat. No.6153377; U.S. Pat. No. 6150399; U.S. Pat. No. 6143749; U.S. Pat. No.6143509; U.S. Pat. No. 6136855; U.S. Pat. No. 6136574; U.S. Pat. No.6133253; U.S. Pat. No. 6130244; U.S. Pat. No. 6130043; U.S. Pat. No.6121257; U.S. Pat. No. 6110675; U.S. Pat. No. 6077828; U.S. Pat. No.6066669; U.S. Pat. No. 6057122; U.S. Pat. No. 6033898; U.S. Pat. No.6030969; U.S. Pat. No. 6022712; U.S. Pat. No. 6020521; U.S. Pat. No.6020471; U.S. Pat. No. 6015902; U.S. Pat. No. 6015815; U.S. Pat. No.6015662; U.S. Pat. No. 5985911; U.S. Pat. No. 5981587; U.S. Pat. No.5981521; U.S. Pat. No. 5981484; U.S. Pat. No. 5976813; U.S. Pat. No.5972898; U.S. Pat. No. 5972896; U.S. Pat. No. 5972664; U.S. Pat. No.5962712; U.S. Pat. No. 5958974; U.S. Pat. No. 5955440; U.S. Pat. No.5952320; U.S. Pat. No. 5939265; U.S. Pat. No. 5932545; U.S. Pat. No.5919638; U.S. Pat. No. 5912372; U.S. Pat. No. 5892070; U.S. Pat. No.5891698; U.S. Pat. No. 5879900; U.S. Pat. No. 5866606; U.S. Pat. No.5863717; U.S. Pat. No. 5861294; U.S. Pat. No. 5859193; U.S. Pat. No.5858356; U.S. Pat. No. 5856194; U.S. Pat. No. 5831115; U.S. Pat. No.5808077; U.S. Pat. No. 5801146; U.S. Pat. No. 5795784; U.S. Pat. No.5783593; U.S. Pat. No. 5776984; U.S. Pat. No. 5756771; U.S. Pat. No.5750176; U.S. Pat. No. 5738657; U.S. Pat. No. 5709888; U.S. Pat. No.5708002; U.S. Pat. No. 5700782; U.S. Pat. No. 5700671; U.S. Pat. No.5698522; U.S. Pat. No. 5698393; U.S. Pat. No. 5683907; U.S. Pat. No.5681960; U.S. Pat. No. 5681842; U.S. Pat. No. 5672605; U.S. Pat. No.5672480; U.S. Pat. No. 5670645; U.S. Pat. No. 5670627; U.S. Pat. No.6544748; U.S. Pat. No. 6541638; U.S. Pat. No. 6538110; U.S. Pat. No.6538015; U.S. Pat. No. 6537794; U.S. Pat. No. 6531612; U.S. Pat. No.6531598; U.S. Pat. No. 6531472; U.S. Pat. No. 6528677; U.S. Pat. No.6528653; U.S. Pat. No. 6528619; U.S. Pat. No. 6528284; U.S. Pat. No.6521631; U.S. Pat. No. 6518293; U.S. Pat. No. 6514736; U.S. Pat. No.6512123; U.S. Pat. No. 6512001; U.S. Pat. No. 6506755; U.S. Pat. No.6504034; U.S. Pat. No. 6503706; U.S. Pat. No. 6492530; U.S. Pat. No.6492353; U.S. Pat. No. 6486329; U.S. Pat. No. 6482847; U.S. Pat. No.6482613; U.S. Pat. No. 6479670; U.S. Pat. No. 6469180; U.S. Pat. No.6469179; U.S. Pat. No. 6462076; U.S. Pat. No. 6452028; U.S. Pat. No.6447992; U.S. Pat. No. 6444829; U.S. Pat. No. 6444441; U.S. Pat. No.6440959; U.S. Pat. No. 6437118; U.S. Pat. No. 6417360; U.S. Pat. No.6403810; U.S. Pat. No. 6395484; U.S. Pat. No. 6391633; U.S. Pat. No.6368826; U.S. Pat. No. 6365386; U.S. Pat. No. 6342594; U.S. Pat. No.6342585; U.S. Pat. No. 6340742; U.S. Pat. No. 6335332; U.S. Pat. No.6333346; U.S. Pat. No. 6331642; U.S. Pat. No. 6331402; U.S. Pat. No.6329538; U.S. Pat. No. 6326397; U.S. Pat. No. 6313143; U.S. Pat. No.6310247; U.S. Pat. No. 6307051; U.S. Pat. No. 6306579; U.S. Pat. No.6303793; U.S. Pat. No. 6284506; U.S. Pat. No. 6281356; U.S. Pat. No.6271408; U.S. Pat. No. 6270960; U.S. Pat. No. 6268214; U.S. Pat. No.6265578; U.S. Pat. No. 6265446; U.S. Pat. No. 6265218; U.S. Pat. No.6262238; U.S. Pat. No. 6262089; U.S. Pat. No. 6252086; U.S. Pat. No.6248897; U.S. Pat. No. 6242601; U.S. Pat. No. 6239151; U.S. Pat. No.6232448; U.S. Pat. No. 6228877; U.S. Pat. No. 6225117; U.S. Pat. No.6221584; U.S. Pat. No. 6211166; U.S. Pat. No. 6207376; U.S. Pat. No.6204414; U.S. Pat. No. 6200989; U.S. Pat. No. 6197804; U.S. Pat. No.6197563; U.S. Pat. No. 6153634; U.S. Pat. No. 6150118; U.S. Pat. No.6450100; U.S. Pat. No. 6143326; U.S. Pat. No. 6133309; U.S. Pat. No.6130239; U.S. Pat. No. 6127155; U.S. Pat. No. 6121055; U.S. Pat. No.6114520; U.S. Pat. No. 6103910; U.S. Pat. No. 6096319; U.S. Pat. No.6069170; U.S. Pat. No. 6060616; U.S. Pat. No. 6060285; U.S. Pat. No.6057426; U.S. Pat. No. 6048887; U.S. Pat. No. 6046012; U.S. Pat. No.6040475; U.S. Pat. No. 6040166; U.S. Pat. No. 6030994; U.S. Pat. No.6027893; U.S. Pat. No. 6022892; U.S. Pat. No. 6011166; U.S. Pat. No.6008417; U.S. Pat. No. 6008209; U.S. Pat. No. 6005098; U.S. Pat. No.6005075; U.S. Pat. No. 6004530; U.S. Pat. No. 6001566; U.S. Pat. No.5986131; U.S. Pat. No. 5976512; U.S. Pat. No. 5973123; U.S. Pat. No.5959113; U.S. Pat. No. 5955452; U.S. Pat. No. 5939408; U.S. Pat. No.5928636; U.S. Pat. No. 5919903; U.S. Pat. No. 5891901; U.S. Pat. No.5891866; U.S. Pat. No. 5888994; U.S. Pat. No. 5856517; U.S. Pat. No.5856317; U.S. Pat. No. 5853721; U.S. Pat. No. 5852176; U.S. Pat. No.5844108; U.S. Pat. No. 5840718; U.S. Pat. No. 5840530; U.S. Pat. No.5831007; U.S. Pat. No. 5811420; U.S. Pat. No. 5808029; U.S. Pat. No.5780607; U.S. Pat. No. 5780597; U.S. Pat. No. 5776895; U.S. Pat. No.5766888; U.S. Pat. No. 5753638; U.S. Pat. No. 5750517; U.S. Pat. No.5750503; U.S. Pat. No. 5747478; U.S. Pat. No. 5705627; U.S. Pat. No.5696103; U.S. Pat. No. 5672513; U.S. Pat. No. 5652353; U.S. Pat. No.5648482; U.S. Pat. No. 5641485; U.S. Pat. No. 5639871; U.S. Pat. No.5637463; U.S. Pat. No. 5612328; U.S. Pat. No. 5610279; U.S. Pat. No.5604099; U.S. Pat. No. 5597899; U.S. Pat. No. 5591840; U.S. Pat. No.RE7918; U.S. Pat. No. 6413938; U.S. Pat. No. 6410528; U.S. Pat. No.6387919; U.S. Pat. No. 6350747; U.S. Pat. No. 6337209; U.S. Pat. No.6329400; U.S. Pat. No. 6319702; U.S. Pat. No. 6307043; U.S. Pat. No.6300490; U.S. Pat. No. 6297223; U.S. Pat. No. 6268391; U.S. Pat. No.6268374; U.S. Pat. No. 6265405; U.S. Pat. No. 6255307; U.S. Pat. No.6252055; U.S. Pat. No. 6248891; U.S. Pat. No. 6207716; U.S. Pat. No.6207669; U.S. Pat. No. 6204249; U.S. Pat. No. 6194211; U.S. Pat. No.6191150; U.S. Pat. No. 6174889; U.S. Pat. No. 6172064; U.S. Pat. No.6169091; U.S. Pat. No. 6140100; U.S. Pat. No. 6124308; U.S. Pat. No.6121238; U.S. Pat. No. 6100273; U.S. Pat. No. 6096786; U.S. Pat. No.6090825; U.S. Pat. No. 6083913; U.S. Pat. No. 6077832; U.S. Pat. No.6056956; U.S. Pat. No. 6054478; U.S. Pat. No. 6051221; U.S. Pat. No.6022720; U.S. Pat. No. 6020346; U.S. Pat. No. 6004968; U.S. Pat. No.5998605; U.S. Pat. No. 5998427; U.S. Pat. No. 5998388; U.S. Pat. No.5981572; U.S. Pat. No. 5977126; U.S. Pat. No. 5958980; U.S. Pat. No.5955488; U.S. Pat. No. 5952334; U.S. Pat. No. 5932546; U.S. Pat. No.5919941; U.S. Pat. No. 5912356; U.S. Pat. No. 5876961; U.S. Pat. No.5872151; U.S. Pat. No. 5856362; U.S. Pat. No. 5854280; U.S. Pat. No.5854270; U.S. Pat. No. 5843917; U.S. Pat. No. 5840990; U.S. Pat. No.5830455; U.S. Pat. No. 5821236; U.S. Pat. No. 5821080; U.S. Pat. No.5817818; U.S. Pat. No. 5817664; U.S. Pat. No. 5808147; U.S. Pat. No.5760224; U.S. Pat. No. 5747472; U.S. Pat. No. 5741806; U.S. Pat. No.5733915; U.S. Pat. No. 5723452; U.S. Pat. No. 5712277; U.S. Pat. No.5708001; U.S. Pat. No. 5690933; U.S. Pat. No. 5681835; U.S. Pat. No.5665754; U.S. Pat. No. 5663154; U.S. Pat. No. 5648347; U.S. Pat. No.5641889; U.S. Pat. No. 5637574; U.S. Pat. No. 5620959; U.S. Pat. No.5567738; U.S. Pat. No. 5565467; U.S. Pat. No. 5561164; U.S. Pat. No.5559235; U.S. Pat. No. 5559156; U.S. Pat. No. 5543406; U.S. Pat. No.5539098; U.S. Pat. No. 5538970; U.S. Pat. No. 5508432; U.S. Pat. No.6495588; U.S. Pat. No. 6495586; U.S. Pat. No. 6369272; U.S. Pat. No.6306854; U.S. Pat. No. 6545022; U.S. Pat. No. 6541634; U.S. Pat. No.6541495; U.S. Pat. No. 6541481; U.S. Pat. No. 6538009; U.S. Pat. No.6537995; U.S. Pat. No. 6531492; U.S. Pat. No. 6531485; U.S. Pat. No.6525196; U.S. Pat. No. 6525067; U.S. Pat. No. 6525048; U.S. Pat. No.6525047; U.S. Pat. No. 6521650; U.S. Pat. No. 6518289; U.S. Pat. No.6518251; U.S. Pat. No. 6509337; U.S. Pat. No. 6506779; U.S. Pat. No.6503908; U.S. Pat. No. 6498172; U.S. Pat. No. 6497869; U.S. Pat. No.6495589; U.S. Pat. No. 6495564; U.S. Pat. No. 6492520; U.S. Pat. No.6492412; U.S. Pat. No. 6492383; U.S. Pat. No. 6485904; U.S. Pat. No.6482825; U.S. Pat. No. 6479513; U.S. Pat. No. 6476040; U.S. Pat. No.6475784; U.S. Pat. No. 6475770; U.S. Pat. No. 6472388; U.S. Pat. No.6465491; U.S. Pat. No. 6465449; U.S. Pat. No. 6462254; U.S. Pat. No.6458951; U.S. Pat. No. 6458822; U.S. Pat. No. 6455572; U.S. Pat. No.6455567; U.S. Pat. No. 6451803; U.S. Pat. No. 6448293; U.S. Pat. No.6448278; U.S. Pat. No. 6441193; U.S. Pat. No. 6441015; U.S. Pat. No.6440982; U.S. Pat. No. 6437151; U.S. Pat. No. 6436977; U.S. Pat. No.6436410; U.S. Pat. No. 6433171; U.S. Pat. No. 6432989; U.S. Pat. No.6432945; U.S. Pat. No. 6429313; U.S. Pat. No. 6426359; U.S. Pat. No.6423708; U.S. Pat. No. 6423705; U.S. Pat. No. 6420343; U.S. Pat. No.6417229; U.S. Pat. No. 6413971; U.S. Pat. No. 6410736; U.S. Pat. No.6410297; U.S. Pat. No. 6407114; U.S. Pat. No. 6403611; U.S. Pat. No.6403599; U.S. Pat. No. 6403592; U.S. Pat. No. 6395733; U.S. Pat. No.6391872; U.S. Pat. No. 6388127; U.S. Pat. No. 6388092; U.S. Pat. No.6387915; U.S. Pat. No. 6387901; U.S. Pat. No. 6387894; U.S. Pat. No.6384039; U.S. Pat. No. 6380396; U.S. Pat. No. 6380219; U.S. Pat. No.6380214; U.S. Pat. No. 6380186; U.S. Pat. No. 6376502; U.S. Pat. No.6372781; U.S. Pat. No. 6372768; U.S. Pat. No. 6362195; U.S. Pat. No.6358951; U.S. Pat. No. 6355670; U.S. Pat. No. 6355662; U.S. Pat. No.6352970; U.S. Pat. No. 6350907; U.S. Pat. No. 6350751; U.S. Pat. No.6342521; U.S. Pat. No. 6335344; U.S. Pat. No. 6333330; U.S. Pat. No.6329412; U.S. Pat. No. 6329397; U.S. Pat. No. 6323232; U.S. Pat. No.6323229; U.S. Pat. No. 6319915; U.S. Pat. No. 6316631; U.S. Pat. No.6313140; U.S. Pat. No. 6310079; U.S. Pat. No. 6306887; U.S. Pat. No.6306875; U.S. Pat. No. 6303636; U.S. Pat. No. 6303628; U.S. Pat. No.6300363; U.S. Pat. No. 6300316; U.S. Pat. No. 6294558; U.S. Pat. No.6294552; U.S. Pat. No. 6288246; U.S. Pat. No. 6288120; U.S. Pat. No.6284773; U.S. Pat. No. 6284764; U.S. Pat. No. 6284757; U.S. Pat. No.6278000; U.S. Pat. No. 6277878; U.S. Pat. No. 6277852; U.S. Pat. No.6274618; U.S. Pat. No. 6271255; U.S. Pat. No. 6270768; U.S. Pat. No.6265429; U.S. Pat. No. 6262046; U.S. Pat. No. 6258824; U.S. Pat. No.6251904; U.S. Pat. No. 6251902; U.S. Pat. No. 6248753; U.S. Pat. No.6248738; U.S. Pat. No. 6248717; U.S. Pat. No. 6242438; U.S. Pat. No.6239147; U.S. Pat. No. 6235764; U.S. Pat. No. 6235750; U.S. Pat. No.6235747; U.S. Pat. No. 6235734; U.S. Pat. No. 6231833; U.S. Pat. No.6229025; U.S. Pat. No. 6225318; U.S. Pat. No. 6218397; U.S. Pat. No.6214872; U.S. Pat. No. 6214870; U.S. Pat. No. 6211208; U.S. Pat. No.6207678; U.S. Pat. No. 6204286; U.S. Pat. No. 6197810; U.S. Pat. No.6197773; U.S. Pat. No. 6197591; U.S. Pat. No. 6194578; U.S. Pat. No.6194439; U.S. Pat. No. 6194438; U.S. Pat. No. 6194436; U.S. Pat. No.6177430; U.S. Pat. No. 6174903; U.S. Pat. No. 6174710; U.S. Pat. No.6156798; U.S. Pat. No. 6153622; U.S. Pat. No. 6153609; U.S. Pat. No.6150377; U.S. Pat. No. 6147074; U.S. Pat. No. 6147061; U.S. Pat. No.6132774; U.S. Pat. No. 6130217; U.S. Pat. No. 6124346; U.S. Pat. No.6124314; U.S. Pat. No. 6124264; U.S. Pat. No. 6118016; U.S. Pat. No.6114568; U.S. Pat. No. 6114395; U.S. Pat. No. 3114367; U.S. Pat. No.6114361; U.S. Pat. No. 6110964; U.S. Pat. No. 6110932; U.S. Pat. No.6107337; U.S. Pat. No. 6107331; U.S. Pat. No. 6107306; U.S. Pat. No.6100301; U.S. Pat. No. 6090852; U.S. Pat. No. 6087392; U.S. Pat. No.6083956; U.S. Pat. No. 6080769; U.S. Pat. No. 6080757; U.S. Pat. No.6077871; U.S. Pat. No. 6077864; U.S. Pat. No. 6074855; U.S. Pat. No.6071935; U.S. Pat. No. 6069175; U.S. Pat. No. 6057309; U.S. Pat. No.6051578; U.S. Pat. No. 6048880; U.S. Pat. No. 6043238; U.S. Pat. No.6043227; U.S. Pat. No. 6043226; U.S. Pat. No. 6034102; U.S. Pat. No.6034082; U.S. Pat. No. 6025350; U.S. Pat. No. 6022978; U.S. Pat. No.6022971; U.S. Pat. No. 6020335; U.S. Pat. No. 6017964; U.S. Pat. No.6001856; U.S. Pat. No. 5994351; U.S. Pat. No. 5990125; U.S. Pat. No.5977131; U.S. Pat. No. 5968944; U.S. Pat. No. 5962479; U.S. Pat. No.5948809; U.S. Pat. No. 5948781; U.S. Pat. No. 5942619; U.S. Pat. No.5936089; U.S. Pat. No. 5935962; U.S. Pat. No. 5932566; U.S. Pat. No.5912357; U.S. Pat. No. 5908930; U.S. Pat. No. 5902830; U.S. Pat. No.5889042; U.S. Pat. No. 5883131; U.S. Pat. No. 5869511; U.S. Pat. No.5863949; U.S. Pat. No. 5861510; U.S. Pat. No. 5861438; U.S. Pat. No.5854275; U.S. Pat. No. 5852059; U.S. Pat. No. 5846965; U.S. Pat. No.5840723; U.S. Pat. No. 5827892; U.S. Pat. No. 5821245; U.S. Pat. No.5773477; U.S. Pat. No. 5756462; U.S. Pat. No. 5747498; U.S. Pat. No.5741790; U.S. Pat. No. 5736534; U.S. Pat. No. 5716961; U.S. Pat. No.5703108; U.S. Pat. No. 5643730; U.S. Pat. No. 5639757; U.S. Pat. No.5618834; U.S. Pat. No. 5607951; U.S. Pat. No. 5593997; U.S. Pat. No.5589482; U.S. Pat. No. 5583137; U.S. Pat. No. 5578612; U.S. Pat. No.5576317; U.S. Pat. No. 5563143; U.S. Pat. No. 5559246; U.S. Pat. No.5559129; U.S. Pat. No. 5552412; U.S. Pat. No. 5545644; U.S. Pat. No.5536722; U.S. Pat. No. 6479284; U.S. Pat. No. 6376235; U.S. Pat. No.6193979; U.S. Pat. No. 5958414; U.S. Pat. No. 5958410; U.S. Pat. No.6544960; U.S. Pat. No. 6544518; U.S. Pat. No. 6541503; U.S. Pat. No.6541492; U.S. Pat. No. 6537983; U.S. Pat. No. 6537774; U.S. Pat. No.6534486; U.S. Pat. No. 6528512; U.S. Pat. No. 6524813; U.S. Pat. No.6521437; U.S. Pat. No. 6518404; U.S. Pat. No. 6515108; U.S. Pat. No.6514992; U.S. Pat. No. 6506878; U.S. Pat. No. 6506781; U.S. Pat. No.6506774; U.S. Pat. No. 6506758; U.S. Pat. No. 6506386; U.S. Pat. No.6503909; U.S. Pat. No. 6500432; U.S. Pat. No. 6498234; U.S. Pat. No.6498166; U.S. Pat. No. 6498155; U.S. Pat. No. 6495606; U.S. Pat. No.6495560; U.S. Pat. No. 6492425; U.S. Pat. No. 6492415; U.S. Pat. No.6492388; U.S. Pat. No. 6492378; U.S. Pat. No. 6492348; U.S. Pat. No.6489325; U.S. Pat. No. 6489139; U.S. Pat. No. 6488934; U.S. Pat. No.6475766; U.S. Pat. No. 6475487; U.S. Pat. No. 6469018; U.S. Pat. No.6465621; U.S. Pat. No. 6465461; U.S. Pat. No. 6465430; U.S. Pat. No.6461836; U.S. Pat. No. 6461614; U.S. Pat. No. 6458814; U.S. Pat. No.6458784; U.S. Pat. No. 6458779; U.S. Pat. No. 6458572; U.S. Pat. No.6455510; U.S. Pat. No. 6455507; U.S. Pat. No. 6451794; U.S. Pat. No.6451785; U.S. Pat. No. 6451556; U.S. Pat. No. 6451320; U.S. Pat. No.6448272; U.S. Pat. No. 6448038; U.S. Pat. No. 6448037; U.S. Pat. No.6448036; U.S. Pat. No. 6447773; U.S. Pat. No. 6447766; U.S. Pat. No.6444208; U.S. Pat. No. 6444198; U.S. Pat. No. 6441008; U.S. Pat. No.6433156; U.S. Pat. No. 6432703; U.S. Pat. No. 6432678; U.S. Pat. No.6432670; U.S. Pat. No. 6428982; U.S. Pat. No. 6426405; U.S. Pat. No.6426197; U.S. Pat. No. 6423508; U.S. Pat. No. 6423507; U.S. Pat. No.6420544; U.S. Pat. No. 6420161; U.S. Pat. No. 6417332; U.S. Pat. No.6414150; U.S. Pat. No. 6413524; U.S. Pat. No. 6410688; U.S. Pat. No.6410555; U.S. Pat. No. 6410529; U.S. Pat. No. 6410286; U.S. Pat. No.6410285; U.S. Pat. No. 6410263; U.S. Pat. No. 6407076; U.S. Pat. No.6406889; U.S. Pat. No. 6403792; U.S. Pat. No. 6403334; U.S. Pat. No.6399573; U.S. Pat. No. 6399343; U.S. Pat. No. 6399053; U.S. Pat. No.6397115; U.S. Pat. No. 6395759; U.S. Pat. No. 6392085; U.S. Pat. No.6391894; U.S. Pat. No. 6391874; U.S. Pat. No. 6391600; U.S. Pat. No.6391589; U.S. Pat. No. 6388055; U.S. Pat. No. 6376653; U.S. Pat. No.6376214; U.S. Pat. No. 6375945; U.S. Pat. No. 6372757; U.S. Pat. No.6372741; U.S. Pat. No. 6372487; U.S. Pat. No. 6372227; U.S. Pat. No.6369086; U.S. Pat. No. 6369068; U.S. Pat. No. 6368823; U.S. Pat. No.6365715; U.S. Pat. No. 6365389; U.S. Pat. No. 6365387; U.S. Pat. No.6365154; U.S. Pat. No. 6362193; U.S. Pat. No. 6361975; U.S. Pat. No.6361970; U.S. Pat. No. 6361967; U.S. Pat. No. 6361965; U.S. Pat. No.6359116; U.S. Pat. No. 6358725; U.S. Pat. No. 6358721; U.S. Pat. No.6358707; U.S. Pat. No. 6358704; U.S. Pat. No. 6358695; U.S. Pat. No.6355689; U.S. Pat. No. 6355465; U.S. Pat. No. 6355463; U.S. Pat. No.6355452; U.S. Pat. No. 6353093; U.S. Pat. No. 6353092; U.S. Pat. No.6352843; U.S. Pat. No. 6352840; U.S. Pat. No. 6350858; U.S. Pat. No.6350857; U.S. Pat. No. 6350856; U.S. Pat. No. 6350600; U.S. Pat. No.6350598; U.S. Pat. No. 6350446; U.S. Pat. No. 6348585; U.S. Pat. No.6348582; U.S. Pat. No. 6348579; U.S. Pat. No. 6348578; U.S. Pat. No.6348342; U.S. Pat. No. 6348341; U.S. Pat. No. 6348340; U.S. Pat. No.6348328; U.S. Pat. No. 6346608; U.S. Pat. No. 6346409; U.S. Pat. No.6346405; U.S. Pat. No. 6346397; U.S. Pat. No. 6346395; U.S. Pat. No.6346393; U.S. Pat. No. 6346392; U.S. Pat. No. 6346388; U.S. Pat. No.6344542; U.S. Pat. No. 6344540; U.S. Pat. No. 6344342; U.S. Pat. No.6342584; U.S. Pat. No. 6342371; U.S. Pat. No. 6342224; U.S. Pat. No.6340564; U.S. Pat. No. 6335433; U.S. Pat. No. 6335424; U.S. Pat. No.6335340; U.S. Pat. No. 6331411; U.S. Pat. No. 6331410; U.S. Pat. No.6329526; U.S. Pat. No. 6329168; U.S. Pat. No. 6326462; U.S. Pat. No.6326172; U.S. Pat. No. 6326170; U.S. Pat. No. 6326167; U.S. Pat. No.6323336; U.S. Pat. No. 6323333; U.S. Pat. No. 6323318; U.S. Pat. No.6320036; U.S. Pat. No. 6319689; U.S. Pat. No. 6319688; U.S. Pat. No.6316239; U.S. Pat. No. 6316237; U.S. Pat. No. 6316219; U.S. Pat. No.6316211; U.S. Pat. No. 6313270; U.S. Pat. No. 6313269; U.S. Pat. No.6312932; U.S. Pat. No. 6310193; U.S. Pat. No. 6310192; U.S. Pat. No.6309866; U.S. Pat. No. 6309856; U.S. Pat. No. 6309854; U.S. Pat. No.6306633; U.S. Pat. No. 6306604; U.S. Pat. No. 6303771; U.S. Pat. No.6303333; U.S. Pat. No. 6303124; U.S. Pat. No. 6300097; U.S. Pat. No.6300094; U.S. Pat. No. 6299883; U.S. Pat. No. 6299880; U.S. Pat. No.6297359; U.S. Pat. No. 6297358; U.S. Pat. No. 6297039; U.S. Pat. No.6297036; U.S. Pat. No. 6297030; U.S. Pat. No. 6297022; U.S. Pat. No.6296851; U.S. Pat. No. 6294661; U.S. Pat. No. 6294652; U.S. Pat. No.6294364; U.S. Pat. No. 6294357; U.S. Pat. No. 6294175; U.S. Pat. No.6294169; U.S. Pat. No. 6291230; U.S. Pat. No. 6291223; U.S. Pat. No.6287836; U.S. Pat. No. 6287810; U.S. Pat. No. 6287807; U.S. Pat. No.6287804; U.S. Pat. No. 6287803; U.S. Pat. No. 6287802; U.S. Pat. No.6287801; U.S. Pat. No. 6284878; U.S. Pat. No. 6284515; U.S. Pat. No.6284489; U.S. Pat. No. 6280990; U.S. Pat. No. 6280971; U.S. Pat. No.6280735; U.S. Pat. No. 6277979; U.S. Pat. No. 6277977; U.S. Pat. No.6277965; U.S. Pat. No. 6277960; U.S. Pat. No. 6277861; U.S. Pat. No.6277620; U.S. Pat. No. 6277597; U.S. Pat. No. 6277595; U.S. Pat. No.6274719; U.S. Pat. No. 6274717; U.S. Pat. No. 6274594; U.S. Pat. No.6274380; U.S. Pat. No. 6274376; U.S. Pat. No. 6274361; U.S. Pat. No.6274139; U.S. Pat. No. 6270999; U.S. Pat. No. 6270992; U.S. Pat. No.6270991; U.S. Pat. No. 6270762; U.S. Pat. No. 6268370; U.S. Pat. No.6268179; U.S. Pat. No. 6268177; U.S. Pat. No. 6268172; U.S. Pat. No.6268156; U.S. Pat. No. 6265188; U.S. Pat. No. 6264955; U.S. Pat. No.6261819; U.S. Pat. No. 6261817; U.S. Pat. No. 6261802; U.S. Pat. No.6258936; U.S. Pat. No. 6258934; U.S. Pat. No. 6258580; U.S. Pat. No.6258578; U.S. Pat. No. 6255471; U.S. Pat. No. 6255468; U.S. Pat. No.6255075; U.S. Pat. No. 6255072; U.S. Pat. No. 6252044; U.S. Pat. No.6251914; U.S. Pat. No. 6251652; U.S. Pat. No. 6251633; U.S. Pat. No.6251631; U.S. Pat. No. 6251630; U.S. Pat. No. 6251629; U.S. Pat. No.6251387; U.S. Pat. No. 6248863; U.S. Pat. No. 6248754; U.S. Pat. No.6248576; U.S. Pat. No. 6248557; U.S. Pat. No. 6248556; U.S. Pat. No.6245891; U.S. Pat. No. 6245778; U.S. Pat. No. 6245550; U.S. Pat. No.6245544; U.S. Pat. No. 6245542; U.S. Pat. No. 6242572; U.S. Pat. No.6242249; U.S. Pat. No. 6242217; U.S. Pat. No. 6239267; U.S. Pat. No.6239138; U.S. Pat. No. 6238900; U.S. Pat. No. 6238887; U.S. Pat. No.6238886; U.S. Pat. No. 6238885; U.S. Pat. No. 6238883; U.S. Pat. No.6238882; U.S. Pat. No. 6238873; U.S. Pat. No. 6235753; U.S. Pat. No.6235510; U.S. Pat. No. 6235285; U.S. Pat. No. 6232441; U.S. Pat. No.6232292; U.S. Pat. No. 6232097; U.S. Pat. No. 6232089; U.S. Pat. No.6232084; U.S. Pat. No. 6229006; U.S. Pat. No. 6228838; U.S. Pat. No.6228627; U.S. Pat. No. 6228625; U.S. Pat. No. 6228619; U.S. Pat. No.6228617; U.S. Pat. No. 6228612; U.S. Pat. No. 6228584; U.S. Pat. No.6228576; U.S. Pat. No. 6228364; U.S. Pat. No. 6225465; U.S. Pat. No.6225457; U.S. Pat. No. 6225102; U.S. Pat. No. 6225098; U.S. Pat. No.6225090; U.S. Pat. No. 6225087; U.S. Pat. No. 6225083; U.S. Pat. No.6224869; U.S. Pat. No. 6222036; U.S. Pat. No. 6222026; U.S. Pat. No.6222016; U.S. Pat. No. 6222014; U.S. Pat. No. 6221631; U.S. Pat. No.6221629; U.S. Pat. No. 6221627; U.S. Pat. No. 6218537; U.S. Pat. No.6218528; U.S. Pat. No. 6218159; U.S. Pat. No. 6217862; U.S. Pat. No.6217861; U.S. Pat. No. 6214858; U.S. Pat. No. 6214844; U.S. Pat. No.6214600; U.S. Pat. No. 6214595; U.S. Pat. No. 6214348; U.S. Pat. No.6214346; U.S. Pat. No. 6211161; U.S. Pat. No. 6210944; U.S. Pat. No.6210940; U.S. Pat. No. 6210674; U.S. Pat. No. 6210673; U.S. Pat. No.6207803; U.S. Pat. No. 6207647; U.S. Pat. No. 6207449; U.S. Pat. No.6207162; U.S. Pat. No. 6204042; U.S. Pat. No. 6204019; U.S. Pat. No.6204015; U.S. Pat. No. 6204014; U.S. Pat. No. 6203800; U.S. Pat. No.6200986; U.S. Pat. No. 6200787; U.S. Pat. No. 6200779; U.S. Pat. No.6200777; U.S. Pat. No. 6200776; U.S. Pat. No. 6200775; U.S. Pat. No.6200774; U.S. Pat. No. 6197931; U.S. Pat. No. 6197793; U.S. Pat. No.6197549; U.S. Pat. No. 6197546; U.S. Pat. No. 6197544; U.S. Pat. No.6197300; U.S. Pat. No. 6197069; U.S. Pat. No. 6194413; U.S. Pat. No.6194174; U.S. Pat. No. 6194170; U.S. Pat. No. 6191304; U.S. Pat. No.6191146; U.S. Pat. No. 6190881; U.S. Pat. No. 6187908; U.S. Pat. No.6187562; U.S. Pat. No. 6187561; U.S. Pat. No. 6187560; U.S. Pat. No.6183990; U.S. Pat. No. 6180387; U.S. Pat. No. 6180384; U.S. Pat. No.6180365; U.S. Pat. No. 6177269; U.S. Pat. No. 6174994; U.S. Pat. No.6174716; U.S. Pat. No. 6174714; U.S. Pat. No. 6174705; U.S. Pat. No.6171840; U.S. Pat. No. 6171838; U.S. Pat. No. 6171835; U.S. Pat. No.6171598; U.S. Pat. No. 6169166; U.S. Pat. No. 6168797; U.S. Pat. No.6166182; U.S. Pat. No. 6165992; U.S. Pat. No. 6165991; U.S. Pat. No.6165989; U.S. Pat. No. 6165771; U.S. Pat. No. 6165766; U.S. Pat. No.6165764; U.S. Pat. No. 6165763; U.S. Pat. No. 6165762; U.S. Pat. No.6165760; U.S. Pat. No. 6165759; U.S. Pat. No. 6165752; U.S. Pat. No.6165751; U.S. Pat. No. 6165472; U.S. Pat. No. 6165462; U.S. Pat. No.6162899; U.S. Pat. No. 6162630; U.S. Pat. No. 6162625; U.S. Pat. No.6162619; U.S. Pat. No. 6162618; U.S. Pat. No. 6160094; U.S. Pat. No.6159964; U.S. Pat. No. 6159949; U.S. Pat. No. 6159716; U.S. Pat. No.6159700; U.S. Pat. No. 6156537; U.S. Pat. No. 6156310; U.S. Pat. No.6153441; U.S. Pat. No. 6150557; U.S. Pat. No. 6150340; U.S. Pat. No.6146863; U.S. Pat. No. 6146846; U.S. Pat. No. 6146845; U.S. Pat. No.6146632; U.S. Pat. No. 6143521; U.S. Pat. No. 6140079; U.S. Pat. No.6140061; U.S. Pat. No. 6136560; U.S. Pat. No. 6136556; U.S. Pat. No.6133420; U.S. Pat. No. 6133006; U.S. Pat. No. 6130069; U.S. Pat. No.6130067; U.S. Pat. No. 6127522; U.S. Pat. No. 6127345; U.S. Pat. No.6127147; U.S. Pat. No. 6126937; U.S. Pat. No. 6124119; U.S. Pat. No.6121414; U.S. Pat. No. 6121028; U.S. Pat. No. 6121018; U.S. Pat. No.6120771; U.S. Pat. No. 6117662; U.S. Pat. No. 6114515; U.S. Pat. No.6114357; U.S. Pat. No. 6114127; U.S. Pat. No. 6111078; U.S. Pat. No.6111074; U.S. Pat. No. 6110934; U.S. Pat. No. 6110899; U.S. Pat. No.6110723; U.S. Pat. No. 6110717; U.S. Pat. No. 6110704; U.S. Pat. No.6110685; U.S. Pat. No. 6107473; U.S. Pat. No. 6107463; U.S. Pat. No.6107309; U.S. Pat. No. 6107071; U.S. Pat. No. 6107058; U.S. Pat. No.6403936; U.S. Pat. No. 6103507; U.S. Pat. No. 6100069; U.S. Pat. No.6100062; U.S. Pat. No. 6100060; U.S. Pat. No. 6100059; U.S. Pat. No.6096868; U.S. Pat. No. 6096748; U.S. Pat. No. 6096518; U.S. Pat. No.6096517; U.S. Pat. No. 6090600; U.S. Pat. No. 6090583; U.S. Pat. No.6090582; U.S. Pat. No. 6090579; U.S. Pat. No. 6087169; U.S. Pat. No.6087142; U.S. Pat. No. 6084086; U.S. Pat. No. 6083924; U.S. Pat. No.6083711; U.S. Pat. No. 6080729; U.S. Pat. No. 6080717; U.S. Pat. No.6080398; U.S. Pat. No. 6077857; U.S. Pat. No. 6077856; U.S. Pat. No.6077855; U.S. Pat. No. 6077677; U.S. Pat. No. 6075137; U.S. Pat. No.6074858; U.S. Pat. No. 6072032; U.S. Pat. No. 6071894; U.S. Pat. No.6071892; U.S. Pat. No. 6071731; U.S. Pat. No. 6071719; U.S. Pat. No.6069239; U.S. Pat. No. 6069158; U.S. Pat. No. 6066717; U.S. Pat. No.6063609; U.S. Pat. No. 6060294; U.S. Pat. No. 6060277; U.S. Pat. No.6060055; U.S. Pat. No. 6057432; U.S. Pat. No. 6057138; U.S. Pat. No.6054559; U.S. Pat. No. 6054465; U.S. Pat. No. 6054308; U.S. Pat. No.6051691; U.S. Pat. No. 6051584; U.S. Pat. No. 6051413; U.S. Pat. No.6051412; U.S. Pat. No. 6051400; U.S. Pat. No. 6048963; U.S. Pat. No.6048716; U.S. Pat. No. 6046209; U.S. Pat. No. 6046208; U.S. Pat. No.6046198; U.S. Pat. No. 6046197; U.S. Pat. No. 6046174; U.S. Pat. No.6046030; U.S. Pat. No. 6043071; U.S. Pat. No. 6043054; U.S. Pat. No.6043053; U.S. Pat. No. 6043052; U.S. Pat. No. 6040163; U.S. Pat. No.6040162; U.S. Pat. No. 6037146; U.S. Pat. No. 6033872; U.S. Pat. No.6031090; U.S. Pat. No. 6030989; U.S. Pat. No. 6030811; U.S. Pat. No.6025390; U.S. Pat. No. 6025180; U.S. Pat. No. 6025175; U.S. Pat. No.6025160; U.S. Pat. No. 6025156; U.S. Pat. No. 6022710; U.S. Pat. No.6022706; U.S. Pat. No. 6020161; U.S. Pat. No. 6020160; U.S. Pat. No.6020159; U.S. Pat. No. 6020157; U.S. Pat. No. 6017728; U.S. Pat. No.6013505; U.S. Pat. No. 6013497; U.S. Pat. No. 6013482; U.S. Pat. No.6013476; U.S. Pat. No. 6010881; U.S. Pat. No. 6010878; U.S. Pat. No.6010877; U.S. Pat. No. 6008213; U.S. Pat. No. 6008050; U.S. Pat. No.6008042; U.S. Pat. No. 6008033; U.S. Pat. No. 6008030; U.S. Pat. No.6008021; U.S. Pat. No. 6008017; U.S. Pat. No. 6008012; U.S. Pat. No.6005074; U.S. Pat. No. 6004556; U.S. Pat. No. 6001972; U.S. Pat. No.6001963; U.S. Pat. No. 6001623; U.S. Pat. No. 6001603; U.S. Pat. No.6001602; U.S. Pat. No. 6001601; U.S. Pat. No. 6001600; U.S. Pat. No.6001362; U.S. Pat. No. 5994111; U.S. Pat. No. 5994101; U.S. Pat. No.5994100; U.S. Pat. No. 5994096; U.S. Pat. No. 5990102; U.S. Pat. No.5989884; U.S. Pat. No. 5989864; U.S. Pat. No. 5989858; U.S. Pat. No.5987390; U.S. Pat. No. 5981525; U.S. Pat. No. 5981223; U.S. Pat. No.5977103; U.S. Pat. No. 5977101; U.S. Pat. No. 5977085; U.S. Pat. No.5976840; U.S. Pat. No. 5976834; U.S. Pat. No. 5972651; U.S. Pat. No.5972606; U.S. Pat. No. 5972346; U.S. Pat. No. 5969184; U.S. Pat. No.5968777; U.S. Pat. No. 5965420; U.S. Pat. No. 5965416; U.S. Pat. No.5965402; U.S. Pat. No. 5962666; U.S. Pat. No. 5962303; U.S. Pat. No.5962295; U.S. Pat. No. 5962259; U.S. Pat. No. 5958734; U.S. Pat. No.5958733; U.S. Pat. No. 5955309; U.S. Pat. No. 5955308; U.S. Pat. No.5955304; U.S. Pat. No. 5952483; U.S. Pat. No. 5952196; U.S. Pat. No.5948669; U.S. Pat. No. 5948657; U.S. Pat. No. 5948642; U.S. Pat. No.5945310; U.S. Pat. No. 5942419; U.S. Pat. No. 5942416; U.S. Pat. No.5942405; U.S. Pat. No. 5942402; U.S. Pat. No. 5939298; U.S. Pat. No.5939284; U.S. Pat. No. 5935835; U.S. Pat. No. 5935816; U.S. Pat. No.5935814; U.S. Pat. No. 5932701; U.S. Pat. No. 5932461; U.S. Pat. No.5932446; U.S. Pat. No. 5929076; U.S. Pat. No. 5929059; U.S. Pat. No.5929045; U.S. Pat. No. 5928920; U.S. Pat. No. 5928895; U.S. Pat. No.5925539; U.S. Pat. No. 5922853; U.S. Pat. No. 5922546; U.S. Pat. No.5919904; U.S. Pat. No. 5919664; U.S. Pat. No. 5919660; U.S. Pat. No.5919491; U.S. Pat. No. 5916891; U.S. Pat. No. 5916766; U.S. Pat. No.5912335; U.S. Pat. No. 5912159; U.S. Pat. No. 5910572; U.S. Pat. No.5910430; U.S. Pat. No. 5910414; U.S. Pat. No. 5891678; U.S. Pat. No.5891672; U.S. Pat. No. 5891670; U.S. Pat. No. 5891667; U.S. Pat. No.5889171; U.S. Pat. No. 5889145; U.S. Pat. No. 5888771; U.S. Pat. No.5888770; U.S. Pat. No. 5885805; U.S. Pat. No. 5885804; U.S. Pat. No.5885800; U.S. Pat. No. 5885572; U.S. Pat. No. 5883255; U.S. Pat. No.5883239; U.S. Pat. No. 5882898; U.S. Pat. No. 5882897; U.S. Pat. No.5882896; U.S. Pat. No. 5882892; U.S. Pat. No. 5882891; U.S. Pat. No.5882889; U.S. Pat. No. 5882885; U.S. Pat. No. 5882871; U.S. Pat. No.5882643; U.S. Pat. No. 5880262; U.S. Pat. No. 5879908; U.S. Pat. No.5874252; U.S. Pat. No. 5874243; U.S. Pat. No. 5871989; U.S. Pat. No.5871967; U.S. Pat. No. 5869660; U.S. Pat. No. 5869290; U.S. Pat. No.5866693; U.S. Pat. No. 5866390; U.S. Pat. No. 5866370; U.S. Pat. No.5866369; U.S. Pat. No. 5866367; U.S. Pat. No. 5866366; U.S. Pat. No.5866365; U.S. Pat. No. 5864036; U.S. Pat. No. 5863777; U.S. Pat. No.5863769; U.S. Pat. No. 5861298; U.S. Pat. No. 5861281; U.S. Pat. No.5858720; U.S. Pat. No. 5858718; U.S. Pat. No. 5858716; U.S. Pat. No.5858709; U.S. Pat. No. 5854020; U.S. Pat. No. 5851798; U.S. Pat. No.5849555; U.S. Pat. No. 5846772; U.S. Pat. No. 5840560; U.S. Pat. No.5840538; U.S. Pat. No. 5837508; U.S. Pat. No. 5834587; U.S. Pat. No.5834276; U.S. Pat. No. 5827708; U.S. Pat. No. 5827689; U.S. Pat. No.5817680; U.S. Pat. No. 5817481; U.S. Pat. No. 5811549; U.S. Pat. No.5811535; U.S. Pat. No. 5801234; U.S. Pat. No. 5795758; U.S. Pat. No.5795757; U.S. Pat. No. 6506383; U.S. Pat. No. 6455043; U.S. Pat. No.6451284; U.S. Pat. No. 6440418; U.S. Pat. No. 6413771; U.S. Pat. No.6399061; U.S. Pat. No. 6300143; U.S. Pat. No. 6270769; U.S. Pat. No.6197311; U.S. Pat. No. 6136310; U.S. Pat. No. 6001358; U.S. Pat. No.5958765; U.S. Pat. No. 5955364; U.S. Pat. No. 5939068; U.S. Pat. No.5866125; U.S. Pat. No. 5840298; U.S. Pat. No. 5811524; U.S. Pat. No.5776456; U.S. Pat. No. 5756096; U.S. Pat. No. 5750105; U.S. Pat. No.5736137; U.S. Pat. No. 5709860; U.S. Pat. No. 5695770; U.S. Pat. No.5693780; U.S. Pat. No. 5681722; U.S. Pat. No. 5658570; U.S. Pat. No.5585103; U.S. Pat. No. 6420518; U.S. Pat. No. 6372453; U.S. Pat. No.6342348; U.S. Pat. No. 6218387; U.S. Pat. No. 6214344; U.S. Pat. No.6165464; U.S. Pat. No. 6124435; U.S. Pat. No. 6066719; U.S. Pat. No.6063585; U.S. Pat. No. 6060303; U.S. Pat. No. 6046048; U.S. Pat. No.6030831; U.S. Pat. No. 6022735; U.S. Pat. No. 6001621; U.S. Pat. No.5879910; U.S. Pat. No. 5849533; U.S. Pat. No. 5821333; U.S. Pat. No.5759775; U.S. Pat. No. 5702938; U.S. Pat. No. 5332671; U.S. Pat. No.6498181; U.S. Pat. No. 6462067; U.S. Pat. No. 6407133; U.S. Pat. No.6375946; U.S. Pat. No. 6305380; U.S. Pat. No. 6245563; U.S. Pat. No.6242473; U.S. Pat. No. 6221893; U.S. Pat. No. 6155266; U.S. Pat. No.6080395; U.S. Pat. No. 6071942; U.S. Pat. No. 6071509; U.S. Pat. No.6063373; U.S. Pat. No. 6003516; U.S. Pat. No. 5961969; U.S. Pat. No.5728378; U.S. Pat. No. 6521403; U.S. Pat. No. 6482588; U.S. Pat. No.6458386; U.S. Pat. No. 6440662; U.S. Pat. No. 6350860; U.S. Pat. No.6346248; U.S. Pat. No. 6204359; U.S. Pat. No. 6132759; U.S. Pat. No.6126935; U.S. Pat. No. 6126935; U.S. Pat. No. 6071519; U.S. Pat. No.6027922; U.S. Pat. No. 5891679; U.S. Pat. No. 5624795; U.S. Pat. No.6544523; U.S. Pat. No. 6534064; U.S. Pat. No. 6531307; U.S. Pat. No.6531276; U.S. Pat. No. 6525102; U.S. Pat. No. 6512102; U.S. Pat. No.6500635; U.S. Pat. No. 6492112; U.S. Pat. No. 6489344; U.S. Pat. No.6489294; U.S. Pat. No. 6489137; U.S. Pat. No. 6479284; U.S. Pat. No.6476207; U.S. Pat. No. 6468986; U.S. Pat. No. 6468790; U.S. Pat. No.6465634; U.S. Pat. No. 6458560; U.S. Pat. No. 6458527; U.S. Pat. No.6458370; U.S. Pat. No. 6451592; U.S. Pat. No. 6448382; U.S. Pat. No.6432668; U.S. Pat. No. 6429302; U.S. Pat. No. 6429001; U.S. Pat. No.6426196; U.S. Pat. No. 6423822; U.S. Pat. No. 642368; U.S. Pat. No.6423544; U.S. Pat. No. 6414120; U.S. Pat. No. 6410326; U.S. Pat. No.6410316; U.S. Pat. No. 6410312; U.S. Pat. No. 6391632; U.S. Pat. No.6391588; U.S. Pat. No. 6387920; U.S. Pat. No. 6376236; U.S. Pat. No.6369029; U.S. Pat. No. 6355247; U.S. Pat. No. 6342372; U.S. Pat. No.6315998; U.S. Pat. No. 6310045; U.S. Pat. No. 6306405; U.S. Pat. No.6303372; U.S. Pat. No. 6303292; U.S. Pat. No. 6300485; U.S. Pat. No.6300484; U.S. Pat. No. 6297367; U.S. Pat. No. 6297048; U.S. Pat. No.6291505; U.S. Pat. No. 6268341; U.S. Pat. No. 6262249; U.S. Pat. No.6262098; U.S. Pat. No. 6251433; U.S. Pat. No. 6248715; U.S. Pat. No.6241982; U.S. Pat. No. 6204020; U.S. Pat. No. 6184354; U.S. Pat. No.6174721; U.S. Pat. No. 6174679; U.S. Pat. No. 6166191; U.S. Pat. No.6156300; U.S. Pat. No. 6146851; U.S. Pat. No. 6143873; U.S. Pat. No.6140483; U.S. Pat. No. 6133029; U.S. Pat. No. 6121240; U.S. Pat. No.6117422; U.S. Pat. No. 6114113; U.S. Pat. No. 6106833; U.S. Pat. No.6103500; U.S. Pat. No. 6103224; U.S. Pat. No. 6096505; U.S. Pat. No.6090621; U.S. Pat. No. 6087178; U.S. Pat. No. 6086901; U.S. Pat. No.6083910; U.S. Pat. No. 6083742; U.S. Pat. No. 6077701; U.S. Pat. No.6074848; U.S. Pat. No. 6071512; U.S. Pat. No. 6069127; U.S. Pat. No.6057093; U.S. Pat. No. 6056959; U.S. Pat. No. 6054561; U.S. Pat. No.6048728; U.S. Pat. No. 6048527; U.S. Pat. No. 6030940; U.S. Pat. No.6030834; U.S. Pat. No. 6025465; U.S. Pat. No. 6025146; U.S. Pat. No.6022953; U.S. Pat. No. 6015694; U.S. Pat. No. 6013432; U.S. Pat. No.6004552; U.S. Pat. No. 6001605; U.S. Pat. No. 5997859; U.S. Pat. No.5997856; U.S. Pat. No. 5994060; U.S. Pat. No. 5977323; U.S. Pat. No.5965382; U.S. Pat. No. 5959084; U.S. Pat. No. 5948647; U.S. Pat. No.5948640; U.S. Pat. No. 5942220; U.S. Pat. No. 5932537; U.S. Pat. No.5932467; U.S. Pat. No. 5925516; U.S. Pat. No. 5922857; U.S. Pat. No.5914266; U.S. Pat. No. 5902582; U.S. Pat. No. 5889156; U.S. Pat. No.5888814; U.S. Pat. No. 5877305; U.S. Pat. No. 5877305; U.S. Pat. No.5874082; U.S. Pat. No. 5874077; U.S. Pat. No. 5872220; U.S. Pat. No.5872095; U.S. Pat. No. 5869050; U.S. Pat. No. 5866114; U.S. Pat. No.5863797; U.S. Pat. No. 5863767; U.S. Pat. No. 5860917; U.S. Pat. No.5858688; U.S. Pat. No. 5856185; U.S. Pat. No. 5849877; U.S. Pat. No.5849586; U.S. Pat. No. 5843883; U.S. Pat. No. 5843723; U.S. Pat. No.5840496; U.S. Pat. No. 5837846; U.S. Pat. No. 5837229; U.S. Pat. No.5830684; U.S. Pat. No. 5830452; U.S. Pat. No. 5824549; U.S. Pat. No.5817306; U.S. Pat. No. 5814469; U.S. Pat. No. 5811267; U.S. Pat. No.5789245; U.S. Pat. No. 5773586; U.S. Pat. No. 5773237; U.S. Pat. No.5766845; U.S. Pat. No. 5763573; U.S. Pat. No. 5760203; U.S. Pat. No.5760039; U.S. Pat. No. 5756312; U.S. Pat. No. 6544523; U.S. Pat. No.6521225; U.S. Pat. No. 6468986; U.S. Pat. No. 6465634; U.S. Pat. No.6458560; U.S. Pat. No. 6451592; U.S. Pat. No. 6426196; U.S. Pat. No.6410326; U.S. Pat. No. 6391632; U.S. Pat. No. 6376236; U.S. Pat. No.6342372; U.S. Pat. No. 6297367; U.S. Pat. No. 6251433; U.S. Pat. No.6204020; U.S. Pat. No. 6191106; U.S. Pat. No. 6156300; U.S. Pat. No.6146851; U.S. Pat. No. 6133029; U.S. Pat. No. 6117983; U.S. Pat. No.6117422; U.S. Pat. No. 6114113; U.S. Pat. No. 6103224; U.S. Pat. No.6087178; U.S. Pat. No. 6022953; U.S. Pat. No. 6015694; U.S. Pat. No.5932537; U.S. Pat. No. 5872095; U.S. Pat. No. 5869050; U.S. Pat. No.5856185; U.S. Pat. No. 5843723; U.S. Pat. No. 5840496; U.S. Pat. No.5837229; U.S. Pat. No. 5824549; U.S. Pat. No. 5817306; U.S. Pat. No.5814469; U.S. Pat. No. 5792450; U.S. Pat. No. 5789245; U.S. Pat. No.5773223; U.S. Pat. No. 5747444; U.S. Pat. No. 5747034; U.S. Pat. No.5725850; U.S. Pat. No. 5681719; U.S. Pat. No. 5672343; U.S. Pat. No.5643563; U.S. Pat. No. 5635175; U.S. Pat. No. 5614183; U.S. Pat. No.5547935; U.S. Pat. No. 5158935; U.S. Pat. No. 6544951; U.S. Pat. No.6531467; U.S. Pat. No. 6528506; U.S. Pat. No. 6525024; U.S. Pat. No.6518032; U.S. Pat. No. 6515173; U.S. Pat. No. 6504022; U.S. Pat. No.6462175; U.S. Pat. No. 6391575; U.S. Pat. No. 6287795; U.S. Pat. No.6270980; U.S. Pat. No. 6251614; U.S. Pat. No. 6200969; U.S. Pat. No.6197750; U.S. Pat. No. 5965703; U.S. Pat. No. 5869519; U.S. Pat. No.5851815; U.S. Pat. No. 5786173; U.S. Pat. No. 6500826; U.S. Pat. No.6315999; U.S. Pat. No. 6204271; U.S. Pat. No. 6117879; U.S. Pat. No.5562900; U.S. Pat. No. 5500359; U.S. Pat. No. 6545027; U.S. Pat. No.6541499; U.S. Pat. No. 6534650; U.S. Pat. No. 6521755; U.S. Pat. No.6521611; U.S. Pat. No. 6509356; U.S. Pat. No. 6500851; U.S. Pat. No.6492392; U.S. Pat. No. 6486179; U.S. Pat. No. 6482824; U.S. Pat. No.6479517; U.S. Pat. No. 6458811; U.S. Pat. No. 6451817; U.S. Pat. No.6444688; U.S. Pat. No. 6440930; U.S. Pat. No. 6437137; U.S. Pat. No.6432983; U.S. Pat. No. 6432982; U.S. Pat. No. 6426417; U.S. Pat. No.RE7806; U.S. Pat. No. 6417200; U.S. Pat. No. 6417199; U.S. Pat. No.6417193; U.S. Pat. No. 6410564; U.S. Pat. No. 6407243; U.S. Pat. No.6403614; U.S. Pat. No. 6403577; U.S. Pat. No. 6399634; U.S. Pat. No.6395755; U.S. Pat. No. 6395730; U.S. Pat. No. 6395719; U.S. Pat. No.6395509; U.S. Pat. No. RE7720; U.S. Pat. No. 6391901; U.S. Pat. No.6391892; U.S. Pat. No. 6384053; U.S. Pat. No. 6380201; U.S. Pat. No.6376230; U.S. Pat. No. 6372936; U.S. Pat. No. 6372759; U.S. Pat. No.6369070; U.S. Pat. No. 6359136; U.S. Pat. No. 6358994; U.S. Pat. No.6355632; U.S. Pat. No. 6353003; U.S. Pat. No. 6350774; U.S. Pat. No.6339094; U.S. Pat. No. 6313151; U.S. Pat. No. 6313122; U.S. Pat. No.6303634; U.S. Pat. No. 6303610; U.S. Pat. No. 6291484; U.S. Pat. No.6288108; U.S. Pat. No. 6288105; U.S. Pat. No. 6288053; U.S. Pat. No.6284756; U.S. Pat. No. 6284751; U.S. Pat. No. 6274601; U.S. Pat. No.6271227; U.S. Pat. No. 6270978; U.S. Pat. No. 6265575; U.S. Pat. No.6265416; U.S. Pat. No. 6262262; U.S. Pat. No. 6258807; U.S. Pat. No.6251921; U.S. Pat. No. 6245802; U.S. Pat. No. 6245352; U.S. Pat. No.6242192; U.S. Pat. No. 6235785; U.S. Pat. No. 6232299; U.S. Pat. No.6228615; U.S. Pat. No. 6221876; U.S. Pat. No. 6221838; U.S. Pat. No.6218425; U.S. Pat. No. 6214841; U.S. Pat. No. 6204260; U.S. Pat. No.6200967; U.S. Pat. No. 6197790; U.S. Pat. No. 6180679; U.S. Pat. No.6180657; U.S. Pat. No. 6180633; U.S. Pat. No. 6175013; U.S. Pat. No.6174921; U.S. Pat. No. 6174908; U.S. Pat. No. 6172100; U.S. Pat. No.6160176; U.S. Pat. No. 6150396; U.S. Pat. No. 6150375; U.S. Pat. No.6147115; U.S. Pat. No. 6147092; U.S. Pat. No. 6143909; U.S. Pat. No.6133458; U.S. Pat. No. 6133457; U.S. Pat. No. 6133452; U.S. Pat. No.6133288; U.S. Pat. No. 6133262; U.S. Pat. No. 6130219; U.S. Pat. No.6124311; U.S. Pat. No. 6124277; U.S. Pat. No. 6121293; U.S. Pat. No.6121292; U.S. Pat. No. 6117861; U.S. Pat. No. 6113876; U.S. Pat. No.6110942; U.S. Pat. No. 6103740; U.S. Pat. No. 6103712; U.S. Pat. No.6096764; U.S. Pat. No. 6090843; U.S. Pat. No. 6090787; U.S. Pat. No.6090168; U.S. Pat. No. 6077852; U.S. Pat. No. 6075151; U.S. Pat. No.6066639; U.S. Pat. No. 6060488; U.S. Pat. No. 6060264; U.S. Pat. No.6057440; U.S. Pat. No. 6057130; U.S. Pat. No. 6037475; U.S. Pat. No.6034104; U.S. Pat. No. 6030986; U.S. Pat. No. 6025382; U.S. Pat. No.6025381; U.S. Pat. No. 6025379; U.S. Pat. No. 6025373; U.S. Pat. No.6025359; U.S. Pat. No. 6020513; U.S. Pat. No. 6020512; U.S. Pat. No.6017930; U.S. Pat. No. 6017914; U.S. Pat. No. 6015807; U.S. Pat. No.6013828; U.S. Pat. No. 6011057; U.S. Pat. No. 6008367; U.S. Pat. No.6004971; U.S. Pat. No. 6001359; U.S. Pat. No. 5998443; U.S. Pat. No.5998442; U.S. Pat. No. 5998441; U.S. Pat. No. 5998434; U.S. Pat. No.5998401; U.S. Pat. No. 5994547; U.S. Pat. No. 5994371; U.S. Pat. No.5994370; U.S. Pat. No. 5990319; U.S. Pat. No. 5990129; U.S. Pat. No.5986109; U.S. Pat. No. 5985898; U.S. Pat. No. 5985865; U.S. Pat. No.5985322; U.S. Pat. No. 5981765; U.S. Pat. No. 5977387; U.S. Pat. No.5977382; U.S. Pat. No. 5977157; U.S. Pat. No. 5977098; U.S. Pat. No.5977093; U.S. Pat. No. 5972888; U.S. Pat. No. 5972675; U.S. Pat. No.5969142; U.S. Pat. No. 5969136; U.S. Pat. No. 5962497; U.S. Pat. No.5962475; U.S. Pat. No. 5962473; U.S. Pat. No. 5959103; U.S. Pat. No.5958969; U.S. Pat. No. 5958917; U.S. Pat. No. 5958916; U.S. Pat. No.5952513; U.S. Pat. No. 5952364; U.S. Pat. No. 5952360; U.S. Pat. No.5952350; U.S. Pat. No. 5948907; U.S. Pat. No. 5948796; U.S. Pat. No.5945324; U.S. Pat. No. 5942530; U.S. Pat. No. 5936084; U.S. Pat. No.5929092; U.S. Pat. No. 5929090; U.S. Pat. No. 5928898; U.S. Pat. No.5919946; U.S. Pat. No. 5919800; U.S. Pat. No. 5916916; U.S. Pat. No.5914319; U.S. Pat. No. 5914246; U.S. Pat. No. 5910505; U.S. Pat. No.5910319; U.S. Pat. No. 5892034; U.S. Pat. No. 5891875; U.S. Pat. No.5889000; U.S. Pat. No. 5886003; U.S. Pat. No. 5885967; U.S. Pat. No.5879919; U.S. Pat. No. 5869497; U.S. Pat. No. 5863929; U.S. Pat. No.5859261; U.S. Pat. No. 5858704; U.S. Pat. No. 5856341; U.S. Pat. No.5856340; U.S. Pat. No. 5856339; U.S. Pat. No. 5851995; U.S. Pat. No.5846974; U.S. Pat. No. 5843984; U.S. Pat. No. 5843976; U.S. Pat. No.5843974; U.S. Pat. No. 5843965; U.S. Pat. No. 5843964; U.S. Pat. No.5843963; U.S. Pat. No. 5843940; U.S. Pat. No. 5843935; U.S. Pat. No.5840747; U.S. Pat. No. 5834488; U.S. Pat. No. 5831017; U.S. Pat. No.5827879; U.S. Pat. No. 5827844; U.S. Pat. No. 5824510; U.S. Pat. No.5821365; U.S. Pat. No. 5821331; U.S. Pat. No. 5817684; U.S. Pat. No.5816260; U.S. Pat. No. 5811421; U.S. Pat. No. 5811415; U.S. Pat. No.5811402; U.S. Pat. No. 5808048; U.S. Pat. No. 5798351; U.S. Pat. No.5792870; U.S. Pat. No. 5792798; U.S. Pat. No. 5792760; U.S. Pat. No.5789400; U.S. Pat. No. 5786463; U.S. Pat. No. 5780461; U.S. Pat. No.5776939; U.S. Pat. No. 5773441; U.S. Pat. No. 5773214; U.S. Pat. No.5770610; U.S. Pat. No. 5770397; U.S. Pat. No. 5760030; U.S. Pat. No.5750708; U.S. Pat. No. 5747524; U.S. Pat. No. 5747510; U.S. Pat. No.5744597; U.S. Pat. No. 5744482; U.S. Pat. No. 5739322; U.S. Pat. No.5734057; U.S. Pat. No. 5732717; U.S. Pat. No. 5731342; U.S. Pat. No.5728724; U.S. Pat. No. 5726186; U.S. Pat. No. 5726168; U.S. Pat. No.5726167; U.S. Pat. No. 5726159; U.S. Pat. No. 5723474; U.S. Pat. No.6541496; U.S. Pat. No. 6531474; U.S. Pat. No. 6528509; U.S. Pat. No.6528508; U.S. Pat. No. 6518291; U.S. Pat. No. 6509363; U.S. Pat. No.6498178; U.S. Pat. No. 6495582; U.S. Pat. No. 6426416; U.S. Pat. No.6423840; U.S. Pat. No. 6407080; U.S. Pat. No. 6395763; U.S. Pat. No.6387641; U.S. Pat. No. 6350741; U.S. Pat. No. 6344465; U.S. Pat. No.6329365; U.S. Pat. No. 6268384; U.S. Pat. No. 6258948; U.S. Pat. No.6225350; U.S. Pat. No. 6204261; U.S. Pat. No. 6162800; U.S. Pat. No.6162790; U.S. Pat. No. 6162613; U.S. Pat. No. 6147080; U.S. Pat. No.6128582; U.S. Pat. No. 6121266; U.S. Pat. No. 6093742; U.S. Pat. No.6054472; U.S. Pat. No. 6011001; U.S. Pat. No. 6008217; U.S. Pat. No.6004768; U.S. Pat. No. 5985863; U.S. Pat. No. 5976529; U.S. Pat. No.5945418; U.S. Pat. No. 5945407; U.S. Pat. No. 5935954; U.S. Pat. No.5932600; U.S. Pat. No. 5912269; U.S. Pat. No. 5883123; U.S. Pat. No.5880152; U.S. Pat. No. 5874424; U.S. Pat. No. 5849296; U.S. Pat. No.5843905; U.S. Pat. No. 5843904; U.S. Pat. No. 5834514; U.S. Pat. No.5807876; U.S. Pat. No. 5763488; U.S. Pat. No. 5744485; U.S. Pat. No.5726184; U.S. Pat. No. 5723459; U.S. Pat. No. 5717092; U.S. Pat. No.5620971; U.S. Pat. No. 5618710; U.S. Pat. No. 5543423; U.S. Pat. No.6544970; U.S. Pat. No. 6540993; U.S. Pat. No. 6537971; U.S. Pat. No.6537964; U.S. Pat. No. 6521618; U.S. Pat. No. 6518272; U.S. Pat. No.6511986; U.S. Pat. No. 6503939; U.S. Pat. No. 6500814; U.S. Pat. No.6498154; U.S. Pat. No. 6482804; U.S. Pat. No. 6479535; U.S. Pat. No.6465508; U.S. Pat. No. 6462032; U.S. Pat. No. 6455568; U.S. Pat. No.6455566; U.S. Pat. No. 6444668; U.S. Pat. No. 6441019; U.S. Pat. No.6440991; U.S. Pat. No. 6436929; U.S. Pat. No. 6432973; U.S. Pat. No.6429214; U.S. Pat. No. 6423308; U.S. Pat. No. 6417214; U.S. Pat. No.6399626; U.S. Pat. No. 6399625; U.S. Pat. No. 6399593; U.S. Pat. No.6395723; U.S. Pat. No. 6063777; U.S. Pat. No. 5436251; U.S. Pat. No.6544959; U.S. Pat. No. 6441161; U.S. Pat. No. 6432631; U.S. Pat. No.6426335; U.S. Pat. No. 6376474; U.S. Pat. No. 6346611; U.S. Pat. No.6344321; U.S. Pat. No. 6331394; U.S. Pat. No. 6280932; US. Pat. No.6274115; U.S. Pat. No. 6232071; U.S. Pat. No. 6110721; U.S. Pat. No.6034118; U.S. Pat. No. 5830653; U.S. Pat. No. 5817781; U.S. Pat. No.5811450; U.S. Pat. No. 5792847; U.S. Pat. No. 5792608; U.S. Pat. No.5763208; U.S. Pat. No. 5756291; U.S. Pat. No. 5705524; U.S. Pat. No.6271344; U.S. Pat. No. 5993812; U.S. Pat. No. 5641663; U.S. Pat. No.6545029; U.S. Pat. No. 6541468; U.S. Pat. No. 6518274; U.S. Pat. No.6512007; U.S. Pat. No. 6500847; U.S. Pat. No. 6500817; U.S. Pat. No.6498037; U.S. Pat. No. 6495545; U.S. Pat. No. 6492335; U.S. Pat. No.6461874; U.S. Pat. No. 6436349; U.S. Pat. No. 6433157; U.S. Pat. No.6432948; U.S. Pat. No. 6420393; U.S. Pat. No. 6420118; U.S. Pat. No.6353006; U.S. Pat. No. 6348192; U.S. Pat. No. 6344476; U.S. Pat. No.6342583; U.S. Pat. No. 6335426; U.S. Pat. No. 6313272; U.S. Pat. No.6309846; U.S. Pat. No. 6294201; U.S. Pat. No. 6291503; U.S. Pat. No.6288081; U.S. Pat. No. 6288063; U.S. Pat. No. 6271342; U.S. Pat. No.6262334; U.S. Pat. No. 6262333; U.S. Pat. No. 6245886; U.S. Pat. No.6225314; U.S. Pat. No. 6218431; U.S. Pat. No. 6200764; U.S. Pat. No.6187799; U.S. Pat. No. 6180417; U.S. Pat. No. 6180380; U.S. Pat. No.6169073; U.S. Pat. No. 6166082; U.S. Pat. No. 6156754; U.S. Pat. No.6133260; U.S. Pat. No. 6130318; U.S. Pat. No. 6107049; U.S. Pat. No.6103925; U.S. Pat. No. 6074615; U.S. Pat. No. 6028176; U.S. Pat. No.6025201; U.S. Pat. No. 6015458; U.S. Pat. No. 6013772; U.S. Pat. No.6013646; U.S. Pat. No. 5986059; U.S. Pat. No. 5973110; U.S. Pat. No.5968795; U.S. Pat. No. 5962633; U.S. Pat. No. 5955571; U.S. Pat. No.5939583; U.S. Pat. No. 5932763; U.S. Pat. No. 5932577; U.S. Pat. No.5928878; U.S. Pat. No. 5925637; U.S. Pat. No. 5911988; U.S. Pat. No.5902888; U.S. Pat. No. 5895765; U.S. Pat. No. 5886043; U.S. Pat. No.5886024; U.S. Pat. No. 5886022; U.S. Pat. No. 5874473; U.S. Pat. No.5863915; U.S. Pat. No. 5861428; U.S. Pat. No. 5859047; U.S. Pat. No.5854277; U.S. Pat. No. 5849893; U.S. Pat. No. 5843761; U.S. Pat. No.5840501; U.S. Pat. No. 5833946; U.S. Pat. No. 5817519; U.S. Pat. No.5804581; U.S. Pat. No. 5789434; U.S. Pat. No. 5760073; U.S. Pat. No.5719181; U.S. Pat. No. 5674754; U.S. Pat. No. 5654407; U.S. Pat. No.5646032; U.S. Pat. No. 5623049; U.S. Pat. No. 6534482; U.S. Pat. No.6464980; U.S. Pat. No. 6419931; U.S. Pat. No. 6413935; U.S. Pat. No.6322789; U.S. Pat. No. 6037135; U.S. Pat. No. 6505126; U.S. Pat. No.6482397; U.S. Pat. No. 6271014; U.S. Pat. No. 6231837; U.S. Pat. No.6063372; U.S. Pat. No. 6874442; U.S. Pat. No. 6385427; U.S. Pat. No.6958007; U.S. Pat. No. 6495521; U.S. Pat. No. 6462017; U.S. Pat. No.6288033; U.S. Pat. No. 6200952; U.S. Pat. No. 6001799; U.S. Pat. No.5939423; U.S. Pat. No. 5849696; U.S. Pat. No. 5308833; U.S. Pat. No.6545160; U.S. Pat. No. 6545003; U.S. Pat. No. 6525026; U.S. Pat. No.6492372; U.S. Pat. No. 6489350; U.S. Pat. No. 6489119; U.S. Pat. No.6479492; U.S. Pat. No. 6465513; U.S. Pat. No. 6451828; U.S. Pat. No.6436904; U.S. Pat. No. 6410781; U.S. Pat. No. 6407066; U.S. Pat. No.6379882; U.S. Pat. No. 6339069; U.S. Pat. No. 6310093; U.S. Pat. No.6270806; U.S. Pat. No. 6221400; U.S. Pat. No. 6140484; U.S. Pat. No.6136786; U.S. Pat. No. 6087091; U.S. Pat. No. 6068858; U.S. Pat. No.6066339; U.S. Pat. No. 6054429; U.S. Pat. No. 6045829; U.S. Pat. No.6001809; U.S. Pat. No. 5994305; U.S. Pat. No. 5891849; U.S. Pat. No.5799663; U.S. Pat. No. 6541626; U.S. Pat. No. 6537973; U.S. Pat. No.6537811; U.S. Pat. No. 6534639; U.S. Pat. No. 6531590; U.S. Pat. No.6531584; U.S. Pat. No. 6528631; U.S. Pat. No. 6525031; U.S. Pat. No.6524854; U.S. Pat. No. 6521775; U.S. Pat. No. 6503756; U.S. Pat. No.6503754; U.S. Pat. No. 6498035; U.S. Pat. No. 6492173; U.S. Pat. No.6492172; U.S. Pat. No. 6492171; U.S. Pat. No. 6492170; U.S. Pat. No.6492111; U.S. Pat. No. 6486313; U.S. Pat. No. 6485974; U.S. Pat. No.6482644; U.S. Pat. No. 6476205; U.S. Pat. No. 6475797; U.S. Pat. No.6468796; U.S. Pat. No. 6468795; U.S. Pat. No. 6465628; U.S. Pat. No.6465439; U.S. Pat. No. 6465250; U.S. Pat. No. 6462184; U.S. Pat. No.6458941; U.S. Pat. No. 6458591; U.S. Pat. No. 6455308; U.S. Pat. No.6455307; U.S. Pat. No. 6451991; U.S. Pat. No. 6451968; U.S. Pat. No.6451602; U.S. Pat. No. 6451538; U.S. Pat. No. 6451524; U.S. Pat. No.6448081; U.S. Pat. No. 6448080; U.S. Pat. No. 6448079; U.S. Pat. No.6444466; U.S. Pat. No. 6444465; U.S. Pat. No. 6444464; U.S. Pat. No.6441150; U.S. Pat. No. 6441130; U.S. Pat. No. 6440943; U.S. Pat. No.6440739; U.S. Pat. No. 6440738; U.S. Pat. No. 6440737; U.S. Pat. No.6437121; U.S. Pat. No. 6436909; U.S. Pat. No. 6436706; U.S. Pat. No.6433159; U.S. Pat. No. 6426221; U.S. Pat. No. 6426220; U.S. Pat. No.6426188; U.S. Pat. No. 6423543; U.S. Pat. No. 6414135; U.S. Pat. No.6410702; U.S. Pat. No. 6410518; U.S. Pat. No. 6410325; U.S. Pat. No.6410324; U.S. Pat. No. 6410323; U.S. Pat. No. 6403781; U.S. Pat. No.6399756; U.S. Pat. No. 6399754; U.S. Pat. No. 6399589; U.S. Pat. No.6399379; U.S. Pat. No. 6399378; U.S. Pat. No. 6395545; U.S. Pat. No.6395544; U.S. Pat. No. 6395492; U.S. Pat. No. 6391636; U.S. Pat. No.6387699; U.S. Pat. No. 6383809; U.S. Pat. No. 6383808; U.S. Pat. No.6380368; U.S. Pat. No. 6380169; U.S. Pat. No. 6379960; U.S. Pat. No.6379698; U.S. Pat. No. 6376661; U.S. Pat. No. 6372492; U.S. Pat. No.6372433; U.S. Pat. No. 6369209; U.S. Pat. No. 6369040; U.S. Pat. No.6368856; U.S. Pat. No. 6365354; U.S. Pat. No. 6359124; U.S. Pat. No.6358931; U.S. Pat. No. 6355483; U.S. Pat. No. 6355482; U.S. Pat. No.6352858; U.S. Pat. No. 6346416; U.S. Pat. No. 6339066; U.S. Pat. No.6335439; U.S. Pat. No. 6335437; U.S. Pat. No. 6335434; U.S. Pat. No.6335194; U.S. Pat. No. 6331399; U.S. Pat. No. 6329203; U.S. Pat. No.6326478; U.S. Pat. No. 6326358; U.S. Pat. No. 6326199; U.S. Pat. No.6323029; U.S. Pat. No. 6322987; U.S. Pat. No. 6319906; U.S. Pat. No.6316626; U.S. Pat. No. 6316259; U.S. Pat. No. 6312900; U.S. Pat. No.6309882; U.S. Pat. No. 6307040; U.S. Pat. No. 6306655; U.S. Pat. No.6306606; U.S. Pat. No. 6303374; U.S. Pat. No. 6300491; U.S. Pat. No.6300486; U.S. Pat. No. 6300320; U.S. Pat. No. 6300319; U.S. Pat. No.6300132; U.S. Pat. No. 6294382; U.S. Pat. No. 6287860; U.S. Pat. No.6284538; U.S. Pat. No. 6284458; U.S. Pat. No. 6277982; U.S. Pat. No.6277967; U.S. Pat. No. 6277640; U.S. Pat. No. 6277636; U.S. Pat. No.6277603; U.S. Pat. No. 6274725; U.S. Pat. No. 6271358; U.S. Pat. No.6271030; U.S. Pat. No. 6271151; U.S. Pat. No. 6265558; U.S. Pat. No.6265216; U.S. Pat. No. 6262241; U.S. Pat. No. 6261840; U.S. Pat. No.6258790; U.S. Pat. No. 6258790; U.S. Pat. No. 6258601; U.S. Pat. No.6258600; U.S. Pat. No. 6255111; U.S. Pat. No. 6255110; U.S. Pat. No.6248586; U.S. Pat. No. 6242590; U.S. Pat. No. 6242589; U.S. Pat. No.6239220; U.S. Pat. No. 6238921; U.S. Pat. No. 6235887; U.S. Pat. No.6235723; U.S. Pat. No. 6232463; U.S. Pat. No. 6232296; U.S. Pat. No.6228648; U.S. Pat. No. 6228642; U.S. Pat. No. 6221850; U.S. Pat. No.6214986; U.S. Pat. No. 6210892; U.S. Pat. No. 6207819; U.S. Pat. No.6204055; U.S. Pat. No. 6200807; U.S. Pat. No. 6197584; U.S. Pat. No.6190869; U.S. Pat. No. 6187587; U.S. Pat. No. 6187586; U.S. Pat. No.6187585; U.S. Pat. No. 6187545; U.S. Pat. No. 6184212; U.S. Pat. No.6180403; U.S. Pat. No. 6180353; U.S. Pat. No. 6177273; U.S. Pat. No.6177246; U.S. Pat. No. 6174870; U.S. Pat. No. 6174868; U.S. Pat. No.6172217; U.S. Pat. No. 6172216; U.S. Pat. No. 6172209; U.S. Pat. No.6171860; U.S. Pat. No. 6169177; U.S. Pat. No. 6169079; U.S. Pat. No.6168950; U.S. Pat. No. 6166199; U.S. Pat. No. 6166188; U.S. Pat. No.6165791; U.S. Pat. No. 6165790; U.S. Pat. No. 6165789; U.S. Pat. No.6165788; U.S. Pat. No. 6165786; U.S. Pat. No. 6165728; U.S. Pat. No.6160152; U.S. Pat. No. 6159734; U.S. Pat. No. 6159697; U.S. Pat. No.6159694; U.S. Pat. No. 6156758; U.S. Pat. No. 6156571; U.S. Pat. No.6153737; U.S. Pat. No. 6153599; U.S. Pat. No. 6153595; U.S. Pat. No.6150162; U.S. Pat. No. 6150129; U.S. Pat. No. 6146829; U.S. Pat. No.6140126; U.S. Pat. No. 6140125; U.S. Pat. No. 6140124; U.S. Pat. No.6136604; U.S. Pat. No. 6133246; U.S. Pat. No. 6133031; U.S. Pat. No.6130088; U.S. Pat. No. 6124484; U.S. Pat. No. 6124445; U.S. Pat. No.6124133; U.S. Pat. No. 6121437; U.S. Pat. No. 6121047; U.S. Pat. No.6117848; U.S. Pat. No. 6117847; U.S. Pat. No. 6114517; U.S. Pat. No.6114513; U.S. Pat. No. 6111094; U.S. Pat. No. 6111085; U.S. Pat. No.6110664; U.S. Pat. No. 6107092; U.S. Pat. No. 6107091; U.S. Pat. No.6103891; U.S. Pat. No. 6100090; U.S. Pat. No. 6096722; U.S. Pat. No.6096543; U.S. Pat. No. 6093816; U.S. Pat. No. 6093811; U.S. Pat. No.6090626; U.S. Pat. No. 6087489; U.S. Pat. No. 6087173; U.S. Pat. No.6083923; U.S. Pat. No. 6080580; U.S. Pat. No. 6080546; U.S. Pat. No.6077833; U.S. Pat. No. 6077709; U.S. Pat. No. 6077672; U.S. Pat. No.6069008; U.S. Pat. No. 6066500; U.S. Pat. No. 6063626; U.S. Pat. No.6060592; U.S. Pat. No. 6054440; U.S. Pat. No. 6054316; U.S. Pat. No.6051699; U.S. Pat. No. 6046321; U.S. Pat. No. 6046320; U.S. Pat. No.6046049; U.S. Pat. No. 6043352; U.S. Pat. No. 6043091; U.S. Pat. No.6043090; U.S. Pat. No. 6040179; U.S. Pat. No. 6040178; U.S. Pat. No.6037176; U.S. Pat. No. 6037142; U.S. Pat. No. 6034233; U.S. Pat. No.6033910; U.S. Pat. No. 6030837; U.S. Pat. No. 6030786; U.S. Pat. No.6025198; U.S. Pat. No. 6020199; U.S. Pat. No. 6020198; U.S. Pat. No.6015894; U.S. Pat. No. 6015892; U.S. Pat. No. 6015712; U.S. Pat. No.6013788; U.S. Pat. No. 6013787; U.S. Pat. No. 6013522; U.S. Pat. No.6010906; U.S. Pat. No. 6008344; U.S. Pat. No. 6008048; U.S. Pat. No.6007995; U.S. Pat. No. 6005087; U.S. Pat. No. 6004814; U.S. Pat. No.6001992; U.S. Pat. No. 6001991; U.S. Pat. No. 6001841; U.S. Pat. No.6001653; U.S. Pat. No. 6001652; U.S. Pat. No. 6001651; U.S. Pat. No.5998419; U.S. Pat. No. 5998206; U.S. Pat. No. 5998148; U.S. Pat. No.5986053; U.S. Pat. No. 5985664; U.S. Pat. No. 5985663; U.S. Pat. No.5985558; U.S. Pat. No. 5981732; U.S. Pat. No. 5981731; U.S. Pat. No.5977341; U.S. Pat. No. 5968826; U.S. Pat. No. 5968748; U.S. Pat. No.5965722; U.S. Pat. No. 5965370; U.S. Pat. No. 5962673; U.S. Pat. No.5962672; U.S. Pat. No. 5959097; U.S. Pat. No. 5959096; U.S. Pat. No.5958773; U.S. Pat. No. 5958772; U.S. Pat. No. 5958771; U.S. Pat. No.5955600; U.S. Pat. No. 5955589; U.S. Pat. No. 5955443; U.S. Pat. No.5952490; U.S. Pat. No. 5952229; U.S. Pat. No. 5951455; U.S. Pat. No.5948903; U.S. Pat. No. 5948902; U.S. Pat. No. 5948898; U.S. Pat. No.5948680; U.S. Pat. No. 5945290; U.S. Pat. No. 5922872; U.S. Pat. No.5922686; U.S. Pat. No. 5919773; U.S. Pat. No. 5916807; U.S. Pat. No.5914269; U.S. Pat. No. 5885970; U.S. Pat. No. 5883082; U.S. Pat. No.5882927; U.S. Pat. No. 5877309; U.S. Pat. No. 5872242; U.S. Pat. No.5872232; U.S. Pat. No. 5866698; U.S. Pat. No. 5859232; U.S. Pat. No.5859221; U.S. Pat. No. 5856455; U.S. Pat. No. 5856099; U.S. Pat. No.5852182; U.S. Pat. No. 5843738; U.S. Pat. No. 5837449; U.S. Pat. No.5821050; U.S. Pat. No. 5817489; U.S. Pat. No. 5811534; U.S. Pat. No.5811232; U.S. Pat. No. 5808027; U.S. Pat. No. 5807838; U.S. Pat. No.5801154; U.S. Pat. No. 5798360; U.S. Pat. No. 5780241; U.S. Pat. No.5756282; U.S. Pat. No. 5750692; U.S. Pat. No. 5747253; U.S. Pat. No.5744362; U.S. Pat. No. 5731438; U.S. Pat. No. 5723335; U.S. Pat. No.5705621; U.S. Pat. No. 5703054; U.S. Pat. No. 5700922; U.S. Pat. No.5698391; U.S. Pat. No. 6544761; U.S. Pat. No. 6541452; U.S. Pat. No.6541249; U.S. Pat. No. 6541224; U.S. Pat. No. 6538121; U.S. Pat. No.6537966; U.S. Pat. No. 6537539; U.S. Pat. No. 6534631; U.S. Pat. No.6534630; U.S. Pat. No. 6534485; U.S. Pat. No. 6531447; U.S. Pat. No.6528289; U.S. Pat. No. 6525174; U.S. Pat. No. 6524826; U.S. Pat. No.6521742; U.S. Pat. No. 6521441; U.S. Pat. No. 6518404; U.S. Pat. No.6518046; U.S. Pat. No. 6511826; U.S. Pat. No. 6509173; U.S. Pat. No.6509170; U.S. Pat. No. 6506882; U.S. Pat. No. 6506569; U.S. Pat. No.6503735; U.S. Pat. No. 6503184; U.S. Pat. No. 6500638; U.S. Pat. No.6495520; U.S. Pat. No. 6195519; U.S. Pat. No. 6495322; U.S. Pat. No.6495129; U.S. Pat. No. 6495128; U.S. Pat. No. 6489138; U.S. Pat. No.6488925; U.S. Pat. No. 6486301; U.S. Pat. No. 6485719; U.S. Pat. No.6482923; U.S. Pat. No. 6482922; U.S. Pat. No. 6482606; U.S. Pat. No.6482408; U.S. Pat. No. 6479633; U.S. Pat. No. 6479254; U.S. Pat. No.6476195; U.S. Pat. No. 6475766; U.S. Pat. No. 6475753; U.S. Pat. No.6475487; U.S. Pat. No. 6472512; U.S. Pat. No. 6468768; U.S. Pat. No.6468765; U.S. Pat. No. 6461823; U.S. Pat. No. 6458349; U.S. Pat. No.6455274; U.S. Pat. No. 6455040; U.S. Pat. No. 6451577; U.S. Pat. No.6451562; U.S. Pat. No. 6448230; U.S. Pat. No. 6448044; U.S. Pat. No.6448043; U.S. Pat. No. 6448042; U.S. Pat. No. 6444790; U.S. Pat. No.6444440; U.S. Pat. No. 6433147; U.S. Pat. No. 6433145; U.S. Pat. No.6433139; U.S. Pat. No. 6432708; U.S. Pat. No. 6423507; U.S. Pat. No.6420526; U.S. Pat. No. 6420135; U.S. Pat. No. 6420116; U.S. Pat. No.6419917; U.S. Pat. No. 6416989; U.S. Pat. No. 6416984; U.S. Pat. No.6413933; U.S. Pat. No. 6413726; U.S. Pat. No. 6410709; U.S. Pat. No.6410701; U.S. Pat. No. 6410506; U.S. Pat. No. 6410268; U.S. Pat. No.6406867; U.S. Pat. No. 6403770; U.S. Pat. No. 6403557; U.S. Pat. No.6403337; U.S. Pat. No. 6403310; U.S. Pat. No. 6395538; U.S. Pat. No.6395514; U.S. Pat. No. 6391853; U.S. Pat. No. 6391589; U.S. Pat. No.6387682; U.S. Pat. No. 6383793; U.S. Pat. No. 6380369; U.S. Pat. No.6379926; U.S. Pat. No. 6379923; U.S. Pat. No. 6372891; U.S. Pat. No.6372473; U.S. Pat. No. 6372456; U.S. Pat. No. 6372454; U.S. Pat. No.6368822; U.S. Pat. No. 6365369; U.S. Pat. No. 6358508; U.S. Pat. No.6355450; U.S. Pat. No. 6346246; U.S. Pat. No. 6344547; U.S. Pat. No.6344543; U.S. Pat. No. 6344198; U.S. Pat. No. 6342581; U.S. Pat. No.6342363; U.S. Pat. No. 6338951; U.S. Pat. No. 6338948; U.S. Pat. No.6337195; U.S. Pat. No. 6333182; U.S. Pat. No. 6329169; U.S. Pat. No.6319700; U.S. Pat. No. 6316609; U.S. Pat. No. 6312937; U.S. Pat. No.6303338; U.S. Pat. No. 6300477; U.S. Pat. No. 6300310; U.S. Pat. No.6294169; U.S. Pat. No. 6294164; U.S. Pat. No. 6287812; U.S. Pat. No.6284504; U.S. Pat. No. 6284486; U.S. Pat. No. 6265543; U.S. Pat. No.6262233; U.S. Pat. No. 6258777; U.S. Pat. No. 6255079; U.S. Pat. No.6255077; U.S. Pat. No. 6251648; U.S. Pat. No. 6245540; U.S. Pat. No.6232291; U.S. Pat. No. 6232100; U.S. Pat. No. 6214580; U.S. Pat. No.6191260; U.S. Pat. No. 6174992; U.S. Pat. No. 6171816; U.S. Pat. No.6156540; U.S. Pat. No. 6153739; U.S. Pat. No. 6153402; U.S. Pat. No.6143519; U.S. Pat. No. 6143498; U.S. Pat. No. 6140093; U.S. Pat. No.6139832; U.S. Pat. No. 6133422; U.S. Pat. No. 6430079; U.S. Pat. No.6130061; U.S. Pat. No. 6130051; U.S. Pat. No. 6120999; U.S. Pat. No.6117426; U.S. Pat. No. 6114145; U.S. Pat. No. 6110893; U.S. Pat. No.6107075; U.S. Pat. No. 6106829; U.S. Pat. No. 6103871; U.S. Pat. No.6100389; U.S. Pat. No. 6090575; U.S. Pat. No. 6087150; U.S. Pat. No.6080722; U.S. Pat. No. 6077692; U.S. Pat. No. 6075124; U.S. Pat. No.6074839; U.S. Pat. No. 6066724; U.S. Pat. No. 6066617; U.S. Pat. No.6063376; U.S. Pat. No. 6060272; U.S. Pat. No. 6057434; U.S. Pat. No.6054308; U.S. Pat. No. 6054289; U.S. Pat. No. 6051222; U.S. Pat. No.6046035; U.S. Pat. No. 6046031; U.S. Pat. No. 6040157; U.S. Pat. No.6030804; U.S. Pat. No. 6028169; U.S. Pat. No. 6027916; U.S. Pat. No.6025154; U.S. Pat. No. 6013483; U.S. Pat. No. 6013477; U.S. Pat. No.6013473; U.S. Pat. No. 6013469; U.S. Pat. No. 6011012; U.S. Pat. No.6008042; U.S. Pat. No. 6008022; U.S. Pat. No. 6008020; U.S. Pat. No.6008018; U.S. Pat. No. 6004780; U.S. Pat. No. 6001606; U.S. Pat. No.5998171; U.S. Pat. No. 5998164; U.S. Pat. No. 5994506; U.S. Pat. No.5994302; U.S. Pat. No. 5994102; U.S. Pat. No. 5986069; U.S. Pat. No.5986060; U.S. Pat. No. 5985614; U.S. Pat. No. 5985601; U.S. Pat. No.5981231; U.S. Pat. No. 5981230; U.S. Pat. No. 5981220; U.S. Pat. No.5981215; U.S. Pat. No. 5977309; U.S. Pat. No. 5968803; U.S. Pat. No.5968797; U.S. Pat. No. 5968780; U.S. Pat. No. 5962411; U.S. Pat. No.5962268; U.S. Pat. No. 5958729; U.S. Pat. No. 5958400; U.S. Pat. No.5955339; U.S. Pat. No. 5952197; U.S. Pat. No. 5948890; U.S. Pat. No.5945321; U.S. Pat. No. 5945309; U.S. Pat. No. 5945303; U.S. Pat. No.5942417; U.S. Pat. No. 5942414; U.S. Pat. No. 5932540; U.S. Pat. No.5929225; U.S. Pat. No. 5928924; U.S. Pat. No. 5928890; U.S. Pat. No.5922572; U.S. Pat. No. 5919658; U.S. Pat. No. 5916769; U.S. Pat. No.5914258; U.S. Pat. No. 5912327; U.S. Pat. No. 5912159; U.S. Pat. No.5910431; U.S. Pat. No. 5880263; U.S. Pat. No. 5877290; U.S. Pat. No.5874240; U.S. Pat. No. 5871969; U.S. Pat. No. 5871729; U.S. Pat. No.5869632; U.S. Pat. No. 5869284; U.S. Pat. No. 5866373; U.S. Pat. No.5861494; U.S. Pat. No. 5861272; U.S. Pat. No. 5859200; U.S. Pat. No.5858705; U.S. Pat. No. 5851814; U.S. Pat. No. 5849286; U.S. Pat. No.5844081; U.S. Pat. No. 5830744; U.S. Pat. No. 5817485; U.S. Pat. No.5817477; U.S. Pat. No. 5798223; U.S. Pat. No. 5792639; U.S. Pat. No.5786204; U.S. Pat. No. 5786193; U.S. Pat. No. 5780286; U.S. Pat. No.5780263; U.S. Pat. No. 6525046; U.S. Pat. No. 6506769; U.S. Pat. No.6506748; U.S. Pat. No. 6498008; U.S. Pat. No. 6492547; U.S. Pat. No.6492529; U.S. Pat. No. 6492393; U.S. Pat. No. 6429377; U.S. Pat. No.6492181; U.S. Pat. No. 6489328; U.S. Pat. No. 6485925; U.S. Pat. No.6476225; U.S. Pat. No. 6476047; U.S. Pat. No. 6465483; U.S. Pat. No.6455677; U.S. Pat. No. 6437147; U.S. Pat. No. 6432995; U.S. Pat. No.6417218; U.S. Pat. No. 6383733; U.S. Pat. No. 6372773; U.S. Pat. No.6372441; U.S. Pat. No. 6362210; U.S. Pat. No. 6358945; U.S. Pat. No.6335016; U.S. Pat. No. 6333325; U.S. Pat. No. 6329415; U.S. Pat. No.6323207; U.S. Pat. No. 6306580; U.S. Pat. No. 6297381; U.S. Pat. No.6291640; U.S. Pat. No. 6284880; U.S. Pat. No. 6284768; U.S. Pat. No.6274322; U.S. Pat. No. 6268365; U.S. Pat. No. 6242453; U.S. Pat. No.6241990; U.S. Pat. No. 6228881; U.S. Pat. No. 6180645; U.S. Pat. No.6172211; U.S. Pat. No. 6156784; U.S. Pat. No. 6136819; U.S. Pat. No.6114335; U.S. Pat. No. 6080763; U.S. Pat. No. 6080570; U.S. Pat. No.6077663; U.S. Pat. No. 6071707; U.S. Pat. No. 6054470; U.S. Pat. No.6043254; U.S. Pat. No. 6022735; U.S. Pat. No. 6010865; U.S. Pat. No.5981273; U.S. Pat. No. 5965404; U.S. Pat. No. 5951982; U.S. Pat. No.5925650; U.S. Pat. No. 5916561; U.S. Pat. No. 5905041; U.S. Pat. No.5871771; U.S. Pat. No. 5861412; U.S. Pat. No. 5846805; U.S. Pat. No.5843441; U.S. Pat. No. 5840563; U.S. Pat. No. 5837712; U.S. Pat. No.5837704; U.S. Pat. No. 5817516; U.S. Pat. No. 5807870; U.S. Pat. No.5798228; U.S. Pat. No. 5789230; U.S. Pat. No. 5767242; U.S. Pat. No.5747488; U.S. Pat. No. 5730983; U.S. Pat. No. 5688793; U.S. Pat. No.5683878; U.S. Pat. No. 5677304; U.S. Pat. No. 5674878; U.S. Pat. No.5661157; U.S. Pat. No. 5658774; U.S. Pat. No. 5654188; U.S. Pat. No.5648248; U.S. Pat. No. 5643919; U.S. Pat. No. 5643729; U.S. Pat. No.5633002; U.S. Pat. No. 5620974; U.S. Pat. No. 5607943; U.S. Pat. No.5605688; U.S. Pat. No. 5602010; U.S. Pat. No. 5582998; U.S. Pat. No.5571809; U.S. Pat. No. 5571806; U.S. Pat. No. 5565452; U.S. Pat. No.5550122; U.S. Pat. No. 5547951; U.S. Pat. No. 5547932.

[0170] U.S. Patent Application Publication 20020160404; U.S. PatentApplication Publication 20020049185; U.S. Patent Application Publication20010053774; U.S. Patent Application Publication 20030059890; U.S.Patent Application Publication 20030059421; U.S. Patent ApplicationPublication 20030055049; U.S. Patent Application Publication20030054381; U.S. Patent Application Publication 20020161528; U.S.Patent Application Publication 20020151573; U.S. Patent ApplicationPublication 20020151563; U.S. Patent Application Publication20020111495; U.S. Patent Application Publication 20020058046; U.S.Patent Application Publication 20030064997; U.S. Patent ApplicationPublication 20030004317; U.S. Patent Application Publication20020172974; U.S. Patent Application Publication 20020164734; U.S.Patent Application Publication 20020127227; U.S. Patent ApplicationPublication 20020123500; U.S. Patent Application Publication20020107196; U.S. Patent Application Publication 20020107195; U.S.Patent Application Publication 20020082202; U.S. Patent ApplicationPublication 20020082200; U.S. Patent Application Publication20020081602; U.S. Patent Application Publication 20020068069; U.S.Patent Application Publication 20010056066; U.S. Patent ApplicationPublication 20010053365; U.S. Patent Application Publication20030059424; U.S. Patent Application Publication 20030026804; U.S.Patent Application Publication 20030021781; U.S. Patent ApplicationPublication 20030003097; U.S. Patent Application Publication20020197255; U.S. Patent Application Publication 20020044930; U.S.Patent Application Publication 20020009444; U.S. Patent ApplicationPublication 20020006404; U.S. Patent Application Publication20020001798; U.S. Patent Application Publication 20010019715; U.S.Patent Application Publication 20010018054; U.S. Patent ApplicationPublication 20010018041; U.S. Patent Application Publication20030065012; U.S. Patent Application Publication 20030036511; U.S.Patent Application Publication 20030017517; U.S. Patent ApplicationPublication 20030017508; U.S. Patent Application Publication20030013130; U.S. Patent Application Publication 20020197260; U.S.Patent Application Publication 20020192699; U.S. Patent ApplicationPublication 20020168375; U.S. Patent Application Publication20020164713; U.S. Patent Application Publication 20020160403; U.S.Patent Application Publication 20020143154; U.S. Patent ApplicationPublication 20020141971; U.S. Patent Application Publication20020123481; U.S. Patent Application Publication 20020111374; U.S.Patent Application Publication 20020106371; U.S. Patent ApplicationPublication 20020103155; U.S. Patent Application Publication20020091248; U.S. Patent Application Publication 20020068354; U.S.Patent Application Publication 20020058325; U.S. Patent ApplicationPublication 20020055125; U.S. Patent Application Publication20020025329; U.S. Patent Application Publication 20010043915; U.S.Patent Application Publication 20030060416; U.S. Patent ApplicationPublication 20020197702; U.S. Patent Application Publication20020155579; U.S. Patent Application Publication 20020147171; U.S.Patent Application Publication 20020128306; U.S. Patent ApplicationPublication 20020103522; U.S. Patent Application Publication20020090666; U.S. Patent Application Publication 20020016651; U.S.Patent Application Publication 20030050222; U.S. Patent ApplicationPublication 20030022211; U.S. Patent Application Publication20030013732; U.S. Patent Application Publication 20030008923; U.S.Patent Application Publication 20020198137; U.S. Patent ApplicationPublication 20020183310; U.S. Patent Application Publication20020183240; U.S. Patent Application Publication 20020183239; U.S.Patent Application Publication 20020137894; U.S. Patent ApplicationPublication 20020197617; U.S. Patent Application Publication20020034538; U.S. Patent Application Publication 20020034506; U.S.Patent Application Publication 20020131969; U.S. Patent ApplicationPublication 20030059918; U.S. Patent Application Publication20020160394; U.S. Patent Application Publication 20030069409; U.S.Patent Application Publication 20030069408; U.S. Patent ApplicationPublication 20030069406; U.S. Patent Application Publication20030069405; U.S. Patent Application Publication 20030068627; U.S.Patent Application Publication 20030065160; U.S. Patent ApplicationPublication 20030065151; U.S. Patent Application Publication20030059908; U.S. Patent Application Publication 20030059875; U.S.Patent Application Publication 20030059874; U.S. Patent ApplicationPublication 20030059431; U.S. Patent Application Publication20030055236; U.S. Patent Application Publication 20030054420; U.S.Patent Application Publication 20030054379; U.S. Patent ApplicationPublication 20030054377; U.S. Patent Application Publication20030054375; U.S. Patent Application Publication 20030054373; U.S.Patent Application Publication 20030054368; U.S. Patent ApplicationPublication 20030050466; U.S. Patent Application Publication20030050443; U.S. Patent Application Publication 20030050442; U.S.Patent Application Publication 20030049732; U.S. Patent ApplicationPublication 20030049703; U.S. Patent Application Publication20030049652; U.S. Patent Application Publication 20030049650; U.S.Patent Application Publication 20030044907; U.S. Patent ApplicationPublication 20030044905; U.S. Patent Application Publication20030044904; U.S. Patent Application Publication 20030044898; U.S.Patent Application Publication 20030044851; U.S. Patent ApplicationPublication 20030040097; U.S. Patent Application Publication20030040088; U.S. Patent Application Publication 20030040081; U.S.Patent Application Publication 20030039994; U.S. Patent ApplicationPublication 20030039993; U.S. Patent Application Publication20030036646; U.S. Patent Application Publication 20030036505; U.S.Patent Application Publication 20030036168; U.S. Patent ApplicationPublication 20030028008; U.S. Patent Application Publication20030027989; U.S. Patent Application Publication 20030027177; U.S.Patent Application Publication 20030023070; U.S. Patent ApplicationPublication 20030023068; U.S. Patent Application Publication20030023044; U.S. Patent Application Publication 20030022338; U.S.Patent Application Publication 20030022314; U.S. Patent ApplicationPublication 20030022312; U.S. Patent Application Publication20030022289; U.S. Patent Application Publication 20030018180; U.S.Patent Application Publication 20030017500; U.S. Patent ApplicationPublication 20030013161; U.S. Patent Application Publication20030012768; U.S. Patent Application Publication 20020197701; U.S.Patent Application Publication 20020192800; U.S. Patent ApplicationPublication 20020188110; U.S. Patent Application Publication20020187526; U.S. Patent Application Publication 20020183503; U.S.Patent Application Publication 20020182683; U.S. Patent ApplicationPublication 20020182200; U.S. Patent Application Publication20020177213; U.S. Patent Application Publication 20020173640; U.S.Patent Application Publication 20020173007; U.S. Patent ApplicationPublication 20020168729; U.S. Patent Application Publication20020168359; U.S. Patent Application Publication 20020165384; U.S.Patent Application Publication 20020165377; U.S. Patent ApplicationPublication 20020165137; U.S. Patent Application Publication20020164768; U.S. Patent Application Publication 20020164714; U.S.Patent Application Publication 20020164707; U.S. Patent ApplicationPublication 20020164694; U.S. Patent Application Publication20020164693; U.S. Patent Application Publication 20020155539; U.S.Patent Application Publication 20020151012; U.S. Patent ApplicationPublication 20020151009; U.S. Patent Application Publication20020150994; U.S. Patent Application Publication 20020150992; U.S.Patent Application Publication 20020150989; U.S. Patent ApplicationPublication 20020150583; U.S. Patent Application Publication20020150578; U.S. Patent Application Publication 20020147149; U.S.Patent Application Publication 20020146791; U.S. Patent ApplicationPublication 20020146778; U.S. Patent Application Publication20020146738; U.S. Patent Application Publication 20020146408; U.S.Patent Application Publication 20020143170; U.S. Patent ApplicationPublication 20020143165; U.S. Patent Application Publication20020142448; U.S. Patent Application Publication 20020137175; U.S.Patent Application Publication 20020137143; U.S. Patent ApplicationPublication 20020132775; U.S. Patent Application Publication20020132331; U.S. Patent Application Publication 20020132329; U.S.Patent Application Publication 20020132305; U.S. Patent ApplicationPublication 20020132304; U.S. Patent Application Publication20020127653; U.S. Patent Application Publication 20020127651; U.S.Patent Application Publication 20020127640; U.S. Patent ApplicationPublication 20020120123; U.S. Patent Application Publication20020119925; U.S. Patent Application Publication 20020119552; U.S.Patent Application Publication 20020119528; U.S. Patent ApplicationPublication 20020115187; U.S. Patent Application Publication20020112112; U.S. Patent Application Publication 20020111325; U.S.Patent Application Publication 20020110867; U.S. Patent ApplicationPublication 20020106741; U.S. Patent Application Publication20020106740; U.S. Patent Application Publication 20020106736; U.S.Patent Application Publication 20020106734; U.S. Patent ApplicationPublication 20020106695; U.S. Patent Application Publication20020103122; U.S. Patent Application Publication 20020102588; U.S.Patent Application Publication 20020098550; U.S. Patent ApplicationPublication 20020098525; U.S. Patent Application Publication20020098515; U.S. Patent Application Publication 20020098163; U.S.Patent Application Publication 20020086396; U.S. Patent ApplicationPublication 20020086365; U.S. Patent Application Publication20020086362; U.S. Patent Application Publication 20020086314; U.S.Patent Application Publication 20020081695; U.S. Patent ApplicationPublication 20020081647; U.S. Patent Application Publication20020081288; U.S. Patent Application Publication 20020072595; U.S.Patent Application Publication 20020072091; U.S. Patent ApplicationPublication 20020072090; U.S. Patent Application Publication20020064869; U.S. Patent Application Publication 20020064829; U.S.Patent Application Publication 20020061551; U.S. Patent ApplicationPublication 20020055144; U.S. Patent Application Publication20020055142; U.S. Patent Application Publication 20020052476; U.S.Patent Application Publication 20020052043; U.S. Patent ApplicationPublication 20020045737; U.S. Patent Application Publication20020042372; U.S. Patent Application Publication 20020042362; U.S.Patent Application Publication 20020042119; U.S. Patent ApplicationPublication 20020031804; U.S. Patent Application Publication20020009773; U.S. Patent Application Publication 20010041350; U.S.Patent Application Publication 20010036650; U.S. Patent ApplicationPublication 20010034334; U.S. Patent Application Publication20010029034; U.S. Patent Application Publication 20010021516; U.S.Patent Application Publication 20030066800; U.S. Patent ApplicationPublication 20030060455; U.S. Patent Application Publication20030027337; U.S. Patent Application Publication 20020137670; U.S.Patent Application Publication 20020127542; U.S. Patent ApplicationPublication 20020102685; U.S. Patent Application Publication20020081279; U.S. Patent Application Publication 20020042084; U.S.Patent Application Publication 20010021383.

[0171] Immunosuppression Section:

[0172] AGI 1096, AtheroGenics; AI 502, AutoImmune; APT 070, AdProTech;AVI 4557, AVI BioPharma; BMS 188667, Bristol-Myers Squibb; CKD 722,Chong Kun Dang; CT 3578, Cell Therapeutics; discodernolide, HarborBranch Institution; everolimus, Novartis; FR 901483, Fujisawa; FTY 720,Mitsubishi Pharma; galaptin L-14-1, Incyte; HMR 1279, Aventis; ISAtx247, Isotechnika; LEA 29Y, Bristol-Myers Squibb; LJP 920, La Jolla;malononitrilamide 715, Aventis; MDAM, University of South Alabama;mycophenolate sodium, Novartis; NE 501, Neose; PG 27, Pharmagenesis; PG94, Pharmagenesis; phellodendrine, Gifu Pharmaceutical University; PIC060, Procept; PRO 1556, Procept; PRO 2844, Procept; RG 1046, Repligen;RWJ 60475, R W Johnson Research Foundation; SPC 100270, Sphinx;thalidomide, Andrulis; thiethazole, Bashkir Medical University; VX 148,Vertex Pharmaceuticals; Xe 9, XenoStat; YM 13650, Yamanouchi. U.S. Pat.No. 6521619; U.S. Pat. No. 6506766; U.S. Pat. No. 6462194; U.S. Pat. No.6451578; U.S. Pat. No. 6395472; U.S. Pat. No. 6380241; U.S. Pat. No.6380207; U.S. Pat. No. 6329386; U.S. Pat. No. 6313104; U.S. Pat. No.6166013; U.S. Pat. No. 6162927; U.S. Pat. No. 6156495; U.S. Pat. No.6124341; U.S. Pat. No. 6121257; U.S. Pat. No. 6110922; U.S. Pat. No.6074817; U.S. Pat. No. 6051374; U.S. Pat. No. 6015815; U.S. Pat. No.5981172; U.S. Pat. No. 5892070; U.S. Pat. No. 5891698; U.S. Pat. No.5888772; U.S. Pat. No. 5843450; U.S. Pat. No. 5767144; U.S. Pat. No.5750413; U.S. Pat. No. 5750176; U.S. Pat. No. 5731434; U.S. Pat. No.5731320; U.S. Pat. No. 5708002; U.S. Pat. No. 5700671; U.S. Pat. No.5672605; U.S. Pat. No. 5643918; U.S. Pat. No. 5622971; U.S. Pat. No.5612350; U.S. Pat. No. 5610009; U.S. Pat. No. 5604234; U.S. Pat. No.5599927; U.S. Pat. No. 5587399; U.S. Pat. No. 5583139; U.S. Pat. No.5563172; U.S. Pat. No. 5561228; U.S. Pat. No. 5561140; U.S. Pat. No.5561139; U.S. Pat. No. 5561137; U.S. Pat. No. 5550146; U.S. Pat. No.5541193; U.S. Pat. No. 5541189; U.S. Pat. No. 5534632; U.S. Pat. No.5530120; U.S. Pat. No. 5530119; U.S. Pat. No. 6538110; U.S. Pat. No.6528653; U.S. Pat. No. 6514736; U.S. Pat. No. 6492353; U.S. Pat. No.6475764; U.S. Pat. No. 6268214; U.S. Pat. No. 6197563; U.S. Pat. No.6162427; U.S. Pat. No. 6150373; U.S. Pat. No. 6040166; U.S. Pat. No.6008209; U.S. Pat. No. 5989888; U.S. Pat. No. 5980888; U.S. Pat. No.5952215; U.S. Pat. No. 5853721; U.S. Pat. No. 5780597; U.S. Pat. No.5766888; U.S. Pat. No. 5696103; U.S. Pat. No. 5641485; U.S. Pat. No.5604099; U.S. Pat. No. 5567809; U.S. Pat. No. 5550039; U.S. Pat. No.5543296; U.S. Pat. No. 5541065; U.S. Pat. No. 5512683; U.S. Pat. No.5468613; U.S. Pat. No. 5451512; U.S. Pat. No. 5391766; U.S. Pat. No.5310893; U.S. Pat. No. 5229163; U.S. Pat. No. 5041266; U.S. Pat. No.6413938; U.S. Pat. No. 6307043; U.S. Pat. No. 6235717; U.S. Pat. No.6207669; U.S. Pat. No. 6204249; U.S. Pat. No. 6174889; U.S. Pat. No.6169091; U.S. Pat. No. 6121238; U.S. Pat. No. 6096786; U.S. Pat. No.6083913; U.S. Pat. No. 6077832; U.S. Pat. No. 6056956; U.S. Pat. No.5998605; U.S. Pat. No. 5998398; U.S. Pat. No. 5998388; U.S. Pat. No.5958980; U.S. Pat. No. 5932546; U.S. Pat. No. 5872151; U.S. Pat. No.5821236; U.S. Pat. No. 5747472; U.S. Pat. No. 5733915; U.S. Pat. No.5690933; U.S. Pat. No. 6521647; U.S. Pat. No. 6492401; U.S. Pat. No.6489478; U.S. Pat. No. 6441193; U.S. Pat. No. 6441176; U.S. Pat. No.6423705; U.S. Pat. No. 6417202; U.S. Pat. No. 6414149; U.S. Pat. No.6403611; U.S. Pat. No. 6403587; U.S. Pat. No. 6395751; U.S. Pat. No.6372768; U.S. Pat. No. 6362198; U.S. Pat. No. 6355670; U.S. Pat. No.6355662; U.S. Pat. No. 6310075; U.S. Pat. No. 6306887; U.S. Pat. No.6294538; U.S. Pat. No. 6274618; U.S. Pat. No. 6271228; U.S. Pat. No.6211208; U.S. Pat. No. 6204286; U.S. Pat. No. 6197786; U.S. Pat. No.6187568; U.S. Pat. No. 6153622; U.S. Pat. No. 6147090; U.S. Pat. No.6147089; U.S. Pat. No. 6140343; U.S. Pat. No. 6140342; U.S. Pat. No.6107331; U.S. Pat. No. 6048880; U.S. Pat. No. 6043238; U.S. Pat. No.6001998; U.S. Pat. No. 5948813; U.S. Pat. No. 5948809; U.S. Pat. No.5852059; U.S. Pat. No. 5849730; U.S. Pat. No. 5747465; U.S. Pat. No.5639757; U.S. Pat. No. 5631235; U.S. Pat. No. 5612316; U.S. Pat. No.5593997; U.S. Pat. No. 5563135; U.S. Pat. No. 5552412; U.S. Pat. No.5506233; U.S. Pat. No. 5494820; U.S. Pat. No. 5482944; U.S. Pat. No.5432183; U.S. Pat. No. 6193979; U.S. Pat. No. 9169068; U.S. Pat. No.6057131; U.S. Pat. No. 6545031; U.S. Pat. No. 6544960; U.S. Pat. No.6514992; U.S. Pat. No. 6506758; U.S. Pat. No. 6500863; U.S. Pat. No.6498155; U.S. Pat. No. 6495560; U.S. Pat. No. 6492348; U.S. Pat. No.6482956; U.S. Pat. No. 6465430; U.S. Pat. No. 6458814; U.S. Pat. No.6455510; U.S. Pat. No. 6455507; U.S. Pat. No. 6455506; U.S. Pat. No.6448260; U.S. Pat. No. 6447766; U.S. Pat. No. 6440993; U.S. Pat. No.6413952; U.S. Pat. No. 6407076; U.S. Pat. No. 6403792; U.S. Pat. No.6399053; U.S. Pat. No. 6391874; U.S. Pat. No. 6391589; U.S. Pat. No.6353116; U.S. Pat. No. 6350446; U.S. Pat. No. 6346531; U.S. Pat. No.6316478; U.S. Pat. No. 6297265; U.S. Pat. No. 6280959; U.S. Pat. No.6274737; U.S. Pat. No. 6271399; U.S. Pat. No. 6239138; U.S. Pat. No.6221889; U.S. Pat. No. 6214858; U.S. Pat. No. 6211200; U.S. Pat. No.6200986; U.S. Pat. No. 6197793; U.S. Pat. No. 6194413; U.S. Pat. No.6191304; U.S. Pat. No. 6191146; U.S. Pat. No. 6174906; U.S. Pat. No.6147111; U.S. Pat. No. 6136828; U.S. Pat. No. 6127371; U.S. Pat. No.6114359; U.S. Pat. No. 6114357; U.S. Pat. No. 6107309; U.S. Pat. No.6096897; U.S. Pat. No. 6087389; U.S. Pat. No. 6080398; U.S. Pat. No.6077857; U.S. Pat. No. 6077856; U.S. Pat. No. 6077855; U.S. Pat. No.6075037; U.S. Pat. No. 6069158; U.S. Pat. No. 6054465; U.S. Pat. No.6051599; U.S. Pat. No. 6051584; U.S. Pat. No. 6046198; U.S. Pat. No.6046197; U.S. Pat. No. 6043374; U.S. Pat. No. 6030989; U.S. Pat. No.6030970; U.S. Pat. No. 6025390; U.S. Pat. No. 6022886; U.S. Pat. No.6020348; U.S. Pat. No. 6017952; U.S. Pat. No. 6015908; U.S. Pat. No.5994100; U.S. Pat. No. 5985886; U.S. Pat. No. 5981551; U.S. Pat. No.5981525; U.S. Pat. No. 5976082; U.S. Pat. No. 5969151; U.S. Pat. No.5968971; U.S. Pat. No. 5929250; U.S. Pat. No. 5929116; U.S. Pat. No.5929106; U.S. Pat. No. 5834469; U.S. Pat. No. 5817683; U.S. Pat. No.5817653; U.S. Pat. No. 5786376; U.S. Pat. No. 5736564; U.S. Pat. No.5719183; U.S. Pat. No. 5719182; U.S. Pat. No. 5716985; U.S. Pat. No.5716984; U.S. Pat. No. 5559105; U.S. Pat. No. 6506383; U.S. Pat. No.6455043; U.S. Pat. No. 6451284; U.S. Pat. No. 6440418; U.S. Pat. No.6413771; U.S. Pat. No. 6399061; U.S. Pat. No. 6136310; U.S. Pat. No.6113898; U.S. Pat. No. 6011138; U.S. Pat. No. 6001358; U.S. Pat. No.5958765; U.S. Pat. No. 5955364; U.S. Pat. No. 5939068; U.S. Pat. No.5866125; U.S. Pat. No. 5840298; U.S. Pat. No. 5811524; U.S. Pat. No.5776456; U.S. Pat. No. 5756096; U.S. Pat. No. 5750105; U.S. Pat. No.5736137; U.S. Pat. No. 5693780; U.S. Pat. No. 5681722; U.S. Pat. No.5658570; U.S. Pat. No. 6420518; U.S. Pat. No. 6372453; U.S. Pat. No.6342348; U.S. Pat. No. 6046048; U.S. Pat. No. 5879910; U.S. Pat. No.5849585; U.S. Pat. No. 5759775; U.S. Pat. No. 6528261; U.S. Pat. No.6511801; U.S. Pat. No. 6440662; U.S. Pat. No. 6346248; U.S. Pat. No.6071519; U.S. Pat. No. 5883238; U.S. Pat. No. 6544951; U.S. Pat. No.6531467; U.S. Pat. No. 6528506; U.S. Pat. No. 6525024; U.S. Pat. No.6515173; U.S. Pat. No. 6200969; U.S. Pat. No. 6197750; U.S. Pat. No.5869519; U.S. Pat. No. 6489296; U.S. Pat. No. 6472387; U.S. Pat. No.6448396; U.S. Pat. No. 6423709; U.S. Pat. No. 6380213; U.S. Pat. No.6372213; U.S. Pat. No. 6344197; U.S. Pat. No. 6303634; U.S. Pat. No.6291446; U.S. Pat. No. 6268344; U.S. Pat. No. 6225301; U.S. Pat. No.6166216; U.S. Pat. No. 6456748; U.S. Pat. No. 6156734; U.S. Pat. No.6103713; U.S. Pat. No. 6008199; U.S. Pat. No. 5846973; U.S. Pat. No.5622932; U.S. Pat. No. 5447941; U.S. Pat. No. 6541496; U.S. Pat. No.6518291; U.S. Pat. No. 6498178; U.S. Pat. No. 6395763; U.S. Pat. No.6344465; U.S. Pat. No. 6136787; U.S. Pat. No. 6128582; U.S. Pat. No.6054472; U.S. Pat. No. 5932600; U.S. Pat. No. 5807876; U.S. Pat. No.5723459; U.S. Pat. No. 5622970; U.S. Pat. No. 5620971; U.S. Pat. No.5516797; U.S. Pat. No. 6521618; U.S. Pat. No. 6451767; U.S. Pat. No.6444694; U.S. Pat. No. 6440991; U.S. Pat. No. 6432973; U.S. Pat. No.6423308; U.S. Pat. No. 6399626; U.S. Pat. No. 6399625; U.S. Pat. No.6127384; U.S. Pat. No. 5830905; U.S. Pat. No. 5633388; U.S. Pat. No.6544959; U.S. Pat. No. 6395888; U.S. Pat. No. 6280932; U.S. Pat. No.5756291; U.S. Pat. No. 6482798; U.S. Pat. No. 6344476; U.S. Pat. No.6288063; U.S. Pat. No. 6130318; U.S. Pat. No. 5928991; U.S. Pat. No.5911165; U.S. Pat. No. 5833946; U.S. Pat. No. 5658746; U.S. Pat. No.5641725; U.S. Pat. No. 5635446; U.S. Pat. No. 5631349; U.S. Pat. No.5541336; U.S. Pat. No. 6288033; U.S. Pat. No. 5939423; U.S. Pat. No.6545160; U.S. Pat. No. 6545003; U.S. Pat. No. 6525026; U.S. Pat. No.6492372; U.S. Pat. No. 6479492; U.S. Pat. No. 6465513; U.S. Pat. No.6436904; U.S. Pat. No. 6410781; U.S. Pat. No. 6407066; U.S. Pat. No.6001809; U.S. Pat. No. 5641745; U.S. Pat. No. 5641515; U.S. Pat. No.6451524; U.S. Pat. No. 6440943; U.S. Pat. No. 6399376; U.S. Pat. No.6369209; U.S. Pat. No. 6368863; U.S. Pat. No. 6326358; U.S. Pat. No.6319906; U.S. Pat. No. 6300491; U.S. Pat. No. 6277967; U.S. Pat. No.6271029; U.S. Pat. No. 6258790; U.S. Pat. No. 6242589; U.S. Pat. No.6232296; U.S. Pat. No. 6221850; U.S. Pat. No. 6169079; U.S. Pat. No.6133246; U.S. Pat. No. 61414517; U.S. Pat. No. 6111094; U.S. Pat. No.6096722; U.S. Pat. No. 6093811; U.S. Pat. No. 6077833; U.S. Pat. No.6015894; U.S. Pat. No. 6001651; U.S. Pat. No. 5968826; U.S. Pat. No.5955443; U.S. Pat. No. 5883082; U.S. Pat. No. 5877309; U.S. Pat. No.5874564; U.S. Pat. No. 5843738; U.S. Pat. No. 5736294; U.S. Pat. No.5591623; U.S. Pat. No. 6544761; U.S. Pat. No. 6541224; U.S. Pat. No.6537966; U.S. Pat. No. 6534631; U.S. Pat. No. 6534485; U.S. Pat. No.6531447; U.S. Pat. No. 6525174; U.S. Pat. No. 6506569; U.S. Pat. No.6503184; U.S. Pat. No. 6495129; U.S. Pat. No. 6495128; U.S. Pat. No.6488925; U.S. Pat. No. 6486301; U.S. Pat. No. 6485719; U.S. Pat. No.6482408; U.S. Pat. No. 6476195; U.S. Pat. No. 6475753; U.S. Pat. No.6472512; U.S. Pat. No. 6455040; U.S. Pat. No. 6451562; U.S. Pat. No.6448230; U.S. Pat. No. 6433147; U.S. Pat. No. 6433145; U.S. Pat. No.6433139; U.S. Pat. No. 6420526; U.S. Pat. No. 6419917; U.S. Pat. No.6410709; U.S. Pat. No. 6406867; U.S. Pat. No. 6403770; U.S. Pat. No.6403557; U.S. Pat. No. 6391589; U.S. Pat. No. 6379926; U.S. Pat. No.6372473; U.S. Pat. No. 6368822; U.S. Pat. No. 6358508; U.S. Pat. No.6344198; U.S. Pat. No. 6342581; U.S. Pat. No. 6337195; U.S. Pat. No.6222019; U.S. Pat. No. 6139832; U.S. Pat. No. 6130061; U.S. Pat. No.6114145; U.S. Pat. No. 6110893; U.S. Pat. No. 6106829; U.S. Pat. No.6100389; U.S. Pat. No. 6080722; U.S. Pat. No. 6077692; U.S. Pat. No.6075124; U.S. Pat. No. 6028169; U.S. Pat. No. 6013477; U.S. Pat. No.6001606; U.S. Pat. No. 5968780; U.S. Pat. No. 5965421; U.S. Pat. No.5958400; U.S. Pat. No. 5942417; U.S. Pat. No. 5880263; U.S. Pat. No.5871729; U.S. Pat. No. 5866373; U.S. Pat. No. 5861494; U.S. Pat. No.5817485; U.S. Pat. No. 5786204; U.S. Pat. No. 5773252; U.S. Pat. No.5763214; U.S. Pat. No. 5733748; U.S. Pat. No. 5728546; U.S. Pat. No.5721113; U.S. Pat. No. 2710019; U.S. Pat. No. 5641657; U.S. Pat. No.5506133; U.S. Pat. No. 6525046; U.S. Pat. No. 6506748; U.S. Pat. No.6492529; U.S. Pat. No. 6492408; U.S. Pat. No. 6492393; U.S. Pat. No.6479508; U.S. Pat. No. 6448281; U.S. Pat. No. 6432995; U.S. Pat. No.6414153; U.S. Pat. No. 6372773; U.S. Pat. No. 6372441; U.S. Pat. No.6365615; U.S. Pat. No. 6358945; U.S. Pat. No. 6355664; U.S. Pat. No.6353013; U.S. Pat. No. 6350763; U.S. Pat. No. 6333325; U.S. Pat. No.6329415; U.S. Pat. No. 6297381; U.S. Pat. No. 6242453; U.S. Pat. No.6228881; U.S. Pat. No. 6172211; U.S. Pat. No. 6080763; U.S. Pat. No.5905041; U.S. Pat. No. 5783576; U.S. Pat. No. 5753647; U.S. Pat. No.5714143; U.S. Pat. No. 5698552;

[0173] U.S. Patent Application Publication 20020111495; U.S. PatentApplication Publication 20030013697; U.S. Patent Application Publication20030059424; U.S. Patent Application Publication 20030026804; U.S.Patent Application Publication 20030021781; U.S. Patent ApplicationPublication 20030003097; U.S. Patent Application Publication20020197255; U.S. Patent Application Publication 20020187146; U.S.Patent Application Publication 20020150580; U.S. Patent ApplicationPublication 20010024648; U.S. Patent Application Publication20010018041; U.S. Patent Application Publication 20020164713; U.S.Patent Application Publication 20020068354; U.S. Patent ApplicationPublication 20020147171; U.S. Patent Application Publication20020128306; U.S. Patent Application Publication 20020123522; U.S.Patent Application Publication 20030013732; U.S. Patent ApplicationPublication 20020169122; U.S. Patent Application Publication20020137894; U.S. Patent Application Publication 20030068627; U.S.Patent Application Publication 20030065151; U.S. Patent ApplicationPublication 20030059908; U.S. Patent Application Publication20030059875; U.S. Patent Application Publication 20030059874; U.S.Patent Application Publication 20030054420; U.S. Patent ApplicationPublication 20030054379; U.S. Patent Application Publication20030054377; U.S. Patent Application Publication 20030054375; U.S.Patent Application Publication 20030054373; U.S. Patent ApplicationPublication 20030054368; U.S. Patent Application Publication20030050442; U.S. Patent Application Publication 20030049703; U.S.Patent Application Publication 20030049652; U.S. Patent ApplicationPublication 20030049650; U.S. Patent Application Publication20030044907; U.S. Patent Application Publication 20030044905; U.S.Patent Application Publication 20030044904; U.S. Patent ApplicationPublication 20030044851; U.S. Patent Application Publication20030040088; U.S. Patent Application Publication 20030039994; U.S.Patent Application Publication 20030039993; U.S. Patent ApplicationPublication 20030036505; U.S. Patent Application Publication20030023070; U.S. Patent Application Publication 20030022338; U.S.Patent Application Publication 20030022314; U.S. Patent ApplicationPublication 20030022312; U.S. Patent Application Publication20030017500; U.S. Patent Application Publication 20020197701; U.S.Patent Application Publication 20020187526; U.S. Patent ApplicationPublication 20020183503; U.S. Patent Application Publication20020182200; U.S. Patent Application Publication 20020177213; U.S.Patent Application Publication 20020173640; U.S. Patent ApplicationPublication 20020168729; U.S. Patent Application Publication20020168359; U.S. Patent Application Publication 20020165384; U.S.Patent Application Publication 20020165137; U.S. Patent ApplicationPublication 20020164694; U.S. Patent Application Publication20020164693; U.S. Patent Application Publication 20020155539; U.S.Patent Application Publication 20020151009; U.S. Patent ApplicationPublication 20020150583; U.S. Patent Application Publication20020150578; U.S. Patent Application Publication 20020143165; U.S.Patent Application Publication 20020132775; U.S. Patent ApplicationPublication 20020115112; U.S. Patent Application Publication20020106736; U.S. Patent Application Publication 20020103122; U.S.Patent Application Publication 20020098525; U.S. Patent ApplicationPublication 20020098163; U.S. Patent Application Publication20020086314; U.S. Patent Application Publication 20020072091; U.S.Patent Application Publication 20020064829; U.S. Patent ApplicationPublication 20020061551; U.S. Patent Application Publication20020055142; U.S. Patent Application Publication 20020042372.

[0174] Hepatitis Section: NM283, Idenix Pharmaceuticals; IP 501,Indevus; JTK-109, Japan Tobacco; levovorin, Ribapharm/Hoffman LaRoche.U.S. Pat. No. 6495533; U.S. Pat. No. 6462081; U.S. Pat. No. 6451796;U.S. Pat. No. 6420391; U.S. Pat. No. 6388122; U.S. Pat. No. 6376484;U.S. Pat. No. 6136834; U.S. Pat. No. 6518429; U.S. Pat. No. 6472526;U.S. Pat. No. 6436960; U.S. Pat. No. 6362320; U.S. Pat. No. 6268363;U.S. Pat. No. 5952227; U.S. Pat. No. 5817314; U.S. Pat. No. 5817297;U.S. Pat. No. 5753234; U.S. Pat. No. 6197298; U.S. Pat. No. 6129916;U.S. Pat. No. 6117982; U.S. Pat. No. 6106865; U.S. Pat. No. 6908626;U.S. Pat. No. 5866129; U.S. Pat. No. 5739306; U.S. Pat. No. 5728814;U.S. Pat. No. 5723125; U.S. Pat. No. 5691447; U.S. Pat. No. 5690934;U.S. Pat. No. 5484907; U.S. Pat. No. 6506604; U.S. Pat. No. 6428953;U.S. Pat. No. 6319494; U.S. Pat. No. 6218187; U.S. Pat. No. 6165782;U.S. Pat. No. 6103521; U.S. Pat. No. 6077947; U.S. Pat. No. 6051427;U.S. Pat. No. 5994136; U.S. Pat. No. 5872005; U.S. Pat. No. 5837544;U.S. Pat. No. 5741899; U.S. Pat. No. 5712149; U.S. Pat. No. 5686281;U.S. Pat. No. 5670148; U.S. Pat. No. 6482407; U.S. Pat. No. 6331525;U.S. Pat. No. 6080571; U.S. Pat. No. 6069133; U.S. Pat. No. 5891432;U.S. Pat. No. 5843770; U.S. Pat. No. 5744326; U.S. Pat. No. 5728518;U.S. Pat. No. 5728399; U.S. Pat. No. 5661023; U.S. Pat. No. 6541515;U.S. Pat. No. 6538112; U.S. Pat. No. 6534506; U.S. Pat. No. 6534312;U.S. Pat. No. 6525074; U.S. Pat. No. 6441017; U.S. Pat. No. 6437165;U.S. Pat. No. 6420418; U.S. Pat. No. 6410534; U.S. Pat. No. 6395743;U.S. Pat. No. 6387903; U.S. Pat. No. 6380249; U.S. Pat. No. 6380228;U.S. Pat. No. 6376496; U.S. Pat. No. 6358985; U.S. Pat. No. 9358956;U.S. Pat. No. 6355643; U.S. Pat. No. 6353099; U.S. Pat. No. 6350755;U.S. Pat. No. 6348570; U.S. Pat. No. 6335343; U.S. Pat. No. 6333335;U.S. Pat. No. 6329376; U.S. Pat. No. 6316436; U.S. Pat. No. 6306891;U.S. Pat. No. 6303637; U.S. Pat. No. 6297239; U.S. Pat. No. 6290967;U.S. Pat. No. 6284755; U.S. Pat. No. 6271402; U.S. Pat. No. 6271252;U.S. Pat. No. 6262055; U.S. Pat. No. 6248756; U.S. Pat. No. 6245806;U.S. Pat. No. 6235735; U.S. Pat. No. 6232111; U.S. Pat. No. 6224880;U.S. Pat. No. 6210904; U.S. Pat. No. 6210683; U.S. Pat. No. 6194458;U.S. Pat. No. 6194210; U.S. Pat. No. 6191171; U.S. Pat. No. 6172076;U.S. Pat. No. 6127390; U.S. Pat. No. 6127366; U.S. Pat. No. 6118043;U.S. Pat. No. 6103723; U.S. Pat. No. 6103487; U.S. Pat. No. 6100293;U.S. Pat. No. 6093737; U.S. Pat. No. 6090948; U.S. Pat. No. 6090841;U.S. Pat. No. 6083980; U.S. Pat. No. 6080870; U.S. Pat. No. 6077853;U.S. Pat. No. 6066738; U.S. Pat. No. 6063930; U.S. Pat. No. 6054466;U.S. Pat. No. 6051590; U.S. Pat. No. 6051574; U.S. Pat. No. 6051238;U.S. Pat. No. 6048859; U.S. Pat. No. 6028201; U.S. Pat. No. 6022890;U.S. Pat. No. 6020347; U.S. Pat. No. 6015817; U.S. Pat. No. 6001835;U.S. Pat. No. 5998408; U.S. Pat. No. 5998407; U.S. Pat. No. 5981562;U.S. Pat. No. 5977134; U.S. Pat. No. 5972984; U.S. Pat. No. 5972966;U.S. Pat. No. 5972942; U.S. Pat. No. 5968965; U.S. Pat. No. 5965578;U.S. Pat. No. 5952371; U.S. Pat. No. 5952347; U.S. Pat. No. 5939557;U.S. Pat. No. 5939439; U.S. Pat. No. 5932590; U.S. Pat. No. 5929094;U.S. Pat. No. 5925651; U.S. Pat. No. 5922883; U.S. Pat. No. 5922706;U.S. Pat. No. 5919785; U.S. Pat. No. 5914889; U.S. Pat. No. 5885995;U.S. Pat. No. 5883119; U.S. Pat. No. 5883105; U.S. Pat. No. 5880140;U.S. Pat. No. 5877191; U.S. Pat. No. 5877184; U.S. Pat. No. 5874594;U.S. Pat. No. 5874452; U.S. Pat. No. 5872136; U.S. Pat. No. 5872116;U.S. Pat. No. 5869682; U.S. Pat. No. 5866545; U.S. Pat. No. 5861297;U.S. Pat. No. 5859035; U.S. Pat. No. 5859015; U.S. Pat. No. 5859012;U.S. Pat. No. 5856326; U.S. Pat. No. 5856322; U.S. Pat. No. 5854265;U.S. Pat. No. 5854264; U.S. Pat. No. 5852010; U.S. Pat. No. 5847112;U.S. Pat. No. 5817678; U.S. Pat. No. 5795771; U.S. Pat. No. 5789438;U.S. Pat. No. 5780492; U.S. Pat. No. 5780488; U.S. Pat. No. 5780467;U.S. Pat. No. 5766603; U.S. Pat. No. 5763574; U.S. Pat. No. 5763478;U.S. Pat. No. 5756528; U.S. Pat. No. 5750549; U.S. Pat. No. 5750539;U.S. Pat. No. 5736413; U.S. Pat. No. 5728386; U.S. Pat. No. 5719147;U.S. Pat. No. 5710171; U.S. Pat. No. 5696156; U.S. Pat. No. 5693648;U.S. Pat. No. 5691336; U.S. Pat. No. 5679705; U.S. Pat. No. 5670504;U.S. Pat. No. 5627202; U.S. Pat. No. 5624936; U.S. Pat. No. 5623057;U.S. Pat. No. 5614384; U.S. Pat. No. 5576338; U.S. Pat. No. 5565560;U.S. Pat. No. 5565473; U.S. Pat. No. 5552473; U.S. Pat. No. 6051596;U.S. Pat. No. 6025364; U.S. Pat. No. 6545170; U.S. Pat. No. 6521597;U.S. Pat. No. 6495544; U.S. Pat. No. 6482849; U.S. Pat. No. 6465686;U.S. Pat. No. 6465518; U.S. Pat. No. 6451838; U.S. Pat. No. 6403830;U.S. Pat. No. 6369096; U.S. Pat. No. 6291509; U.S. Pat. No. 6126945;U.S. Pat. No. 6071947; U.S. Pat. No. 5858999; U.S. Pat. No. 5795986;U.S. Pat. No. 5773522; U.S. Pat. No. 5691334; U.S. Pat. No. 5661008;U.S. Pat. No. 6528515; U.S. Pat. No. 6518425; U.S. Pat. No. 6410546;U.S. Pat. No. 6215004; U.S. Pat. No. 6188988; U.S. Pat. No. 6081786;U.S. Pat. No. 6451842; U.S. Pat. No. 6362177; U.S. Pat. No. 6322770;U.S. Pat. No. 6518013; U.S. Pat. No. 6479055; U.S. Pat. No. 6348568;U.S. Pat. No. 6228983; U.S. Pat. No. 6093794; U.S. Pat. No. 6068973;U.S. Pat. No. 6060065; U.S. Pat. No. 6054265; U.S. Pat. No. 6020459;U.S. Pat. No. 6017536; U.S. Pat. No. 6013263; U.S. Pat. No. 6548663;U.S. Pat. No. 6537520; U.S. Pat. No. 6524553; U.S. Pat. No. 6518014;U.S. Pat. No. 6511648; U.S. Pat. No. 6495565; U.S. Pat. No. 6479052;U.S. Pat. No. 6458783; U.S. Pat. No. 6455523; U.S. Pat. No. 6399773;U.S. Pat. No. 6387926; U.S. Pat. No. 6333186; U.S. Pat. No. 6262236;U.S. Pat. No. 6207650; U.S. Pat. No. 6456746; U.S. Pat. No. 6083902;U.S. Pat. No. 6077507; U.S. Pat. No. 6048966; U.S. Pat. No. 6027655;U.S. Pat. No. 6011029; U.S. Pat. No. 5993800; U.S. Pat. No. 5968510;U.S. Pat. No. 5968001; U.S. Pat. No. 5962420; U.S. Pat. No. 5962026;U.S. Pat. No. 5885796; U.S. Pat. No. 5858253; U.S. Pat. No. 5851795;U.S. Pat. No. 5844095; U.S. Pat. No. 5804428; U.S. Pat. No. 5795780;U.S. Pat. No. 5795571; U.S. Pat. No. 5792344; U.S. Pat. No. 5776336;U.S. Pat. No. 5773614; U.S. Pat. No. 5773418; U.S. Pat. No. 5770194;U.S. Pat. No. 5763411; U.S. Pat. No. 5763410; U.S. Pat. No. 5750657;U.S. Pat. No. 5739288; U.S. Pat. No. 5618964; U.S. Pat. No. 5610314.

[0175] U.S. Patent Application Publication 20020086364; U.S. PatentApplication Publication 20030008837; U.S. Patent Application Publication20020173030; U.S. Patent Application Publication 20020045594; U.S.Patent Application Publication 20030060645.

[0176] HIV Section: U.S. Pat. No. 6521743; U.S. Pat. No. 6495533; U.S.Pat. No. 6451796; U.S. Pat. No. 6441131; U.S. Pat. No. 6407206; U.S.Pat. No. 6376484; U.S. Pat. No. 6436834; U.S. Pat. No. 6521595; U.S.Pat. No. 5817314; U.S. Pat. No. 5773468; U.S. Pat. No. 5696134; U.S.Pat. No. 5679687; U.S. Pat. No. 5670517; U.S. Pat. No. 6136815; U.S.Pat. No. 5922727; U.S. Pat. No. 6548286; U.S. Pat. No. 6521602; U.S.Pat. No. 6506604; U.S. Pat. No. 4628953; U.S. Pat. No. 6420345; U.S.Pat. No. 6413943; U.S. Pat. No. 6407221; U.S. Pat. No. 6406861; U.S.Pat. No. 6319905; U.S. Pat. No. 6319494; U.S. Pat. No. 6218187; U.S.Pat. No. 6465782; U.S. Pat. No. 6103521; U.S. Pat. No. 6077947; U.S.Pat. No. 6051427; U.S. Pat. No. 5994136; U.S. Pat. No. 5872005; U.S.Pat. No. 5858740; U.S. Pat. No. 5837544; U.S. Pat. No. 5834256; U.S.Pat. No. 5741899; U.S. Pat. No. 5712149; U.S. Pat. No. 5686281; U.S.Pat. No. 5686279; U.S. Pat. No. 5670148; U.S. Pat. No. 5958718; U.S.Pat. No. 5683986; U.S. Pat. No. 5593973; U.S. Pat. No. 6482407; U.S.Pat. No. 6331525; U.S. Pat. No. 6328976; U.S. Pat. No. 6080571; U.S.Pat. No. 6069133; U.S. Pat. No. 6017543; U.S. Pat. No. 5928930; U.S.Pat. No. 5916806; U.S. Pat. No. 5895650; U.S. Pat. No. 5891432; U.S.Pat. No. 5885578; U.S. Pat. No. 5853725; U.S. Pat. No. 5843770; U.S.Pat. No. 5744326; U.S. Pat. No. 5728399; U.S. Pat. No. 5661023; U.S.Pat. No. 6545023; U.S. Pat. No. 6544988; U.S. Pat. No. 6542903; U.S.Pat. No. 6541515; U.S. Pat. No. 6538002; U.S. Pat. No. 6534505; U.S.Pat. No. 6534312; U.S. Pat. No. 6531617; U.S. Pat. No. 6531484; U.S.Pat. No. 6525025; U.S. Pat. No. 6518273; U.S. Pat. No. 6511994; U.S.Pat. No. 6506908; U.S. Pat. No. 6506777; U.S. Pat. No. 6500844; U.S.Pat. No. 6498161; U.S. Pat. No. 6492516; U.S. Pat. No. 6489354; U.S.Pat. No. 6489343; U.S. Pat. No. 6482952; U.S. Pat. No. 6479512; U.S.Pat. No. 6478967; U.S. Pat. No. 6476054; U.S. Pat. No. 6476045; U.S.Pat. No. 6472410; U.S. Pat. No. 6458830; U.S. Pat. No. 6455548; U.S.Pat. No. 6448249; U.S. Pat. No. 6444811; U.S. Pat. No. 6444666; U.S.Pat. No. 6440680; U.S. Pat. No. 6432981; U.S. Pat. No. 6432953; U.S.Pat. No. 6420382; U.S. Pat. No. 6420376; U.S. Pat. No. 6403596; U.S.Pat. No. 6403347; U.S. Pat. No. 6399619; U.S. Pat. No. 6395905; U.S.Pat. No. 6395766; U.S. Pat. No. 6395743; U.S. Pat. No. 6395499; U.S.Pat. No. 6384244; U.S. Pat. No. 6384018; U.S. Pat. No. 6380249; U.S.Pat. No. 6379556; U.S. Pat. No. 6372764; U.S. Pat. No. 6372754; U.S.Pat. No. 6372425; U.S. Pat. No. 6365360; U.S. Pat. No. 6362201; U.S.Pat. No. 6362009; U.S. Pat. No. 6358979; U.S. Pat. No. 6358694; U.S.Pat. No. 6350744; U.S. Pat. No. 6332138; U.S. Pat. No. 6313364; U.S.Pat. No. 6313138; U.S. Pat. No. 6313125; U.S. Pat. No. 6310203; U.S.Pat. No. 6306891; U.S. Pat. No. 6306874; U.S. Pat. No. 6303593; U.S.Pat. No. 6297235; U.S. Pat. No. 6291457; U.S. Pat. No. 6290965; U.S.Pat. No. 6271402; U.S. Pat. No. 6271347; U.S. Pat. No. 6265434; U.S.Pat. No. 6262103; U.S. Pat. No. 6262055; U.S. Pat. No. 6248755; U.S.Pat. No. 6245806; U.S. Pat. No. 6245759; U.S. Pat. No. 6229010; U.S.Pat. No. 6225320; U.S. Pat. No. 6214972; U.S. Pat. No. 6214846; U.S.Pat. No. 6214564; U.S. Pat. No. 6214354; U.S. Pat. No. 6211174; U.S.Pat. No. 6207687; U.S. Pat. No. 6200975; U.S. Pat. No. 6187316; U.S.Pat. No. 6180634; U.S. Pat. No. 6172077; U.S. Pat. No. 6171832; U.S.Pat. No. 6166037; U.S. Pat. No. 6156895; U.S. Pat. No. 6156787; U.S.Pat. No. 6156761; U.S. Pat. No. 6143773; U.S. Pat. No. 6140349; U.S.Pat. No. 6136827; U.S. Pat. No. 6136824; U.S. Pat. No. 6127365; U.S.Pat. No. 6124327; U.S. Pat. No. 6124319; U.S. Pat. No. 6123964; U.S.Pat. No. 6121325; U.S. Pat. No. 6118043; U.S. Pat. No. 6110716; U.S.Pat. No. 6110701; U.S. Pat. No. 6103513; U.S. Pat. No. 6096766; U.S.Pat. No. 6096742; U.S. Pat. No. 6083949; U.S. Pat. No. 6080740; U.S.Pat. No. 6071928; U.S. Pat. No. 6071927; U.S. Pat. No. 6071916; U.S.Pat. No. 6060469; U.S. Pat. No. 6046195; U.S. Pat. No. 6043387; U.S.Pat. No. 6031079; U.S. Pat. No. 6013644; U.S. Pat. No. 5997880; U.S.Pat. No. 5985896; U.S. Pat. No. 5985874; U.S. Pat. No. 5985597; U.S.Pat. No. 5981759; U.S. Pat. No. 5977371; U.S. Pat. No. 5977364; U.S.Pat. No. 5968934; U.S. Pat. No. 5965565; U.S. Pat. No. 5962485; U.S.Pat. No. 5962462; U.S. Pat. No. 5958723; U.S. Pat. No. 5955480; U.S.Pat. No. 5939414; U.S. Pat. No. 5922744; U.S. Pat. No. 5919776; U.S.Pat. No. 5885999; U.S. Pat. No. 5880125; U.S. Pat. No. 5877316; U.S.Pat. No. 5877184; U.S. Pat. No. 5877182; U.S. Pat. No. 5874629; U.S.Pat. No. 5871981; U.S. Pat. No. 5869281; U.S. Pat. No. 5866397; U.S.Pat. No. 5861512; U.S. Pat. No. 5861297; U.S. Pat. No. 5859041; U.S.Pat. No. 5858738; U.S. Pat. No. 5858737; U.S. Pat. No. 5849568; U.S.Pat. No. 5846978; U.S. Pat. No. 5840847; U.S. Pat. No. 5840308; U.S.Pat. No. 5840306; U.S. Pat. No. 5837719; U.S. Pat. No. 5830892; U.S.Pat. No. 5824540; U.S. Pat. No. 5820870; U.S. Pat. No. 5811462; U.S.Pat. No. 5811423; U.S. Pat. No. 5811422; U.S. Pat. No. 5807841; U.S.Pat. No. 5804578; U.S. Pat. No. 5798442; U.S. Pat. No. 5792778; U.S.Pat. No. 5783582; U.S. Pat. No. 5780291; U.S. Pat. No. 5776954; U.S.Pat. No. 5767124; U.S. Pat. No. 5763574; U.S. Pat. No. 5763469; U.S.Pat. No. 5760180; U.S. Pat. No. 5759842; U.S. Pat. No. 5759789; U.S.Pat. No. 5747540; U.S. Pat. No. 5736524; U.S. Pat. No. 5733907; U.S.Pat. No. 5731317; U.S. Pat. No. 5728840; U.S. Pat. No. 5728808; U.S.Pat. No. 5728695; U.S. Pat. No. 5723615; U.S. Pat. No. 5721251; U.S.Pat. No. 5721250; U.S. Pat. No. 5717100; U.S. Pat. No. 5717097; U.S.Pat. No. 5410286; U.S. Pat. No. 5700364; U.S. Pat. No. 5698741; U.S.Pat. No. 5693803; U.S. Pat. No. 5693648; U.S. Pat. No. 5683999; U.S.Pat. No. 5668132; U.S. Pat. No. 5665720; U.S. Pat. No. 5663467; U.S.Pat. No. 5663341; U.S. Pat. No. 5663333; U.S. Pat. No. 5663171; U.S.Pat. No. 5663169; U.S. Pat. No. 5658756; U.S. Pat. No. 5656606; U.S.Pat. No. 5650412; U.S. Pat. No. 6548636; U.S. Pat. No. 6451313; U.S.Pat. No. 6344545; U.S. Pat. No. 6342586; U.S. Pat. No. 6261763; U.S.Pat. No. 6187748; U.S. Pat. No. 6177549; U.S. Pat. No. 6107019; U.S.Pat. No. 6083478; U.S. Pat. No. 6034223; U.S. Pat. No. 5886163; U.S.Pat. No. 5869624; U.S. Pat. No. 5817767; U.S. Pat. No. 6451543; U.S.Pat. No. 6326468; U.S. Pat. No. 6217873; U.S. Pat. No. 6174530; U.S.Pat. No. 6168784; U.S. Pat. No. 6001364; U.S. Pat. No. 6506770; U.S.Pat. No. 6489472; U.S. Pat. No. 6365583; U.S. Pat. No. 6025364; U.S.Pat. No. 6001826; U.S. Pat. No. 5900430; U.S. Pat. No. 5817807; U.S.Pat. No. 6538006; U.S. Pat. No. 6531139; U.S. Pat. No. 6509361; U.S.Pat. No. 6500840; U.S. Pat. No. 6500667; U.S. Pat. No. 6492386; U.S.Pat. No. 6486322; U.S. Pat. No. 6482849; U.S. Pat. No. 6455559; U.S.Pat. No. 6452007; U.S. Pat. No. 6451838; U.S. Pat. No. 6420534; U.S.Pat. No. 6414013; U.S. Pat. No. 6387900; U.S. Pat. No. 6376180; U.S.Pat. No. 6335342; U.S. Pat. No. 6265604; U.S. Pat. No. 6231887; U.S.Pat. No. 6218418; U.S. Pat. No. 6211386; U.S. Pat. No. 6191124; U.S.Pat. No. 6169181; U.S. Pat. No. 6153379; U.S. Pat. No. 6147095; U.S.Pat. No. H1,892; U.S. Pat. No. 6124306; U.S. Pat. No. 6121313; U.S. Pat.No. 6114365; U.S. Pat. No. 6096512; U.S. Pat. No. 6084075; U.S. Pat. No.6077963; U.S. Pat. No. 6060600; U.S. Pat. No. 6043248; U.S. Pat. No.5981537; U.S. Pat. No. 5910570; U.S. Pat. No. 5876968; U.S. Pat. No.5866589; U.S. Pat. No. 5852195; U.S. Pat. No. 5759852; U.S. Pat. No.5753518; U.S. Pat. No. 5739350; U.S. Pat. No. 5739021; U.S. Pat. No.5700788; U.S. Pat. No. 5691350; U.S. Pat. No. 5686610; U.S. Pat. No.5686486; U.S. Pat. No. 5594115; U.S. Pat. No. 5554541; U.S. Pat. No.6528515; U.S. Pat. No. 6518425; U.S. Pat. No. 6410546; U.S. Pat. No.6215004; U.S. Pat. No. 6188988; U.S. Pat. No. 6081786; U.S. Pat. No.5785975; U.S. Pat. No. RE7781; U.S. Pat. No. 6322770; U.S. Pat. No.6313124; U.S. Pat. No. 6313110; U.S. Pat. No. 6303780; U.S. Pat. No.6297410; U.S. Pat. No. 6291504; U.S. Pat. No. 6288297; U.S. Pat. No.6281352; U.S. Pat. No. 6271380; U.S. Pat. No. 6271237; U.S. Pat. No.6268379; U.S. Pat. No. 6265406; U.S. Pat. No. 6245769; U.S. Pat. No.6238695; U.S. Pat. No. 6235957; U.S. Pat. No. 6235733; U.S. Pat. No.6225317; U.S. Pat. No. 6218534; U.S. Pat. No. 6218386; U.S. Pat. No.6214851; U.S. Pat. No. 6204262; U.S. Pat. No. 6191131; U.S. Pat. No.6175009; U.S. Pat. No. 6174912; U.S. Pat. No. 6147210; U.S. Pat. No.6143743; U.S. Pat. No. 6140320; U.S. Pat. No. 6136809; U.S. Pat. No.6127375; U.S. Pat. No. 6124302; U.S. Pat. No. 3124289; U.S. Pat. No.6103737; U.S. Pat. No. 6060491; U.S. Pat. No. 6060478; U.S. Pat. No.6054597; U.S. Pat. No. 6049019; U.S. Pat. No. 6028237; U.S. Pat. No.5998614; U.S. Pat. No. 5985867; U.S. Pat. No. 5932726; U.S. Pat. No.5932570; U.S. Pat. No. 5925789; U.S. Pat. No. 5925635; U.S. Pat. No.5912348; U.S. Pat. No. 5886191; U.S. Pat. No. 5880295; U.S. Pat. No.5879659; U.S. Pat. No. 5877312; U.S. Pat. No. 5877170; U.S. Pat. No.5874430; U.S. Pat. No. 6541020; U.S. Pat. No. 6518013; U.S. Pat. No.6479055; U.S. Pat. No. 6475491; U.S. Pat. No. 6469136; U.S. Pat. No.6440656; U.S. Pat. No. 6348568; U.S. Pat. No. 6281331; U.S. Pat. No.6258782; U.S. Pat. No. 6228983; U.S. Pat. No. 6093794; U.S. Pat. No.6068973; U.S. Pat. No. 6060065; U.S. Pat. No. 6054265; U.S. Pat. No.6017536; U.S. Pat. No. 6015881; U.S. Pat. No. 6013263; U.S. Pat. No.6548663; U.S. Pat. No. 6548546; U.S. Pat. No. 6548525; U.S. Pat. No.6548047; U.S. Pat. No. 6537520; U.S. Pat. No. 6525069; U.S. Pat. No.6525056; U.S. Pat. No. 6524553; U.S. Pat. No. 6521759; U.S. Pat. No.6521636; U.S. Pat. No. 6521614; U.S. Pat. No. 6521592; U.S. Pat. No.6518271; U.S. Pat. No. 6518014; U.S. Pat. No. 6511648; U.S. Pat. No.6503898; U.S. Pat. No. 6495565; U.S. Pat. No. 6495548; U.S. Pat. No.6492515; U.S. Pat. No. 6492400; U.S. Pat. No. 6489320; U.S. Pat. No.6486180; U.S. Pat. No. 6482919; U.S. Pat. No. 6479052; U.S. Pat. No.6479034; U.S. Pat. No. 6476034; U.S. Pat. No. 6475521; U.S. Pat. No.6472510; U.S. Pat. No. 6469024; U.S. Pat. No. 6469006; U.S. Pat. No.6462037; U.S. Pat. No. 6455522; U.S. Pat. No. 6452000; U.S. Pat. No.6451999; U.S. Pat. No. 6441001; U.S. Pat. No. 6423718; U.S. Pat. No.6416740; U.S. Pat. No. 6407103; U.S. Pat. No. 6399793; U.S. Pat. No.6399773; U.S. Pat. No. 6391919; U.S. Pat. No. 6380184; U.S. Pat. No.6376459; U.S. Pat. No. 6365589; U.S. Pat. No. 6362180; U.S. Pat. No.6358950; U.S. Pat. No. 6333186; U.S. Pat. No. 6331316; U.S. Pat. No.6262096; U.S. Pat. No. 6239146; U.S. Pat. No. 6228872; U.S. Pat. No.6224910; U.S. Pat. No. 6207650; U.S. Pat. No. 6132992; U.S. Pat. No.H1893; U.S. Pat. No. 6107305; U.S. Pat. No. 6096762; U.S. Pat. No.6090914; U.S. Pat. No. 6087383; U.S. Pat. No. 6083902; U.S. Pat. No.6040321; U.S. Pat. No. 5968510; U.S. Pat. No. 5962415; U.S. Pat. No.5885796; U.S. Pat. No. 5880106; U.S. Pat. No. 5877282; U.S. Pat. No.5851795; U.S. Pat. No. 5844095; U.S. Pat. No. 5807734; U.S. Pat. No.5795572; U.S. Pat. No. 5773253; U.S. Pat. No. 5770197; U.S. Pat. No.5774314; U.S. Pat. No. 5719132; U.S. Pat. No. 5672698; U.S. Pat. No.5667989; U.S. Pat. No. 5644065; U.S. Pat. No. 5637481; U.S. Pat. No.5580756; U.S. Pat. No. 5521288; U.S. Pat. No. 5521066; U.S. Pat. No.5492910; U.S. Pat. No. 6534058; U.S. Pat. No. 6433155; U.S. Pat. No.6309880; U.S. Pat. No. 5981278; U.S. Pat. No. 5854400; U.S. Pat. No.5834599; U.S. Pat. No. 5739306; U.S. Pat. No. 5728814; U.S. Pat. No.5691447; U.S. Pat. No. 5652333; U.S. Pat. No. 5514776; U.S. Pat. No.5849911; U.S. Pat. No. 6166004; U.S. Pat. No. 6087383.

[0177] U.S. Patent Application Publication 20030032619 A1; U.S. PatentApplication Publication 20030023061; U.S. Patent Application Publication20030008837; U.S. Patent Application Publication 20020081293; U.S.Patent Application Publication 20030027825; U.S. Patent ApplicationPublication 20020045594; U.S. Patent Application Publication20010049439; U.S. Patent Application Publication 20010041702; U.S.Patent Application Publication 20030052839; U.S. Patent ApplicationPublication 20020155429; U.S. Patent Application Publication20020045161; U.S. Patent Application Publication 20010046512; U.S.Patent Application Publication 20020081629; U.S. Patent ApplicationPublication 20020169282; U.S. Patent Application Publication20020132975; U.S. Patent Application Publication 20020081629; U.S.Patent Application Publication 20020068298; U.S. Patent ApplicationPublication 20020064819; U.S. Patent Application Publication20020037315; U.S. Patent Application Publication 20010021391; U.S.Patent Application Publication 20010018208; U.S. Patent ApplicationPublication 20010016324; U.S. Patent Application Publication20030060645; U.S. Patent Application Publication 20020012989.

[0178] Cancer Section: U.S. Pat. No. 6521743; U.S. Pat. No. 6500916;U.S. Pat. No. 6441131; U.S. Pat. No. 6407206; U.S. Pat. No. 5859042;U.S. Pat. No. 5756084; U.S. Pat. No. 5698520; U.S. Pat. No. 5629204;U.S. Pat. No. 5563048; U.S. Pat. No. 5508450; U.S. Pat. No. 6518429;U.S. Pat. No. 6500846; U.S. Pat. No. 6472526; U.S. Pat. No. 6436960;U.S. Pat. No. 6384061; U.S. Pat. No. 6316644; U.S. Pat. No. 6268363;U.S. Pat. No. 6191342; U.S. Pat. No. 6028195; U.S. Pat. No. 5780472;U.S. Pat. No. 6441135; U.S. Pat. No. 6436639; U.S. Pat. No. 6433155;U.S. Pat. No. 6197298; U.S. Pat. No. 6129916; U.S. Pat. No. 6117982;U.S. Pat. No. 6106835; U.S. Pat. No. 5981278; U.S. Pat. No. 5908626;U.S. Pat. No. 5834599; U.S. Pat. No. 5723125; U.S. Pat. No. 5281699;U.S. Pat. No. 6534058; U.S. Pat. No. 6414037; U.S. Pat. No. 6211247;U.S. Pat. No. 6022901; U.S. Pat. No. 6008260; U.S. Pat. No. 6548286;U.S. Pat. No. 6544771; U.S. Pat. No. 6521602; U.S. Pat. No. 6506604;U.S. Pat. No. 6436394; U.S. Pat. No. 6432700; U.S. Pat. No. 6420345;U.S. Pat. No. 6413943; U.S. Pat. No. 6407221; U.S. Pat. No. 6406861;U.S. Pat. No. 6319494; U.S. Pat. No. 6218487; U.S. Pat. No. 6140111;U.S. Pat. No. 6103521; U.S. Pat. No. 6077947; U.S. Pat. No. 9051427;U.S. Pat. No. 6037177; U.S. Pat. No. 5872005; U.S. Pat. No. 5858740;U.S. Pat. No. 5837544; U.S. Pat. No. 5834256; U.S. Pat. No. 5741899;U.S. Pat. No. 5712149; U.S. Pat. No. 5686281; U.S. Pat. No. 5686279;U.S. Pat. No. 5670148; U.S. Pat. No. 5958718; U.S. Pat. No. 5763417;U.S. Pat. No. 5683986; U.S. Pat. No. 5593973; U.S. Pat. No. 6482407;U.S. Pat. No. 6328976; U.S. Pat. No. 6017543; U.S. Pat. No. 5928930;U.S. Pat. No. 5916806; U.S. Pat. No. 5895650; U.S. Pat. No. 5891432;U.S. Pat. No. 5885578; U.S. Pat. No. 5853725; U.S. Pat. No. 5256767;U.S. Pat. No. 6545023; U.S. Pat. No. 6544988; U.S. Pat. No. 6541515;U.S. Pat. No. 6538112; U.S. Pat. No. 6538021; U.S. Pat. No. 6538008;U.S. Pat. No. 6538002; U.S. Pat. No. 6534510; U.S. Pat. No. 6534506;U.S. Pat. No. 6534312; U.S. Pat. No. 6531484; U.S. Pat. No. 6528503;U.S. Pat. No. 6525083; U.S. Pat. No. 6525074; U.S. Pat. No. 6521646;U.S. Pat. No. 6521625; U.S. Pat. No. 6518273; U.S. Pat. No. 6515011;U.S. Pat. No. 6514527; U.S. Pat. No. 6511994; U.S. Pat. No. 6509347;U.S. Pat. No. 6506777; U.S. Pat. No. 6500869; U.S. Pat. No. 6500844;U.S. Pat. No. 6500841; U.S. Pat. No. 6498165; U.S. Pat. No. 6498161;U.S. Pat. No. 6498151; U.S. Pat. No. 6495713; U.S. Pat. No. 6491930;U.S. Pat. No. 6489354; U.S. Pat. No. 6489343; U.S. Pat. No. 6486204;U.S. Pat. No. 6486194; U.S. Pat. No. 6486142; U.S. Pat. No. 6486141;U.S. Pat. No. 6482840; U.S. Pat. No. 6479518; U.S. Pat. No. 6479512;U.S. Pat. No. 6479486; U.S. Pat. No. 6476054; U.S. Pat. No. 6476045;U.S. Pat. No. 6472410; U.S. Pat. No. 6472403; U.S. Pat. No. 6472398;U.S. Pat. No. 6468735; U.S. Pat. No. 6465509; U.S. Pat. No. 6465484;U.S. Pat. No. 6465444; U.S. Pat. No. 6462050; U.S. Pat. No. 6458935;U.S. Pat. No. 6458830; U.S. Pat. No. 6458790; U.S. Pat. No. 6458551;U.S. Pat. No. 6455548; U.S. Pat. No. 6455532; U.S. Pat. No. 6448429;U.S. Pat. No. 6448274; U.S. Pat. No. 6444680; U.S. Pat. No. 6441017;U.S. Pat. No. 6440680; U.S. Pat. No. 6437165; U.S. Pat. No. 6436965;U.S. Pat. No. 6436962; U.S. Pat. No. 6436402; U.S. Pat. No. 6436374;U.S. Pat. No. 6432981; U.S. Pat. No. 6432971; U.S. Pat. No. 6432953;U.S. Pat. No. 6432952; U.S. Pat. No. 6428983; U.S. Pat. No. 6426353;U.S. Pat. No. 3420418; U.S. Pat. No. 6420382; U.S. Pat. No. 6420376;U.S. Pat. No. 6413955; U.S. Pat. No. 6410583; U.S. Pat. No. 6410563;U.S. Pat. No. 6410548; U.S. Pat. No. 6410534; U.S. Pat. No. 6410534;U.S. Pat. No. 6410526; U.S. Pat. No. 6410270; U.S. Pat. No. 6407241;U.S. Pat. No. 6403584; U.S. Pat. No. 6399636; U.S. Pat. No. 6399619;U.S. Pat. No. 6399592; U.S. Pat. No. 6395743; U.S. Pat. No. 6391305;U.S. Pat. No. 6387932; U.S. Pat. No. 6387911; U.S. Pat. No. 6387903;U.S. Pat. No. 6387893; U.S. Pat. No. 6380249; U.S. Pat. No. 6380228;U.S. Pat. No. 6380203; U.S. Pat. No. 6376509; U.S. Pat. No. 6376499;U.S. Pat. No. 6376496; U.S. Pat. No. 6375929; U.S. Pat. No. 6372764;U.S. Pat. No. 6372754; U.S. Pat. No. 6372733; U.S. Pat. No. 6369275;U.S. Pat. No. 6369084; U.S. Pat. No. 6369082; U.S. Pat. No. 6365592;U.S. Pat. No. 6362327; U.S. Pat. No. 6362201; U.S. Pat. No. 6359115;U.S. Pat. No. 6358985; U.S. Pat. No. 6358979; U.S. Pat. No. 6358970;U.S. Pat. No. 6358956; U.S. Pat. No. 6356873; U.S. Pat. No. 6355643;U.S. Pat. No. 6355611; U.S. Pat. No. 6353099; U.S. Pat. No. 6352997;U.S. Pat. No. 6350760; U.S. Pat. No. 6350755; U.S. Pat. No. 6350745;U.S. Pat. No. 6348572; U.S. Pat. No. 6348184; U.S. Pat. No. 6355343;U.S. Pat. No. 6333335; U.S. Pat. No. 6329421; U.S. Pat. No. 6329380;U.S. Pat. No. 6329376; U.S. Pat. No. 6326372; U.S. Pat. No. 6316472;U.S. Pat. No. 6316444; U.S. Pat. No. 6316437; U.S. Pat. No. 6316436;U.S. Pat. No. 6313138; U.S. Pat. No. 6306891; U.S. Pat. No. 6306874;U.S. Pat. No. 6303637; U.S. Pat. No. 6303593; U.S. Pat. No. 6297249;U.S. Pat. No. 6297239; U.S. Pat. No. 6294559; U.S. Pat. No. 6294534;U.S. Pat. No. 6291511; U.S. Pat. No. 6288078; U.S. Pat. No. 6284755;U.S. Pat. No. 6281391; U.S. Pat. No. 6280740; U.S. Pat. No. 6277839;U.S. Pat. No. 6277357; U.S. Pat. No. 6271402; U.S. Pat. No. 6271252;U.S. Pat. No. 6268378; U.S. Pat. No. 6268377; U.S. Pat. No. 6268376;U.S. Pat. No. 6265434; U.S. Pat. No. 6265403; U.S. Pat. No. 6262055;U.S. Pat. No. 6252116; U.S. Pat. No. 6248756; U.S. Pat. No. 6248755;U.S. Pat. No. 6245806; U.S. Pat. No. 6245759; U.S. Pat. No. 6242493;U.S. Pat. No. 6239173; U.S. Pat. No. 6239132; U.S. Pat. No. 6235741;U.S. Pat. No. 6235735; U.S. Pat. No. 6232311; U.S. Pat. No. 6232308;U.S. Pat. No. 6229010; U.S. Pat. No. 6228871; U.S. Pat. No. 6228867;U.S. Pat. No. 6225320; U.S. Pat. No. 6222048; U.S. Pat. No. 6222015;U.S. Pat. No. 6221888; U.S. Pat. No. 6214846; U.S. Pat. No. 6214564;U.S. Pat. No. 6211224; U.S. Pat. No. 6211210; U.S. Pat. No. 3211197;U.S. Pat. No. 6211191; U.S. Pat. No. 6211184; U.S. Pat. No. 6211174;U.S. Pat. No. 6210904; U.S. Pat. No. 6207798; U.S. Pat. No. 6204378;U.S. Pat. No. 6204275; U.S. Pat. No. 6204273; U.S. Pat. No. 6204034;U.S. Pat. No. 6204011; U.S. Pat. No. 6200993; U.S. Pat. No. 6200957;U.S. Pat. No. 6197975; U.S. Pat. No. 9194458; U.S. Pat. No. 6194210;U.S. Pat. No. 6191171; U.S. Pat. No. 6187298; U.S. Pat. No. 6180650;U.S. Pat. No. 6180642; U.S. Pat. No. 6180624; U.S. Pat. No. 6177404;U.S. Pat. No. 6174874; U.S. Pat. No. 6174858; U.S. Pat. No. 6174540;U.S. Pat. No. 6172080; U.S. Pat. No. 6172077; U.S. Pat. No. 6172076;U.S. Pat. No. 6169188; U.S. Pat. No. 6166037; U.S. Pat. No. 6162813;U.S. Pat. No. 6162805; U.S. Pat. No. 6162804; U.S. Pat. No. 6160118;U.S. Pat. No. 6159989; U.S. Pat. No. 9159975; U.S. Pat. No. 9156772;U.S. Pat. No. 6156767; U.S. Pat. No. 6153787; U.S. Pat. No. 6150522;U.S. Pat. No. 6150352; U.S. Pat. No. 6147088; U.S. Pat. No. 6147078;U.S. Pat. No. 6146617; U.S. Pat. No. 6143864; U.S. Pat. No. 6140515;U.S. Pat. No. 6140508; U.S. Pat. No. 6140349; U.S. Pat. No. 6140324;U.S. Pat. No. 6140073; U.S. Pat. No. 6136853; U.S. Pat. No. 6136827;U.S. Pat. No. 6136824; U.S. Pat. No. 6133297; U.S. Pat. No. 6133292;U.S. Pat. No. 6130334; U.S. Pat. No. 6130204; U.S. Pat. No. 6127545;U.S. Pat. No. 5127390; U.S. Pat. No. 6127366; U.S. Pat. No. 6127365;U.S. Pat. No. 6127333; U.S. Pat. No. 3124319; U.S. Pat. No. 6123964;U.S. Pat. No. 6121325; U.S. Pat. No. 6117888; U.S. Pat. No. 6117880;U.S. Pat. No. 6110931; U.S. Pat. No. 6110915; U.S. Pat. No. 6110701;U.S. Pat. No. 6110697; U.S. Pat. No. 6107087; U.S. Pat. No. 6103723;U.S. Pat. No. 6103513; U.S. Pat. No. 6103487; U.S. Pat. No. 6100293;U.S. Pat. No. 6096766; U.S. Pat. No. 6096742; U.S. Pat. No. 6093737;U.S. Pat. No. 6093717; U.S. Pat. No. 6090948; U.S. Pat. No. 6090944;U.S. Pat. No. 6090841; U.S. Pat. No. 6087373; U.S. Pat. No. 6083980;U.S. Pat. No. 6083949; U.S. Pat. No. 6080876; U.S. Pat. No. 6080870;U.S. Pat. No. 6080740; U.S. Pat. No. 6077858; U.S. Pat. No. 6077853;U.S. Pat. No. 6077847; U.S. Pat. No. 6071936; U.S. Pat. No. 6071928;U.S. Pat. No. 6071927; U.S. Pat. No. 6069163; U.S. Pat. No. 6068987;U.S. Pat. No. 6066738; U.S. Pat. No. 6066648; U.S. Pat. No. 6063930;U.S. Pat. No. 6063811; U.S. Pat. No. 6063796; U.S. Pat. No. 6063783;U.S. Pat. No. 6060469; U.S. Pat. No. 6060038; U.S. Pat. No. 6057338;U.S. Pat. No. 6057324; U.S. Pat. No. 6057319; U.S. Pat. No. 6054466;U.S. Pat. No. 6054455; U.S. Pat. No. 6051590; U.S. Pat. No. 6054574;U.S. Pat. No. 6048869; U.S. Pat. No. 6048861; U.S. Pat. No. 6048859;U.S. Pat. No. 6046217; U.S. Pat. No. 6046195; U.S. Pat. No. 6043358;U.S. Pat. No. 6040463; U.S. Pat. No. 6040450; U.S. Pat. No. 6040319;U.S. Pat. No. 6040311; U.S. Pat. No. 6034089; U.S. Pat. No. 6031079;U.S. Pat. No. 6030788; U.S. Pat. No. 6028201; U.S. Pat. No. 6025372;U.S. Pat. No. 6025366; U.S. Pat. No. 6022890; U.S. Pat. No. 6020347;U.S. Pat. No. 6020343; U.S. Pat. No. 6020339; U.S. Pat. No. 6017944;U.S. Pat. No. 6017926; U.S. Pat. No. 6017925; U.S. Pat. No. 6015817;U.S. Pat. No. 6015801; U.S. Pat. No. 6014631; U.S. Pat. No. 6013644;U.S. Pat. No. 6011038; U.S. Pat. No. 6008207; U.S. Pat. No. 6004984;U.S. Pat. No. 6004976; U.S. Pat. No. 6004960; U.S. Pat. No. 6004950;U.S. Pat. No. 6001844; U.S. Pat. No. 6001843; U.S. Pat. No. 6001835;U.S. Pat. No. 5998464; U.S. Pat. No. 5998432; U.S. Pat. No. 5998408;U.S. Pat. No. 5998407; U.S. Pat. No. 5998362; U.S. Pat. No. 5994412;U.S. Pat. No. 5994379; U.S. Pat. No. 5994362; U.S. Pat. No. 5994300;U.S. Pat. No. 5990107; U.S. Pat. No. 5985901; U.S. Pat. No. 5985896;U.S. Pat. No. 5985892; U.S. Pat. No. 5985874; U.S. Pat. No. 5985597;U.S. Pat. No. 5985278; U.S. Pat. No. 5981584; U.S. Pat. No. 5981576;U.S. Pat. No. 5981562; U.S. Pat. No. 5981550; U.S. Pat. No. 5981546;U.S. Pat. No. 5977134; U.S. Pat. No. 5972996; U.S. Pat. No. 5972984;U.S. Pat. No. 5972975; U.S. Pat. No. 5972966; U.S. Pat. No. 5972942;U.S. Pat. No. 5972938; U.S. Pat. No. 5972913; U.S. Pat. No. 5969107;U.S. Pat. No. 5968974; U.S. Pat. No. 5968965; U.S. Pat. No. 5968958;U.S. Pat. No. 5968934; U.S. Pat. No. 5968924; U.S. Pat. No. 5968800;U.S. Pat. No. 5968482; U.S. Pat. No. 5965612; U.S. Pat. No. 5965578;U.S. Pat. No. 5965565; U.S. Pat. No. 5962485; U.S. Pat. No. 5962462;U.S. Pat. No. 5952371; U.S. Pat. No. 5952341; U.S. Pat. No. 5952321;U.S. Pat. No. 5952216; U.S. Pat. No. 5948750; U.S. Pat. No. 5945412;U.S. Pat. No. 5939557; U.S. Pat. No. 5939439; U.S. Pat. No. 5935968;U.S. Pat. No. 5935578; U.S. Pat. No. 5932590; U.S. Pat. No. 5932582;U.S. Pat. No. 5932559; U.S. Pat. No. 5929094; U.S. Pat. No. 5925655;U.S. Pat. No. 5925651; U.S. Pat. No. 5925631; U.S. Pat. No. 5922883;U.S. Pat. No. 5922837; U.S. Pat. No. 5922744; U.S. Pat. No. 5922742;U.S. Pat. No. 5922706; U.S. Pat. No. 5922588; U.S. Pat. No. 5919937;U.S. Pat. No. 5919792; U.S. Pat. No. 5919785; U.S. Pat. No. 5919776;U.S. Pat. No. 5914341; U.S. Pat. No. 5914323; U.S. Pat. No. 5912322;U.S. Pat. No. 5910573; U.S. Pat. No. 5910497; U.S. Pat. No. 5908842;U.S. Pat. No. 5900414; U.S. Pat. No. 5891889; U.S. Pat. No. 5891863;U.S. Pat. No. 5888516; U.S. Pat. No. 5886005; U.S. Pat. No. 5885999;U.S. Pat. No. 5885995; U.S. Pat. No. 5883267; U.S. Pat. No. 5883119;U.S. Pat. No. 5883105; U.S. Pat. No. 5880280; U.S. Pat. No. 5880140;U.S. Pat. No. 5880132; U.S. Pat. No. 5880125; U.S. Pat. No. 5879657;U.S. Pat. No. 5877316; U.S. Pat. No. 5877191; U.S. Pat. No. 5877184;U.S. Pat. No. 5877182; U.S. Pat. No. 5874594; U.S. Pat. No. 5874452;U.S. Pat. No. 5872150; U.S. Pat. No. 5872136; U.S. Pat. No. 5872126;U.S. Pat. No. 5872116; U.S. Pat. No. 5869682; U.S. Pat. No. 5866679;U.S. Pat. No. 5866573; U.S. Pat. No. 5866553; U.S. Pat. No. 5866540;U.S. Pat. No. 5866397; U.S. Pat. No. 5861419; U.S. Pat. No. 5859035;U.S. Pat. No. 5859015; U.S. Pat. No. 5859012; U.S. Pat. No. 5856326;U.S. Pat. No. 5854265; U.S. Pat. No. 5854265; U.S. Pat. No. 5854264;U.S. Pat. No. 5854245; U.S. Pat. No. 5852010; U.S. Pat. No. 5849943;U.S. Pat. No. 5849764; U.S. Pat. No. 5849736; U.S. Pat. No. 5849726;U.S. Pat. No. 5849693; U.S. Pat. No. 5844093; U.S. Pat. No. 5843953;U.S. Pat. No. 5843924; U.S. Pat. No. 5840924; U.S. Pat. No. 5840746;U.S. Pat. No. 5840306; U.S. Pat. No. 5834228; U.S. Pat. No. 5830892;U.S. Pat. No. 5824782; U.S. Pat. No. 5824678; U.S. Pat. No. 5821261;U.S. Pat. No. 5821118; U.S. Pat. No. 5820870; U.S. Pat. No. 5817700;U.S. Pat. No. 5817678; U.S. Pat. No. 5811441; U.S. Pat. No. 5811431;U.S. Pat. No. 5811422; U.S. Pat. No. 5807865; U.S. Pat. No. 5804578;U.S. Pat. No. 5798442; U.S. Pat. No. 5798229; U.S. Pat. No. 5795754;U.S. Pat. No. 5789587; U.S. Pat. No. 5789558; U.S. Pat. No. 5789438;U.S. Pat. No. 5789413; U.S. Pat. No. 5783709; U.S. Pat. No. 5783582;U.S. Pat. No. 5780492; U.S. Pat. No. 5780488; U.S. Pat. No. 5780467;U.S. Pat. No. 5780455; U.S. Pat. No. 5780437; U.S. Pat. No. 5780291;U.S. Pat. No. 5777134; U.S. Pat. No. 5777112; U.S. Pat. No. 5773411;U.S. Pat. No. 5767291; U.S. Pat. No. 5767124; U.S. Pat. No. 5767118;U.S. Pat. No. 5763478; U.S. Pat. No. 5763361; U.S. Pat. No. 5760180;U.S. Pat. No. 5760054; U.S. Pat. No. 5760029; U.S. Pat. No. 5760028;U.S. Pat. No. 5760018; U.S. Pat. No. 5756528; U.S. Pat. No. 5756507;U.S. Pat. No. 5756480; U.S. Pat. No. 6451313; U.S. Pat. No. 6342586;U.S. Pat. No. 6187748; U.S. Pat. No. 6177549; U.S. Pat. No. 6083478;U.S. Pat. No. 6034223; U.S. Pat. No. 6417182; U.S. Pat. No. 6413953;U.S. Pat. No. 6284752; U.S. Pat. No. 6217845; U.S. Pat. No. 5900430;U.S. Pat. No. 6548071; U.S. Pat. No. 6545170; U.S. Pat. No. 6537990;U.S. Pat. No. 6531494; U.S. Pat. No. 6531470; U.S. Pat. No. 6531128;U.S. Pat. No. 6528301; U.S. Pat. No. 6525193; U.S. Pat. No. 6525041;U.S. Pat. No. 6521597; U.S. Pat. No. 6518427; U.S. Pat. No. 6515135;U.S. Pat. No. 6514498; U.S. Pat. No. 6512112; U.S. Pat. No. 6509361;U.S. Pat. No. 6500840; U.S. Pat. No. 6495544; U.S. Pat. No. 6492386;U.S. Pat. No. 6486322; U.S. Pat. No. 6486172; U.S. Pat. No. 6482955;U.S. Pat. No. 6482920; U.S. Pat. No. 6482827; U.S. Pat. No. 6479510;U.S. Pat. No. 6479261; U.S. Pat. No. 6476068; U.S. Pat. No. 6465686;U.S. Pat. No. 6465518; U.S. Pat. No. 6458768; U.S. Pat. No. 6455559;U.S. Pat. No. 6455290; U.S. Pat. No. 6451838; U.S. Pat. No. 6441188;U.S. Pat. No. 6441005; U.S. Pat. No. 6440694; U.S. Pat. No. 6436967;U.S. Pat. No. 6436913; U.S. Pat. No. 6432999; U.S. Pat. No. 6420379;U.S. Pat. No. 6414013; U.S. Pat. No. 6403830; U.S. Pat. No. 6403603;U.S. Pat. No. 6403563; U.S. Pat. No. 6395708; U.S. Pat. No. 6387900;U.S. Pat. No. 6387643; U.S. Pat. No. 6376617; U.S. Pat. No. 6340680;U.S. Pat. No. 6355342; U.S. Pat. No. 6307064; U.S. Pat. No. 6303329;U.S. Pat. No. 6287593; U.S. Pat. No. 6284463; U.S. Pat. No. 6277985;U.S. Pat. No. 6274580; U.S. Pat. No. 6245742; U.S. Pat. No. 6245358;U.S. Pat. No. 6239152; U.S. Pat. No. 6218418; U.S. Pat. No. 6214860;U.S. Pat. No. 6211192; U.S. Pat. No. 6210930; U.S. Pat. No. 6200746;U.S. Pat. No. 6197299; U.S. Pat. No. 6187758; U.S. Pat. No. 6184216;U.S. Pat. No. 6180601; U.S. Pat. No. 6177573; U.S. Pat. No. 6177453;U.S. Pat. No. 6177408; U.S. Pat. No. 6172202; U.S. Pat. No. 6169181;U.S. Pat. No. 6166080; U.S. Pat. No. 6165980; U.S. Pat. No. 6159935;U.S. Pat. No. 6153642; U.S. Pat. No. 6147073; U.S. Pat. No. 6126945;U.S. Pat. No. 6114365; U.S. Pat. No. 6114345; U.S. Pat. No. 6098632;U.S. Pat. No. 6093721; U.S. Pat. No. 6087377; U.S. Pat. No. 6087340;U.S. Pat. No. 6084075; U.S. Pat. No. 6077700; U.S. Pat. No. 6074851;U.S. Pat. No. 6057452; U.S. Pat. No. 6057326; U.S. Pat. No. 6045808;U.S. Pat. No. 6040306; U.S. Pat. No. 5990120; U.S. Pat. No. 5989869;U.S. Pat. No. 5977082; U.S. Pat. No. 5965739; U.S. Pat. No. 5965563;U.S. Pat. No. 5955617; U.S. Pat. No. 5955466; U.S. Pat. No. 5955319;U.S. Pat. No. 5939100; U.S. Pat. No. 5922750; U.S. Pat. No. 5922728;U.S. Pat. No. 2916897; U.S. Pat. No. 5912263; U.S. Pat. No. 5912183;U.S. Pat. No. 5908846; U.S. Pat. No. 5905149; U.S. Pat. No. 5902788;U.S. Pat. No. 5900435; U.S. Pat. No. 5869514; U.S. Pat. No. 5861318;U.S. Pat. No. 5858999; U.S. Pat. No. 5858363; U.S. Pat. No. 5856333;U.S. Pat. No. 5852195; U.S. Pat. No. 5849710; U.S. Pat. No. 5847148;U.S. Pat. No. 5840899; U.S. Pat. No. 5840745; U.S. Pat. No. 5821363;U.S. Pat. No. 5801167; U.S. Pat. No. 5798097; U.S. Pat. No. 5795986;U.S. Pat. No. 5786190; U.S. Pat. No. 5777104; U.S. Pat. No. 5776947;U.S. Pat. No. 5776458; U.S. Pat. No. 5773522; U.S. Pat. No. 5767282;U.S. Pat. No. 5759852; U.S. Pat. No. 5753629; U.S. Pat. No. 5739350;U.S. Pat. No. 5736515; U.S. Pat. No. 5728713; U.S. Pat. No. 5719265;U.S. Pat. No. 5719177; U.S. Pat. No. 5719159; U.S. Pat. No. 5719135;U.S. Pat. No. 5716823; U.S. Pat. No. 5712300; U.S. Pat. No. 5712260;U.S. Pat. No. 5703075; U.S. Pat. No. 5700788; U.S. Pat. No. 5695966;U.S. Pat. No. 5691350; U.S. Pat. No. 5686486; U.S. Pat. No. 5674693;U.S. Pat. No. 5663346; U.S. Pat. No. 5652250; U.S. Pat. No. 5652125;U.S. Pat. No. 6528515; U.S. Pat. No. 6410546; U.S. Pat. No. 6188988;U.S. Pat. No. 6081786; U.S. Pat. No. 6544417; U.S. Pat. No. 6531477;U.S. Pat. No. RE7781; U.S. Pat. No. 6322770; U.S. Pat. No. 6319937; U.S.Pat. No. 6313124; U.S. Pat. No. 6303609; U.S. Pat. No. 6291504; U.S.Pat. No. 6281352; U.S. Pat. No. 6271380; U.S. Pat. No. 6268379; U.S.Pat. No. 6265400; U.S. Pat. No. 6254852; U.S. Pat. No. 6251364; U.S.Pat. No. 6245937; U.S. Pat. No. 6245769; U.S. Pat. No. 6241962; U.S.Pat. No. 6214851; U.S. Pat. No. 6214834; U.S. Pat. No. 6191131; U.S.Pat. No. 6185453; U.S. Pat. No. 6174912; U.S. Pat. No. 6153628; U.S.Pat. No. 6143743; U.S. Pat. No. 6136809; U.S. Pat. No. 6130231; U.S.Pat. No. 6124289; U.S. Pat. No. 6114328; U.S. Pat. No. 6110910; U.S.Pat. No. 6103737; U.S. Pat. No. 6060478; U.S. Pat. No. 6056958; U.S.Pat. No. 6022523; U.S. Pat. No. 6004955; U.S. Pat. No. 5912348; U.S.Pat. No. 5888970; U.S. Pat. No. 5879659; U.S. Pat. No. 5874441; U.S.Pat. No. 6541020; U.S. Pat. No. 6518013; U.S. Pat. No. 6479055; U.S.Pat. No. 6348568; U.S. Pat. No. 6258782; U.S. Pat. No. 6228983; U.S.Pat. No. 6093794; U.S. Pat. No. 6068973; U.S. Pat. No. 6060065; U.S.Pat. No. 6054265; U.S. Pat. No. 6017536; U.S. Pat. No. 6013263; U.S.Pat. No. 6548663; U.S. Pat. No. 6548047; U.S. Pat. No. 6544981; U.S.Pat. No. 6541242; U.S. Pat. No. 6538103; U.S. Pat. No. 6537988; U.S.Pat. No. 6537520; U.S. Pat. No. 6534038; U.S. Pat. No. 6528283; U.S.Pat. No. 6525203; U.S. Pat. No. 6525069; U.S. Pat. No. 6525056; U.S.Pat. No. 6525044; U.S. Pat. No. 6524554; U.S. Pat. No. 6524553; U.S.Pat. No. 6521814; U.S. Pat. No. 6521759; U.S. Pat. No. 6521592; U.S.Pat. No. 6521436; U.S. Pat. No. 6521211; U.S. Pat. No. 6518421; U.S.Pat. No. 6518292; U.S. Pat. No. 6518271; U.S. Pat. No. 6518052; U.S.Pat. No. 6517814; U.S. Pat. No. 6515136; U.S. Pat. No. 6515117; U.S.Pat. No. 6515004; U.S. Pat. No. 6511973; U.S. Pat. No. 6511648; U.S.Pat. No. 6509333; U.S. Pat. No. 6503898; U.S. Pat. No. 6498257; U.S.Pat. No. 6495565; U.S. Pat. No. 6495548; U.S. Pat. No. 6492400; U.S.Pat. No. 6486180; U.S. Pat. No. 6482919; U.S. Pat. No. 6482842; U.S.Pat. No. 6479034; U.S. Pat. No. 6476242; U.S. Pat. No. 6476226; U.S.Pat. No. 6476034; U.S. Pat. No. 6472510; U.S. Pat. No. 6469024; U.S.Pat. No. 6469006; U.S. Pat. No. 6465424; U.S. Pat. No. 6458943; U.S.Pat. No. 6458835; U.S. Pat. No. 6458783; U.S. Pat. No. 6455575; U.S.Pat. No. 6455523; U.S. Pat. No. 6455522; U.S. Pat. No. 6455024; U.S.Pat. No. 6451575; U.S. Pat. No. 6448264; U.S. Pat. No. 6441001; U.S.Pat. No. 6436930; U.S. Pat. No. 6433198; U.S. Pat. No. 6432944; U.S.Pat. No. 6416740; U.S. Pat. No. 6416733; U.S. Pat. No. 6414156; U.S.Pat. No. 6414126; U.S. Pat. No. 6414014; U.S. Pat. No. 6414002; U.S.Pat. No. 6413514; U.S. Pat. No. 6407124; U.S. Pat. No. 6407103; U.S.Pat. No. 6403054; U.S. Pat. No. 6399773; U.S. Pat. No. 6399638; U.S.Pat. No. 6395784; U.S. Pat. No. 6392053; U.S. Pat. No. 6391279; U.S.Pat. No. 6387926; U.S. Pat. No. 6380395; U.S. Pat. No. 6380184; U.S.Pat. No. 6376459; U.S. Pat. No. 6365749; U.S. Pat. No. 6362217; U.S.Pat. No. 6362180; U.S. Pat. No. 6358950; U.S. Pat. No. 6348337; U.S.Pat. No. 6344450; U.S. Pat. No. 6335324; U.S. Pat. No. 6333186; U.S.Pat. No. 6331570; U.S. Pat. No. 6326379; U.S. Pat. No. 6320045; U.S.Pat. No. 6319948; U.S. Pat. No. 6316438; U.S. Pat. No. 6313308; U.S.Pat. No. 6312692; U.S. Pat. No. 6307071; U.S. Pat. No. 6297233; U.S.Pat. No. 6291684; U.S. Pat. No. 6271248; U.S. Pat. No. 6271242; U.S.Pat. No. 6268375; U.S. Pat. No. 6268173; U.S. Pat. No. 6262236; U.S.Pat. No. 6262096; U.S. Pat. No. 6262094; U.S. Pat. No. 6251682; U.S.Pat. No. 6242614; U.S. Pat. No. 6239146; U.S. Pat. No. 6239133; U.S.Pat. No. 6235740; U.S. Pat. No. 6228872; U.S. Pat. No. 6218375; U.S.Pat. No. 6215000; U.S. Pat. No. 6214869; U.S. Pat. No. 6214852; U.S.Pat. No. 6214345; U.S. Pat. No. 6210669; U.S. Pat. No. 6201140; U.S.Pat. No. 6194601; U.S. Pat. No. 6184395; U.S. Pat. No. 6184256; U.S.Pat. No. 6183734; U.S. Pat. No. 6180651; U.S. Pat. No. 6162622; U.S.Pat. No. 6156746; U.S. Pat. No. 6143030; U.S. Pat. No. 6136336; U.S.Pat. No. 6132992; U.S. Pat. No. 6132722; U.S. Pat. No. 6107305; U.S.Pat. No. 6096762; U.S. Pat. No. 6090914; U.S. Pat. No. 6087368; U.S.Pat. No. 6083902; U.S. Pat. No. 6083713; U.S. Pat. No. 6080774; U.S.Pat. No. 6077507; U.S. Pat. No. 6060506; U.S. Pat. No. 6051228; U.S.Pat. No. 6048966; U.S. Pat. No. 6046314; U.S. Pat. No. 6043265; U.S.Pat. No. 6040321; U.S. Pat. No. 6028112; U.S. Pat. No. 6020507; U.S.Pat. No. 6020145; U.S. Pat. No. 6019988; U.S. Pat. No. 6017935; U.S.Pat. No. 6011029; U.S. Pat. No. 6008347; U.S. Pat. No. 6008251; U.S.Pat. No. 5998172; U.S. Pat. No. 5993800; U.S. Pat. No. 5990109; U.S.Pat. No. 5981571; U.S. Pat. No. 5981218; U.S. Pat. No. 5980896; U.S.Pat. No. 5977386; U.S. Pat. No. 5968768; U.S. Pat. No. 5968510; U.S.Pat. No. 5965723; U.S. Pat. No. 5962420; U.S. Pat. No. 5962026; U.S.Pat. No. 5958442; U.S. Pat. No. 5948817; U.S. Pat. No. 5945561; U.S.Pat. No. 5945513; U.S. Pat. No. 5939446; U.S. Pat. No. 5932447; U.S.Pat. No. 5922596; U.S. Pat. No. 5919671; U.S. Pat. No. 5919650; U.S.Pat. No. 5916560; U.S. Pat. No. 5912264; U.S. Pat. No. 5908934; U.S.Pat. No. 5907033; U.S. Pat. No. 5902822; U.S. Pat. No. 5889031; U.S.Pat. No. 5886149; U.S. Pat. No. 5885961; U.S. Pat. No. 5885796; U.S.Pat. No. 5879929; U.S. Pat. No. 5877282; U.S. Pat. No. 5877210; U.S.Pat. No. 5876950; U.S. Pat. No. 5876718; U.S. Pat. No. 5874536; U.S.Pat. No. 5872214; U.S. Pat. No. 5869045; U.S. Pat. No. 5861151; U.S.Pat. No. 5856529; U.S. Pat. No. 5856507; U.S. Pat. No. 5854392; U.S.Pat. No. 5851795; U.S. Pat. No. 5849923; U.S. Pat. No. 5849733; U.S.Pat. No. 5846998; U.S. Pat. No. 5846990; U.S. Pat. No. 5846985; U.S.Pat. No. 5844095; U.S. Pat. No. 5844085; U.S. Pat. No. 5840929; U.S.Pat. No. 5840854; U.S. Pat. No. 5840673; U.S. Pat. No. 5830995; U.S.Pat. No. 5827869; U.S. Pat. No. 5821263; U.S. Pat. No. 5814307; U.S.Pat. No. 5811440; U.S. Pat. No. 5811098; U.S. Pat. No. 5808151; U.S.Pat. No. 5807734; U.S. Pat. No. 5804428; U.S. Pat. No. 5801152; U.S.Pat. No. 5795572; U.S. Pat. No. 5792456; U.S. Pat. No. 5780473; U.S.Pat. No. 5780470; U.S. Pat. No. 5773464; U.S. Pat. No. 5773461; U.S.Pat. No. 5773435; U.S. Pat. No. 5773418; U.S. Pat. No. 5773253; U.S.Pat. No. 5770197; U.S. Pat. No. 5770194; U.S. Pat. No. 5763411; U.S.Pat. No. 5763410; U.S. Pat. No. 5760084; U.S. Pat. No. 5760038; U.S.Pat. No. 5753709; U.S. Pat. No. 5705657; U.S. Pat. No. 5747037; U.S.Pat. No. 5739288; U.S. Pat. No. 5736578; U.S. Pat. No. 5736536; U.S.Pat. No. 5728821; U.S. Pat. No. 5723437; U.S. Pat. No. 5719132; U.S.Pat. No. 5708146; U.S. Pat. No. 5703129; U.S. Pat. No. 5693666; U.S.Pat. No. 5693627; U.S. Pat. No. 5688926; U.S. Pat. No. 5688781; U.S.Pat. No. 5681930; U.S. Pat. No. 5677328; U.S. Pat. No. 5667989; U.S.Pat. No. 5667987; U.S. Pat. No. 5665761; U.S. Pat. No. 5661186; U.S.Pat. No. 5661185; U.S. Pat. No. 6168784.

[0179] U.S. Patent Application Publication 20030069298; U.S. PatentApplication Publication 20030045565; U.S. Patent Application Publication20030013739; U.S. Patent Application Publication 20020169191; U.S.Patent Application Publication 20020136784; U.S. Patent ApplicationPublication 20020122836; U.S. Patent Application Publication20030036661; U.S. Patent Application Publication 20020106727; U.S.Patent Application Publication 20020031510; U.S. Patent ApplicationPublication 20020012989; U.S. Patent Application Publication20020137769; U.S. Patent Application Publication 20020111491; U.S.Patent Application Publication 20030060615; U.S. Patent ApplicationPublication 20030023061; U.S. Patent Application Publication20020168342; U.S. Patent Application Publication 20030055239; U.S.Patent Application Publication 20030032789; U.S. Patent ApplicationPublication 20030032160; U.S. Patent Application Publication20030027825; U.S. Patent Application Publication 20020136744; U.S.Patent Application Publication 20020045605; U.S. Patent ApplicationPublication 20020045594; U.S. Patent Application Publication20020037888; U.S. Patent Application Publication 20010041702; U.S.Patent Application Publication 20020151485; U.S. Patent ApplicationPublication 20030052839.

[0180] Transplantation Section: U.S. Pat. No. 6462081; U.S. Pat. No.6358960; U.S. Pat. No. 6262293; U.S. Pat. No. 6235780; U.S. Pat. No.6228866; U.S. Pat. No. 6110969; U.S. Pat. No. 6110930; U.S. Pat. No.6043275; U.S. Pat. No. 5892099; U.S. Pat. No. 5756084; U.S. Pat. No.5563048; U.S. Pat. No. 6458934; U.S. Pat. No. 6191342; U.S. Pat. No.5928893; U.S. Pat. No. 6534058; U.S. Pat. No. 6441135; U.S. Pat. No.6433155; U.S. Pat. No. 6129916; U.S. Pat. No. 5872222; U.S. Pat. No.5614611; U.S. Pat. No. 5543144; U.S. Pat. No. 6211247; U.S. Pat. No.6022901; U.S. Pat. No. 6544771; U.S. Pat. No. 6514752; U.S. Pat. No.6506604; U.S. Pat. No. 6432700; U.S. Pat. No. 6428953; U.S. Pat. No.6407221; U.S. Pat. No. 6406861; U.S. Pat. No. 6319905; U.S. Pat. No.6319494; U.S. Pat. No. 6218187; U.S. Pat. No. 6165782; U.S. Pat. No.6140111; U.S. Pat. No. 6139835; U.S. Pat. No. 6077947; U.S. Pat. No.6051427; U.S. Pat. No. 5994136; U.S. Pat. No. 5837544; U.S. Pat. No.5741899; U.S. Pat. No. 5712149; U.S. Pat. No. 5686281; U.S. Pat. No.5670148; U.S. Pat. No. 5574205; U.S. Pat. No. 6545023; U.S. Pat. No.6538112; U.S. Pat. No. 6538002; U.S. Pat. No. 6531484; U.S. Pat. No.6525025; U.S. Pat. No. 6511994; U.S. Pat. No. 6506777; U.S. Pat. No.6500844; U.S. Pat. No. 6498165; U.S. Pat. No. 6498161; U.S. Pat. No.6489354; U.S. Pat. No. 6482840; U.S. Pat. No. 6476054; U.S. Pat. No.6472410; U.S. Pat. No. 6455548; U.S. Pat. No. 6444811; U.S. Pat. No.6437165; U.S. Pat. No. 6432981; U.S. Pat. No. 6420418; U.S. Pat. No.6403584; U.S. Pat. No. 6399619; U.S. Pat. No. 6372764; U.S. Pat. No.6372733; U.S. Pat. No. 6362201; U.S. Pat. No. 6358979; U.S. Pat. No.6353099; U.S. Pat. No. 6329380; U.S. Pat. No. 6316444; U.S. Pat. No.6303637; U.S. Pat. No. 6303593; U.S. Pat. No. 6291511; U.S. Pat. No.6280760; U.S. Pat. No. 6271252; U.S. Pat. No. 6265434; U.S. Pat. No.6248755; U.S. Pat. No. 6221888; U.S. Pat. No. 6210904; U.S. Pat. No.6194458; U.S. Pat. No. 6191171; U.S. Pat. No. 6166159; U.S. Pat. No.6166037; U.S. Pat. No. 6147053; U.S. Pat. No. 6140349; U.S. Pat. No.6136827; U.S. Pat. No. 6124319; U.S. Pat. No. 6118043; U.S. Pat. No.6110701; U.S. Pat. No. 6103513; U.S. Pat. No. 6100293; U.S. Pat. No.6090841; U.S. Pat. No. 6083980; U.S. Pat. No. 6069163; U.S. Pat. No.6051590; U.S. Pat. No. 6043358; U.S. Pat. No. 6022890; U.S. Pat. No.6020347; U.S. Pat. No. 6013644; U.S. Pat. No. 5998408; U.S. Pat. No.5972975; U.S. Pat. No. 5962462; U.S. Pat. No. 5958723; U.S. Pat. No.5952371; U.S. Pat. No. 5919776; U.S. Pat. No. 5908842; U.S. Pat. No.5902577; U.S. Pat. No. 5885960; U.S. Pat. No. 5883119; U.S. Pat. No.5880280; U.S. Pat. No. 5877184; U.S. Pat. No. 5874594; U.S. Pat. No.5861297; U.S. Pat. No. 5849736; U.S. Pat. No. 5837220; U.S. Pat. No.5821261; U.S. Pat. No. 5811441; U.S. Pat. No. 5798442; U.S. Pat. No.5798229; U.S. Pat. No. 5795904; U.S. Pat. No. 5777105; U.S. Pat. No.5763478; U.S. Pat. No. 5760180; U.S. Pat. No. 5760029; U.S. Pat. No.5760028; U.S. Pat. No. 5728808; U.S. Pat. No. 5710159; U.S. Pat. No.5707844; U.S. Pat. No. 5700839; U.S. Pat. No. 5696156; U.S. Pat. No.5696119; U.S. Pat. No. 5693648; U.S. Pat. No. 5679705; U.S. Pat. No.5670504; U.S. Pat. No. 5668159; U.S. Pat. No. 5639759; U.S. Pat. No.5631282; U.S. Pat. No. 5629322; U.S. Pat. No. 5616571; U.S. Pat. No.5578609; U.S. Pat. No. 5565560; U.S. Pat. No. 5558864; U.S. Pat. No.6365583; U.S. Pat. No. 6051596; U.S. Pat. No. 6537990; U.S. Pat. No.6482920; U.S. Pat. No. 6458768; U.S. Pat. No. 6403563; U.S. Pat. No.6368481; U.S. Pat. No. 6291509; U.S. Pat. No. 6253771; U.S. Pat. No.6177408; U.S. Pat. No. 6165980; U.S. Pat. No. 6153642; U.S. Pat. No.6071947; U.S. Pat. No. 5880098; U.S. Pat. No. 5821363; U.S. Pat. No.5798097; U.S. Pat. No. 5776947; U.S. Pat. No. 5759784; U.S. Pat. No.5753629; U.S. Pat. No. 5728713; U.S. Pat. No. 5703071; U.S. Pat. No.5691334; U.S. Pat. No. 5646118; U.S. Pat. No. 5594005; U.S. Pat. No.5556855; U.S. Pat. No. 5549669; U.S. Pat. No. 5504092; U.S. Pat. No.6319937; U.S. Pat. No. 6306886; U.S. Pat. No. 6303609; U.S. Pat. No.6265400; U.S. Pat. No. 6214834; U.S. Pat. No. 6185453; U.S. Pat. No.6153628; U.S. Pat. No. 6130231; U.S. Pat. No. 6114328; U.S. Pat. No.6110910; U.S. Pat. No. 6004955; U.S. Pat. No. 5874441; U.S. Pat. No.6544981; U.S. Pat. No. 6525069; U.S. Pat. No. 6521759; U.S. Pat. No.6521592; U.S. Pat. No. 6515136; U.S. Pat. No. 6515004; U.S. Pat. No.6511973; U.S. Pat. No. 6492400; U.S. Pat. No. 6486180; U.S. Pat. No.6482919; U.S. Pat. No. 6482842; U.S. Pat. No. 6476226; U.S. Pat. No.6469024; U.S. Pat. No. 6455024; U.S. Pat. No. 6448264; U.S. Pat. No.6441001; U.S. Pat. No. 6436930; U.S. Pat. No. 6413514; U.S. Pat. No.6407124; U.S. Pat. No. 6399773; U.S. Pat. No. 6395767; U.S. Pat. No.6372215; U.S. Pat. No. 6344450; U.S. Pat. No. 6313308; U.S. Pat. No.6312692; U.S. Pat. No. 6297233; U.S. Pat. No. 6271248; U.S. Pat. No.6262096; U.S. Pat. No. 6239133; U.S. Pat. No. 6235740; U.S. Pat. No.6214852; U.S. Pat. No. 6210669; U.S. Pat. No. 6183734; U.S. Pat. No.6160134; U.S. Pat. No. 6132992; U.S. Pat. No. 6107320; U.S. Pat. No.6107305; U.S. Pat. No. 6090914; U.S. Pat. No. 6083713; U.S. Pat. No.6080774; U.S. Pat. No. 6051228; U.S. Pat. No. 6043265; U.S. Pat. No.6040321; U.S. Pat. No. 6020145; U.S. Pat. No. 6011059; U.S. Pat. No.5998172; U.S. Pat. No. 5993800; U.S. Pat. No. 5990109; U.S. Pat. No.5980896; U.S. Pat. No. 5968768; U.S. Pat. No. 5968510; U.S. Pat. No.5962415; U.S. Pat. No. 5939446; U.S. Pat. No. 5916560; U.S. Pat. No.5885796; U.S. Pat. No. 5877210; U.S. Pat. No. 5876718; U.S. Pat. No.5874100; U.S. Pat. No. 5869045; U.S. Pat. No. 5856507; U.S. Pat. No.5854392; U.S. Pat. No. 5851795; U.S. Pat. No. 5846998; U.S. Pat. No.5846990; U.S. Pat. No. 5846985; U.S. Pat. No. 5844095; U.S. Pat. No.5827869; U.S. Pat. No. 5814307; U.S. Pat. No. 5795780; U.S. Pat. No.5795571; U.S. Pat. No. 5780473; U.S. Pat. No. 5773253; U.S. Pat. No.5770197; U.S. Pat. No. 5760038; U.S. Pat. No. 5747037; U.S. Pat. No.5723437; U.S. Pat. No. 5709859; U.S. Pat. No. 5693627; U.S. Pat. No.5637481; U.S. Pat. No. 5612359; U.S. Pat. No. 5583242; U.S. Pat. No.5580756; U.S. Pat. No. 5565491; U.S. Pat. No. 5521288; U.S. Pat. No.5514696; U.S. Pat. No. 6465016.

[0181] U.S. Patent Application Publication 20030060615; U.S. PatentApplication Publication 20030023061; U.S. Patent Application Publication20030008837; U.S. Patent Application Publication 20020081293; U.S.Patent Application Publication 20020173030; U.S. Patent ApplicationPublication 20020019360; U.S. Patent Application Publication20030004191; U.S. Patent Application Publication 20020031510; U.S.Patent Application Publication 20020012989.

1. A method of inhibiting the first-pass effect of a material takenorally by a patient which is subject to the first-pass effect,comprising the step of co-administering to said patient said materialand a compound comprising one of the following cores:

wherein said material is selected from the group consisting of:amprenavir saquinavir tipranavir VX-950 VX-702 VX-175 VX-385 BILN 2061ONO-4128 paclitaxel TMC114 docetaxel HCV-371, and VP
 50406. 2. Acomposition comprising a material and a compound comprising one of thefollowing cores:

wherein said material is selected from the group consisting of:amprenavir saquinavir tipranavir VX-950 VX-702 VX-175 VX-385 BILN 2061ONO-4128 paclitaxel TMC114 docetaxel HCV-371, and VP 50406.